KEGG   ENZYME: 4.1.3.32
Entry
EC 4.1.3.32                 Enzyme                                 

Name
2,3-dimethylmalate lyase;
2,3-dimethylmalate pyruvate-lyase;
(2R,3S)-2,3-dimethylmalate pyruvate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)
Reaction(IUBMB)
(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate [RN:R01355]
Reaction(KEGG)
R01355
Substrate
(2R,3S)-2,3-dimethylmalate [CPD:C03652]
Product
propanoate [CPD:C00163];
pyruvate [CPD:C00022]
History
EC 4.1.3.32 created 1981
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20454  2,3-dimethylmalate lyase
Genes
GQU: AWC35_01530
FHA: CDV26_05960
HCO: LOKO_02505
HCAM: I4484_05190
CPAU: EHF44_18850
PEW: KZJ38_30925
BPAR: BN117_0676(bcpA)
BBH: BN112_2717(bcpA)
BBR: BB0718(bcpA)
BBX: BBS798_0696(bcpA)
ODI: ODI_R0009
LIH: L63ED372_02665(dml_2)
UPL: DSM104440_01949(dml)
DFL: DFE_2439
DTO: TOL2_C32170(prpB)
RID: RIdsm_00986(dml_3)
SHUM: STHU_28130(bcpA_2)
SVC: STVA_27150(bcpA_2)
EFF: skT53_09420(bcpA)
SAY: TPY_1957(prpB)
GEK: kuro4_04500(bcpA)
TAE: TepiRe1_0449(Dml)
STED: SPTER_39090(dml)
MTY: MTOK_12610(prpB)
MMAR: MODMU_4056
PDX: Psed_4635
PSEA: WY02_01050
PSEE: FRP1_09770
PAUT: Pdca_36590(bcpA)
AIH: Aiant_14510(prpB)
SDYN: Mal52_03470(dml)
PLON: Pla110_27420(dml)
TLI: Tlie_1837
 » show all
Reference
1  [PMID:527937]
  Authors
Pirzer P, Lill U, Eggerer H.
  Title
Nicotinic acid metabolism. 2,3-Dimethylmalate lyase.
  Journal
Hoppe Seylers Z Physiol Chem 360:1693-702 (1979)
DOI:10.1515/bchm2.1979.360.2.1693
  Sequence
Reference
2  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.32
IUBMB Enzyme Nomenclature: 4.1.3.32
ExPASy - ENZYME nomenclature database: 4.1.3.32
BRENDA, the Enzyme Database: 4.1.3.32
CAS: 73562-28-4

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