KEGG   ENZYME: 4.1.3.32
Entry
EC 4.1.3.32                 Enzyme                                 
Name
2,3-dimethylmalate lyase;
2,3-dimethylmalate pyruvate-lyase;
(2R,3S)-2,3-dimethylmalate pyruvate-lyase
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
(2R,3S)-2,3-dimethylmalate pyruvate-lyase (propanoate-forming)
Reaction(IUBMB)
(2R,3S)-2,3-dimethylmalate = propanoate + pyruvate [RN:R01355]
Reaction(KEGG)
R01355
Substrate
(2R,3S)-2,3-dimethylmalate [CPD:C03652]
Product
propanoate [CPD:C00163];
pyruvate [CPD:C00022]
History
EC 4.1.3.32 created 1981
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20454  2,3-dimethylmalate lyase
Genes
GQUAWC35_01530
SLIGGTU79_03990
FHACDV26_05960
HCOLOKO_02505
HCAMI4484_05190
CPAUEHF44_18850
PEWKZJ38_30925
BPARBN117_0676(bcpA)
BBHBN112_2717(bcpA)
BBRBB0718(bcpA)
BBXBBS798_0696(bcpA)
ODIODI_R0009
BOZDBV39_03915
PARKLSG25_18010 LSG25_18815
ACKC380_20060
LIHL63ED372_02665(dml_2)
UPLDSM104440_01949(dml)
DFLDFE_2439
DTOTOL2_C32170(prpB)
DMMdnm_064600
NANNO0S08_05205
ORMHTY61_08845
KMNHW532_10930
ARUIG6M88_20685
AVQHRR99_16285
NEOCYG48_16600
RIDRIdsm_00986(dml_3)
PARUCYR75_10275
PSHQF3W81_11580
PARJJ4G78_07830
RAPRHOA_3844(Dml)
SHUMSTHU_28130(bcpA_2)
SVCSTVA_27150(bcpA_2)
STELSTAQ_38210(bcpA_2)
ABSAZOBR_p330056
ABQABAZ39_28815
AZTTSH58p_31825
EFFskT53_09420(bcpA)
CAHCAETHG_2513
ACOLK5I23_11355
LASAL9O85_02780 L9O85_04450
CASPNQ535_09980
DORDesor_0458
DGIDesgi_2645
ACAEHYG86_14530
SAYTPY_1957(prpB)
SAPSulac_2154
GEKkuro4_04500(bcpA)
TEPTepRe1_0405
TAETepiRe1_0449(Dml)
NTHNther_2154
STEDSPTER_39090(dml)
MTYMTOK_12610(prpB)
RAVAAT18_21745
RKOJWS14_17170
DIZCT688_06965
SBATG4Z16_31580
MUZH4N58_12845
BSDBLASA_3403
MMARMODMU_4056
AMQAMETH_3328
AACDLWP59_10150 LWP59_17900
ATHML1857_19500
PDXPsed_4635
PSEAWY02_01050
PSEEFRP1_09770
PSEQAD006_17330
PECQAD017_25165
PAUTPdca_36590(bcpA)
PBROHOP40_34515
PPELH6H00_31555
AIHAiant_14510(prpB)
RMARGBA65_08220
SBAEDSM104329_05580(dml_2)
AFLOHEQ12_05420
KBSEPA93_17300
SDYNMal52_03470(dml)
PLONPla110_27420(dml)
ACOAmico_1318
TLITlie_1837
AMOAnamo_1755
PPIOCE91St28_16560
SRUBC2R22_03360
SCASSACC_14220
SULABFU36_12520
SULEGFS03_03475
SULOGFS33_07745
SULLEWF20_07395
MEMJMJ1HA_1418
MHKDFR87_12740
MPRUDFR88_00255
MJNMjAS7_2235
NCLC5F47_01365
NOXC5F49_01340
NUEC5F50_01645
NICDSQ20_01510
 » show all
Reference
1  [PMID:527937]
  Authors
Pirzer P, Lill U, Eggerer H.
  Title
Nicotinic acid metabolism. 2,3-Dimethylmalate lyase.
  Journal
Hoppe Seylers Z Physiol Chem 360:1693-702 (1979)
DOI:10.1515/bchm2.1979.360.2.1693
  Sequence
Reference
2  [PMID:16894175]
  Authors
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ.
  Title
Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri.
  Journal
Proc Natl Acad Sci U S A 103:12341-6 (2006)
DOI:10.1073/pnas.0601635103
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.32
IUBMB Enzyme Nomenclature: 4.1.3.32
ExPASy - ENZYME nomenclature database: 4.1.3.32
BRENDA, the Enzyme Database: 4.1.3.32
CAS: 73562-28-4

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