KEGG   ENZYME: 4.2.1.149
Entry
EC 4.2.1.149                Enzyme                                 
Name
crotonobetainyl-CoA hydratase;
CaiD;
L-carnityl-CoA dehydratase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming]
Reaction(IUBMB)
L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O [RN:R10675]
Reaction(KEGG)
R10675
Substrate
L-carnitinyl-CoA [CPD:C20750]
Product
(E)-4-(trimethylammonio)but-2-enoyl-CoA [CPD:C20748];
H2O [CPD:C00001]
Comment
The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].
History
EC 4.2.1.149 created 2014
Orthology
K08299  crotonobetainyl-CoA hydratase
Genes
ECOb0036(caiD)
ECJJW0035(caiD)
ECDECDH10B_0037(caiD)
EBWBWG_0034(caiD)
ECOKECMDS42_0029(caiD)
ECEZ0042(caiD)
ECSECs_0039(caiD)
ECFECH74115_0040(caiD)
ETWECSP_0039(caiD)
ELXCDCO157_0038
EOIECO111_0037(caiD)
EOJECO26_0037(caiD)
EOHECO103_0038(caiD)
ECOOECRM13514_0037(caiD)
ECOHECRM13516_0039(caiD)
ESLO3K_21365
ESOO3O_04020
ESMO3M_21265
ECKEC55989_0036(caiD)
ECGE2348C_0037(caiD)
EOKG2583_0038(caiD)
ELRECO55CA74_00180
ELHETEC_0036
ECWEcE24377A_0038(caiD)
EUNUMNK88_36
ECPECP_0036
ENAECNA114_0023(caiD)
ECOSEC958_0170(caiD)
ECVAPECO1_1945(caiD)
ECOAAPECO78_03640
ECXEcHS_A0040(caiD)
ECMEcSMS35_0037(caiD)
ECYECSE_0037
ECRECIAI1_0038(caiD)
ECQECED1_0035(caiD)
EUMECUMN_0038(caiD)
ECTECIAI39_0037(caiD)
EOCCE10_0037(caiD)
EBRECB_00040(caiD)
EBLECD_00040(caiD)
EBEB21_00039(caiD)
EBDECBD_3579
ECIUTI89_C0042(caiD)
EIHECOK1_0035(caiD)
ECZECS88_0039(caiD)
ECCc0045(caiD)
ELOEC042_0038(caiD)
ELNNRG857_00190
ESEECSF_0041
ECLEcolC_3619
EKOEKO11_3876
EKFKO11_00180(caiD)
EABECABU_c00410(caiD)
EDHEcDH1_3563
EDJECDH1ME8569_0035(caiD)
ELUUM146_22960
ELWECW_m0036(caiD)
ELLWFL_00180(caiD)
ELCi14_0038(caiD)
ELDi02_0038(caiD)
ELPP12B_c0031(caiD)
ELFLF82_0260(caiD)
ECOLLY180_00185
ECOIECOPMV1_00037(caiD_1)
ECOJP423_00180
EFEEFER_0044(caiD)
EALEAKF1_ch1386(caiD)
EMAC1192_12795
ESZFEM44_14675(caiD)
STYSTY0080(caiD)
STTt0071(caiD)
SEXSTBHUCCB_810
SENTTY21A_00365
STMSTM0070(caiD)
SEOSTM14_0083(caiD)
SEVSTMMW_00721
SEYSL1344_0071(caiD)
SEMSTMDT12_C00710
SEJSTMUK_0071(caiD)
SEBSTM474_0073(caiD)
SEFUMN798_0078(caiD)
SETUSTU288_00350
SETCCFSAN001921_17070
SENRSTMDT2_00711(caiD)
SENDDT104_00711(caiD)
SENICY43_00345
SEENSE451236_06360
SPTSPA0071(caiD)
SEKSSPA0067
SPQSPAB_00086
SEISPC_0075(caiD)
SECSCH_0064(caiD)
SEHSeHA_C0074
SHBSU5_0705
SENHCFSAN002069_08880
SEEHSEEH1578_09380
SEESNSL254_A0074
SENNSN31241_10490
SEWSeSA_A0078
SEASeAg_B0077
SENSQ786_00345
SEDSeD_A0076
SEGSG0073(caiD)
SELSPUL_0075(caiD)
SEGASPUCDC_0075(caiD)
SETSEN0071(caiD)
SENAAU38_00345
SENOAU37_00345
SENVAU39_00345
SENQAU40_00380
SENLIY59_00360
SENJCFSAN001992_10675
SEECCFSAN002050_06800
SEEBSEEB0189_019035
SEEPI137_00325
SENBBN855_730(caiD)
SENEIA1_00355
SENCSEET0819_07240
SESSARI_02930
SBGSBG_0055(caiD)
SBZA464_58
SBVN643_00265
SALZEOS98_18890
SFLSF0033(caiD)
SFXS0035(caiD)
SFVSFV_0030(caiD)
SFESFxv_0034(caiD)
SFNSFy_0042
SFSSFyv_0046
SFTNCTC1_00033(caiD)
SSNSSON_0042(caiD)
SDYSDY_0058(caiD)
SDZAsd1617_00063
SHQA0259_04020
CROROD_00381(caiD)
CKOCKO_03347
CFDCFNIH1_09890
CBRAA6J81_13220
CWECO701_18230
CYOCD187_20370
CPOTFOB25_07465(caiD)
CFQC2U38_03510
CSEDJY391_18155(caiD)
CAMAF384_00195
CAFAL524_22270
CIFAL515_04985
CFARCI104_04635
CIRC2U53_04695
CIEAN232_00010
CPARCUC49_00175
CTELGBC03_25660(caiD)
CITZE4Z61_13405(caiD)
CARSE1B03_04725(caiD)
EBTEBL_c33170(caiD)
ESCEntcl_2478
KLEAO703_09845
METYMRY16398_47870(caiD)
ASUBNLZ15_03185(caiD)
YREHEC60_04850(caiD)
KINAB182_21550
PDZHHA33_24115(caiD)
PSGCG163CM_28670(caiD)
EBFD782_3833
EBCC2U52_03245
PMRPMI2658(caiD)
PMIBBB2000_2649(caiD)
PVLAOB99_14525
PVGCRN77_06400
PHAUPH4a_04765
PROTBTA34_14505
PCOLF1325_16720(caiD)
PCIBF9282_17065(caiD)
PPEEI6G31_11885(caiD)
PRGRB151_007330(caiD)
PHEINCTC12003_00741(caiD)
PRQCYG50_11980(caiD)
EICNT01EI_2956
ETRETAE_2660(caiD)
ETDETAF_2398
ETEETEE_0761
ETCETAC_12780
EDWQY76_07195
EDLAAZ33_14070(caiD)
EHOA9798_03970
HAVAT03_19285
HPARAL518_07310
OPODSM2777_06100
LPVHYN51_05060
PRAGEKN56_12475(caiD)
LRINCTC12151_02501(caiD)
SLOShew_2672
SSESsed_3225
SPLSpea_4034
SHLShal_0224
SWPswp_4934
SALGBS332_05375
SLJEGC82_18060
SCAATUM17387_35790(caiD)
NAXHC341_11765(caiD)
GAIIMCC3135_12755(caiD)
BCHBcen2424_0177
BXEBxe_C0322
VEIVeis_3503
CRXCRECT_1855(caiD)
PAUUE8A73_006725
MLOmlr5044
MLNA9174_02185
MCIMesci_0427
MOPMesop_0439
MAMMesau_00647
MAMOA6B35_06080
MESWA9K65_002145
MESMEJ066_09365
MESPC1M53_02975
MHUAMCHK_6109(caiD)
MJREB229_02220
MERDEB233_02335
MESRFGU64_17225(caiD)
MOHIHQ72_01600(caiD)
MESOBSQ44_22625
HOEIMCC20628_02948
AAKAA2016_1883
AMIHCO731_02018(caiD)
PHTBLM14_08020
PHYLHB779_13100(caiD)
NIYFQ775_14120(caiD)
KMNHW532_09375(caiD)
SMESMc01641(caiD)
SMKSinme_2233
SMQSinmeB_2077
SMXSM11_chr1006(caiD)
SMIBN406_02077(caiD)
SMEGC770_GR4Chr2312
SMELSM2011_c01641(caiD)
SMERDU99_12620
SMDSmed_2177
RHINGR_c21610
SFHSFHH103_02057(caiD)
SFDUSDA257_c45520(caiD)
SIXBSY16_546
SAMESAMCFNEI73_Ch2523(caiD)
SINOSS05631_c23110
EADOV14_3675
EAHFA04_11405
ESJSJ05684_c23160
EAKEKH55_2240
EMXFKV68_14635(caiD)
ARAArad_9264
RETRHE_PC00129
RELREMIM1_PB00143(caiD)
REPIE4803_PD00564(caiD)
REIIE4771_PE00579(caiD)
RLEpRL100378 pRL110025(caiD)
RLTRleg2_4496
RLGRleg_6427
RLBRLEG3_02200
RLURLEG12_05430
RTRRTCIAT899_PC04720
RGARGR602_PC01930(caiD)
RHNAMJ98_PB00186(caiD)
RPHAAMC79_PA00228(caiD)
RHXAMK02_PB00200(caiD)
RHKKim5_PD00537(caiD)
REZAMJ99_PA00186(caiD)
RJGCCGE525_28950
RHRCKA34_20740
RADCO657_34200
RIIFFM53_035785(caiD)
RHIDFFM81_022455(caiD)
RBQJ2J99_26490(caiD)
RLNJ0663_29190(caiD)
RBANJ2J98_28810(caiD)
RRGJ3P73_33665(caiD)
RLSHB780_06655(caiD)
RAWNE851_06410
RSULN2599_20995
NENNCHU2750_44880(caiD)
SHZshn_12110
SZOK8M09_10840(caiD)
SOJK6301_09590(caiD)
OINIAR37_19850(caiD) IAR37_19855(caiD)
BICLMTR13_25655
NOHG5V57_30520(caiD)
LAPACP90_08775
LABRCHH27_11740
LABPFJ695_03415(caiD)
LABTFIU93_14330(caiD1)
LAGGB0E33_20850
SILSPO2706(caiD-1) SPOA0285(caiD-2)
SITTM1040_2793
RUAD1823_20420
RUTFIU92_19795(caiD3)
JANJann_3750 Jann_3824
RDERD1_0613(caiD)
RLIRLO149_c000760(caiD)
RPONG3256_17965(caiD)
PGAPGA1_c34200(caiD)
PGLPGA2_c32410(caiD)
PGDGal_03487
PHPPhaeoP97_03321(caiD)
PPICPhaeoP14_03227(caiD)
PHQD1820_12070
OATOAN307_c01290(caiD)
OAROA238_c47080(caiD)
OTMOSB_31140(caiD)
OCTFTO60_02315(caiD)
LMDMETH_20470
LEJETW24_19425(caiD)
LAQUR2C4_18445(caiD)
LEVETW23_19765(caiD)
LCAEK3721_17955(caiD)
MALGMALG_01859
YPACCEW88_20160
TPROGa0080559_TMP3876
SUAMBOO69_17795
SULZC1J03_22110
SULIC1J05_06970 C1J05_19880
SULDB5M07_09545
SPOTG6548_16195
SMEDJNX03_13670(caiD)
SINLDSM14862_00287(dpgD) DSM14862_02686(caiD)
SPSESULPSESMR1_03035(caiD)
TOMBWR18_00715
RIDRIdsm_00642(caiD_1) RIdsm_04076(caiD_5)
ROMEI983_04465 EI983_14380
ROHFIU89_03985(caiD)
AHTANTHELSMS3_00030(caiD)
THAACFI11_00810
MALUKU6B_41080(caiD)
PAMIJCM7686_pAMI6p079
PKDF8A10_13515(caiD)
PPANESD82_07895
PTPRCA23_c04470(caiD)
RMBK529_013695
DONBSK21_10365
LVSLOKVESSMR4R_02271(caiD)
GFUKM031_05375(caiD)
SALOEF888_13845
SEDIEBB79_11295 EBB79_22480
PSEBEOK75_06680(caiD) EOK75_14575(caiD)
PAEDG5B38_05425(caiD) G5B38_10250(caiD)
MONG8E03_13250
PAMOBAR1_01805
PALWPSAL_036230(caiD)
CACTHZ995_05560(caiD)
RBZB9057_03240
THASC6Y53_14720(caiD)
HDHG5B40_03925(caiD)
GCEKYE46_03995(caiD)
NSMJO391_19410(caiD)
ACROK3J57_14715(caiD)
NDRHT578_01825
SALSala_1808
SPHKSKP52_16250
SMAGAN936_15975
SMAZLH19_02315
STERAOA14_11420
SPHQBWQ93_10915
SPHXE5675_04315
SPHUSPPYR_2860(caiD)
SPPHKFK14_08130
HTQFRZ44_11750(caiD) FRZ44_19970(caiD) FRZ44_47680
HADHFRZ61_11970(caiD) FRZ61_27270(caiD) FRZ61_44380(caiD) FRZ61_45410
NACINUH88_15650
SNEANBZ79_03370
BFDNCTC4823_03672(caiD)
MPAMAP_2645c(echA1)
MAOMAP4_1173
MAVIRC58_05820
MAVURE97_05815
MAVMAV_1277 MAV_2597
MITOCO_11860 OCO_13790
MIAOCU_11810 OCU_14260
MIDMIP_01900
MYOOEM_12000
MCHIAN480_06995
MIROCQ_11880 OCQ_28700
MMALCKJ54_05755
MMANMMAN_28130 MMAN_41980
MSAMycsm_04989
MULMUL_0972(echA1_1)
MMIMMAR_4317(echA1_1)
MMAEMMARE11_41310(echA1_1)
MLIMULP_04515(echA1_1)
MPSEMPSD_44540
MSHOMSHO_17550
MMCMmcs_4079
MKMMkms_4155
MJLMjls_4093 Mjls_4309
MMMW7S_05790
MKNMKAN_07490
MYVG155_22570
MYEAB431_06615
MGOAFA91_14630
MDXBTO20_08550
MSHGMSG_03869
MFJMFLOJ_47970
MSTOMSTO_52030
MSIMMSIM_37940
MSAKMSAS_21500
MKUI2456_20315
MGROFZ046_26260
MXEMYXE_14510
MNVMNVI_05690
MPAGC0J29_23630
MNMMNVM_07160
MGORH0P51_21965
MCOOMCOO_19830
MBAIMB901379_03773(caiD_4)
MSEOMSEO_26470 MSEO_30240
MHEKJMUB5695_01387 JMUB5695_01931
MGAUMGALJ_29570
MLJMLAC_07400
MBRDMBRA_27910
MSHJMSHI_03510
MKRMKOR_40760
MDFK0O62_22210
MMAMK3U93_18710
MHOLK3U96_06215
MHERK3U94_03945 K3U94_06205
MSENK3U95_21655
MPAEK0O64_06195
MSPGF6B93_17255
MOTLTS72_03700
MVMMJO54_06375
MRFMJO55_20740
MPAAMKK62_05955
MCROMI149_06905
MSMMSMEG_1155 MSMEG_5198
MSGMSMEI_5063
MSBLJ00_25710
MSNLI99_25715
MSHLI98_25720
MVAMvan_4588
MGIMflv_2117
MSPMspyr1_15440
MCBMycch_4000
MNED174_21215
MYNMyAD_20805
MFTXA26_46280
MPHLMPHLCCUG_04147(caiD_3)
MVQMYVA_4366
MLLB1R94_06555
MRHMycrhN_3594
MTHN4412656_03465(caiD_7)
MHASMHAS_02938(caiD_1)
MDUMDUV_01330 MDUV_19620 MDUV_30990
MCHTMCHIJ_25860
MDRMDOR_28750
MAUUNCTC10437_04319(caiD_4)
MMAGMMAD_42460
MMORMMOR_19880
MFXMFAL_38130
MAICMAIC_43390
MIJMINS_38220
MALVMALV_21610 MALV_48800
MTYMTOK_04080
MPSCMPSYJ_22590
MARZMARA_54590
MGADMGAD_52890
MHEVMHEL_09540
MSARMSAR_27290
MANYMANY_26590
MAUBMAUB_43890
MPOFMPOR_46530
MPHUMPHO_25530
MMUCC1S78_005580
MMATMMAGJ_05020
MBOKMBOE_27610 MBOE_59020
MFGK6L26_09210
MSEIMSEDJ_54650
MFLVNCTC10271_01151(caiD_4)
MCEEMCEL_44570
MBRML2Z93_000833
MJDJDM601_1118(echA1_1)
MTER4434518_01077(echA1_1)
MMINMMIN_27540
MHIBMHIB_06500
MPAKMIU77_04375
NFANFA_29420(echA13)
NFRERS450000_01146(caiD_2)
NOZDMB37_01565
NADNCTC11293_03570(caiD_6)
ROPROP_71000
RCRNCTC10994_01638(caiD_5)
RTMG4H71_12225
RGOKYT97_15210 KYT97_23170
ROZCBI38_34350
GOMD7316_02519(dpgD_2)
GJIH1R19_06265
GHNMVF96_20695
DKNNHB83_17000
SCADDN051_01780
YIALO772_01745
LDNH9L06_00835
ARTArth_1079
AAUAAur_1078
PNVJMY29_05095
NOYEXE57_03890(caiD)
NANOG5V58_03210(caiD)
NOQLN652_15065
PDXPsed_2574
 » show all
Reference
1  [PMID:11409545]
  Authors
Engemann C, Elssner T, Kleber HP
  Title
Biotransformation of crotonobetaine to L(-)-carnitine in Proteus sp.
  Journal
Arch Microbiol 175:353-9 (2001)
DOI:10.1007/s002030100272
  Sequence
Reference
2  [PMID:11551212]
  Authors
Elssner T, Engemann C, Baumgart K, Kleber HP
  Title
Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli.
  Journal
Biochemistry 40:11140-8 (2001)
DOI:10.1021/bi0108812
  Sequence
[eco:b0036]
Reference
3  [PMID:15731894]
  Authors
Engemann C, Elssner T, Pfeifer S, Krumbholz C, Maier T, Kleber HP
  Title
Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp.
  Journal
Arch Microbiol 183:176-89 (2005)
DOI:10.1007/s00203-005-0760-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.149
IUBMB Enzyme Nomenclature: 4.2.1.149
ExPASy - ENZYME nomenclature database: 4.2.1.149
BRENDA, the Enzyme Database: 4.2.1.149

DBGET integrated database retrieval system