KEGG   ENZYME: 4.2.1.171
Entry
EC 4.2.1.171                Enzyme                                 
Name
cis-L-3-hydroxyproline dehydratase;
cis-L-3-hydroxyproline hydro-lyase;
c3LHypD
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
cis-3-hydroxy-L-proline hydro-lyase (1-pyrroline-2-carboxylate-forming)
Reaction(IUBMB)
cis-3-hydroxy-L-proline = 1-pyrroline-2-carboxylate + H2O [RN:R11625]
Reaction(KEGG)
R11625
Substrate
cis-3-hydroxy-L-proline [CPD:C19706]
Product
1-pyrroline-2-carboxylate [CPD:C03564];
H2O [CPD:C00001]
History
EC 4.2.1.171 created 2017
Pathway
ec00330  Arginine and proline metabolism
Orthology
K09123  cis-L-3-hydroxyproline dehydratase
K21624  cis-L-3-hydroxyproline dehydratase
Genes
FGR: FGSG_12672
FPU: FPSE_04942
FVR: FVEG_06026
FOX: FOXG_08647
NHE: NECHADRAFT_47437 NECHADRAFT_75968
TRE: TRIREDRAFT_59073
TRR: M419DRAFT_74960
PLJ: VFPFJ_04120
PTKZ: JDV02_004404
CFJ: CFIO01_08286
CHIG: CH63R_05392
PFY: PFICI_14003
ANI: AN8629.2
AFM: AFUA_6G00490
NFI: NFIA_047620
AOR: AO090005000232 AO090011000420
ANG: ANI_1_578044(An05g02230)
AFV: AFLA_003015 AFLA_007807
ALUC: AKAW2_81366A
ACHE: ACHE_30838S
APUU: APUU_10326S APUU_12323S
PCS: Pc16g03150
AALT: CC77DRAFT_973712
FFU: CLAFUR5_10550
SMIN: v1.2.027818.t1(symbB.v1.2.027818.t1)
PTI: PHATRDRAFT_47407
FCY: FRACYDRAFT_147078
TPS: THAPSDRAFT_263799
AAF: AURANDRAFT_25937
EHX: EMIHUDRAFT_464728
SLIG: GTU79_12535
PAO: Pat9b_4270
TCI: A7K98_03655
PAE: PA1259
PAEV: N297_1298
PAEI: N296_1298
PAU: PA14_47930
PAP: PSPA7_4133
PAG: PLES_40531
PAF: PAM18_3772
PNC: NCGM2_2141
PAEB: NCGM1900_1317
PDK: PADK2_19355
PSG: G655_18875
PRP: M062_06850
PAEP: PA1S_19620
PAER: PA1R_gp4865
PAEM: U769_19460
PAEL: T223_20710
PAES: SCV20265_4155
PAEU: BN889_01338(acnD)
PAEG: AI22_14345
PAEC: M802_1295
PAEO: M801_1298
PALC: A0T30_01495
PMUI: G4G71_28390
PNT: G5B91_04390
PPAA: B7D75_18885
POR: APT59_02410
PFE: PSF113_3724(acnD)
PCG: AXG94_01235
PMED: E3Z27_15360
PBA: PSEBR_a3202
PBC: CD58_14035
PDR: H681_03730
PFZ: AV641_10920
PALK: PSAKL28_28670
PRH: LT40_08305
PFK: PFAS1_24885
PPSL: BJP27_16675
PSET: THL1_3344 THL1_3354
PUM: HGP31_13910
PGG: FX982_00231
PPSH: G5J76_14175
PVK: EPZ47_13980
PBZ: GN234_05105
PKH: JLK41_24650
PDW: BV82_1493
PVW: HU752_014605 HU752_019980
PQI: KH389_15865
PAZE: KSS91_13940
PALV: KSS97_15470
PTK: EXN22_15850
PZA: HU749_017235
PCAS: LOY40_14815
PSTT: CH92_01045
MBS: MRBBS_3090(tfdDII) MRBBS_3771
MPQ: ABA45_14590 ABA45_17665
MSQ: BKP64_15685
MARA: D0851_07090
ABC: ACICU_02599
ABX: ABK1_2717
ABZ: ABZJ_02793
ABR: ABTJ_01114
ABD: ABTW07_2847
ABH: M3Q_2866
ABJ: BJAB07104_02757
ABAJ: BJAB0868_02639
ABW: BL01_04805
TLO: J9253_15835 J9253_15855
THIP: N838_12815 N838_12860 N838_12870 N838_25860
SPIU: SPICUR_01015
SROS: BBH56_00085
HAM: HALO1339
HSI: BOX17_15820
HOL: HORIV_50720
MRZ: KDW95_05240
THIN: CRN91_06570
BYI: BYI23_C003400
BUE: BRPE67_CCDS08810
PLG: NCTC10937_03090(acnD_2)
CDN: BN940_10836
XYK: GT347_12675
MLO: mll7353
MLN: A9174_28980
MCI: Mesci_5127 Mesci_5761
MCIC: A4R28_01460
MOP: Mesop_5709 Mesop_6338
MAM: Mesau_05204 Mesau_05810
MAMO: A6B35_11260 A6B35_31395 A6B35_31430
MESW: A9K65_028120
MESM: EJ066_15875
MESP: C1M53_22690 C1M53_25745
MHUA: MCHK_0861
MJR: EB229_29560
MERD: EB233_25595
MOH: IHQ72_30340
AAK: AA2016_4178
AMIH: CO731_04096(ykfB)
PHT: BLM14_28020
NKI: KW403_09930
SME: SM_b20269
SMK: Sinme_3904
SMQ: SinmeB_4401
SMX: SM11_pD1342
SMI: BN406_06397
SMEG: C770_GR4pD1328
SMEL: SM2011_b20269
SMER: DU99_32025
SMD: Smed_3862
RHI: NGR_c20510
SFH: SFHH103_04919
SIX: BSY16_2983
ESJ: SJ05684_b60010
EAK: EKH55_4112
EMX: FKV68_08830 FKV68_18765 FKV68_29340
EGI: PZN02_002064
EAD: OV14_a1338
EAH: FA04_26875
ATU: Atu4683
ATA: AWN88_02300
AGR: AGROH133_09591
ATF: Ach5_44050
AGC: BSY240_1189
ARO: B0909_14110
AGT: EYD00_22635
ASAL: CFBP5507_15640
RIR: BN877_II1777
RPUS: CFBP5875_22530
RLE: pRL120183
RLT: Rleg2_2920 Rleg2_6270
RLG: Rleg_2143
RHL: LPU83_0079
RHV: BA939_17435
RHR: CKA34_24580
RAD: CO657_07130 CO657_14970
ROY: G3A56_25895 G3A56_27920
RII: FFM53_000485
RRG: J3P73_13310
RROS: D4A92_14680
RAW: NE851_02080
RHT: NT26_0740
RFV: RFYW14_00933
SHZ: shn_20870
SZO: K8M09_18915
PDES: FE840_011060
BOI: BLM15_16215
BOF: FQV39_07085
BAPA: BBC0178_003880
SNO: Snov_0156
STAR: G3545_19660
LNE: FZC33_04685
ANC: GBB76_15705
APRA: G3A50_11695 G3A50_17100
APOL: K9D25_02010
MOC: BB934_22210
PEM: OF122_09000
DEQ: XM25_06480
MMYR: MXMO3_02558
YTI: FNA67_10595
PLEO: OHA_1_00386
AUA: M673_01845
AUB: LXB15_02640
LAP: ACP90_03845
LABR: CHH27_14510 CHH27_14515 CHH27_14520 CHH27_16900
LABP: FJ695_09465 FJ695_25345 FJ695_25350 FJ695_25355
LABT: FIU93_09480(hpbD2)
LAGG: B0E33_15405
ACUT: MRB58_03890
SIL: SPO0606 SPO1594 SPO1595
RUA: D1823_12765 D1823_12770 D1823_12775 D1823_21560
RUT: FIU92_00705(hpbD1) FIU92_00710(hpbD2) FIU92_00715(hpbD3) FIU92_20915(hpbD5)
RCON: K3740_13660
LMD: METH_03715 METH_03720 METH_21600
LEJ: ETW24_04555 ETW24_04565 ETW24_21125
LAQU: R2C4_00195
LEV: ETW23_15635 ETW23_15645 ETW23_22605
LCAE: K3721_03860 K3721_19995
YPAC: CEW88_21655
SULZ: C1J03_24310 C1J03_24880
SULI: C1J05_17360
SULD: B5M07_16970
SINL: DSM14862_03938
SFAV: PL335_15950
RMM: ROSMUCSMR3_03766
ROK: RAK1035_2606
ROM: EI983_11265 EI983_11280 EI983_11285
ROH: FIU89_04720(hpbD)
AHT: ANTHELSMS3_01689
HAT: RC74_17905
LSAL: KBK07_17620
RHP: LPB142_00840
RBL: B6K69_11125
PDE: Pden_4854
PAMI: JCM7686_pAMI5p194
PCON: B0A89_11820
PARU: CYR75_12385
PARS: DRW48_02020
PAAK: FIU66_17575
PKD: F8A10_10085
PPAN: ESD82_09110 ESD82_09265
PSAN: HGN31_03530
PMEH: JWJ88_18830
GEH: HYN69_18950
GFU: KM031_16585
TAW: EI545_04775
PSEB: EOK75_17430
LIT: FPZ52_12375
PAED: G5B38_02540 G5B38_08205 G5B38_08210
PALW: PSAL_037680
CACT: HZ995_06700 HZ995_06705 HZ995_06920
CMAG: CBW24_05650
FAP: GR316_11095
SINR: O5O51_10065
AALK: LGT41_0005615
AMYL: QBD29_01610 QBD29_15440 QBD29_15445
SECH: B18_18030
KSC: CD178_02790
NTN: D5366_04125
HTQ: FRZ44_05750
HADH: FRZ61_05880
APM: HIMB5_00009000
APB: SAR116_0305
ALK: ALEK_0483
PNW: SYK_15540
SCIA: HUG15_20565
MDX: BTO20_21610
MMAG: MMAD_17950
CCYC: SCMU_39940
ROP: ROP_33630
ROA: Pd630_LPD07639
RKO: JWS14_15390
SVL: Strvi_4532
SPHV: F9278_41770
MANT: BHD05_12270
ARQ: BWQ92_12360
MPH: MLP_31270
ROO: G5S37_15600
PSL: Psta_4279
PIR: VN12_04975(hpbD)
RUL: UC8_12350(hpbD)
RML: FF011L_25140(hpbD)
ROL: CA51_17900(hpbD)
AHEL: Q31a_31920(hpbD)
LCRE: Pla8534_37390(hpbD)
BVO: Pan97_28130(hpbD)
RLC: K227x_20600(hpbD)
PLM: Plim_2539
PEH: Spb1_33100(hpbD)
FMR: Fuma_04875(ykfB_3)
MRI: Mal4_18100(hpbD)
GES: VT84_28150(hpbD)
GOG: C1280_02595
GMS: SOIL9_51450
TIM: GMBLW1_09120
LRS: PX52LOC_08191
FTJ: FTUN_7844
ULI: ETAA1_44860(hpbD)
TSPH: KIH39_25405
AGV: OJF2_01180(hpbD)
HBS: IPV69_07755
PFER: IRI77_22655
GBA: J421_4704
HDF: AArcSl_2466
 » show all
Reference
1  [PMID:25608448]
  Authors
Zhang X, Kumar R, Vetting MW, Zhao S, Jacobson MP, Almo SC, Gerlt JA
  Title
A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily.
  Journal
J Am Chem Soc 137:1388-91 (2015)
DOI:10.1021/ja5103986
  Sequence
[ag:EAV42585]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.171
IUBMB Enzyme Nomenclature: 4.2.1.171
ExPASy - ENZYME nomenclature database: 4.2.1.171
BRENDA, the Enzyme Database: 4.2.1.171

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (7074)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (350)   
   KEGG MGENES (5284)   
   RefGene (1438)   
Protein sequence (15)   
   UniProt (10)   
   SWISS-PROT (5)   
DNA sequence (12)   
   GenBank (6)   
   EMBL (6)   
Protein domain (12)   
   InterPro (12)   
All databases (7120)   

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