KEGG   ENZYME: 4.2.1.48
Entry
EC 4.2.1.48                 Enzyme                                 
Name
D-glutamate cyclase;
D-glutamate hydro-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
D-glutamate hydro-lyase (cyclizing; 5-oxo-D-proline-forming)
Reaction(IUBMB)
D-glutamate = 5-oxo-D-proline + H2O [RN:R01583]
Reaction(KEGG)
R01583
Substrate
D-glutamate [CPD:C00217]
Product
5-oxo-D-proline [CPD:C02237];
H2O [CPD:C00001]
Comment
Also acts on various derivatives of D-glutamate.
History
EC 4.2.1.48 created 1972
Pathway
ec00470  D-Amino acid metabolism
ec01100  Metabolic pathways
Orthology
K22210  D-glutamate cyclase
Genes
HSA80017(DGLUCY)
PTR453104(DGLUCY)
PPS100971567(DGLUCY)
GGO101153207(DGLUCY)
PON100172319(DGLUCY)
NLE100586901(DGLUCY)
MCC700168(DGLUCY)
MCF102135732(DGLUCY)
MTHB126959650
CSAB103229551(C24H14orf159)
CATY105596569
PANU101012503(DGLUCY)
TGE112628451(DGLUCY)
RRO104656701(DGLUCY)
RBB108523309(CUNH14orf159)
TFN117071547(DGLUCY)
PTEH111538216(DGLUCY)
SBQ101047007
CSYR103275586(CUNH14orf159)
MMUR105876286(C3H14orf159)
OGA100949551(DGLUCY)
MMU217830(Dglucy)
MCAL110306840(C12H14orf159)
MPAH110324645(C7H14orf159)
RNO362769(Dglucy)
MCOC116080006(Dglucy)
MUN110558364(CUNH14orf159)
CGE100753550(Dglucy)
MAUA101828173(Dglucy)
PLEU114705025(Dglucy)
MORG121434364(Dglucy)
MFOT126507214
AAMP119818709(Dglucy)
NGI103724611(CUNH14orf159)
HGL101711224
CPOC100735106(Dglucy)
CCAN109699498(CUNH14orf159)
NCAR124976082
TUP102469364
CFA100688910(DGLUCY)
VVP112907347(DGLUCY)
VLG121492493(DGLUCY)
AML100482436(DGLUCY)
UMR103670181
UAH113267360(DGLUCY)
UAR123798891(DGLUCY)
ELK111148542
LLV125104759
MPUF101689641
ORO101371157
EJU114204443(DGLUCY)
ZCA113909354(DGLUCY)
MLX118002490(DGLUCY)
NSU110571747(DGLUCY)
PYU121032192(DGLUCY)
PBG122468118(DGLUCY)
LRUF124512240
PTG102949759
PPAD109274456(CUNH14orf159)
AJU106987920(DGLUCY)
HHV120232099(DGLUCY)
SSC100626547(C7H14orf159)
CFR102521322(DGLUCY)
CBAI105079860
CDK105095965(DGLUCY)
VPC102529318(DGLUCY)
BACU102999377
LVE103084864
OOR101287758
DLE111175940(DGLUCY)
PSIU116746127(DGLUCY)
ECB100063012(DGLUCY)
EPZ103558013
EAI106825335(DGLUCY)
MYB102252495
MYD102753826
MMYO118659289(DGLUCY)
MLF102432492(DGLUCY)
MNA107531588
PKL118712976(DGLUCY)
HAI109382680(CUNH14orf159)
DRO112311934(DGLUCY)
SHON118976806(DGLUCY)
AJM119037910(DGLUCY)
PDIC114492950(DGLUCY)
PHAS123808597(DGLUCY)
MMF118636098(DGLUCY)
RFQ117023309(DGLUCY)
PALE102898067(DGLUCY)
PGIG120619609(DGLUCY)
PVP105300806(DGLUCY)
RAY107515436
MJV108399442(CUNH14orf159)
TOD119239281(DGLUCY)
SARA101546022
LAV100659904(DGLUCY)
DNM101419340(DGLUCY)
MDO100017774(C1H14orf159)
GAS123234039(DGLUCY)
SHR100931620(DGLUCY)
PCW110217799(CUNH14orf159)
OAA100083826(DGLUCY)
GGA423409(C5H14orf159)
PCOC116228912(DGLUCY)
MGP100539918(DGLUCY)
CJO107315200(DGLUCY)
NMEL110402184(C6H14orf159)
APLA101791243(DGLUCY)
ACYG106036649(DGLUCY)
AFUL116489751(DGLUCY)
TGU100229540(DGLUCY)
LSR110471379(DGLUCY)
SCAN103826477(DGLUCY)
PMOA120503771(DGLUCY)
OTC121332518(DGLUCY)
PRUF121355992(DGLUCY)
GFR102037421
FAB101806679(C5H14orf159)
PHI102108442
PMAJ107205561(DGLUCY)
CCAE111929884(DGLUCY)
CCW104685987(DGLUCY)
CBRC103612114(CUNH14orf159)
ETL114058212(DGLUCY)
ZAB102073109(DGLUCY)
ACHL103800958
FPG101913280
FCH102058374(DGLUCY)
CLV102096431(CUNH14orf159)
EGZ104135348
NNI104022218
PLET104625060
PCRI104028681
PCAO104053883
ACUN113480812(DGLUCY)
TALA104364674(DGLUCY)
PADL103912999
AFOR103900294(CUNH14orf159)
ACHC115333825(DGLUCY)
HALD104323816
CCRI104161490
CSTI104559936
EHS104503047
CMAC104483647
MUI104545233
FGA104078679
GSTE104263081
LDI104350567
MNB103769010
OHA104331484
NNT104402204
DPUB104304113
PGUU104468771
ACAR104526349(DGLUCY)
AVIT104266984
CVF104286944
CUCA104059622
AAM106482923
AROW112972654(DGLUCY)
NPD112953467(DGLUCY)
TGT104568817
DNE112990234(DGLUCY)
SCAM104153782
ASN102380281(DGLUCY)
AMJ102576478(CUNH14orf159)
CPOO109321685(CUNH14orf159)
GGN109298523(CUNH14orf159)
PSS102453950(DGLUCY)
CMY102931212(DGLUCY)
CPIC101937326(DGLUCY)
TST117876192(DGLUCY)
CABI116816894(DGLUCY)
MRV120403369(DGLUCY)
ACS100562196(c1h14orf159)
PVT110086580(CUNH14orf159)
SUND121914907(DGLUCY)
PBI103063698(DGLUCY)
PMUR107297288(DGLUCY)
CTIG120309571(DGLUCY)
TSR106546543
PGUT117665912(DGLUCY)
VKO123026939(DGLUCY)
PMUA114591021(DGLUCY)
ZVI118078179(DGLUCY)
GJA107113340
STOW125426641(DGLUCY)
XLA108698713(dglucy.L)
XTR549215(dglucy)
NPR108788696(CUNH14orf159)
RTEM120921213(DGLUCY)
BBUF120982146(DGLUCY)
BGAR122922084(DGLUCY)
DRE560387(c17h14orf159)
SRX107730207
SANH107679776
SGH107582942
CCAR109107902(c34h14orf159)
CAUA113117328(dglucy)
PPRM120476230(dglucy)
MAMB125269384(dglucy)
AMEX103041880(dglucy)
EEE113574126(dglucy)
TRU101064729(dglucy)
PLEP121953640(dglucy)
SLUC116065766(dglucy)
ECRA117935476(dglucy)
ESP116669961(dglucy)
PFLV114546972(dglucy)
GAT120833002(dglucy)
PPUG119227288(dglucy)
MSAM119910853(dglucy)
CUD121526235 121526683
ALAT119019729(dglucy)
MZE101472904(dglucy)
ONL100699337(dglucy)
OAU116327984(dglucy)
OLA101156702(dglucy)
OML112145000(dglucy)
XMA102226444(dglucy)
XCO114134371(dglucy)
XHE116709043(dglucy)
PRET103460669
PFOR103154203
PLAI106940573
PMEI106909503
GAF122845725(dglucy)
CVG107101552
CTUL119785374(dglucy)
GMU124855425(dglucy)
NFU107391670(csgr16h14orf159)
KMR108247027(dglucy)
ALIM106521235
NWH119427802(dglucy)
AOCE111576395 111576396
MCEP125023124(dglucy)
CSEM103383443 103383463
POV109628237(cunh14orf159)
SSEN122782986(dglucy)
HHIP117756188(dglucy)
HSP118116005(dglucy)
LCF108886860 108896079 108897871
XGL120795425(dglucy)
HCQ109519777 109519787
BPEC110163870 110166339(cunh14orf159)
MALB109965009(cunh14orf159)
BSPL114848488(dglucy)
SASA106611165(cssa09h14orf159)
STRU115162142(dglucy)
OTW112256792(dglucy)
OMY110505723(dglucy)
OGO124046597(dglucy)
ONE115138649(dglucy)
SALP111963420(dglucy)
SNH120023204(dglucy)
CCLU121544321(dglucy)
ELS105015466(dglucy)
SFM108933257(dglucy)
PKI111852007(dglucy)
AANG118225631(dglucy)
LOC102682775(clg7h14orf159) 102692206
PSPA121323817 121329475(dglucy)
ARUT117402760 117424686 117974027
LCM102346195
CMK103189663(dglucy)
RTP109913902(cunh14orf159)
BFO118417907 118420680 118421745
BBEL109473801 109482494
CIN100180171 100182513
SCLV120326613
SPU577417
APLC110976733 110976775
SKO100368287
NVE5517941 5520806
EPA110237437 110242750
ATEN116306890 116306892
ADF107345094
AMIL114947960 114963825
PDAM113669485 113670518 113670519 113671845 113671883
SPIS111323950 111333603 111339366
DGT114520257
XEN124441941
HMG100204445
AQU100637788
SREPTSG_03849
TGOTGME49_254760
SMINv1.2.019446.t1(symbB.v1.2.019446.t1) v1.2.019446.t2(symbB.v1.2.019446.t2)
FCYFRACYDRAFT_234119
SPARSPRG_00060
GTTGUITHDRAFT_115230
NGRNAEGRDRAFT_67691
TVATVAG_2v0267260
PCAFDSC91_003834 DSC91_007304
PACSFAZ98_16120 FAZ98_16130 FAZ98_30245
PANDDRB87_00220 DRB87_00230
BBHBN112_2783
BBMBN115_0626
BBXBBS798_0630
PIGEGT29_25985
DIHG7047_04775
SIMPC6571_14745 C6571_14755
DMSE8L03_06740
MESOBSQ44_13830
SMQSinmeB_6592
SMIBN406_06782
SMERDU99_19640
SFHSFHH103_04193
SAMESAMCFNEI73_pC1585
SINOSS05631_a42580 SS05631_a42600
ESJSJ05684_a37780
BOFFQV39_07995
PSTGE8M01_06755
CIDP73_2835
PABYGa0080574_TMP528
SAGUCDO87_23055
RSUNHU_04230
RHMB5V46_17770
PAEDG5B38_21360
KNAB0W47_14230
HADHFRZ61_46790
FWADCMF_00955
LPILLIP_2227
MGOAFA91_03835
BLBBBMN68_890
BLZBLGT_03245
BLABLA_0133
BLCBalac_0142
BLTBalat_0142
BBBBIF_01419
BBCBLC1_0133
BNMBALAC2494_00981
BLVBalV_0138
BLWW7Y_0140
BLSW91_0141
BANIBl12_0130
BANLBLAC_00730
BANMEN10_00730
BDEBDP_0108
BDNBBDE_0098
BTPD805_1222
RIVRiv7116_1919
FISFIS3754_24270
GMRGmarT_08600
GIMF1728_09980
GPNPan110_09310
MRIMal4_49100
SDYNMal52_21760
PLONPla110_04020
GOGC1280_24635
TIMGMBLW1_22520
LRSPX52LOC_06605
FTJFTUN_6987
TSPHKIH39_25660
FFOFFONT_0039
CSUCSUB_C1123
BARCAOA65_1114
 » show all
Reference
1  [PMID:14087295]
  Authors
MEISTER A, BUKENBERGER MW, STRASSBURGER M.
  Title
THE OPTICALLY-SPECIFIC  ENZYMATIC CYCLIZATION OF D-GLUTAMATE.
  Journal
Biochem Z 338:217-29 (1963)
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.48
IUBMB Enzyme Nomenclature: 4.2.1.48
ExPASy - ENZYME nomenclature database: 4.2.1.48
BRENDA, the Enzyme Database: 4.2.1.48
CAS: 37290-80-5

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