KEGG   ENZYME: 4.2.2.1
Entry
EC 4.2.2.1                  Enzyme                                 
Name
hyaluronate lyase;
hyaluronidase (ambiguous);
glucuronoglycosaminoglycan lyase (ambiguous);
spreading factor;
mucinase (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
Sysname
hyaluronate lyase
Reaction(IUBMB)
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. [RN:R02465 R06242]
Reaction(KEGG)
R02465 R06242(G)
Comment
The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
History
EC 4.2.2.1 created 1961 as EC 4.2.99.1, transferred 1972 to EC 4.2.2.1, modified 2001
Orthology
K01727  hyaluronate lyase
Genes
CTUCTU_30970
YEFFORC2_p069
YRUBD65_2430
MWIMNY66_01525
VVYVV0533 VV0534
VFIVF_A0994
VFMVFMJ11_A1113
PTREI9H09_17445
BUTX994_6505(xly)
MALIEYF70_16965
HFEHFELIS_14140
HBIHBZC1_15820
HHMBN341_6200
BCZpE33L466_0352(xalA)
BBYCY96_17710
BWDCT694_29655
BCIRC2I06_04330
BLENNCTC4824_01128 NCTC4824_01130 NCTC4824_03984
BSEBsel_0843
PSUAFLK61_26370
SAUSA2003(hysA)
SAVSAV2202(hysA)
SAWSAHV_2186(hysA)
SAHSaurJH1_2271
SAJSaurJH9_2232
SAMMW2129(hysA)
SASSAS2103
SARSAR1892(hysA1) SAR2292(hysA2)
SACSACOL2194(hysA)
SAXUSA300HOU_2197(hysA)
SAASAUSA300_2161(hysA)
SAOSAOUHSC_02463
SAENWMN_2106(hysA)
SADSAAV_2263
SUUM013TW_2169
SUVSAVC_09900
SUESAOV_2247
SUJSAA6159_01731 SAA6159_02114
SUKSAA6008_02243(hysA)
SUCECTR2_2063
SUTSAT0131_02378
SUQHMPREF0772_10989 HMPREF0772_11345
SUZMS7_2224
SUDST398NM01_1880 ST398NM01_2262
SUXSAEMRSA15_21070(hysA2)
SUWSATW20_23400(hysA)
SUGSAPIG1880 SAPIG2262
SUFSARLGA251_16860(hysA) SARLGA251_19960(hysA)
SAUASAAG_00036 SAAG_01706
SAUERSAU_001662(hysA) RSAU_002045(hysA2)
SAUNSAKOR_02172
SAUSSA40_1956(hysA)
SAUUSA957_2040(hysA)
SAUGSA268_2111(hysA)
SAUZSAZ172_2305(hysA)
SAUTSAI1T1_2016390(hysA)
SAUJSAI2T2_1016400(hysA)
SAUKSAI3T3_1016390(hysA)
SAUQSAI4T8_1016400(hysA)
SAUVSAI7S6_1016390
SAUWSAI5S5_1016330
SAUXSAI6T6_1016340
SAUYSAI8T7_1016370
SAUFX998_2189
SABSAB1663(hysA1) SAB2082(hysA2)
SUYSA2981_2139(hysA)
SAUBC248_1856(hysA1) C248_2244(hysA2)
SAUMBN843_22440
SAUCCA347_2289
SAURSABB_04270(hysA)
SAUIAZ30_11650
SAUDCH52_07940
SAMSNI36_10880
SUHSAMSHR1132_20330
SHUSHYC_11715(hysA)
SAGQEP23_10455
SSHNCTC13712_02147(hylB)
SSACI6I31_03920
SRAILN051_02175
LWIUE46_14495 UE46_15580
PJDPjdr2_3195
PMSKNP414_02262 KNP414_05237 KNP414_05560
PMQPM3016_2533 PM3016_4630 PM3016_4924
PMWB2K_12830 B2K_24000 B2K_25515
PLVERIC2_c23740
PBDPBOR_18695
PAENP40081_18995
PAEQR50912_17565
PSONJI735_00335 JI735_00345
PSWUSY83_13390
PVOPVOR_25993
PLUTEI981_02180 EI981_02185
PCHIPC41400_11265
PBKBack11_31760 Back11_31770
PBACHUB98_02505
PTRIKDC22_23180 KDC22_23190
PALOE6C60_3615
CCHLFPL14_08820
SPYSPy_1032(hylA)
SPZM5005_Spy0757(hylA)
SPYMM1GAS476_0819(hylA)
SPYAA20_0798c
SPMspyM18_1014(hylA)
SPGSpyM3_0665(hylA)
SPSSPs1188
SPHMGAS10270_Spy0874(hylA)
SPIMGAS10750_Spy0909(hylA)
SPJMGAS2096_Spy0830(hylA)
SPKMGAS9429_Spy0871(hylA)
SPAM6_Spy0782
SPBM28_Spy0736(hylA)
STGMGAS15252_0784(hylA)
STXMGAS1882_0780(hylA)
SOZSpy49_0811c(hylA)
STZSPYALAB49_000782
SPYHL897_03945
SPNSP_0314
SPDSPD_0287
SPRspr0286(hysA)
SPWSPCG_0322
SJJSPJ_0310
SNVSPNINV200_02820
SPXSPG_0285(hyl)
SNTSPT_0364
SNDMYY_0397
SPNNT308_01575
SNESPN23F02890
SPVSPH_0426
SNCHMPREF0837_10617
SNMSP70585_0379
SPPSPP_0350
SNIINV104_02610
SPNGHMPREF1038_00364(hysA)
SNBSP670_0382
SNPSPAP_0347
SNUSPNA45_01722
SAGSAG1197
SANgbs1270
SAKSAK_1284(hylB)
SGCA964_1170
SAGSSaSA20_1016(hylB)
SAGLGBS222_1026(hylB)
SAGMBSA_12760
SAGIMSA_13200
SAGRSAIL_13150
SAGPV193_05585
SAGCDN94_05585
SAGTGBSCOH1_1103
SAGEEN72_06630
SAGGEN73_06165
SUPYYK_05005
SSTSSUST3_1226
SSUYYB51_6050
SSQSSUD9_1371
SRPSSUST1_0748
SSUIT15_0747
SEZSez_1299(hylB)
SEQSZO_06680
SEQUQ426_02630
SDSSDEG_0654
SDGSDE12394_03510
SDAGGS_0628(hylB)
SDCSDSE_0694(hylB)
SDQSDSE167_0713(hylB)
STKSTP_1167
SIESCIM_1362
SIBSIR_1547
SIUSII_1533
SANCSANR_1718
SCGSCI_1642
SCONSCRE_1598
SCOSSCR2_1598
SIKK710_0217
SIQDQ08_01045
SIODW64_01040
SIZSI82_01295
SRQSR187_3375
SMENSAMEA4412692_1386(hylA)
SURNNCTC13766_00112(hylB_1) NCTC13766_00113(hylB_2)
SOSINT76_10670
LCALSEI_2686
LCZLCAZH_2685
LCSLCBD_2903
LCELC2W_2877
LCWBN194_28200
LCLLOCK919_2937
LPILBPG_01276
LPAPLBPC_2659
LCBLCABL_28750(xalA)
LCXLCA12A_0375
LRLLC705_02696(xalA)
LRALRHK_2805
LROLOCK900_2695
LRCLOCK908_2776
CPABG6534_05695
EFAEF0818 EF3023
EFLEF62_0109
EFIOG1RF_10550 OG1RF_12303
EFDEFD32_0629 EFD32_2606
EFSEFS1_2467
EFNDENG_02916
EFQDR75_1758
ENEENT_22740
EFTM395_11255
EHREHR_14305
EMUEMQU_2462
EGAAL523_06180
ESSATZ33_14390
ETHCK496_10330
ELACI4Q40_11295
ECECNCTC12421_00019
EIEENLAB_20640
GADK8O88_08775
CPFCPF_0394
CPRCPR_0390
CBNCbC4_2106
CBVU729_2500
CSEPCP523_01355
BHANCGC63_02885 CGC63_14875
CSHClosa_2597
LBWC3V36_09935
ERHERH_0150(hylA) ERH_0765(hylB)
ERSK210_01660 K210_07905
BULLJOS54_07575
SCOSCO5534(SC1C2.15)
SMASAVERM_2704
SGRSGR_291
SGBWQO_33115
SCBSCAB_26801
SHYSHJG_6645
SHOSHJGH_6405
SCTSCAT_4363
SCYSCATT_43510
SVESVEN_5221
SDVBN159_0958 BN159_2862
SALSSLNWT_4661
SFISFUL_16
SCIB446_25985
SALUDC74_5664
SALLSAZ_29920
SLVSLIV_10835
SGUSGLAU_23805
SVTSVTN_26825
STREGZL_03204
SCWTU94_23365
SLDT261_2519
SLCSL103_28195
STRCAA958_24125
SAMBSAM23877_5289
SPRISPRI_4720
SCZABE83_00480
SCXAS200_15735
SRWTUE45_06045(xly)
SLEsle_21210(sle_21210)
SPAVSpa2297_23435
STRTA8713_00365 A8713_22525
SCLFBB341_06495
SGSAVL59_08750
STSIA4E84_28340
SALWCP975_31340
SGMGCM10017557_23350
SLSSLINC_5976
SNRSNOUR_13955
STRDNI25_11545
SVUB1H20_33735
SPUNBFF78_03435
SGVB1H19_28315
SLAUSLA_5431
SALFSMD44_01144
SALJSMD11_2031
SLXSLAV_04325(xly)
STROSTRMOE7_27170
SFKKY5_5711
SNZDC008_24835
SGEDWG14_02529(xly)
SRJSRO_0644
SLKSLUN_28075
SGDELQ87_11925
SQZFQU76_24730
SCYAEJ357_32680
SASTCD934_09335
SKACP970_04240 CP970_12530
SVNCP980_03870
SHAWCEB94_28975
SRKFGW37_23350
SFICEIZ62_08725
SPADDVK44_25640
SAQUEJC51_33905 EJC51_41950
SGFHEP81_00629
SCAVCVT27_32625
SRIMCP984_11465
SSUBCP968_31185
SPHVF9278_35050
SCINCP977_33110
SPACB1H29_10935
STSUB7R87_24740
SCHACP983_12950
SGXH4W23_28340
SCOECP976_30575
SSPBCP982_06315
SPLACP981_27530
SBROGQF42_30420 GQF42_39675
STUIGCM10017668_50460
SATAC5746_03170 C5746_29510 C5746_36050
SHUNDWB77_02354(xly_1) DWB77_06443(xly_2) DWB77_06490(xly_3)
SCYGS1361_27505(xly)
SFEUIM697_35535
SLIAHA039_09355
SDWK7C20_26190
SCALI6J39_33470
SAUHSU9_024925
SMOBJ7W19_23170
SXNIAG42_02145 IAG42_05180 IAG42_32435
SGJIAG43_30120
SHKJ2N69_32955
SANUK7396_10630
SDDD9753_10340
SACTDMT42_10045
SGOBtest1122_22970
SINEKI385_31415
SLFJEQ17_14750
SDECL3078_32175
KABB7C62_00095
LXLKDY119_02305(hysA)
MTSMTES_2849
MIXAB663_001102
FRPAX769_05830
ARTArth_1698
ARRARUE_c32170
ARMART_3702
AREAL755_00180 AL755_04595
ARWMB46_19365
ARNCGK93_17430
AAUAAur_3068
PNVJMY29_14850 JMY29_16365
BCVBcav_4062
LMOIVV02_06880
PSEIGCE65_02310
HALTIM660_00335 IM660_00365 IM660_14490
RHALLQF10_05115 LQF10_16250
RSUALQF12_12370
PACPPA0380
PAKHMPREF0675_3415
PAVTIA2EST22_01875
PAXTIA2EST36_01855
PAZTIA2EST2_01795
PAWPAZ_c03930(hylB)
PADTIIST44_06625
PCNTIB1ST10_01945
PACCPAC1_01925
PACHPAGK_0394
PACNTIA1EST1_01875
CACNRN83_02370
PRLBCB70_04600
MIKFOE78_16715
TESBW730_12375
PRVG7070_17430
KFLKfla_2021
KQIF1D05_13565
SROSros_4208
NOABKM31_31155 BKM31_46745 BKM31_51920 BKM31_55970
NOWGBF35_40595 GBF35_50865
NCXNocox_19595(xly1) Nocox_41810(xly4)
NGNLCN96_14075 LCN96_45090 LCN96_49450 LCN96_55380
AMDAMED_5970
AMNRAM_30620
AMMAMES_5886
AMZB737_5886
AOIAORI_4997
AJAAJAP_14535
AMYCCU254_22185
AMYBBKN51_17440
AABA4R43_15665
AMYYYIM_14790(xly)
AORISD37_24605
AACDLWP59_20510
PHHAFB00_01910
KALKALB_2559
ATLAthai_07180 Athai_37990 Athai_61400 Athai_66290
CAICaci_4980 Caci_6725
SNASnas_0850
GLYK3N28_09530
VBAIMCC26134_14310
TBETrebr_1552 Trebr_1554 Trebr_1556
FMOC4N19_04620 C4N19_04660
CSOMMKD34_01125 MKD34_01155
LGOJCM16774_1532
SMFSmon_0117 Smon_0125
PMERINE87_03105
COPRCop2CBH44_00640
AITAI2BBH_05660 AI2BBH_05670 AI2BBH_18540
HMUHmuk_3227
HALZE5139_16020
HALLLC1Hm_4133(hysA)
 » show all
Reference
1  [PMID:13762462]
  Authors
LINKER A, HOFFMAN P, MEYER K, SAMPSON P, KORN ED.
  Title
The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to alpha-keto acid by bacterial enzymes.
  Journal
J Biol Chem 235:3061-5 (1960)
Reference
2  [PMID:14943668]
  Authors
MEYER K, RAPPORT MM.
  Title
Hyaluronidases.
  Journal
Adv Enzymol Relat Subj Biochem 13:199-236 (1952)
DOI:10.1002/9780470122587.ch6
Reference
3  [PMID:5642600]
  Authors
Moran F, Nasuno S, Starr MP.
  Title
Extracellular and intracellular polygllacturonic acid trans-eliminases of Erwinia carotovora.
  Journal
Arch Biochem Biophys 123:298-306 (1968)
DOI:10.1016/0003-9861(68)90138-0
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.1
IUBMB Enzyme Nomenclature: 4.2.2.1
ExPASy - ENZYME nomenclature database: 4.2.2.1
BRENDA, the Enzyme Database: 4.2.2.1
CAS: 37259-53-3

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