KEGG   ENZYME: 4.2.3.11
Entry
EC 4.2.3.11                 Enzyme                                 

Name
sabinene-hydrate synthase;
sabinene hydrate cyclase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)
Reaction(IUBMB)
geranyl diphosphate + H2O = sabinene hydrate + diphosphate [RN:R02006]
Reaction(KEGG)
R02006
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
sabinene hydrate [CPD:C02462];
diphosphate [CPD:C00013]
Comment
Both cis- and trans- isomers of sabinene hydrate are formed. (3R)-Linalyl diphosphate is an intermediate in the reaction
History
EC 4.2.3.11 created 1992 as EC 4.6.1.9, transferred 2000 to EC 4.2.3.11
Pathway
ec00902  Monoterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:3401015]
  Authors
Hallahan TW, Croteau R.
  Title
Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis).
  Journal
Arch Biochem Biophys 264:618-31 (1988)
DOI:10.1016/0003-9861(88)90328-1
Reference
2  [PMID:2916845]
  Authors
Hallahan TW, Croteau R.
  Title
Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate.
  Journal
Arch Biochem Biophys 269:313-26 (1989)
DOI:10.1016/0003-9861(89)90113-6
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.11
IUBMB Enzyme Nomenclature: 4.2.3.11
ExPASy - ENZYME nomenclature database: 4.2.3.11
BRENDA, the Enzyme Database: 4.2.3.11
CAS: 117164-95-1

KEGG   REACTION: R02006
Entry
R02006                      Reaction                               

Name
Geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming)
Definition
Geranyl diphosphate + H2O <=> Sabinene hydrate + Diphosphate
Equation
Reaction class
RC00635  C00341_C02462
Enzyme
Pathway
rn00902  Monoterpenoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Other DBs
RHEA: 19568

DBGET integrated database retrieval system