KEGG   ENZYME: 4.2.3.47
Entry
EC 4.2.3.47                 Enzyme                                 
Name
beta-farnesene synthase;
farnesene synthase;
terpene synthase 10;
terpene synthase 10-B73;
TPS10
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-beta-farnesene-forming]
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate [RN:R08695]
Reaction(KEGG)
R08695
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
(E)-beta-farnesene [CPD:C09666];
diphosphate [CPD:C00013]
History
EC 4.2.3.47 created 2010
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12645  epi-isozizaene 5-monooxygenase / beta-farnesene synthase
K14174  beta-farnesene/exo-alpha-bergamotene synthase
K15793  acyclic sesquiterpene synthase
K22064  beta-farnesene synthase
Genes
CIT102609183 102614249
PVY116119561 116136104 116140808
MINC123193041 123193184 123218451 123219543
BDI100833760
ATS109780592 109783760
TDC119356231 119356232 119365401 119365402
TAES100873133 123041882 123041883 123054327 123190213 123191849
TUA125533918 125539513
SBI8072328 8080876
ZMA100274033 541974 732751
SITA101771563
SVS117862601
PVIR120640652 120683675
PHAI112898865
SCOSCO5223(SC7E4.20)
SALBXNR_1579
SMASAVERM_3031(cyp14)
SHYSHJG_6336
SHOSHJGH_6097
SDVBN159_3154
SALSSLNWT_2071
SCIB446_24615
SLVSLIV_12250
SGUSGLAU_22465
SCWTU94_21770
SAMBSAM23877_5011
SCXAS200_17630
SRWTUE45_05743
STRFASR50_23825
SLEsle_25170(sle_25170)
SPAVSpa2297_22090
STRTA8713_21095
SGSAVL59_06870
STSIA4E84_26815
SKYD0C37_09630
SALWCP975_23795
SGMGCM10017557_26710
SCADDN051_14270
SPHWNFX46_06120
SLSSLINC_5615
SPLULK06_022340
STRDNI25_13050
SSIAA7J05_12560
SPUNBFF78_14830
SALFSMD44_05800
SFKKY5_5349
SNZDC008_23215
SGEDWG14_02916
SRJSRO_2585
SDXC4B68_13425
SGDELQ87_13270
SCYAEJ357_30820
SASTCD934_10765
SNQCP978_22470
SKACP970_14415
SHAWCEB94_27440
SGALCP966_24285
SFYGFH48_14920
SAQUEJC51_32140
SGFHEP81_02793
SSEOD0Z67_19540
SFUGCNQ36_23700
SPACB1H29_12435
SCHACP983_14565
SCOECP976_28740
SSPBCP982_27725
SBROGQF42_28700
STUIGCM10017668_47530
SCHFIPT68_24090
SCYGS1361_25900
SFEUIM697_37485
SVDCP969_25545
SPRACP972_23865
SROIIAG44_13190
SXNIAG42_11635
SHKJ2N69_24780
SDDD9753_11940
SACTDMT42_26025
SLFJEQ17_16410
SAOVG3H79_11730
SDURM4V62_15475
 » show all
Reference
1  [PMID:19858213]
  Authors
Zhao B, Lei L, Vassylyev DG, Lin X, Cane DE, Kelly SL, Yuan H, Lamb DC, Waterman MR
  Title
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site.
  Journal
J Biol Chem 284:36711-9 (2009)
DOI:10.1074/jbc.M109.064683
  Sequence
[sco:SCO5223]
Reference
2  [PMID:15896363]
  Authors
Picaud S, Brodelius M, Brodelius PE
  Title
Expression, purification and characterization of recombinant (E)-beta-farnesene synthase from Artemisia annua.
  Journal
Phytochemistry 66:961-7 (2005)
DOI:10.1016/j.phytochem.2005.03.027
Reference
3  [PMID:19646721]
  Authors
Kollner TG, Gershenzon J, Degenhardt J
  Title
Molecular and biochemical evolution of maize terpene synthase 10, an enzyme of indirect defense.
  Journal
Phytochemistry 70:1139-45 (2009)
DOI:10.1016/j.phytochem.2009.06.011
Reference
4  [PMID:16418295]
  Authors
Schnee C, Kollner TG, Held M, Turlings TC, Gershenzon J, Degenhardt J
  Title
The products of a single maize sesquiterpene synthase form a volatile defense signal that attracts natural enemies of maize herbivores.
  Journal
Proc Natl Acad Sci U S A 103:1129-34 (2006)
DOI:10.1073/pnas.0508027103
  Sequence
[zma:732751]
Reference
5  [PMID:11642326]
  Authors
Maruyama T, Ito M, Honda G
  Title
Molecular cloning, functional expression and characterization of (E)-beta farnesene synthase from Citrus junos.
  Journal
Biol Pharm Bull 24:1171-5 (2001)
DOI:10.1248/bpb.24.1171
  Sequence
Reference
6  [PMID:9371761]
  Authors
Crock J, Wildung M, Croteau R
  Title
Isolation and bacterial expression of a sesquiterpene synthase cDNA clone from peppermint (Mentha x piperita, L.) that produces the aphid alarm pheromone (E)-beta-farnesene.
  Journal
Proc Natl Acad Sci U S A 94:12833-8 (1997)
DOI:10.1073/pnas.94.24.12833
Reference
7  [PMID:12481088]
  Authors
Schnee C, Kollner TG, Gershenzon J, Degenhardt J
  Title
The maize gene terpene synthase 1 encodes a sesquiterpene synthase catalyzing the formation of (E)-beta-farnesene, (E)-nerolidol, and (E,E)-farnesol after herbivore damage.
  Journal
Plant Physiol 130:2049-60 (2002)
DOI:10.1104/pp.008326
  Sequence
[zma:541974]
Reference
8  [PMID:15921711]
  Authors
Huber DP, Philippe RN, Godard KA, Sturrock RN, Bohlmann J
  Title
Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii.
  Journal
Phytochemistry 66:1427-39 (2005)
DOI:10.1016/j.phytochem.2005.04.030
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.47
IUBMB Enzyme Nomenclature: 4.2.3.47
ExPASy - ENZYME nomenclature database: 4.2.3.47
BRENDA, the Enzyme Database: 4.2.3.47

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