KEGG   ENZYME: 4.3.99.4
Entry
EC 4.3.99.4                 Enzyme                                 
Name
choline trimethylamine-lyase;
cutC (gene name)
Class
Lyases;
Carbon-nitrogen lyases;
Other carbon-nitrogen lyases
Sysname
choline trimethylamine-lyase (acetaldehyde-forming)
Reaction(IUBMB)
choline = trimethylamine + acetaldehyde [RN:R10285]
Reaction(KEGG)
R10285
Substrate
choline [CPD:C00114]
Product
trimethylamine [CPD:C00565];
acetaldehyde [CPD:C00084]
Comment
The enzyme utilizes a glycine radical to break the C-N bond in choline. Found in choline-degrading anaerobic bacteria.
History
EC 4.3.99.4 created 2013
Orthology
K20038  choline trimethylamine-lyase
Genes
ECPECP_4600
ECTECIAI39_4211
EOCCE10_4248
ECIUTI89_C4964
ELUUM146_22045
EFEEFER_1995
ECANCWI88_16610(cutC)
KPRKPR_0821
KPBFH42_20250
KVAKvar_4520
KPEKPK_4883
KVQSP68_17815
KOXKOX_09770
KOEA225_0656
KOYJ415_27975
KOMHR38_08490
KOKKONIH1_03490
KOCAB185_32690
KQUAVR78_07575
EAEEAE_10070
EARCCG31976
KLLBJF97_04030
KLWDA718_25030(cutC)
KGRJJJ10_24475(cutC)
RORRORB6_15750
RONTE10_05280
RPLNB1209_23720
RAODSD31_22540(cutC)
REEelectrica_04429(bssA_2)
EBTEBL_c07460
KIENCTC12125_01928(csdB_1)
KASKATP_29140(cutC_2)
LEIC2U54_12990(cutC)
LERGNG29_08160(cutC)
LEAGNG26_07795(cutC)
YREHEC60_11550(cutC)
IZHFEM41_20680(cutC)
EBFD782_3573
EBUCUC76_12255(cutC)
SMAFD781_0477
SFWWN53_11110
SFGAV650_06355
SRZAXX16_0069
SERMCLM71_02375(cutC)
SRHZFO014_07615(cutC)
ECAECA3768
PATREV46_18475
PATOGZ59_37640
PCTPC1_3543
PCVBCS7_17765
PWAPecwa_3714
PPARA8F97_00095
PECW5S_3855
PWSA7983_03620
PBRAB5S52_03785
PARII2D83_04105(cutC)
BGJAWC36_11290
ERWIGN242_15600(cutC)
PMRPMI2716
PMIBBB2000_2716
PVLAOB99_14810
PVGCRN77_06060(cutC)
PHAUPH4a_05120(cutC)
PROTBTA34_14845
PCOLF1325_17050(cutC)
PCIBF9282_17410(cutC)
PPEEI6G31_11550(cutC)
PRGRB151_038860(bssA)
PALACO695_06855(cutC)
PHEINCTC12003_03419(csdB)
PRQCYG50_19285(cutC)
PRJNCTC6933_03477(csdB)
MWIMNY66_01680(cutC)
PFQQQ39_10975
VFUvfu_A00327
PGHFH974_04435(cutC)
MYAMORIYA_2257(cutC)
AHAAHA_1330
AHYAHML_07230
AHDAI20_12520
AHRV428_07450
AHPV429_07455
AHJV469_16045
AHIVU14_16045
AAJBOQ57_06470
AALLI6G90_11510(cutC)
PCAPcar_0937
PACEA6070_03930
DDSDdes_1357
DFIAXF13_01055
DEFCNY67_08905(cutC)
DDEDde_3039 Dde_3282
DSADesal_0468
DHYDESAM_21354
PSELGM415_17810(cutC)
PBIZLWC08_01655(cutC) LWC08_03585(cutC)
DPSDP1823
DEOCAY53_01550
DOVDSCO28_56630(pflD_1)
DALKDSCA_27500(pflD)
DEKDSLASN_11590(cutC) DSLASN_11760
SDGSDE12394_10005
SDAGGS_1829(pflD)
SDQSDSE167_2084
SIESCIM_0634
SIKK710_0229
SIQDQ08_01100
SIODW64_01095
SIZSI82_01350
SRQSR187_4385
SMENSAMEA4412692_2069(csdB)
ESSATZ33_06450
EGVEGCR1_04740(cutC) EGCR1_04815(cutC)
EAVEH197_03025(cutC)
ERAFJ9537_16430(cutC)
VPIBW732_05620
CTCCTC_01449
CTETBN906_01604
CBOCBO2118
CBACLB_2055
CBHCLC_2060
CBYCLM_2326
CBLCLK_1571
CBKCLL_A1453
CBBCLD_2523
CBICLJ_B2322
CBNCbC4_1734
CBTCLH_1376
CBFCLI_2161
CBMCBF_2145
CBJH04402_02123
CKLCKL_3002
CKRCKR_2652
CLJCLJU_c39830(pflB3)
CAHCAETHG_1829
CBVU729_818
CSQCSCA_1998 CSCA_4483
CLDCLSPO_c21310(pflD1)
CACECACET_c30180(pflD3)
CCKCcar_04680 Ccar_19035
CFMBJL90_00710
CCHVBTM20_11075
CARGRSJ17_18930
CDRKB9W14_09555 B9W14_22580
CSEPCP523_12430(cutC)
CFERD4Z93_03610 D4Z93_07710(cutC)
CLOSDMR38_19860(cutC)
AMTAmet_1986 Amet_3836
AOEClos_2398 Clos_2688
GFEGferi_19275
HHWNCTC503_01836(csdB_1)
CRSFQB35_03225(cutC)
CAPREQM14_09350
CPYCphy_1417
LACYA4V08_24145
CSHClosa_4018
ARFAR1Y2_3056
CPROCPRO_22300(bssA)
CDFCD630_11200(pflD)
PDCCDIF630_01264
CDCCD196_0973(dhaB1)
CDLCDR20291_0951(dhaB1)
PDFCD630DERM_11200(pflD)
EACEAL2_808p07030(pflD)
TEBT8CH_2113(cutC)
DSYDSY5006
DHDDhaf_4905
DDHDesde_4197
DORDesor_5421
DAIDesaci_1172 Desaci_1570
DMIDesmer_4389
DRMDred_3278
DRUDesru_2090 Desru_2143
DFGB0537_00305
FWADCMF_12665
EMTCPZ25_013730
ELIMB2M23_03595
AMIJEQM06_03460(cutC)
AMICAmi3637_03445(cutC) Ami3637_06840
ABUTAmi103574_05650(cutC)
ETMCE91St48_06050 CE91St48_08470(pflD_2) CE91St48_34310
AVGI6H45_07905(cutC)
AOBI6H46_01860(cutC)
SEDZJYG23_13220(cutC)
MHWACT01_04810
MEGDKB62_05650
PFTJBW_03217
STEDSPTER_31890(cutC_3) SPTER_38880(cutC_5)
AINAcin_2025(pflD)
OLSOlsu_0306
TIOINP52_02315(cutC)
CPORBED41_04350 BED41_04450 BED41_11825
 » show all
Reference
1  [PMID:23151509]
  Authors
Craciun S, Balskus EP
  Title
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme.
  Journal
Proc Natl Acad Sci U S A 109:21307-12 (2012)
DOI:10.1073/pnas.1215689109
  Sequence
[dde:Dde_3282] [dds:Ddes_1357]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.99.4
IUBMB Enzyme Nomenclature: 4.3.99.4
ExPASy - ENZYME nomenclature database: 4.3.99.4
BRENDA, the Enzyme Database: 4.3.99.4

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