Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2 (epoxyethane) to C6 (1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system (comprising EC 126.96.36.199 (2-hydroxypropyl-CoM lyase; component I), EC 188.8.131.52 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 184.108.40.2068 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 220.127.116.119 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
EC 18.104.22.168 created 2001 as EC 22.214.171.124, transferred 2005 to EC 126.96.36.199