CTP diphosphate-lyase (cyclizing);
pycC (gene name) (ambiguous)
Phosphorus-oxygen lyases (only sub-subclass identified to date)
CTP diphosphate-lyase (cyclizing; 3',5'-cyclic-CMP-forming)
CTP = 3',5'-cyclic CMP + diphosphate [RN:
In bacteria and archaea the enzyme's product, cCMP, functions as a second messenger in bacterial immunity against viruses. The enzyme is synthesized following phage infection and activates immune effectors that execute an antiviral response.
EC 188.8.131.52 created 1989
Cech SY, Ignarro LJ.
Cytidine 3',5'-monophosphate (cyclic CMP) formation by homogenates of mouse liver.
Newton, R.P., Salih, S.G., Hakeem, N.A., Kingston, E.E. and Beynon, J.H.
3',5'-Cyclic UMP, -cyclic IMP, -cyclic TMP and related enzymes in mammalian tissues.
Biochem Soc Trans 13:1134-1135 (1985)
Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R.
Cyclic CMP and cyclic UMP mediate bacterial immunity against phages.
ExplorEnz - The Enzyme Database: 184.108.40.206
ExPASy - ENZYME nomenclature database: 220.127.116.11
BRENDA, the Enzyme Database: 18.104.22.168