KEGG   ENZYME: 5.1.3.23
Entry
EC 5.1.3.23                 Enzyme                                 
Name
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase;
UDP-GlcNAc3NAcA 2-epimerase;
UDP-alpha-D-GlcNAc3NAcA 2-epimerase;
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase;
WbpI;
WlbD
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase
Reaction(IUBMB)
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [RN:R09600]
Reaction(KEGG)
R09600
Substrate
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725]
Product
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate [CPD:C19745]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens [1]. The enzyme is highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates [1].
History
EC 5.1.3.23 created 2007
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K13019  UDP-GlcNAc3NAcA epimerase
Genes
PLUplu4804(wblH)
PLUMA4R40_23895
PAYPAU_04319(wblH)
PTTVY86_07555
PAKHB0X70_24585
PLUICE143_24625
AVTNCTC3438_01782(mnaA)
PAEPA3148(wbpI)
PAEVN297_3260
PAEIN296_3260
PAECM802_3258
PAEOM801_3125
PDRH681_23245
PSESPSCI_2869
PANHHU763_007170(wecB)
MARIACP86_02290
MARAD0851_05390
MARJMARI_04700(wbpI)
ADSFPL17_13915
SSESsed_2967
SGLAFJ709_05420
SVMKDH10_000090(wecB)
PPISB1L02_14620
PVBJ5X90_03260(wecB)
PFLICTT31_02675
AAUSEP12_05170
LALAT746_12790
CATEC2869_15630
ALKMNKI27_13895(wecB)
CBSCOXBURSA331_A1108
CBDCBUD_0907
CBGCbuG_1159(wecB)
CBCCbuK_0710(wecB)
CEYCleRT_10730
LSSNCTC12082_00069(wecB)
FRXF7310_06795
CYYCPC19_11130
THIMKFB96_04765(wecB)
TNITVNIR_0699(wecB_[C])
TTITHITH_05805
HTTHZS52_20515(wecB)
MMWMmwyl1_0835
MPRIMP3633_3239
MFOIJSY38_06670(wecB)
TORR615_06315
MGEOCFI10_13585
OMEOLMES_5518
SUTRL0B52_03945(wecB)
VMSLVJ82_06325(wecB)
LHKLHK_02802
PPNODA70_17285
LMIRNCTC12852_00313(mnaA_2)
BPEBP0090(bplD)
BPCBPTD_0086(bplD)
BPERBN118_0159(wlbD)
BPETB1917_0093(bplD)
BPEUQ425_2030(bplD)
BPARBN117_0150(wlbD)
BPABPP0152(bplD)
BBHBN112_3259(wlbD)
BBRBB0152(bplD)
BBMBN115_0141(wlbD)
BBXBBS798_0151(bplD)
BPTBpet4819(wlbD)
BHOD560_1331
BHMD558_1320
BHZACR54_00107(wbpI)
BTRMSAMEA390648701339(wlbD)
BPDZBBN53_20155
TEQTEQUI_1017
TEAKUI_0418
TEGKUK_0136
OUEI6G29_01430(wecB)
AAVAave_0953
ACKC380_07320
DLAI6G47_27680(wecB)
HYLLPB072_07130
MASWAM586_10875
TTWLCC91_03265(wecB)
HMSHMU06640
HBIHBZC1_15210
HETBBW65_04710
HCLNCTC13205_01069(mnaA)
HSHNHP194022_04670(wbpI)
WSUWS2189(WBPI)
TDNSuden_1418
CCOCCC13826_0521
CBLACBLAS_0721
ABUAbu_0692
PACOAACT_0957
HBVABIV_0881
GLOGlov_1505
GSBGSUB_15300
GPLM1B72_07930(wecB)
PEFA7E78_01570
DHYDESAM_20348
DDNDND132_2429
PSEFPSDVSF_24170
DSXGD604_09830
DSFUWK_02413
DEOCAY53_06115
DOLDole_1828
DWDDSCW_06940
DAODesac_2653
EAAI862_07330
MESPC1M53_01175
PMOBHG718_00065(wecB)
RBSRHODOSMS8_00383(wbpI)
AGCBSY240_4586
SZOK8M09_00485(wecB)
BRKCWS35_31810
BQBJ4P68_0006725(wecB)
MIVC4E04_13610 C4E04_13650
MICOGDR74_06705
HNIW911_00410
CMBCSW64_01275
RCONK3740_17755(wecB)
SPOTG6548_17145(wecB)
PZHCX676_22395
HBCAEM38_13070 AEM38_13090
SPHOC3E99_07045
SPHUSPPYR_1658(wbpI)
PHAOHF685_11090(wecB)
ERRDVR09_11335
MAIMICA_1024
MANA11S_979
BDCDOE51_07915
SBFJCM31447_25060
BMETBMMGA3_15100
BDAFSZ17_21460
BACIB1NLA3E_20895
BONA361_24855
CSUAIM538_21360(wecB)
CFIRNAF01_22635(wecB)
CSOALIS82_24390(wecB)
GKAGK3162
GTEGTCCBUS3UF5_35310
GTKGT3570_15435
GTMGT3921_03270
BCALCWI35_12110
GYCGYMC61_3253
GYAGYMC52_3284
GCTGC56T3_3173
GGHGHH_c32370(mnaA)
GELIB49_07975
GSEGT50_07665
GZAIC807_11880(wecB)
PTBDER53_03255(wecB)
AAMYGFC30_485
VNECFK40_05105
VNTOLD84_03170(wecB)
LAOAOX59_11995
LEXLen3610_17430
AQTFN924_03245
PSYHD0S48_07325
PSYOPB01_04645
RUEDT065_00075
MARYLAU42_03945(wecB)
PODPODO_28510
PNPIJ22_38280
PALBEJC50_29130
ATHEK3F53_17210(wecB)
CHEBHH215_20205(wecB)
SURLBI350_15330
LFBC1X05_15860
TVUAB849_005655
KPULGXN76_15365(wecB)
KEBGXN75_16725(wecB)
PABSJIR001_30170
CBOCBO3100
CBACLB_3129
CBHCLC_3002
CBYCLM_3506
CBLCLK_2494
CBKCLL_A3182
CBBCLD_1440
CBICLJ_B3366
CBTCLH_2927
CBFCLI_3159
CBMCBF_3148
CBJH04402_03177
CBECbei_4627
CBZCbs_4627
CBEILF65_05170
CKLCKL_3166
CKRCKR_2804
CLJCLJU_c34070
CCBClocel_3137
CSRCspa_c53520
CSBCLSA_c41270
CAHCAETHG_1305(wecB)
CSQCSCA_4791
CLDCLSPO_c18630 CLSPO_c31990
CCKCcar_17245
CBUTATN24_15745
CTYKCTK_C08720
CEUA7L45_12065
CTAEBGI42_12630
CDRKB9W14_20915
CDYF3K33_23555
CFERD4Z93_01765
CGASJ1C67_09865(wecB)
CLOSDMR38_17075
CGELpsyc5s11_49940
HHWNCTC503_01993(wecB)
RBPB6259_08160
CCELCCDG5_0710
EHAEthha_0669
CAPREQM14_12865
CAMLH6X83_09690(wecB)
CLFGJQ69_02340
CFEMHCR03_17330(wecB)
DORDesor_5330
DAIDesaci_4441
DMIDesmer_4332
PTHPTH_0384(WecB) PTH_1103(WecB)
DFGB0537_15540
DKUDesku_0874
AACXDEACI_0260
ELMELI_2561
SAYTPY_3671(wecB)
SAPSulac_3370
STHRBXT84_14970
MDVC5Q96_07715
TTETTE0661(WecB2)
MASMahau_0358
TBZBK011_02350
BSOLFSW04_03495
CWOCwoe_5917
PARNNBH00_24920(wecB)
SBAEDSM104329_04159(wbpI_1) DSM104329_05200(wbpI_2)
ELEElen_0637
EUZDVS28_a1719
HHGXM38_017570(wbpI)
GLPGlo7428_3721
OXYHCG48_01150(wecB)
GEIGEI7407_2308
GLJGKIL_0481(wecB)
CALHIJ00_16800
DEWDGWBC_0899
DFODform_01826(wecB)
RRSRoseRS_4430
RCARcas_0784
CAGCagg_0816 Cagg_1972
PSUBPelsub_P0628
CAPCLDAP_36180
THUGKNN16_05605(wecB)
DSWQR90_12670
DRDLMT64_11870(wecB)
TTHTT_C0285
PUVPUV_00130
AHELQ31a_45020(wbpI_1)
LCREPla8534_69410(wbpI)
PBSPlabr_1618
TPEDTPE_0207
TRMJO41_03110
TRZGWP43_02850
TMEDDWB79_01350
SPEREW093_13210 EW093_13440
TPXTurpa_0308
ABAAcid345_3306
GMAAciX8_3530
TRSTerro_1265
TALBFTW19_11825
FCII6I83_02405(wecB)
ACOAmico_1720
TLITlie_1813
AMOAnamo_1187
BUNBun01g_30650(wbpI)
BSTEK6V31_02460(wecB)
PPNPalpr_1323
PGOLK6V26_13515(wecB)
TFOBFO_2566
TOHBCB71_09295
OSPOdosp_0942
BVIRI6J59_01690(wecB) I6J59_14280(wecB)
TTZFHG85_09800
BACCBRDCF_p1451(wecB)
DORIFH5T_09075
RMGRhom172_0568
RBARAWN76_007345
CPICpin_4757
NIAA8C56_08555
FLASY85_01715
PGINFRZ67_02945
SBXCA265_19270
SPIBG8759_15505(wecB)
CHRWKA713_08525(wecB)
RUNDR864_23725
FKAKM029_13900(wecB)
CAPHCGC49_04830
ZGAZOBELLIA_1741(wecB)
SPONHME9304_01541(wbpI)
TDIAUW17_08820
TENLPB136_00970
TMPF9Y86_02255 F9Y86_04655
LUTLupro_12975
LULLPB138_15100
WFUAXE80_02790
SALTAO058_00370
EMARD1013_01185
PSYNE9099_06875
ASAGFGM00_16585
FBEFF125_16525
CARHEGY05_16490
FTEFluta_0726 Fluta_2189
FLUCHH17_06355
CRMK6119_19005(wecB)
OHOOweho_1403
CHYDH4K34_02735(wecB)
PTANCRYO30217_01158(wbpI_2)
SHYRLA303_04925(wecB)
BBAUAEM51_07985
MROMROS_2673
CPRVCYPRO_2717
CACICLOAM1218(wecB)
SAFSULAZ_0353
TMMTmari_0610
TMITHEMA_01615
TMWTHMA_0626
TMQTHMB_0626
TMXTHMC_0626
TPTTpet_0300 Tpet_0308
TNPTnap_0392 Tnap_0427
TRQTRQ2_0326
THQT2812B_01620
THZCELL2_01685
TLETlet_1207
TTATheth_1610
PHYAJ81_08730
TMETmel_0366
THPBG95_04935
THERY592_05005
FNOFnod_0568
FPEFerpe_0132
FIANA23_00760(wecB)
OCYOSSY52_03120
PMOPmob_0933 Pmob_1288
MPZMarpi_1253
MARNLN42_06735
KOLKole_1631
ASACATHSA_0040
CNICalni_1804
DTHDICTH_0427
DTUDtur_0574
ALAMRT761_00505(wbpI)
BIHBIP78_0584
MVNMevan_0198
MVOMvol_0232
MFIDSM1535_0247
METTCIT01_00335
PFIPFC_03140
PYCTQ32_02915
TSITSIB_2024
THMCL1_0830
THSTES1_1887
TTDA3L14_00440
THYA3L12_02955
THEIK1720_03030(wecB)
MBYMSBRM_0005 MSBRM_0792
MBWMSBRW_0943 MSBRW_2602
MBARMSBR2_0018
MBAKMSBR3_1166 MSBR3_1605
MMACMSMAC_1844
MVCMSVAZ_0005
MEKMSKOL_0025
MLSMSLAZ_1033 MSLAZ_1853 MSLAZ_1949
METMMSMTP_0932
MEFMSWH1_0729
MEQMSWHS_0769 MSWHS_0879
MSJMSSAC_1840 MSSAC_3566
MSZMSSIH_3108 MSSIH_3704
MSWMSSIT_2437 MSSIT_3165 MSSIT_3783
MBUMbur_2022
MHAZBHR79_03050
MHZMetho_1732
MTPMthe_1235
MCJMCON_2577(wecB)
MHUMhun_0382
MRTJKHC33_15080(wecB)
MEMMemar_1605
MBGBN140_0822(wecB1) BN140_2091(wecB3)
MEMAMMAB1_1080 MMAB1_2721
MCHKMchiMG62_18100
MSUMOH143_02235(wecB)
MFOMetfor_1414
RCIRCIX1930(wecB)
HJEHacjB3_10370
HALXM0R89_17775(wecB)
HAXZM0R88_18115(wecB)
HMUHmuk_2022
HALZE5139_13240
HALLLC1Hm_1346(wecB2)
HAZPGBQ70_13255
HALIBV210_19220
HPELHZS54_05795(wecB)
HLTI7X12_00715(wecB)
HMEHFX_6231(wecB)
HGIABY42_18105
HALEG3A49_06295(wecB)
HAERDU502_04900
HSSJ7656_09670(wecB)
HALGHUG10_14630(wecB)
HALUHUG12_21355(wecB)
HDABB347_15095
NMGNmag_0676
HXAHalxa_0889
NPENatpe_1304
HJTDVR14_15700
NGENatgr_0273
HRUHalru_0617 Halru_1009
HLRHALLA_13145
HLCCHINAEXTREME15900
NAJB1756_01065
NAGAArcMg_2149
NANAArc1_1538
NBGDV706_19910
NASGCU68_21140
ACFAciM339_0818
THBN186_08030
NVNNVIE_008910
NEVNTE_02143
NFNNFRAN_0194 NFRAN_0785(wecB)
NDVNDEV_0205(wecB2)
AGWQT03_C0001G0650
 » show all
Reference
1  [PMID:17346239]
  Authors
Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS.
  Title
Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:123-30 (2007)
DOI:10.1042/BJ20070017
  Sequence
[pae:PA3148] [bpe:BP0090]
Reference
2
  Authors
Westman, E.L., McNally, D.J., Rejzek, M., Miller, W.L., Kannathasan, V.S., Preston, A., Maskell, D.J., Field, R.A., Brisson, J.R. and Lam, J.S.
  Title
Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens.
  Journal
Biochem J 405:625 (2007)
Reference
3  [PMID:11526328]
  Authors
Sri Kannathasan V, Staines AG, Dong CJ, Field RA, Preston AG, Maskell DJ, Naismith JH.
  Title
Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase.
  Journal
Acta Crystallogr D Biol Crystallogr 57:1310-2 (2001)
DOI:10.1107/S0907444901010885
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.23
IUBMB Enzyme Nomenclature: 5.1.3.23
ExPASy - ENZYME nomenclature database: 5.1.3.23
BRENDA, the Enzyme Database: 5.1.3.23

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