KEGG   ENZYME: 5.1.3.24
Entry
EC 5.1.3.24                 Enzyme                                 
Name
N-acetylneuraminate epimerase;
sialic acid epimerase;
N-acetylneuraminate mutarotase;
NanM;
NanQ
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
N-acetyl-alpha-neuraminate 2-epimerase
Reaction(IUBMB)
N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate (oveall reaction) [RN:R09797];
(1a) N-acetyl-alpha-neuraminate = aceneuramate [RN:R12769];
(1b) aceneuramate = N-acetyl-beta-neuraminate [RN:R12770]
Reaction(KEGG)
Substrate
N-acetyl-alpha-neuraminate [CPD:C19909];
aceneuramate [CPD:C22382]
Product
N-acetyl-beta-neuraminate [CPD:C19910];
aceneuramate [CPD:C22382]
Comment
Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation. This enzyme accelerates maturotation to the beta form via the open form (which also occurs as a slow spontaneous reaction). The open form is necessary for further metabolism by the bacteria.
History
EC 5.1.3.24 created 2011, modified 2021
Orthology
K17948  N-acetylneuraminate epimerase
Genes
ECOb4310(nanM)
ECJJW5777(yjhT)
ECDECDH10B_4513(yjhT)
EBWBWG_4008(nanM)
ECEZ5906(yjhT)
ECSECs_5269(yjhT)
ECFECH74115_5814
ETWECSP_5392(yjhT)
ELXCDCO157_4954
EOIECO111_5164(nanM)
EOJECO26_5507(nanM)
EOHECO103_5091(nanM)
ECOOECRM13514_5553(yjhT)
ECOHECRM13516_5268(yjhT)
ECGE2348C_4617(yjhT)
EOKG2583_5111(yjhT)
ELRECO55CA74_24620
ELHETEC_4622
ECWEcE24377A_4909
ECPECP_4643
ENAECNA114_4554(yjhT)
ECOSEC958_0038 EC958_3297
ECVAPECO1_2121(yjhT)
ECOAAPECO78_02685
ECXEcHS_A4535
ECMEcSMS35_4835
ECYECSE_4582
ECRECIAI1_4523(yjhT)
ECQECED1_4916 ECED1_5194(yjhT)
EUMECUMN_3380 ECUMN_4915(yjhT)
ECTECIAI39_4781(yjhT)
EOCCE10_5054(nanM)
EBRECB_04177(yjhT)
EBLECD_04177(nanM)
EBEB21_04139(nanM)
EBDECBD_3727
ECIUTI89_C5006
EIHECOK1_4808
ECZECS88_4927(yjhT)
ECCc3634 c5388
ELOEC042_4821
ELNNRG857_21740
ESEECSF_4250
EKOEKO11_4006
EKFKO11_23175(nanM)
EABECABU_c33050 ECABU_c49520
EDHEcDH1_3688
EDJECDH1ME8569_4169(yjhT)
ELUUM146_22235
ELWECW_m4667(nanM)
ELLWFL_22730(nanM)
ELCi14_3329 i14_4906
ELDi02_3329 i02_4906
ELFLF82_3478(yjhT)
ECOLLY180_22610
ECOIECOPMV1_04756(nanM)
ECOJP423_16480 P423_24505
EALEAKF1_ch1544
ESZFEM44_14110
STYSTY1167
STTt1790
SEXSTBHUCCB_19010
SENTTY21A_09095
STMSTM1130
SEOSTM14_1293
SEVSTMMW_11391
SEYSL1344_1068
SEMSTMDT12_C11490
SEJSTMUK_1098
SEBSTM474_1124
SEFUMN798_1175
SETUSTU288_01980
SETCCFSAN001921_11530
SENRSTMDT2_10651
SENDDT104_11101
SENICY43_05765
SEENSE451236_11495
SPQSPAB_02408
SEISPC_2619
SECSCH_1080(yjhT)
SEHSeHA_C1240
SHBSU5_01759
SENHCFSAN002069_03375
SEEHSEEH1578_14875
SEESNSL254_A1225
SENNSN31241_21970
SEWSeSA_A1195
SEDSeD_A1205
SELSPUL_1927
SEGASPUCDC_1913
SETSEN0991
SENAAU38_05120
SENOAU37_05110
SENVAU39_05110
SENQAU40_05745
SENLIY59_05215
SENJCFSAN001992_05995
SEEBSEEB0189_013925
SEEPI137_08760
SENBBN855_10880
SENEIA1_05560
SESSARI_01870
SALZEOS98_13950
SFLSF4212(yjhT)
SFXS4469(yjhT)
SFVSFV_4217(yjhT)
SFESFxv_4595
SFNSFy_6049
SFSSFyv_6119
SFTNCTC1_04579(yjhT)
SSNSSON_4472(yjhT)
SBOSBO_4360(yjhT)
SHQA0259_03230
YPEYPO1858
YPKy2448
YPHYPC_2405
YPAYPA_1237
YPNYPN_2265
YPMYP_1535
YPPYPDSF_1267
YPGYpAngola_A2044
YPZYPZ3_1871
YPTA1122_16570
YPDYPD4_1647
YPXYPD8_1903
YPWCH59_3308(nanM)
YPJCH55_817(nanM)
YPVBZ15_1692(nanM)
YPLCH46_3265(nanM)
YPSYPTB1729
YPOBZ17_771(nanM)
YPIYpsIP31758_2260
YPYYPK_2362
YPBYPTS_1861
YPQDJ40_491(nanM)
YPUBZ21_1083(nanM)
YPRBZ20_245(nanM)
YPCBZ23_1364(nanM)
YPFBZ19_1157(nanM)
YENYE1943
YEPYE105_C1753
YEYY11_13781
YEWCH47_1375(nanM)
YETCH48_3365(nanM)
YEFFORC2_2489
YEEYE5303_22951
YSIBF17_17915
YFRAW19_918(nanM)
YKRCH54_744
YROCH64_268(nanM)
YRUBD65_2428(nanM)
YRBUGYR_12510
YAKACZ76_00835
YMADA391_09450
YHID5F51_10580
YCAF0T03_12955
YMOHRD69_13900
YASN0H69_16095
PVGCRN77_04700
PCOLF1325_18500
PCIBF9282_19070
PPEEI6G31_10245
MMKMU9_1237
ETRETAE_0932
ETDETAF_0868(nanM)
ETEETEE_2873
ETCETAC_04450
EDWQY76_15510
EDLAAZ33_04945
EHOA9798_12110
HINHI_0148
HITNTHI0235
HIPCGSHiEE_02545
HIQCGSHiGG_03330
HIFHIBPF_19720
HILHICON_13250
HIUHIB_02010
HIER2846_0489(nanM)
HIZR2866_0439(nanM)
HIKHifGL_000825(nanM)
HIAH733_0032(nanM)
HIHNF38_04680
HIWNTHI477_01181(nanM)
HICNTHIC486_00883(nanM)
HIXNTHI723_01555(nanM)
HAYC3V42_06650
HPITNCTC13334_00443(nanM)
HHZNCTC10839_01822(nanM)
HAEGNCTC8502_01090(nanM)
HSEML3077_04460
PMUPM1707
PMVPMCN06_2150(nanM)
PULNT08PM_2044
PMPPmu_20710(nanM)
PMULDR93_654(nanM)
PSKYA6B44_10030
PATLKGI96_08820
PCAIK7G93_001403
AAPNT05HA_0541
AAZADJ80_06975
AATD11S_1586
AAOANH9381_1957
AAND7S_00408
AAHCF65_02476
AACNAANUM_1474
AACTACT75_01640
ASEGNCTC10977_01728(nanM)
GANUMN179_01671
APAGEIA51_10115
AVTNCTC3438_00937(nanM)
RPNENCTC8284_03406(nanM_2)
RHEYFEE42_05575
RHAEIHV77_04775
OOIA6A10_03740
FCLA4G17_06630
BHUDA6A11_01695
VCHVC_1774
VCFIR04_14055
VCSMS6_1547
VCEVch1786_I1268
VCQEN18_12020
VCJVCD_002596
VCIO3Y_08590
VCOVC0395_A1372
VCRVC395_1888
VCMVCM66_1712
VCLVCLMA_A1536
VCZVAB027_2447
VVUVV2_0726
VVYVVA1196 VVA1197
VVMVVMO6_04100 VVMO6_04101
VVLVV93_v1c41230 VV93_v1c41240
VEUIXK98_05330
VMIAL543_04580
VSCVSVS12_03139(nanM) VSVS12_03140
VSHBSZ05_25890 BSZ05_25895
PDSCAY62_15090
SPLSpea_1514
PSYPCNPT3_07910
CHJNCTC10426_00703(nanM)
RHGEXZ61_13475
HFRG5S34_08795
GLCJQN73_01825
SCLsce5357
AAKAA2016_4369
BMEBMEII0856
BMELDK63_2392
BMIBMEA_B0390
BMZBM28_B0384
BMGBM590_B0382
BMWBMNI_II0375
BMEEDK62_3015
BMFBAB2_0809
BMBBruAb2_0789
BMCBAbS19_II07480
BAABAA13334_II01485
BABODK55_2765
BABRDO74_3181
BABTDK49_2474
BABBDK48_3032
BABUDK53_2768
BABSDK51_2252
BABCDO78_2289
BSUIBSSP1_II0367
BSUPBSPT1_II0365
BSUVBSPT2_II0368
BSUCBSSP2_II0371
BMTBSUIS_B0415
BSZDK67_2419
BSWIY71_13135
BSGIY72_12675
BOVBOV_A0355
BCSBCAN_B0415
BSKBCA52141_II0611
BOLBCOUA_II0412
BCARDK60_2139
BCASDA85_12455
BMRBMI_II409
BPPBPI_II394
BPVDK65_2091
BCETV910_200826
BRUBFS01_14195
BRJBKD03_02810
BIOBR141012304_20247
DEIC4375_16440
DSALK1X15_12935
PARUCYR75_06050
LGYT479_08755
GOTAXE85_00555
GMONCTC11323_00012(nanM)
GEQCG018_02310
GSAFOC50_04420
GHANCTC10459_00013(nanM)
VIJJNUCC6_03350
DPMFNV33_08660
CBUTATN24_15385
MHWACT01_13190
SELEADJ74_04330
SELOAXE86_05610
MHGMHY_00950
MFUNGXM21_10670
KFLKfla_0128
DDRDeide_3p01141
DFCDFI_16055
DEINDAAJ005_09570
DPHEHF33_19580
OBTOPIT5_23745
AGLPYTT_1911
ROOG5S37_09935
LUOHHL09_03715
PSLPsta_1238
PIRVN12_17085(nanM_1)
ROLCA51_38050(nanM_1)
PLSVT03_21000(nanM_2)
TIMGMBLW1_20220 GMBLW1_44300
LRSPX52LOC_04974
ULIETAA1_10650(nanM_1)
PBUL21SP3_00912(nanM)
HBSIPV69_02750
BRMBmur_2467
BPOBP951000_0927
BPJB2904_orf437
BPIPBPP43_10440
BPWWESB_2249
BIPBint_0697
BHPBHAMNSH16_10710
PFERIRI77_27135
FNCHMPREF0946_01160
FNTHMPREF0405_00242
FHWRN87_04355
FVAFV113G1_02100
FULC4N20_05260
FMOC4N19_06915
FGOC4N16_07160
FNFBSQ88_06540
FCII6I83_10425
SMFSmon_1051
BXYBXY_44770
BOABovatus_01545(nanM_1)
BCACCGC64_15640
BCAEA4V03_11380
BVUBVU_4137
BDOEL88_15600
BDHGV66_22005
PCOPI6J50_17260
PBTING2E5B_2376
PMUCING2E5A_0814(nanM)
PETPEIBARAKI_6556
PSACPSM36_2234
PDIBDI_2949
PARCCI960_20980
TFOBFO_2210
PARYA4V02_10410
COPRCop2CBH44_31290
PMZHMPREF0659_A6641
PDNHMPREF9137_2436
PDTPrede_1040
PROHMPREF0669_00713
PFUSADJ77_09660
PEOAS203_02645
PJECRM71_09425
POCNCTC13071_00094(nanM)
DORIFH5T_13875
CHITFW415_22780
NSONIASO_04270 NIASO_17355
NIAA8C56_20460
FGGFSB75_00725
ARKD6B99_12645
AGIFSB73_06750
FLSGLV81_17610
LACSH4075_08735
PHEPhep_2212 Phep_3255 Phep_3569
PEPAQ505_14410
PGSCPT03_08035 CPT03_13135
PROEH9L23_05800
SHGSph21_4585
SHTKO02_01190
SPHNBV902_06625
SMIZ4412673_03728(nanM_2)
SPSCE2P86_07235
SPHZE3D81_00295 E3D81_09385
SPHEGFH32_00785 GFH32_12215
SDJNCTC13534_05183(nanM_2)
STHANCTC11429_02641(nanM_1) NCTC11429_04305(nanM_2)
SMUII6J00_22050
SSIYJVX97_26645
MRUBDEO27_011530
MGIKGO620_002240
OLIFKG96_20860
SBXCA265_04840
SLISlin_2624
ASWUHUW51_05915
COCCoch_2065
COLAM608_02860
CHGAXF12_07720
CAPNCBG49_11685
CLKCGC53_09515
CSPUCGC55_13480
CAPFFOC45_03360
ELTFGE20_11205
 » show all
Reference
1  [PMID:18063573]
  Authors
Severi E, Muller A, Potts JR, Leech A, Williamson D, Wilson KS, Thomas GH
  Title
Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT.
  Journal
J Biol Chem 283:4841-9 (2008)
DOI:10.1074/jbc.M707822200
  Sequence
[eco:b4310]
Reference
2  [PMID:33895133]
  Authors
Kentache T, Thabault L, Deumer G, Haufroid V, Frederick R, Linster CL, Peracchi A, Veiga-da-Cunha M, Bommer GT, Van Schaftingen E.
  Title
The metalloprotein YhcH is an anomerase providing N-acetylneuraminate aldolase with the open form of its substrate.
  Journal
J Biol Chem 296:100699 (2021)
DOI:10.1016/j.jbc.2021.100699
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.24
IUBMB Enzyme Nomenclature: 5.1.3.24
ExPASy - ENZYME nomenclature database: 5.1.3.24
BRENDA, the Enzyme Database: 5.1.3.24

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