gerF (gene name);
tylJ (gene name);
chmJ (gene name);
mydH (gene name)
Racemases and epimerases;
Acting on carbohydrates and derivatives
dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-gulose [RN:
The enzyme is involved in the biosynthetic pathway of dTDP-6-deoxy-alpha-D-allose, which is converted to mycinose after attachment to the aglycones of several macrolide antibiotics, including tylosin, chalcomycin, dihydrochalcomycin, and mycinamicin II.
EC 18.104.22.168 created 2013
ec00523 Polyketide sugar unit biosynthesis
ec01110 Biosynthesis of secondary metabolites
K13312 dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
K19855 dTDP-4-dehydro-6-deoxy-D-glucose 3-epimerase
Sohng JK, Kim HJ, Nam DH, Lim DO, Han JM, Lee HJ, Yoo JC
Cloning, expression, and biological function of a dTDP-deoxyglucose epimerase (gerF) gene from Streptomyces sp. GERI-155.
Thuy TT, Liou K, Oh TJ, Kim DH, Nam DH, Yoo JC, Sohng JK
Biosynthesis of dTDP-6-deoxy-beta-D-allose, biochemical characterization of dTDP-4-keto-6-deoxyglucose reductase (GerKI) from Streptomyces sp. KCTC 0041BP.
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM
Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
ExplorEnz - The Enzyme Database: 22.214.171.124
ExPASy - ENZYME nomenclature database: 126.96.36.199