KEGG   ENZYME: 5.1.3.28
Entry
EC 5.1.3.28                 Enzyme                                 

Name
UDP-N-acetyl-L-fucosamine synthase;
WbjD;
Cap5G
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
UDP-2-acetamido-2,6-dideoxy-beta-L-talose 2-epimerase
Reaction(IUBMB)
UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine [RN:R10676]
Reaction(KEGG)
R10676
Substrate
UDP-2-acetamido-2,6-dideoxy-beta-L-talose [CPD:C20768]
Product
UDP-N-acetyl-beta-L-fucosamine [CPD:C20774]
Comment
Isolated from the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Involved in bacterial polysaccharide biosynthesis.
History
EC 5.1.3.28 created 2014
Pathway
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K24258  UDP-N-acetyl-L-fucosamine synthase
Genes
EOJ: ECO26_2943(fnl3)
ECOO: ECRM13514_2752(fnlC)
ECOH: ECRM13516_2620(fnlC)
EAB: ECABU_c23600(fnlC)
ELP: P12B_c2136(capG)
SBZ: A464_2211
SBV: N643_09260
ECAN: CWI88_07920
CCON: AFK62_12525
CUI: AFK65_12835
CTU: CTU_27290
YFR: AW19_2185
YKR: CH54_3601
ASY: AUT07_00150(wbpI)
HPAS: JL26_05865
PMU: PM1009(wbjD)
PMV: PMCN06_0221(wecB)
PMP: Pmu_01520(wbjD)
PMUL: DR93_960
PDAG: 4362423_00267(wbjD)
THEH: G7079_07110(wecB)
VFI: VF_0193(rffE)
PAEB: NCGM1900_3149(wbjD)
PPUH: B479_06965
PFS: PFLU_1659(fnl3)
PMAN: OU5_1707
PEN: PSEEN1502
PUM: HGP31_08960(wecB)
PPSH: G5J76_11630(wecB)
PALI: A3K91_0728
ABAD: ABD1_00600(wecB)
ABAU: IX87_14890
PNG: PNIG_a0509(wecB)
MBS: MRBBS_2500(wecB)
FTD: AS84_1080
FTY: CH70_512
FRC: KX01_1759
TXA: HQN79_09380(wecB)
TEE: Tel_08640
GAI: IMCC3135_22515(wbpI)
APAC: S7S_10525
AVR: B565_2779
OCE: GU3_12820
CFON: HZU75_02530(wecB)
PPNO: DA70_17330
PPNM: LV28_13495
CABA: SBC2_28920(wbpI)
ODI: ODI_R2815
AJS: Ajs_3032
CBX: Cenrod_0486(wecB-1)
HYB: Q5W_21535
CBAA: SRAA_0130
CBAB: SMCB_0541
HSE: Hsero_4220(wecB)
GCA: Galf_2832
EBA: ebA5890
APET: ToN1_17460(wecB)
AZA: AZKH_0897
AZQ: G3580_04700(wecB)
ABT: ABED_0640
GUR: Gura_1696
GBM: Gbem_1623(wbjD)
DEU: DBW_1520
DFL: DFE_2837
DTO: TOL2_C08110(wecB)
DMM: dnm_096980(wecB2)
RHT: NT26_3155(capG)
SNO: Snov_3209
HDN: Hden_0187
MARU: FIU81_15475(wbpI)
PAMO: BAR1_15465
SECH: B18_28740
BBA: Bd1695(capG)
BNC: BCN_5194
BFD: NCTC4823_03154(mnaA_3)
PSYO: PB01_03870
SAU: SA0150(capG)
SAV: SAV0155(capG)
SAW: SAHV_0154(capG)
SAM: MW0130(cap8G)
SAS: SAS0130
SAR: SAR0157(capG)
SAC: SACOL0142(cap5G)
SAA: SAUSA300_0158(cap5G)
SAE: NWMN_0101(capG)
SAD: SAAV_0123(cap5G)
SUE: SAOV_0102
SUJ: SAA6159_00139(cap5G)
SUK: SAA6008_00133(cap5G)
SUC: ECTR2_112
SUZ: MS7_0149
SUX: SAEMRSA15_01210(capG)
SUW: SATW20_01660(capG)
SUG: SAPIG0169
SUF: SARLGA251_01290(capG)
SAUA: SAAG_00638
SAUE: RSAU_000109(capG)
SAUS: SA40_0122(capG)
SAUU: SA957_0137(capG)
SAUG: SA268_0134(capG)
SAUT: SAI1T1_2001100(capG)
SAUJ: SAI2T2_1001100(capG)
SAUK: SAI3T3_1001100(capG)
SAUQ: SAI4T8_1001100(capG)
SAUV: SAI7S6_1001100(capG)
SAUW: SAI5S5_1001090(capG)
SAUX: SAI6T6_1001100(capG)
SAUY: SAI8T7_1001100(capG)
SAUF: X998_0138
SAB: SAB0096(capG)
SUY: SA2981_0156(capG)
SAUB: C248_0144(capG)
SAUM: BN843_1610
SAUC: CA347_166
SAUR: SABB_01686(wecB)
SAUI: AZ30_00815
SAUD: CH52_04950
SAMS: NI36_00710
SHA: SH0394(capG)
SHH: ShL2_00299(cap5G)
SLN: SLUG_03260(capG)
SAGQ: EP23_07985(wecB)
SARL: SAP2_22720
SSH: NCTC13712_00110(mnaA_1)
LGZ: NCTC10812_01729(mnaA_1)
LLR: llh_0480
SPN: SP_0360(cps4L)
MPS: MPTP_0533
MPX: MPD5_1384
CARC: NY10_926
JAR: G7057_08185(wecB) G7057_08370(wecB)
FPR: FP2_31560
BPB: bpr_I0346
BFI: CIY_26620
BHU: bhn_I0402
CPY: Cphy_3502
CSO: CLS_28760
HSD: SD1D_1289
ACEL: acsn021_22610(capG)
EAC: EAL2_c20130(wecB)
SLP: Slip_0165
DRM: Dred_3031
ELM: ELI_4557
ALKA: J0B03_04220(wecB)
PUF: UFO1_4149
ERH: ERH_0860(wecB)
ERD: G7062_06985(wecB)
EIO: H9L01_07870(wecB)
ACL: ACL_1043(wecB2)
AAXA: NCTC10138_00338(mnaA)
MBJ: KQ51_00736(wbpI)
CPEG: CPELA_00505(wbpI)
CGK: CGERO_00495(wbpI)
CPSO: CPPEL_00480(wbpI)
CSUR: N24_0492
LXX: Lxx05070(wbjD)
CFL: Cfla_0759
DCO: SAMEA4475696_2249(mnaA)
AUS: IPK37_01970(wecB)
TDF: H9L22_12375(wecB)
NDK: I601_1758(wbpI)
MCAB: HXZ27_11025(wecB)
MSAG: GCM10017556_43860(rffE)
MCRA: ID554_03055(wecB)
VER: HUT12_10085(wecB)
DFC: DFI_17505
OBG: Verru16b_02064(wbpI)
ROO: G5S37_11400(wecB)
RUL: UC8_50250(wbpI)
MFF: MFFC18_22190(wbpI)
PND: Pla175_07570(wbpI)
PBU: L21SP3_00952(wbpI_1)
PBP: STSP1_00659(wbpI_1)
LIL: LA_1645(wecB)
LIE: LIF_A1331(wecB)
LIC: LIC_12139(rffE)
LIS: LIL_12273(wecB)
FVA: FV113G1_07640(wbpI)
BTH: BT_0383
BTHO: Btheta7330_02109(wbpI_2) Btheta7330_02997(wbpI_4)
BFS: BF9343_1827(wcgT)
BCEL: BcellWH2_04979(wbpI_2)
PRU: PRU_0103
DORI: FH5T_21515
CPI: Cpin_4750
CHIH: GWR21_01130(wecB)
FPS: FP1285(fnlC)
FBR: FBFL15_1034(fnlC)
FIN: KQS_03325(fnlC)
COC: Coch_1112
CBAT: M666_12270
DDO: I597_2181(wbpI)
MLT: VC82_2497
NDO: DDD_3540(fnlC)
MESQ: C7H62_1056
CGLE: NCTC11432_02308(mnaA)
CTAI: NCTC12078_01303(mnaA)
CTAK: 4412677_01079(mnaA)
CJG: NCTC13459_02734(mnaA)
CANT: NCTC13489_01521(mnaA)
ESTE: HNV03_12275(wecB)
PPH: Ppha_0560
THER: Y592_04245
DTN: DTL3_0981
CABY: Cabys_3396
 » show all
Reference
1  [PMID:12464616]
  Authors
Kneidinger B, O'Riordan K, Li J, Brisson JR, Lee JC, Lam JS
  Title
Three highly conserved proteins catalyze the conversion of UDP-N-acetyl-D-glucosamine to precursors for the biosynthesis of O antigen in Pseudomonas aeruginosa O11 and capsule in Staphylococcus aureus type 5. Implications for the UDP-N-acetyl-L-fucosamine biosynthetic pathway.
  Journal
J Biol Chem 278:3615-27 (2003)
DOI:10.1074/jbc.M203867200
Reference
2  [PMID:15778500]
  Authors
Mulrooney EF, Poon KK, McNally DJ, Brisson JR, Lam JS
  Title
Biosynthesis of UDP-N-acetyl-L-fucosamine, a precursor to the biosynthesis of lipopolysaccharide in Pseudomonas aeruginosa serotype O11.
  Journal
J Biol Chem 280:19535-42 (2005)
DOI:10.1074/jbc.M500612200
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.28
IUBMB Enzyme Nomenclature: 5.1.3.28
ExPASy - ENZYME nomenclature database: 5.1.3.28
BRENDA, the Enzyme Database: 5.1.3.28

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