KEGG   ENZYME: 5.1.3.33
Entry
EC 5.1.3.33                 Enzyme                                 

Name
2-epi-5-epi-valiolone epimerase;
CetB;
EVE
Class
Isomerases;
Racemases and epimerases;
Acting on carbohydrates and derivatives
Sysname
2-epi-5-epi-valiolone 2-epimerase
Reaction(IUBMB)
2-epi-5-epi-valiolone = 5-epi-valiolone [RN:R11079]
Reaction(KEGG)
R11079
Substrate
2-epi-5-epi-valiolone [CPD:C17691]
Product
5-epi-valiolone [CPD:C17694]
Comment
The enzyme, characterized from the bacterium Actinomyces sp. Lu 9419, is involved in the biosynthesis of the antitumor agent cetoniacytone A.
History
EC 5.1.3.33 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K20431  2-epi-5-epi-valiolone epimerase
Genes
SHY: SHJG_0279
SHO: SHJGH_0113
MCAB: HXZ27_14360
Reference
1  [PMID:19101977]
  Authors
Wu X, Flatt PM, Xu H, Mahmud T
  Title
Biosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.
  Journal
Chembiochem 10:304-14 (2009)
DOI:10.1002/cbic.200800527
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.1.3.33
IUBMB Enzyme Nomenclature: 5.1.3.33
ExPASy - ENZYME nomenclature database: 5.1.3.33
BRENDA, the Enzyme Database: 5.1.3.33

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