KEGG   ENZYME: 5.3.3.12
Entry
EC 5.3.3.12                 Enzyme                                 
Name
L-dopachrome isomerase;
dopachrome tautomerase;
tyrosinase-related protein 2;
TRP-1;
TRP2;
TRP-2;
tyrosinase-related protein-2;
dopachrome Delta7,Delta2-isomerase;
dopachrome Delta-isomerase;
dopachrome conversion factor;
dopachrome isomerase;
dopachrome oxidoreductase;
dopachrome-rearranging enzyme;
DCF;
DCT;
dopachrome keto-enol isomerase;
L-dopachrome-methyl ester tautomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
Sysname
L-dopachrome keto-enol isomerase
Reaction(IUBMB)
L-dopachrome = 5,6-dihydroxyindole-2-carboxylate [RN:R03673]
Reaction(KEGG)
R03673
Substrate
L-dopachrome [CPD:C01693]
Product
5,6-dihydroxyindole-2-carboxylate [CPD:C04185]
Comment
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase).
History
EC 5.3.3.12 created 1992, modified 1999, modified 2005
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K01827  dopachrome tautomerase
K22203  dopachrome tautomerase
Genes
HSA1638(DCT)
PTR452622(DCT)
PPS100975768(DCT)
GGO101133130(DCT)
PON100438537(DCT)
NLE100595345(DCT)
MCC694577(DCT)
MCF102127456(DCT)
MTHB126940576
CSAB103214664(DCT)
CATY105574488(DCT)
PANU101001052(DCT)
TGE112610757(DCT)
RRO104658800(DCT)
RBB108519938(DCT)
TFN117063613(DCT)
PTEH111546588 113219501
CJC100389709(DCT)
CSYR103250749(DCT)
MMUR105874178(DCT)
LCAT123648840(DCT)
OGA100944933(DCT)
MMU13190(Dct)
MCAL110308926(Dct)
MPAH110325053(Dct)
RNO290484(Dct)
MCOC116084949(Dct)
MUN110565610 110565611
CGE100764118(Dct)
MAUA101835607(Dct)
PLEU114692467(Dct)
MORG121462201(Dct)
MFOT126506680
AAMP119800423(Dct)
NGI103729035(Dct)
HGL101716269(Dct)
CPOC100718804(Dct)
CCAN109702871(Dct)
DORD105990527(Dct)
DSP122110161(Dct)
NCAR124985370
OCU100353923(DCT)
OPI101518434(DCT)
TUP102484655(DCT)
CFA485520(DCT)
CLUD118351990(DCT)
VVP112923776(DCT)
VLG121477106(DCT)
AML100467156(DCT)
UMR103657595(DCT)
UAH113251084(DCT)
UAR123801147(DCT)
ELK111147121
LLV125095875
MPUF101684393(DCT)
ORO101381485(DCT)
EJU114215890(DCT)
ZCA113920649(DCT)
MLX118009126(DCT)
NSU110585843(DCT)
FCA101094977(DCT)
PYU121037800(DCT)
PBG122483962(DCT)
LRUF124515037
PTG102953286(DCT)
PPAD109264168(DCT)
AJU106984228(DCT)
HHV120240859(DCT)
BTA280761(DCT)
BOM102285590(DCT)
BIU109566904(DCT)
BBUB102401407(DCT)
CHX102169882(DCT)
OAS100170232(DCT)
ODA120883297(DCT)
CCAD122447364(DCT)
SSC574066(DCT)
CFR102519441
CBAI105072676(DCT)
BACU103009988(DCT)
LVE103070463(DCT)
OOR101273282(DCT)
DLE111176330(DCT)
PCAD102981621(DCT)
PSIU116743104(DCT)
ECB100058776(DCT)
EPZ103559368(DCT)
EAI106846221(DCT)
MYB102258295(DCT)
MYD102754085(DCT)
MMYO118651415(DCT)
MLF102437796(DCT)
MNA107545906(DCT)
PKL118730283(DCT)
HAI109395407(DCT)
DRO112310734(DCT)
SHON118994793(DCT)
AJM119039673(DCT)
PDIC114508881(DCT)
PHAS123818646(DCT)
MMF118622628(DCT)
RFQ117021812(DCT)
PALE102883222(DCT)
PGIG120582216(DCT)
PVP105289012(DCT)
RAY107513731(DCT)
MJV108405185(DCT)
TOD119259810(DCT)
SARA101549963(DCT)
LAV100656003(DCT)
TMU101340616
DNM101444242(DCT)
MDO100027305(DCT)
GAS123239909(DCT)
SHR100920202(DCT)
PCW110193809(DCT)
OAA100081295(DCT)
GGA395775(DCT)
PCOC116240283(DCT)
MGP100543862(DCT)
CJO107308023(DCT)
NMEL110392912(DCT)
APLA101792699(DCT)
ACYG106045352(DCT)
AFUL116499607(DCT)
TGU100230498(DCT)
LSR110470581(DCT)
SCAN103812281(DCT)
PMOA120512313(DCT)
OTC121346000(DCT)
PRUF121359377(DCT)
GFR102032174(DCT)
FAB101812075(DCT)
PHI102103043(DCT)
PMAJ107199948(DCT)
CCAE111944860(DCT)
CCW104685963(DCT)
CBRC103614469(DCT)
ETL114057672(DCT)
ZAB102064691(DCT)
ACHL103806684(DCT)
FPG101918681(DCT)
FCH102059594(DCT)
CLV102092544(DCT)
EGZ104122461(DCT)
NNI104014398(DCT)
PLET104618978(DCT)
PCRI104028885(DCT)
ACUN113484458(DCT)
TALA104365935(DCT)
PADL103918279(DCT)
AFOR103898237(DCT)
ACHC115350766(DCT)
HALD104317900(DCT)
CCRI104163727(DCT)
CSTI104554470(DCT)
EHS104510312(DCT)
CMAC104474914(DCT)
MUI104543271(DCT)
FGA104082389(DCT)
GSTE104251797(DCT)
LDI104352234(DCT)
MNB103770216(DCT)
OHA104336513(DCT)
NNT104410153(DCT)
DPUB104301146(DCT)
PGUU104468360(DCT)
ACAR104518362(DCT)
AVIT104270471(DCT)
CVF104292274(DCT)
AAM106491647(DCT)
AROW112965268(DCT)
NPD112948239(DCT)
TGT104577981(DCT)
DNE112994818(DCT)
SCAM104139288(DCT)
ASN102378044(DCT)
AMJ102571729(DCT)
CPOO109306400(DCT)
GGN109303437(DCT)
PSS102443459(DCT)
CMY102934273(DCT)
CPIC101935852(DCT)
TST117871456(DCT)
CABI116827992(DCT)
MRV120373338(DCT)
ACS100557746(dct)
PVT110073874(DCT)
SUND121925848(DCT)
PBI103062097(DCT)
PMUR107293449(DCT)
CTIG120305581(DCT)
TSR106540695(DCT)
PGUT117665497(DCT)
VKO123027223(DCT)
PMUA114596563(DCT)
ZVI118085756(DCT)
GJA107116639(DCT)
STOW125431933(DCT)
XLA100381161(dct.L)
XTR549915(dct)
NPR108786125(DCT)
RTEM120926304(DCT)
BBUF120995857(DCT)
BGAR122932435(DCT)
DRE58074(dct)
SRX107722116(dct)
SANH107662564 107666652
SGH107558385(dct) 107567421
CCAR109052004 109082707
CAUA113108219(dct)
PPRM120479170(dct)
MAMB125270888(dct)
IPU108266888(dct)
PHYP113524332(dct)
SMEO124379653(dct)
TFD113642088(dct)
AMEX103044028(dct)
EEE113590857(dct)
TRU101077388(dct)
TNGGSTEN00026098G001
LCO104922692(dct)
NCC104947502(dct)
CGOB115026433(dct)
ELY117251450(dct)
EFO125899928(dct)
PLEP121949434(dct)
SLUC116047673(dct)
ECRA117952782(dct)
ESP116698024(dct)
PFLV114564055(dct)
GAT120834197(dct)
PPUG119229029(dct)
MSAM119904151(dct)
CUD121522844(dct)
ALAT119026500(dct)
MZE101480314(dct)
ONL100693792(dct)
OAU116319310(dct)
OLA101166914(dct)
OML112154757(dct)
XMA102224148(dct)
XCO114148268(dct)
XHE116723222(dct)
PRET103459953(dct)
PFOR103134252(dct)
PLAI106954957(dct)
PMEI106922902(dct)
GAF122840051(dct)
CVG107092114(dct)
CTUL119793910(dct)
GMU124871178(dct)
NFU107389964(dct)
KMR108239787(dct)
ALIM106528179(dct)
NWH119419636(dct)
AOCE111569955(dct)
MCEP125017766(dct)
CSEM103392019(dct)
POV109631435(dct)
SSEN122765224(dct)
HHIP117755095(dct)
HSP118120408(dct)
LCF108901600
SDU111218368(dct)
SLAL111662191(dct)
XGL120801630(dct)
HCQ109523392(dct)
BPEC110173138(dct)
MALB109958128(dct)
BSPL114847193(dct)
SASA100136917(dct) 100137092 106582441 106586271
STRU115155512 115160816 115160817
OTW112224185 112234462 112237246
OMY110501902 110520164 110520165
OGO124030708 124042904 124043915
ONE115109693 115109696 115131330
SALP111975947
SNH120057890 120057891 120063703
CCLU121536738 121554972
ELS105024741 105024769
SFM108942570(dct)
PKI111834142(dct)
AANG118214508(dct)
LOC102683063(dct)
PSPA121320910(dct)
ARUT117406809(dct)
LCM102360769(DCT)
CMK103176933(dct)
RTP109915622(dct)
BFO118407975 118431962 118431963
BBEL109486120 109486121
CIN100187516
SCLV120335869 120345801 120345802
DMEDmel_CG18550(yellow-f) Dmel_CG8063
DER6552582 6553564
DSIDsimw501_GD20528(Dsim_GD20528) Dsimw501_GD20529(Dsim_GD20529)
DYADyak_GE24474 Dyak_GE24475
DSR110187658
DPO6897182
DPE6587497
DMN108154170
DWI6647655 6647725
DGR6563412
DMODmoj_GI24232
DAZ108617366
DNV115562285
DHE111594489
CCAT101458997
BOD106615115
RZE108363995
MDE101889119
SCAC106089790
LCQ111677337
LSQ119612599
HIS119651400
AGAAgaP_AGAP003095 AgaP_AGAP003096 AgaP_AGAP003097 AgaP_AGAP004324
ACOZ120948805 120953921 120953922 120953924
AARA120893185 120893186 120893187 120908778
ASTE118502828 118505408 118505410 118505411
AAG5563570 5563593 5563621
AALB109412583 109412586 109412587 109433602 109433623 115259651
CQUCpipJ_CPIJ002393 CpipJ_CPIJ002394 CpipJ_CPIJ002395
CPII120426684
BCOO119066578 119067886 119067888 119072305 119083251 119084422 119085262
TCA657666(Y-f)
DPA109544651
SOY115887591
ATD109609256
NVL108566790
APLN108741681 108741682
PPYR116163570
BMOR101737203(yellow-11) 101737351 101737492 101738044 101738170 101738305 101738564 101738837 101740731 101741665 101741808 101741957 105841421 693000(Y-fa) 693002(Y-fb) 693004(Y-f2) 693006
BMAN114240104 114240105 114240199 114240221 114240222 114243745 114243750 114245737 114245738 114245740 114245769 114245811 114245812 114245834 114251500 114251509 114252251 114252906
MSEX115451342 115452856
DPLKGM_215143A KGM_215143B
BANY112051002 112051004
NIQ126779989
PMAC106713422 106713423
PPOT106103071 106103072
PXU106126016 106126017
PRAP110997292 110997307 123690450 123690452
ZCE119838530 119838578
HAW110383034 110383035 110383392
HZE124644429 124644430
TNL113509028
SLIU111359817 111359823
OFU114360988 114360989
PXY105380741 105382882
CFEL113367310
TSPTsp_01297 Tsp_13809
 » show all
Reference
1  [PMID:8573077]
  Authors
Solano F, Jimenez-Cervantes C, Martinez-Liarte JH, Garcia-Borron JC, Jara JR, Lozano JA.
  Title
Molecular mechanism for catalysis by a new zinc-enzyme, dopachrome tautomerase.
  Journal
Biochem J 313 ( Pt 2):447-53 (1996)
DOI:10.1042/bj3130447
  Sequence
[mmu:13190]
Reference
2  [PMID:2106316]
  Authors
Pawelek JM.
  Title
Dopachrome conversion factor functions as an isomerase.
  Journal
Biochem Biophys Res Commun 166:1328-33 (1990)
DOI:10.1016/0006-291X(90)91011-G
Reference
3  [PMID:9794786]
  Authors
Pennock JL, Behnke JM, Bickle QD, Devaney E, Grencis RK, Isaac RE, Joshua GW, Selkirk ME, Zhang Y, Meyer DJ
  Title
Rapid purification and characterization of L-dopachrome-methyl ester tautomerase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi.
  Journal
Biochem J 335 ( Pt 3):495-8 (1998)
DOI:10.1042/bj3350495
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.12
IUBMB Enzyme Nomenclature: 5.3.3.12
ExPASy - ENZYME nomenclature database: 5.3.3.12
BRENDA, the Enzyme Database: 5.3.3.12
CAS: 130122-81-5

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