KEGG   ENZYME: 5.3.3.23
Entry
EC 5.3.3.23                 Enzyme                                 
Name
S-methyl-5-thioribulose 1-phosphate isomerase;
rlp (gene name);
5-methylthioribulose-1-phosphate isomerase (incorrect)
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
Sysname
S-methyl-5-thio-D-ribulose 1-phosphate 1,3-isomerase
Reaction(IUBMB)
(1) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-xylulose 5-phosphate [RN:R12718];
(2) S-methyl-5-thio-D-ribulose 1-phosphate = S-methyl-1-thio-D-ribulose 5-phosphate [RN:R12719]
Reaction(KEGG)
R12718 R12719
Substrate
S-methyl-5-thio-D-ribulose 1-phosphate [CPD:C04582]
Product
S-methyl-1-thio-D-xylulose 5-phosphate [CPD:C22359];
S-methyl-1-thio-D-ribulose 5-phosphate [CPD:C22360]
Comment
The enzyme, characterized from the bacterium Rhodospirillum rubrum, participates in methionine salvage from S-methyl-5'-thioadenosine. It is a RuBisCO-like protein (RLP) that is not capable of carbon fixation, and catalyses an isomerization reaction that converts S-methyl-5-thio-D-ribulose 1-phosphate to a 3:1 mixture of S-methyl-1-thioxylulose 5-phosphate and S-methyl-1-thioribulose 5-phosphate. The reaction is an overall 1,3-proton transfer, which likely consists of two 1,2-proton transfer events.
History
EC 5.3.3.23 created 2021
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K25035  S-methyl-5-thioribulose 1-phosphate isomerase
Genes
TIGTHII_1875
TVIThivi_3125
TMBThimo_2808
MPURMARPU_02945
TSYTHSYN_18660
THIPN838_17160
AEHMlg_1168
HHAHhal_0467
HHKHH1059_21120
NAXHC341_12515
WMAWM2015_1506
GBIPG2T_15060
URUDSM104443_00902(rlp)
UPLDSM104440_00833(rlp)
RBHB4966_02745
AZQG3580_15325
ZPAC3497_02360
BEBABWI17_00100
AVMJQX13_26820
RPODE0E05_11385
EADOV14_a1403(rbcL2)
EAHFA04_32095
AGCBSY240_2265
RGRFZ934_26435
RROSD4A92_22320
SHZshn_03045
SZOK8M09_22355
OANOant_4835
OAHDR92_3716
OCRHGK82_15725
OCLGTN27_21815
RPARPA2169(rlp1)
RPBRPB_3227
RPCRPC_2184
RPDRPD_2233
RPERPE_3678
RPTRpal_2462
RPXRpdx1_3352
BOIBLM15_28100
MSLMsil_1244
MTUNMTUNDRAET4_0551(rlp)
RVARvan_0192
MMYRMXMO3_03233
MBRYB1812_01625
MMEDMame_01572(mtnW)
PSINCAK95_04585
PALXGQA70_22075
TAWEI545_09990
BOOE2K80_13610
RAPRHOA_5230(rlp)
RRURru_A1998
RRFF11_10265
RPMRSPPHO_02788
ECOGFIV45_10500
CSQCSCA_0270
CDRKB9W14_17145
CCLClocl_1256
DMTDESME_06720
VPRVpar_1263
VATB7L28_06360
VRM44547418_01345(mtnW)
VDNNCTC11831_00612(mtnW)
VNKVEIT17_05550
DPNBCB69_04975
DHODia5BBH33_01050
PUFUFO1_2836
STEDSPTER_05100(mtnW)
PSEIGCE65_00440
ORZFNH13_15325
PLANA1s21148_06230
EUZDVS28_a1210
CAPCLDAP_27010(mtnW)
MRBMrub_0902
MREK649_04150
MSVMesil_0322
MTAIMtai_v1c06550
OPROcepr_2186
MCADPan265_23960(mtnW)
RMRRmar_1894
RMGRhom172_0971
CPRVCYPRO_1179
TLETlet_1684
NDENIDE1881(rlp)
NMVNITMOv2_0456(rlp)
NJANSJP_2757
 » show all
Reference
1  [PMID:18826254]
  Authors
Imker HJ, Singh J, Warlick BP, Tabita FR, Gerlt JA.
  Title
Mechanistic diversity in the RuBisCO superfamily: a novel isomerization reaction catalyzed by the RuBisCO-like protein from Rhodospirillum rubrum.
  Journal
Biochemistry 47:11171-3 (2008)
DOI:10.1021/bi801685f
Reference
2  [PMID:23042035]
  Authors
Erb TJ, Evans BS, Cho K, Warlick BP, Sriram J, Wood BM, Imker HJ, Sweedler JV, Tabita FR, Gerlt JA.
  Title
A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis.
  Journal
Nat Chem Biol 8:926-32 (2012)
DOI:10.1038/nchembio.1087
  Sequence
[rru:Rru_A1998]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.23
IUBMB Enzyme Nomenclature: 5.3.3.23
ExPASy - ENZYME nomenclature database: 5.3.3.23
BRENDA, the Enzyme Database: 5.3.3.23

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