KEGG   ENZYME: 5.3.99.4
Entry
EC 5.3.99.4                 Enzyme                                 
Name
prostaglandin-I synthase;
prostacyclin synthase;
prostacycline synthetase;
prostagladin I2 synthetase;
PGI2 synthase;
PGI2 synthetase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
Sysname
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase
Reaction(IUBMB)
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate [RN:R02267]
Reaction(KEGG)
R02267
Substrate
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E,15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate
Comment
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into prostaglandin I2 (prostacyclin).
History
EC 5.3.99.4 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K01831  prostacyclin synthase
Genes
HSA5740(PTGIS)
PTR458323(PTGIS)
PPS100987973(PTGIS)
GGO101132214(PTGIS)
PON100440673(PTGIS)
NLE100592236(PTGIS)
MCC703407(PTGIS)
MCF102123511(PTGIS)
MTHB126964381
CSAB103244560(PTGIS)
CATY105585406(PTGIS)
PANU101015498(PTGIS)
TGE112633809(PTGIS)
RRO104678532(PTGIS)
RBB108539469(PTGIS)
TFN117068897(PTGIS)
PTEH111521024(PTGIS)
CJC100403062(PTGIS)
SBQ101034236(PTGIS)
CSYR103264305(PTGIS)
MMUR105866470(PTGIS)
LCAT123622705(PTGIS)
OGA100950088(PTGIS)
MMU19223(Ptgis)
MCAL110289735(Ptgis)
MPAH110318865(Ptgis)
RNO25527(Ptgis)
MCOC116091420(Ptgis)
MUN110549006(Ptgis)
CGE100757024(Ptgis)
MAUA101832459(Ptgis)
PLEU114692661(Ptgis)
MORG121460257(Ptgis)
MFOT126495663
AAMP119814555(Ptgis)
NGI103735556(Ptgis)
HGL101700601(Ptgis)
CPOC100734621(Ptgis)
CCAN109690523(Ptgis)
DORD105991642(Ptgis)
DSP122127890(Ptgis)
NCAR124975994
OCU103346149
OPI101516658(PTGIS)
TUP102496170(PTGIS)
CFA100856661(PTGIS)
CLUD112674100(PTGIS)
VVP112931895(PTGIS)
VLG121478064(PTGIS)
AML100466540(PTGIS)
UMR103669841(PTGIS)
UAH113258701(PTGIS)
UAR123775935(PTGIS)
ELK111141584
LLV125109103
MPUF101671387(PTGIS)
ORO101382580(PTGIS)
EJU114225538(PTGIS)
ZCA113938092(PTGIS)
MLX118023956(PTGIS)
NSU110576722(PTGIS)
FCA101082050(PTGIS)
PYU121020122(PTGIS)
PBG122467288(PTGIS)
LRUF124504362
PTG102952139(PTGIS)
PPAD109272209(PTGIS)
AJU106986024(PTGIS)
HHV120230439(PTGIS)
BTA282021(PTGIS)
BOM102279286(PTGIS)
BIU109567538
BBUB102391623(PTGIS)
CHX100860894(PTGIS)
OAS101116418(PTGIS)
ODA120869080(PTGIS)
CCAD122448178(PTGIS)
SSC100126284(PTGIS)
CFR102521764(PTGIS)
CBAI105071862(PTGIS)
CDK105087868(PTGIS)
VPC102541985(PTGIS)
BACU103018962(PTGIS)
LVE103069768(PTGIS)
OOR101285307(PTGIS)
DLE111186649(PTGIS) 111187839
PCAD102985868 114483838(PTGIS)
PSIU116739916(PTGIS) 116761081
ECB100071412(PTGIS)
EPZ103541173(PTGIS)
EAI106825769(PTGIS)
MYB102249227(PTGIS)
MYD102772939(PTGIS)
MMYO118663392(PTGIS)
MLF102427459(PTGIS)
MNA107540608(PTGIS)
PKL118707885(PTGIS)
HAI109381877(PTGIS)
DRO112303771(PTGIS)
SHON118996479(PTGIS)
AJM119065200(PTGIS)
PDIC114506671(PTGIS)
PHAS123815195(PTGIS)
MMF118618421(PTGIS)
RFQ117015885(PTGIS)
PALE102885283(PTGIS)
PGIG120603782(PTGIS)
PVP105296058(PTGIS)
RAY107510328(PTGIS)
MJV108391976(PTGIS)
TOD119236360(PTGIS)
SARA101552132(PTGIS)
LAV100669854(PTGIS)
TMU101360898
DNM101431527(PTGIS)
MDO100029131(PTGIS)
GAS123233545(PTGIS)
SHR100924178(PTGIS)
PCW110206638(PTGIS)
OAA100076102(PTGIS)
ASN102380148(PTGIS)
AMJ102570396(PTGIS)
CPOO109313135(PTGIS)
GGN109292458(PTGIS)
PSS102459815(PTGIS)
CMY102929462(PTGIS)
CPIC101948711(PTGIS)
TST117885954(PTGIS)
CABI116815882(PTGIS)
MRV120380169(PTGIS)
ACS100565699(ptgis)
PVT110071794(PTGIS)
SUND121929525(PTGIS)
PBI103056719(PTGIS)
PMUR107290825(PTGIS)
CTIG120311576(PTGIS)
TSR106539549(PTGIS)
PGUT117663569(PTGIS)
VKO123028456(PTGIS)
PMUA114599622(PTGIS)
ZVI118089309(PTGIS)
GJA107122715
STOW125433394(PTGIS)
XLA108700877(ptgis.L)
XTR100492372(ptgis)
NPR108803621
RTEM120918948(PTGIS)
BBUF121004288(PTGIS)
BGAR122940309(PTGIS)
DRE559148(ptgis)
SRX107708106 107713538
SANH107667039 107680687
SGH107555969 107561003(ptgis)
CCAR109052726 109056482
CAUA113050312 113097085
PPRM120459861(ptgis)
MAMB125273493(ptgis)
IPU108271893 108272147(ptgis)
PHYP113533815 113536922
SMEO124382830(ptgis) 124385911
TFD113642707(ptgis) 113643075
AMEX103027408 103041888
EEE113569647 113578002
TRU101069230 101079540
TNGGSTEN00012489G001 GSTEN00027310G001 GSTEN00027470G001
LCO104920521 104928129(ptgis)
NCC104950923 104965629
CGOB115008341 115008599
ELY117257285(ptgis) 117257379
EFO125887345 125895416(ptgis)
PLEP121956234 121958442(ptgis)
SLUC116041731 116051588(ptgis)
ECRA117943749(ptgis) 117943957
ESP116687286 116688089
PFLV114554500 114554558
GAT120834951(ptgis) 120835857
PPUG119229980 119230097(ptgis)
MSAM119885948(ptgis) 119886340
CUD121507016(ptgis) 121507099
ALAT119020588 119021399(ptgis)
MZE101476415 101482090
ONL100693506 100703351
OAU116333908 116334268(ptgis)
OLA101170919(ptgis)
OML112144503 112144760
XMA102218429 102224227
XCO114135636 114136163
XHE116710528 116711125
PRET103464557 103465211
PFOR103137429 103150691
PLAI106950329(ptgis) 106959003
PMEI106923751 106931052(ptgis)
GAF122833576(ptgis) 122834642
CVG107093334 107096113(ptgis)
CTUL119772186(ptgis) 119779959
GMU124857072 124857121(ptgis)
NFU107385183 107385744
KMR108231375(ptgis) 108235780
ALIM106516065 106517980(ptgis)
NWH119412756(ptgis) 119412831
AOCE111575285 111575521
MCEP125006184(ptgis) 125006984
CSEM103385737 103385896(ptgis)
POV109629045(ptgis) 109638533
SSEN122768072(ptgis) 122768404
HHIP117761812 117761956(ptgis)
HSP118104431 118104899(ptgis)
LCF108889866
SDU111222105(ptgis) 111222893
SLAL111657863 111660836(ptgis)
XGL120782896 120806916(ptgis)
HCQ109522667 109531485
BPEC110168753 110168791(ptgis)
MALB109964506(ptgis)
BSPL114856271 114856369(ptgis)
SASA106565340 106565585 106583179 106583533
STRU115150334 115150522 115207896 115208094
OTW112214994(ptgis) 112217010 112254650 112254827
OMY110494089(ptgis) 110494258 110528167 110529007
OGO124002969 124003982 124019180 124019605
ONE115140159 115142963 115143122 115146132
SALP111963902 111966323 111969616 111970136
SNH120025390 120025923(ptgis) 120064563 120064608
CCLU121575874(ptgis) 121575916 121577574 121578164
ELS105017022(ptgis) 105026471
SFM108923412 108939002(ptgis)
PKI111833099 111840521(ptgis)
AANG118207232(ptgis) 118211429
LOC102688932(ptgis)
PSPA121297677 121319212
ARUT117416641 117428392
LCM102358660(PTGIS)
CMK103190529(ptgis)
RTP109914197
 » show all
Reference
1  [PMID:6338016]
  Authors
DeWitt DL, Smith WL.
  Title
Purification of prostacyclin synthase from bovine aorta by immunoaffinity  chromatography. Evidence that the enzyme is a hemoprotein.
  Journal
J Biol Chem 258:3285-93 (1983)
Reference
2  [PMID:7023490]
  Authors
Ullrich V, Castle L, Weber P.
  Title
Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase.
  Journal
Biochem Pharmacol 30:2033-6 (1981)
DOI:10.1016/0006-2952(81)90218-5
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.4
IUBMB Enzyme Nomenclature: 5.3.99.4
ExPASy - ENZYME nomenclature database: 5.3.99.4
BRENDA, the Enzyme Database: 5.3.99.4
CAS: 65802-86-0

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