KEGG   ENZYME: 5.4.99.58
Entry
EC 5.4.99.58                Enzyme                                 
Name
methylornithine synthase;
PylB
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
Sysname
L-lysine carboxy-aminomethylmutase
Reaction(IUBMB)
L-lysine = (3R)-3-methyl-D-ornithine [RN:R10010]
Reaction(KEGG)
R10010
Substrate
L-lysine [CPD:C00047]
Product
(3R)-3-methyl-D-ornithine [CPD:C20277]
Comment
The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.
History
EC 5.4.99.58 created 2012
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K16180  methylornithine synthase
Genes
DATHRM2_15240(bioB2)
DOVDSCO28_05090
WHJH9Q79_07365(pylB)
DSYDSY4958
DHDDhaf_4857
DDHDesde_0574
DORDesor_1148 Desor_1623 Desor_3055
DMIDesmer_1592 Desmer_2996
DAEDtox_0028
FWADCMF_07900 DCMF_16375 DCMF_28145 DCMF_28345
AACXDEACI_4244
TJRTherJR_0023
DGIDesgi_3925
ELIMB2M23_05175
AMIJEQM06_09285(pylB)
AMICAmi3637_11535(pylB)
ABUTAmi103574_12095(pylB)
ETMCE91St48_13120
TPZTph_c27770
AARAcear_0357
MANAMAMMFC1_01955(bioB_2)
METFCFE53_03540
MMILsm9_0396(hcgA)
MBAMbar_A0838
MBYMSBRM_0156
MBWMSBRW_0163
MBARMSBR2_2225
MBAKMSBR3_2276
MACMA_0154(bioB)
MMAMM_1444
MMAZMmTuc01_1502
MMJMSMAS_3220
MMACMSMAC_3242
MVCMSVAZ_3360
MEKMSKOL_3319
MLSMSLAZ_3210
METMMSMTP_3120
MEFMSWH1_3069
MEQMSWHS_3280
MSJMSSAC_0136
MSZMSSIH_0123
MSWMSSIT_0127
MTHRMSTHT_1933
MTHEMSTHC_1350
MHORMSHOH_3966
MFZAOB57_008965(pylB)
MBUMbur_2085(pylB)
MMETMCMEM_0284
MELOJ7W08_11515(pylB)
MMHMmah_0282
MHAZBHR79_02110
MEVMetev_0937
MZHMzhil_1026
MPYMpsy_1722(bioB)
MZIHWN40_00970(pylB)
MHZMetho_0021
MEAMMU439_04805(pylB)
TARTALC_00497
MAXMMALV_04280
MERMMINT_08920
MEARMpt1_c05690(pylB2)
MEUZKRP56_05620(pylB)
MARCAR505_1324
 » show all
Reference
1  [PMID:21455182]
  Authors
Gaston MA, Zhang L, Green-Church KB, Krzycki JA
  Title
The complete biosynthesis of the genetically encoded amino acid pyrrolysine from lysine.
  Journal
Nature 471:647-50 (2011)
DOI:10.1038/nature09918
  Sequence
[mac:MA_0154]
Reference
2  [PMID:22095926]
  Authors
Quitterer F, List A, Eisenreich W, Bacher A, Groll M
  Title
Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis.
  Journal
Angew Chem Int Ed Engl 51:1339-42 (2012)
DOI:10.1002/anie.201106765
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.58
IUBMB Enzyme Nomenclature: 5.4.99.58
ExPASy - ENZYME nomenclature database: 5.4.99.58
BRENDA, the Enzyme Database: 5.4.99.58

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