KEGG   ENZYME: 6.2.1.11
Entry
EC 6.2.1.11                 Enzyme                                 

Name
biotin---CoA ligase;
biotinyl-CoA synthetase;
biotin CoA synthetase;
biotinyl coenzyme A synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
biotin:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA [RN:R01075]
Reaction(KEGG)
R01075;
(other) R01074 R03762
Substrate
ATP [CPD:C00002];
biotin [CPD:C00120];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
biotinyl-CoA [CPD:C01894]
History
EC 6.2.1.11 created 1972
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:14257635]
  Authors
CHRISTNER JE, SCHLESINGER MJ, COON MJ.
  Title
ENZYMATIC ACTIVATION OF BIOTIN. BIOTINYL ADENYLATE FORMATION.
  Journal
J Biol Chem 239:3997-4005 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.11
IUBMB Enzyme Nomenclature: 6.2.1.11
ExPASy - ENZYME nomenclature database: 6.2.1.11
BRENDA, the Enzyme Database: 6.2.1.11
CAS: 37318-60-8

KEGG   REACTION: R01074
Entry
R01074                      Reaction                               

Name
biotin:CoA ligase (AMP-forming);
biotin:apo-[carboxylase] ligase (AMP-forming);
ATP:biotin adenylyltransferase
Definition
ATP + Biotin <=> Diphosphate + Biotinyl-5'-AMP
Equation
Comment
first step of two-step reaction (R01075, R04562, R04563, R04582 or R04604)
subsequently R05145 or R03762
Reaction class
RC00043  C00120_C05921
Enzyme
6.2.1.11        6.3.4.9         6.3.4.10        6.3.4.11        
6.3.4.15
Pathway
rn00780  Biotin metabolism
rn01100  Metabolic pathways
Orthology
K01942  biotin---protein ligase [EC:6.3.4.9 6.3.4.10 6.3.4.11 6.3.4.15]
K01947  biotin---[acetyl-CoA-carboxylase] ligase / type III pantothenate kinase [EC:6.3.4.15 2.7.1.33]
K03524  BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
Other DBs
RHEA: 31118

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