KEGG   ENZYME: 6.2.1.2
Entry
EC 6.2.1.2                  Enzyme                                 
Name
medium-chain acyl-CoA ligase;
fadK (gene name);
lvaE (gene name);
butyryl-CoA synthetase;
fatty acid thiokinase (medium chain);
acyl-activating enzyme;
fatty acid elongase;
fatty acid activating enzyme;
fatty acyl coenzyme A synthetase;
butyrate---CoA ligase;
butyryl-coenzyme A synthetase;
L-(+)-3-hydroxybutyryl CoA ligase;
short-chain acyl-CoA synthetase;
medium-chain acyl-CoA synthetase;
butanoate:CoA ligase (AMP-forming)
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
medium-chain fatty acid:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + a medium-chain fatty acid + CoA = AMP + diphosphate + a medium-chain acyl-CoA [RN:R00389]
Reaction(KEGG)
R00389 > R01176
Substrate
ATP [CPD:C00002];
medium-chain fatty acid [CPD:C21925];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
medium-chain acyl-CoA [CPD:C21926]
Comment
Acts on fatty acids from C4 to C11 and on the corresponding 3-hydroxy and 2,3- or 3,4-unsaturated acids. The enzyme from the bacterium Pseudomonas putida also acts on 4-oxo and 4-hydroxy derivatives.
History
EC 6.2.1.2 created 1961, modified 2011, modified 2018
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K01896  medium-chain acyl-CoA synthetase
K01913  acetate/butyrate---CoA ligase
K23617  medium-chain acyl-CoA ligase, mitochondrial
K23618  acyl-activating enzyme 11/12
K23756  medium-chain acyl-CoA ligase / lipoate-activating enzyme
Genes
HSA116285(ACSM1) 123876(ACSM2A) 142827(ACSM6) 341392(ACSM4) 348158(ACSM2B) 54988(ACSM5) 6296(ACSM3) 80221(ACSF2)
PTR101058263(ACSM1) 107968805(ACSM5) 107973209 451813(ACSM4) 453974(ACSM2A) 455121(ACSF2) 467918(ACSM2B) 741543(ACSM6) 742192(ACSM3)
PPS100968187(ACSM6) 100972336 100973540 100984659 100986228(ACSF2) 100992481(ACSM4) 100994660 100994985 100995253(ACSM3)
GGO101142919(ACSM6) 101148413(ACSM5) 101149125 101149339(ACSM4) 101149481 101151788(ACSM3) 101151901(ACSF2) 101153106(ACSM1) 115932803
PON100171624(ACSM3) 100172872(ACSF2) 100442712 100444065 100444423 100449779(ACSM6) 100452655(ACSM5) 100459933(ACSM4)
NLE100583035(ACSF2) 100584025(ACSM5) 100591808(ACSM6) 100599336(ACSM3) 100601481 100604255(ACSM4) 101178788 115833719 115833922
MCC100427705 696124(ACSM5) 696244 696498(ACSM1) 696622(ACSM3) 702474(ACSF2) 722167(ACSM4)
MCF101864763(ACSF2) 102120589(ACSM5) 102121480 102123380(ACSM1) 102126505(ACSM3) 102142462(ACSM4)
CSAB103218505(ACSM4) 103229269(ACSM5) 103229287(ACSM2B) 103229298(ACSM1) 103229351(ACSM3) 103231985(ACSM6) 103242934(ACSF2)
CATY105571918(ACSM6) 105579436(ACSF2) 105583065(ACSM4) 105586470(ACSM3) 105586560(ACSM1) 105586584 105586603(ACSM5)
PANU100997350 101008358(ACSF2) 101008883(ACSM4) 101017612(ACSM5) 101017967(ACSM2B) 101018326(ACSM1) 101019516(ACSM3)
TGE112609136(ACSF2) 112614314(ACSM5) 112614780(ACSM3) 112614781 112614782(ACSM1) 112635201(ACSM4)
RRO104678561 104680277(ACSF2) 104682073(ACSM5) 104682074(ACSM2B) 104682075(ACSM1) 104682078(ACSM3)
RBB108513900(ACSM5) 108513927 108513946(ACSM1) 108514016(ACSM3) 108516427(ACSF2)
TFN117067216(ACSF2) 117077786 117087527(ACSM3) 117087530(ACSM1) 117087533 117087534(ACSM5) 117090923(ACSM4)
PTEH111537571(ACSF2) 111551185(ACSM5) 111551195(ACSM3) 111551197(ACSM1) 111551198 111555897(ACSM4)
CJC100385335(ACSF2) 100385629(ACSM5) 100385986(ACSM2B) 100386695(ACSM3) 100390897(ACSM4) 100392977(ACSM6)
SBQ101039328(ACSM6) 101048755 101049288 101050441(ACSM3) 101050654(ACSM4) 101054189(ACSF2)
CSYR103249862(ACSF2) 103261139(ACSM2B) 103261140(ACSM5) 103263527(ACSM3) 103263530(ACSM4) 103272478
MMUR105855227(ACSM5) 105855229 105855230(ACSM1) 105885117(ACSF2) 105885317(ACSM3) 105885318(ACSM4) 105885320(ACSM6)
LCAT123620467(ACSF2) 123632446(ACSM5) 123632447(ACSM2B) 123632450 123632451(ACSM6) 123632455(ACSM3)
OGA100951146(ACSM3) 100951985(ACSM4) 100952297(ACSM6) 100952915(ACSF2) 100953148 100953777(ACSM5) 100961636
MMU117147(Acsm1) 20216(Acsm3) 233799(Acsm2) 233801(Acsm4) 264895(Acsf2) 272428(Acsm5)
MCAL110297662(Acsm5) 110297667(Acsm1) 110297791(Acsm2b) 110298435(Acsm4) 110298807(Acsm3) 110304550(Acsf2)
MPAH110316032(Acsm3) 110323274(Acsm5) 110324507(Acsm4) 110325118(Acsm2b) 110326344(Acsm1) 110331605(Acsf2)
RNO246263(Acsm2) 24763(Acsm3) 353317(Acsm4) 361637(Acsm5) 361638(Acsm1) 619561(Acsf2)
MCOC116077682(Acsf2) 116100882 116102866(Acsm5) 116102869(Acsm1) 116102872(Acsm4) 116102877(Acsm3)
MUN110547837(Acsm1) 110547853(Acsm3) 110547856(Acsm4) 110552055(Acsf2) 110558215 110558216 110558219 110558220
CGE100751305(Acsm3) 100755056 100755162 100767354 100767739 100768417(Acsf2)
MAUA101829208(Acsm1) 101836492(Acsm3) 101837019(Acsm4) 101837286 101838011(Acsm5) 101843223(Acsf2)
PLEU114692157(Acsm5) 114692158 114692159(Acsm1) 114692160(Acsm4) 114692164(Acsm3) 114692891(Acsf2)
MORG121456434(Acsf2) 121457516(Acsm3) 121457564(Acsm5) 121457585 121457640(Acsm1) 121457685(Acsm4)
MFOT126502310 126502317 126502319 126502320 126502364 126510497
AAMP119807351 119811322(Acsf2) 119817522(Acsm5) 119820116(Acsm4) 119825600 119825619(Acsm2b)
NGI103738389(Acsf2) 103742760(Acsm3) 103742762(Acsm4) 103742763(Acsm1) 103742764(Acsm2a) 103742767(Acsm5)
HGL101698533(Acsm4) 101703873(Acsm3) 101706188(Acsf2) 101711830(Acsm5) 101712192(Acsm2a) 101712893(Acsm1)
CPOC100714657(Acsf2) 100729957 100730233 100733357(Acsm5) 100735784(Acsm4) 100736064(Acsm3)
CCAN109678356(Acsm3) 109681504(Acsf2) 109696818(Acsm2b) 109696819(Acsm5) 109696824(Acsm1) 109699471(Acsm4)
DORD105981806(Acsm3) 105982171 105982204 105982241(Acsm5) 106003268(Acsf2)
DSP122096209 122096210(Acsm5) 122103341(Acsf2) 122116144(Acsm3) 122116190 122116193 122116194
NCAR124969888 124970382 124970503 124970589 124970727 124979282
OCU100340861(ACSF2) 100342192(ACSM2B) 100345414(ACSM3) 100350992(ACSM4) 100352247(ACSM1) 100352493(ACSM5) 100354024
OPI101517652(ACSM3) 101524957 101527991(ACSF2) 101533894 101534134(ACSM5)
TUP102472841(ACSF2) 102475928(ACSM4) 102478447(ACSM3) 102480423(ACSM1) 102480846(ACSM5)
CFA479821 479822 480551(ACSF2) 608888(ACSM3) 609009(ACSM5)
CLUD112640284(ACSM3) 112640285 112640294 112640298(ACSM5) 112655630(ACSF2)
VVP112917860(ACSF2) 112923250 112923378(ACSM5) 112923379 112923386(ACSM3)
VLG121473552(ACSF2) 121486563(ACSM3) 121486678 121487415 121487669(ACSM5)
AML100465944(ACSM3) 100466940(ACSM4) 100474727(ACSF2) 100474845(ACSM1) 100475101 100476094(ACSM5)
UMR103660404(ACSF2) 103668660(ACSM5) 103668661(ACSM1) 103668662
UAH113265618(ACSF2) 113267498 113267499(ACSM3) 113270722 113270723 113270724(ACSM5)
UAR123775568(ACSM1) 123775571 123775576(ACSM5) 123776818(ACSF2) 123793858(ACSM4) 123793860(ACSM3)
ELK111145517 111145715 111151498 111156008 111156054 111156105 111156117
LLV125087435 125090824 125090825 125090827 125090828 125090829 125090837
MPUF101674522(ACSM3) 101680153 101688355(ACSM1) 101688643 101688926(ACSM5) 101691085(ACSF2)
ORO101366672 101367835(ACSM1) 101370381(ACSF2) 101376361(ACSM5) 101382988(ACSM3) 101384131(ACSM4)
EJU114199691(ACSM1) 114199696 114201158(ACSF2) 114202178(ACSM3) 114202184
ZCA113932553 113932767(ACSM3) 113932768 113933034(ACSM1) 113933035(ACSM5) 113939458(ACSF2)
MLX117999165(ACSM3) 117999173 118024125 118024126 118024763(ACSF2) 118026596(ACSM5)
NSU110582263(ACSM3) 110582264 110587842 110593281(ACSF2)
FCA101082455(ACSM3) 101083228 101083474 101090661(ACSF2) 101092980(ACSM5)
PYU121019423(ACSM3) 121019433(ACSM5) 121019813 121024605 121025898
PBG122471169 122471587(ACSM3) 122471594(ACSM5) 122471595 122485375(ACSF2)
LRUF124513230 124517806 124517845 124517964 124518026
PTG102954003 102954285(ACSM5) 102957684(ACSM4) 102965614(ACSF2) 102968571(ACSM3)
PPAD109247289(ACSF2) 109255539(ACSM3) 109255541 109278418(ACSM5) 109278419
AJU106970464 106970521(ACSM3) 106970530 106970531(ACSM5) 106985171(ACSF2)
HHV120225624 120225628(ACSM5) 120227120 120227306 120227575 120229158(ACSF2) 120232762(ACSM3) 120232776
BTA100298888(ACSM5) 100299006(ACSM4) 282576(ACSM1) 512227(ACSM2B) 533798(ACSM3) 768237(ACSF2)
BOM102269733(ACSM3) 102270868(ACSM4) 102271152(ACSM1) 102271620(ACSM2B) 102273415(ACSM5) 102286919(ACSF2)
BIU109574170(ACSF2) 109578487(ACSM3) 109578603(ACSM1) 109578666(ACSM2B) 109578712(ACSM5)
BBUB102394278(ACSF2) 102400565(ACSM1) 102401419(ACSM4) 102403896(ACSM3) 102412341 102413115(ACSM5)
CHX102180366(ACSM5) 102181180(ACSM2B) 102182065(ACSF2) 102182274(ACSM1) 102183382(ACSM4) 102185052(ACSM3)
OAS101105582(ACSF2) 101112785(ACSM5) 101120131 101120375(ACSM1) 101120794(ACSM4) 101121307(ACSM3)
ODA120867327(ACSF2) 120875439(ACSM5) 120875507(ACSM3) 120875522(ACSM2B) 120875532(ACSM1) 120882537(ACSM4)
CCAD122433263(ACSM3) 122433274(ACSM4) 122433374 122433375(ACSM1) 122433456(ACSM5) 122443320(ACSF2)
SSC100510957(ACSM2B) 100511318(ACSM5) 100512220(ACSM3) 100512595(ACSM4) 100512859(ACSF2)
CFR102504377(ACSM5) 102504633 102504896(ACSM1) 102505166(ACSM4) 102505419(ACSM3) 102521532(ACSF2)
CBAI105064613(ACSF2) 105073703(ACSM4) 105073706(ACSM3) 105073707(ACSM1) 105073708 105073709(ACSM5)
CDK105091128(ACSM3) 105091129(ACSM1) 105091130(ACSM2B) 105091131(ACSM5) 105091161(ACSM4) 105097727(ACSF2)
VPC102534861(ACSM5) 102535111(ACSM1) 102535354(ACSM4) 102535856(ACSM3) 102542642 102545942(ACSF2)
BACU102997916 102999357(ACSF2) 102999573 103005605 103017973(ACSM3) 103018256 103020396
LVE103069868(ACSF2) 103073448(ACSM3) 103077137(ACSM5) 103089263
OOR101271827 101277146(ACSF2) 101287714 101288721(ACSM3)
DLE111166460(ACSF2) 111171037 111182281(ACSM3) 111182306
PCAD102985736(ACSM5) 102988009 102995241(ACSF2) 112064828
PSIU116739913 116739914 116740087(ACSM3) 116740477 116745177(ACSF2)
ECB100057758 100068270 100068672(ACSM3) 100068752(ACSM4) 100069942(ACSF2) 106780831
EPZ103543057 103544441(ACSM5) 103549558(ACSF2) 103564588(ACSM3) 103564591 103564592 103566614
EAI106826350(ACSF2) 106839004(ACSM3) 106839008 106841734(ACSM4) 106841736(ACSM5) 106841738 106846143
MYB102240990 102241291(ACSM3) 102247262(ACSF2) 102259872 102260013
MYD102755299(ACSM2A) 102755589(ACSM3) 102760086(ACSM4) 102762433 102773394(ACSF2)
MMYO118652923 118655818(ACSM3) 118656328 118656329 118656597 118656801(ACSM2B) 118672320(ACSF2)
MLF102417459 102421623 102425858 102433003 102433316 102440336(ACSM2B) 102441161(ACSM3) 102443165(ACSF2)
MNA107529840(ACSF2) 107544730 107544731 107544755 107544773(ACSM3)
PKL118704871 118704872 118704873 118726493(ACSF2) 118731488 118731509
HAI109380753(ACSF2) 109386530(ACSM1) 109386545 109386559(ACSM3) 109386584(ACSM2B) 109386585
DRO112304836 112304838(ACSM2B) 112316241(ACSF2)
SHON118993402 118993403 118993414 118994231(ACSF2)
AJM119037430(ACSF2) 119040944 119053529(ACSM4)
PDIC114503320(ACSF2) 114504129(ACSM2B) 114504207(ACSM5) 114507062
PHAS123817270(ACSF2) 123825559(ACSM2B) 123825613
MMF118633924(ACSF2) 118641455(ACSM3) 118641456 118642295 118642390
RFQ117013016(ACSF2) 117019408 117019409(ACSM1) 117019413 117019544(ACSM3)
PALE102878400(ACSM3) 102887888(ACSF2)
PGIG120584568(ACSM3) 120588953(ACSF2) 120600542 120600543
PVP105295401(ACSF2) 105306055(ACSM3) 105311378(ACSM4) 105311379 105311518
RAY107511417 107516069(ACSM3) 107516071 107516072 107516828 107516829 107516830 107516831 107516832 107516833 107517597(ACSF2)
MJV108384402(ACSF2) 108386682 108400240(ACSM1) 108401066
TOD119230967(ACSF2) 119240191 119240192(ACSM5) 119240271(ACSM6) 119241859(ACSM3) 119241862(ACSM4) 119241863 119241867 119242359 119253947
SARA101543727(ACSM1) 101543975(ACSM4) 101544237(ACSM3) 101546893(ACSF2) 101547297(ACSM6) 101554456 101554723(ACSM5)
LAV100668288 100668576(ACSM1) 100669114(ACSF2) 100669418(ACSM3)
TMU101343241 101343496 101347901 101348158 101348667 101352795
DNM101414226(ACSM5) 101415550 101416094 101418472(ACSF2) 101425882 101430483(ACSM3) 101435427 101440527
MDO100025369(ACSF2) 100026263(ACSM5) 100026277(ACSM2A) 100026318 100026355(ACSM3) 100619197 107650413
GAS123234382 123234404 123247387(ACSF2) 123249952 123249963 123249974
SHR100919699(ACSF2) 100927836(ACSM5) 100932504 100932766
PCW110193481(ACSM3) 110193489(ACSM5) 110193490 110193508 110193529 110198392(ACSF2)
OAA100076750 100077223 100077301 100077345 100087575(ACSF2) 100089732
GGA422102(ACSF2) 426991(ACSM4L) 426992(ACSM5) 426999(ACSM3)
PCOC116230333 116230337 116230342(ACSM3) 116232386(ACSF2)
MGP100538703(ACSF2) 100540035 100540188 100540655(ACSM3)
CJO107321005 107321021 107321023 107322306(ACSF2)
NMEL110405930 110405956 110406018 110407329(ACSF2)
APLA101792571 101792898 101793210 101793832 101800621(ACSF2)
ACYG106033473 106033474 106033477 106033478 106034658(ACSF2)
AFUL116495223 116495396 116495464 116495491 116496736(ACSF2)
TGU100231857 101233842(ACSF2) 105759942
LSR110475545 110475547 110484380(ACSF2)
SCAN103817691 103817888 103819823(ACSF2)
PMOA120505589(ACSF2) 120513011 120513012 120513015
OTC121334388 121334389 121338389(ACSF2)
PRUF121350634 121350816 121363866(ACSF2)
GFR102035848 102036022(ACSM3) 102036355 102041295(ACSF2)
FAB101819702(ACSF2) 101821476 101821679 101822002(ACSM4)
PHI102103002 102106553 102106930 102112013(ACSF2)
PMAJ107211182 107211183 107212425(ACSF2)
CCAE111935998 111936000 111937350(ACSF2)
CCW104684877 104684878 104694291(ACSF2) 120409632
CBRC103615463 103615464 103615625 103625051(ACSF2)
ETL114055953(ACSF2) 114058261 114065942
ZAB102065247(ACSF2) 102068749 102071406
ACHL103798693 103808545(ACSF2)
FPG101910320 101910669(ACSM3) 101917536(ACSF2) 101918246 101918428
FCH102047417 102052611 102052785 102054361(ACSF2)
CLV102088507 102088808 102089184(ACSM3) 102090038(ACSF2)
EGZ104125415(ACSF2) 104135868 104135869
NNI104015040 104015041 104015042 104020685(ACSF2)
PLET104617962 104624943(ACSM3) 104626894
PCRI104024586 104036844 104038100(ACSF2)
ACUN113485629 113485660 113485661 113486691(ACSF2)
TALA104355817 104360244(ACSF2) 104364193 104365466 104365467
PADL103916690(ACSF2) 103917597 103917598
AFOR103899234(ACSF2) 103900843 103900844 103900845
ACHC115335576 115335994 115342085(ACSF2)
HALD104311824 104316401 104318714(ACSF2)
CCRI104154816 104154838 104155148 104158696(ACSF2) 104159101
CSTI104549605 104550364 104555211 104557555(ACSF2) 104560947
EHS104502783 104503036 104509181 104515642(ACSF2)
CMAC104473673(ACSM3) 104477540 104477541 104477542 104486358(ACSF2)
MUI104533998 104537033(ACSF2) 104546862 104546870
FGA104069911(ACSM3) 104077325 104077327 104080567(ACSF2)
GSTE104250991 104258580 104258581 104258582 104260813(ACSF2)
LDI104340441 104345259(ACSF2) 104349167 104349168 104349169
MNB103773596 103776185 103776187 103776189 103781504
OHA104333666 104333667 104333668 104333669 104337025(ACSF2)
NNT104407866 104407867 104409870(ACSF2)
DPUB104299068 104299078 104299089 104310113(ACSF2)
PGUU104469258(ACSF2) 104469998(ACSM3) 104470085 104470088 104470089
ACAR104518249 104521200 104521201 104521202 104529775(ACSF2)
AVIT104267853 104268093(ACSF2) 104277123 104277124 104277125
AAM106491284 106491314 106491316 106491352 106500044(ACSF2)
AROW112974398 112974399 112974400 112974401 112977720(ACSF2)
NPD112953738(ACSF2) 112959941 112959990 112959993 112960044
TGT104569072(ACSF2) 104570979 104575867 104575868 104580544
DNE112982547(ACSF2) 112990392 112990394 112990395
SCAM104146715(ACSF2) 104149670 104149671 104149672 104149673
ASN102378620 102378870 102379120(ACSM3) 102381294(ACSF2) 102387189 102387447
AMJ102564227(ACSM3) 102564624 102564848 102568110 102568342(ACSM4) 102575727(ACSF2)
CPOO109314850 109314851 109314852 109314853 109315210(ACSF2)
GGN109297652(ACSF2)
PSS102445731 102445968 102446448 102450712 102453416(ACSF2)
CMY102937054 102937734 102937966 102938073(ACSF2) 119567221
CPIC101938767 101939672 101939958 101940230 101946772(ACSF2)
TST117884209 117884419 117884450 117884556 117887353(ACSF2)
CABI116827522(ACSF2) 116837580 116837581 116837605 116837606
MRV120373063(ACSM3) 120373454 120373524 120374053 120383722(ACSF2)
ACS100561027(acsf2) 100561664 100561854 100562048 100563167(acsm5) 100563359(acsm3) 103282993
PVT110082173 110082181 110082182 110082183 110082214 110082218 110082224 110091192(ACSF2)
SUND121914497 121914590 121914955 121923845(ACSF2) 121937570 121937571(ACSM5)
PBI103051903 103052141 103052383 103057323 103058749 103064756(ACSM3) 103065469
PMUR107283779(ACSF2) 107296908 107296915 107297018 107297094 107297102
CTIG120307746(ACSF2) 120315684 120315686 120315687 120315689 120315759
TSR106543986 106543994 106555363(ACSF2)
PGUT117663083(ACSF2) 117670792 117670794 117670809 117670810
VKO123018153(ACSF2) 123024916 123024917 123025084 123025159 123025160
PMUA114584347 114584395(ACSM5) 114584514 114584642 114584910 114584911 114590174 114590519
ZVI118079790(ACSF2) 118092472 118092473(ACSM3) 118092728 118092732 118092764 118093117 118093174
GJA107110028(ACSF2) 107114573 107114575 107114576 107114577 107114579
STOW125429319(ACSF2) 125431426 125431619 125431680 125431690 125432117
XLA108701096(acsf2.L) 108702792(acsf2.S) 444799(acsm3.L)
XTR100491087(acsm3) 100497121(acsf2)
NPR108791737(ACSM3) 108796400(ACSF2)
RTEM120918875(ACSF2) 120943515(ACSM3)
BBUF121005307(ACSF2) 121007723(ACSM3)
BGAR122942484(ACSF2)
DRE100002035(acsm3) 751707(acsf2)
SRX107706880 107727305
SANH107657083 107660274 107675647 107698803
SGH107552752 107582759 107600064
CCAR109099152 109099931(acsf2) 109111417(acsm3)
CAUA113045387 113056159 113075806 113111533
PPRM120474512(acsf2) 120495383(acsm3)
MAMB125250272(acsm3) 125254931(acsf2)
IPU108258929 108273869(acsf2) 108280839(acsm3)
PHYP113527446(acsf2) 113528402 113533609
SMEO124388675(acsf2) 124402964(acsm3)
TFD113638943(acsf2) 113639615 113640685(acsm3)
AMEX103031662 103037666(acsf2)
EEE113568123 113579428(acsf2)
TRU101070796 101074035 105416457
TNGGSTEN00007139G001 GSTEN00019733G001 GSTEN00022275G001 GSTEN00022277G001
LCO104928976 104940305
NCC104944427 104960330(acsf2)
CGOB115011767 115012213 115024831
ELY117247009(acsf2) 117268146 117268325 117268547 117268800
EFO125879478 125879969 125879976 125880388(acsf2)
PLEP121957085 121957086 121958496(acsf2)
SLUC116059519 116059741 116061052(acsf2)
ECRA117936519(acsf2) 117958155
ESP116670897 116703047
PFLV114547848 114569439 114569440
GAT120819593(acsf2) 120827896
PPUG119212804(acsf2) 119220623
MSAM119890778 119915557(acsf2)
CUD121503746 121503766 121527960(acsf2) 121529229
ALAT119009706(acsf2) 119014224
MZE101484291(acsf2) 101486716
ONL100692150 100698949
OAU116317706 116335621(acsf2)
OLA101165265(acsf2)
OML112154391(acsf2)
XMA102237186
XCO114152293 114159611
XHE116727537 116735914
PRET103468809(acsf2) 103481746
PFOR103140919(acsf2) 103152407
PLAI106946619(acsf2) 106960913
PMEI106915985 106925888(acsf2)
GAF122821995 122823471(acsf2)
CVG107098447 107102464
CTUL119782479(acsf2) 119794862
GMU124863248 124875340(acsf2)
NFU107387470 107393615
KMR108241268 108241272 108250656(acsf2)
ALIM106529911(acsf2) 106535991
NWH119421705 119421706 119424193(acsf2)
AOCE111564602 111586066
MCEP124997380 125022559(acsf2)
CSEM103392710 103392711 103392713 103398855
POV109642345 109642346 109642858 109643986
SSEN122758938(acsf2) 122760229 122785420 122785421
HHIP117753454(acsf2) 117766418 117766419
HSP118100215(acsf2) 118123356 118123516
LCF108892016
SDU111220043 111227032
SLAL111655423 111657754
XGL120786869 120794531(acsf2)
HCQ109518556(acsf2) 109524735
BPEC110153718 110154229(acsf2) 110168585 110168593
MALB109953863 109953958 109962709 109965860
BSPL114845344(acsf2) 114845350
SASA106569657 106579292 106596227 106602020 106602021 106606225 106606226 106606353
STRU115157455 115158847(acsf2) 115171898 115171899 115208128
OTW112223615(acsf2) 112235672(acsm3) 112240867 121844790
OMY110485294 110487496 110491521(acsf2) 110530736(acsm3) 110538874 110539071
OGO124009539(acsm3) 124021799 124048284(acsf2)
ONE115106490(acsf2) 115125120
SALP111956980(acsm3) 111977493(acsf2)
SNH120039054(acsm3) 120041848 120041865 120046211(acsf2)
CCLU121535460(acsm3) 121543309(acsf2) 121551848 121551849 121555369
ELS105006992(acsf2) 105024576(acsm3)
SFM108926102(acsm3) 108935721(acsf2)
PKI111845537(acsm3) 111849153 111849182(acsf2)
AANG118216853(acsf2) 118220180(acsm3)
LOC102682727 102685872(acsf2)
PSPA121295712(acsf2) 121309588 121330849(acsm3)
ARUT117418309(acsm3) 117423316(acsf2)
LCM102348417(ACSM3) 102361353(ACSF2)
CMK103175647(acsf2) 103188271(acsm3)
RTP109914823(acsm3) 109914830 109930172(acsf2)
BFO118406023 118409902 118412201 118413923 118413927 118413948 118414095 118418550 118419463 118422191 118422278 118423369 118423618 118425823 118425824 118426502 118429626 118430884 118430886
BBEL109462768 109466350 109467980 109469350 109469693 109469900 109474194 109474224 109480632 109482985
CIN100181179
SCLV120340660 120341794 120346490
SPU100891254 100891330 105438697 115922164 578862 592091 593448 593582 752623
APLC110979784 110980284 110989798
SKO100367782 100368062 100369038 100371181 100371644 100374370 100375010 100375383 100375580 100377461 100377913 100377958 100378453 100378635 100378783 102804727 102804956 102810315
DMEDmel_CG12512(CG12512)
DER113564074 6540651
DSE6613476
DSIDsimw501_GD22652(Dsim_GD22652)
DYADyak_GE19001
DAN6498321
DSR110177656 110187383
DPO6903573
DPE6593305
DMN108162311
DWI6642228
DGR6561729
DMODmoj_GI21922
DAZ108610068
DNV115562762
DHE111599074
DVI6628125
CCAT101451261 101454584 101461216
BOD106619327 106619335 118682165
RZE108359980 108369706 108369708
MDE101893361
SCAC106081261 106081262 106081265
LCQ111683790 111683823
LSQ119607588 119607694
HIS119652622 119661476
AGAAgaP_AGAP008557
ACOZ120957580
AARA120903490
ASTE118512513
AAG5564950 5575209 5575211
AALB109410244 109417644 109417645 109417648 115255406 115255411 115255412 115255413 115255421 115255517
CQUCpipJ_CPIJ000423 CpipJ_CPIJ000424 CpipJ_CPIJ000425 CpipJ_CPIJ000427
CPII120415791 120419953 120419959 120420094 120420406 120420412
BCOO119079321 119080426 119082603
AME552475(ACSF2)
ACER107996159
ALAB122719840
BIM100747755
BBIF117212275
BVK117238082
BVAN117164810
BTER100648190
BPYO122566897
CCAL108623646
OBB114872080
MGEN117227142
NMEA116432590
CGIG122396048
SOC105205760
MPHA105841057
AEC105150500
ACEP105625916
PBAR105422241
VEM105568201
HST105188587
DQU106744856
CFO105248550 105255179 112638838 112639309 112639578
FEX115246313
LHU105671936
PGC109857104
OBO105274909
PCF106786684
PFUC122515603
VPS122635688
NVI100122351
CSOL105364123
TPRE106657299
MDL103575983
CGLO123270664
FAS105273854
DAM107038626
AGIF122855386
LHT122503179
CCIN107266024
TCA662861
DPA109538574 109545770
SOY115881860 115881861
ATD109593924
CSET123312881
AGB108905830 108905832
LDC111511837 111511838
NVL108566415
APLN108743655
PPYR116162607 116164250 116164860 116166494 116169589 116173949 116176982 116176983 116176984 116176986 116176987
OTU111426037
BMOR101742019
BMAN114250555
MSEX115440636
DPLKGM_201059 KGM_212593
BANY112053239
NIQ126771270
PMAC106710062 106710063
PPOT106106790
PXU106123976
PRAP111002740
ZCE119834420
HAW110384428
HZE124629891
TNL113497778
SLIU111348589
OFU114361428
PXY105383254 105389866
API100160541 100162568 100165363 103310260
DNX107164269 107169584 107171916
AGS114129694 114130064 114130065
RMD113551257 113551258 113552344
BTAB109042220 109042221
DCI103513852 103513853 103519047
CLEC106664881
HHAL106683112 106688552 106688560
NLU111055988
PHUPhum_PHUM236360
FOC113207145 113214545 113217278
TPAL117645466 117646476 117647365
ZNE110827885 110827899 110827900 110827955 110831482 110834540
CSEC111866863 111869916 111871061 111871332 111871334 111872142
FCD110844238 110849507
DPXDAPPUDRAFT_54086
DMK116926211 116926416 116926441
PVM113802710 113802711 113806957
PJA122251609 122264040
PCHN125033342 125035794 125036016
HAME121870381 121872623
PCLA123759374 123769148
PTRU123505127 123506247
HAZT108681226
EAF111696455 111712233
LSM121117207 121123126 121123127 121123129
PPOI119103348 119111101 119112671
ISCIscW_ISCW001345 IscW_ISCW013647 IscW_ISCW017692 IscW_ISCW023313
DSV119434046 119453245 119458028 119458481 119459291 119460731 119460732 119460736 119461822 119461973
RSAN119373571 119374780 119396454 119396457 119396458 119396459 119397145 119399933 119405135
RMP119168451 119173898 119173899 119174058 119174654 119174655 119180154 119185286 119187506
VDE111243265 111247701 111248230 111249329 111254120
VJA111259121 111267248 111271567 111272006 111272528
TUT107365887
DFR124493997 124494236
CSCU111628808 111629231 111629232 111629241 111636577 111641051
PTEP107446563 107448220 107448233 107451913 107451914
SDM118189641 118199051
LOALOAG_14723
HROHELRODRAFT_80632
LGILOTGIDRAFT_179592 LOTGIDRAFT_239446
PCAN112559445 112559589 112571982
BGT106066559
GAE121375493 121378952 121381113 121389117
HRF124121286 124121294 124134813 124138053 124138054 124138926 124146473 124151384
HRJ124258588 124258706 124263647 124267353 124274721 124289357 124289890
CRG105324586 105326462 105339855 105339921 105340074
MYI110441499 110447756
PMAX117317491 117318032 117318082 117318206 117318208 117318209 117328029 117328745 117333523 117342804
MMER123523365 123526507 123527168 123527818 123528029 123538707 123538747 123538894 123539377 123539378 123550819 123557367 123557658 123563624
OBI106869167 106871436
OSN115211773 115212218 115215039 115215238 115218481
LAK106164658 106166148 106168453 106176119
NVE116605460 5498255 5498675 5503871 5509130 5516184 5522093
EPA110240611 110244766
ATEN116289349 116289465 116290209 116290980 116291005 116301250 116302548
ADF107338061 107343715 107354529
AMIL114960875 114961120
PDAM113665316 113673158 113673165 113683955
SPIS111333941 111333942 111336198 111340554
DGT114524855 114524903
XEN124447345
HMG100203680 101237579
ATHAT1G65890(AAE12) AT1G66120(AAE11) AT3G16910(AAE7)
ALY9319100 9324545
CRB17893002 17894170 17895157 17895221
CSAT104701180 104746027 104750369 104750392 104753582 104765534 104787601 104787603 104787629 104789589
EUSEUTSA_v10018332mg EUTSA_v10018337mg EUTSA_v10020385mg
BRP103831071 103849091 103852300 103869727
BNA106380228 106396379 106396380 106401277 106423200 106426260 106452074 111199499
BOE106295493 106325369 106336187
RSZ108816663 108833606 108834635 108844609
THJ104802600 104820274 104820275
CPAP110813640 110816097
CIT102625074 102626351 102626647 102626941
CICCICLE_v10004641mg CICLE_v10004645mg CICLE_v10004649mg CICLE_v10006792mg CICLE_v10011382mg
PVY116122776 116122829 116124537
MINC123221618 123225057
TCC18601263 18603611
GRA105777138 105790398 105796889 105796890 105798883 105803655
GHI107888947 107892107 107896613 107908127 107908505 107912867 107916951 107933220 107933241 121208465 121214488
GAB108454854 108466010 108469157 108474880 108475844 108489391
DZI111279596 111306910 111313615
EGR104440961 104441592 104441673 104449758 104449770 104449787 104449788
GMX100777882 100786381 100792142 100808187 100811706 100819630
GSJ114367524 114382308 114393522 114396782 114419987
PVUPHAVU_003G111400g PHAVU_006G086100g PHAVU_006G122900g
VRA106769132 106774385 106775629
VAR108341216 108347898
VUN114178007 114186597 114188793
CCAJ109798391 109811435 109814189
APRC113846022 113851423 113865999 113874456
MTR11419002 11422889 25486581
CAM101489437 101508595
LJALj0g3v0112059.1(Lj0g3v0112059.1) Lj0g3v0188849.1(Lj0g3v0188849.1) Lj4g3v2269810.1(Lj4g3v2269810.1) Lj4g3v2270890.1(Lj4g3v2270890.1) Lj6g3v0378000.1(Lj6g3v0378000.1) Lj6g3v1549210.1(Lj6g3v1549210.1)
ADU107458085 107463059 107481001
AIP107609805 107631407 107639048
AHF112702604 112703390 112723147 112733788 112766328 112791691
LANG109330033 109330118 109345159 109363067
FVE101293821 101314929
RCN112191493 112195288 112197158
PPER18782999 18789170
PMUM103323121 103327358
PAVI110763740 110765078
PDUL117622389 117632361
MDM103403560 103423955 103426220 114827069
PXB103933879 103940498 103956796 103956797 103959327 103959928
ZJU107415987 107433245
MNT112091178 21384774 21391130
CSV101209903 101210048
CMO103483883 103501376
BHJ120072746 120081656 120092557
MCHA111009333
CMAX111470789 111474294 111479361 111487678
CMOS111431279 111441765 111457941
CPEP111778211 111791747 111799968
RCU8258785 8258786
JCU105636132 105643512 105643513
HBR110632937 110632938 110638917 110638931 110666895
MESC110600764 110602102 110607773 110622903
POP112324670 18099805 18106559 18106561 7458915 7471118 7479664 7487416
PEU105122780 105135224 105135225 105136931 105136932 105137374 105139219
PALZ118030353 118033282 118047926 118053020 118053021 118062484
JRE108982505 108988258 109010091
QSU112007287 112039569
QLO115971601 115976193
TWL119989440 119999231 120013599
VVI100244843 100253077 100267152
VRI117913672 117913811 117914672
SLY101257932 101259973 101264780 101265715 112940025
SPEN107005763 107006622 107010994 107011728 107011729 107014633 107019709
SOT102581870 102590201 102594072 102603540
SSTN125847422 125847832 125859536 125863218 125870802
CANN107851004 107859652 107859653 107869830 107878670 124895307
NTA107761717 107763644 107770426 107783557 107787646 107791229 107806807 107809019 107815113
NSY104226904 104230340 104238582 104243209 104247004
NTO104085241 104087598 104099199 104111985
NAU109206380 109226963 109232129 109241295 109243512
INI109167683 109176096
ITR116002418 116012009
SIND105156854 105175974 105178908
OEU111387046 111393404 111401222 111408345
EGT105949018 105960781 105961837
SSPL121773916 121776548 121783222 121788027 121796084 121797029 121799814
HAN110883560 110884950 110891490 110899769 110901920 110915616 110918299
ECAD122578077 122582214 122583966
LSV111895832 111902318 111902319 111908610 111915365
CCAV112513567 112513667 112515155 112519787
DCR108196447 108202452 108216374 108220682
CSIN114269396 114292547 114294845 114322620
BVG104885453 104888403 104891259
SOE110774740 110787826 110788646 110798214
CQI110691648 110692320 110697212 110707262 110711131 110738064
NNU104598812 104605106 104606992
MING122058458 122059539 122073418 122073670
TSS122645277 122663941 122669143
PSOM113290563 113298304 113299676 113303202 113306202 113333087 113346882
NCOL116247082 116261028 116262904
OSA4331500 4332592 4332593 4347816
DOSAOs03t0130100-01(Os03g0130100) Os03t0305000-01(Os03g0305000) Os03t0305100-01(Os03g0305100) Os09t0555800-00(Os09g0555800)
OBR102699295 102704643 102706996 102720964
BDI100831811 100835277 100835764 100836068
ATS109737755 109737766 109750389 109759498 109759510 109759513 109761099 109767198 109774603
TDC119273702 119282707 119285477 119285478 119291859 119296343 119297894 119302961 119303969 119306125 119306141 119311641 119319326 119352507 119358464 119368981
TAES123042917 123050805 123050807 123085654 123085655 123086607 123089404 123092373 123092374 123097693 123097694 123098858 123104769 123108296 123116847 123116864 123125420 123125478 123186710
TUA125511321 125534533 125551919 125551920 125556625
SBI8061436 8083997 8083998
ZMA100191849 100281089 100281397 103639585
SITA101758375 101758784 101784986
SVS117835972 117835973 117836309
PVIR120647434 120652634 120652635 120691028 120692843
PHAI112875923 112876023 112876869
PDA103696748 103700954 103704643 103708848 103717609 103724260
EGU105035081 105045056 105055352 105057401 105058900
MUS103972138 103977657 103985797 103990681 103998089
DCT110095803 110111355 110115861
PEQ110030858 110035006
AOF109838174 109848028
ATR18445085 18445371
SMOSELMODRAFT_440085 SELMODRAFT_81559
PPP112286775
PPEIPpBr36_10065
BFUBCIN_11g02680
CIMCIMG_01663
CPWCPC735_048150
PBLPAAG_04973
PBNPADG_04827
BGHBDBG_03632
AALTCC77DRAFT_930906
ZTRMYCGRDRAFT_86361
PFJMYCFIDRAFT_51989
FFUCLAFUR5_09361
NAXHC341_08730
DMLDmul_11310(acsA1)
DALDalk_0007
DLIdnl_12470 dnl_12530
DMMdnm_063620
SMAGAN936_02825
SMAZLH19_18430
SWISwit_4371
SPHJBSL82_04390
SMICSmB9_03750
DCADesca_1425
DRUDesru_1970
DFGB0537_09375
DKUDesku_1227
DGIDesgi_1917
HMOHM1_0898
HCVFTV88_0428
SAYTPY_0169(acs)
SAPSulac_0146
CTHMCFE_1747
MASMahau_0484
MPSEMPSD_39150
MGADMGAD_59150
MSARMSAR_07670
MHIBMHIB_08500
KVRCIB50_0000777(fadK)
WIKH8R18_01010
RRDRradSPS_0423
KBSEPA93_37245
TYETHEYE_A0580
DTPJZK55_14810
 » show all
Reference
1  [PMID:13084616]
  Authors
MAHLER HR, WAKIL SJ, BOCK RM.
  Title
Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids.
  Journal
J Biol Chem 204:453-68 (1953)
Reference
2  [PMID:14285249]
  Authors
MASSARO EJ, LENNARZ WJ.
  Title
THE PARTIAL PURIFICATION AND CHARACTERIZATION OF A BACTERIAL FATTY ACYL COENZYME A SYNTHETASE.
  Journal
Biochemistry 4:85-90 (1965)
DOI:10.1021/bi00877a015
Reference
3  [PMID:14253428]
  Authors
WEBSTER LT Jr, GEROWIN LD, RAKITA L.
  Title
PURIFICATION AND CHARACTERISTICS OF A BUTYRYL COENZYME A SYNTHETASE FROM BOVINE HEART MITOCHONDRIA.
  Journal
J Biol Chem 240:29-33 (1965)
Reference
4  [PMID:15213221]
  Authors
Morgan-Kiss RM, Cronan JE
  Title
The Escherichia coli fadK (ydiD) gene encodes an anerobically regulated short chain acyl-CoA synthetase.
  Journal
J Biol Chem 279:37324-33 (2004)
DOI:10.1074/jbc.M405233200
Reference
5  [PMID:28947739]
  Authors
Rand JM, Pisithkul T, Clark RL, Thiede JM, Mehrer CR, Agnew DE, Campbell CE, Markley AL, Price MN, Ray J, Wetmore KM, Suh Y, Arkin AP, Deutschbauer AM, Amador-Noguez D, Pfleger BF
  Title
A metabolic pathway for catabolizing levulinic acid in bacteria.
  Journal
Nat Microbiol 2:1624-1634 (2017)
DOI:10.1038/s41564-017-0028-z
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.2
IUBMB Enzyme Nomenclature: 6.2.1.2
ExPASy - ENZYME nomenclature database: 6.2.1.2
BRENDA, the Enzyme Database: 6.2.1.2
CAS: 9080-51-7

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