Involved with EC 22.214.171.124
(D-alanine---D-alanine ligase), EC 126.96.36.199
(UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase) or EC 188.8.131.52
(UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase), EC 184.108.40.206
(UDP-N-acetylmuramate---L-alanine ligase) and EC 220.127.116.11
(UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase) in the synthesis of a cell-wall peptide (click here) for diagram. This enzyme also catalyses the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-centre), linking the D-Ala-D-Ala to the carboxy group of the L-centre. This activity was previously attributed to EC 18.104.22.168
, which has since been deleted.