KEGG   ENZYME: 6.3.2.36
Entry
EC 6.3.2.36                 Enzyme                                 
Name
4-phosphopantoate---beta-alanine ligase;
phosphopantothenate synthetase;
TK1686 protein
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
(R)-4-phosphopantoate:beta-alanine ligase (AMP-forming)
Reaction(IUBMB)
ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate [RN:R09379]
Reaction(KEGG)
R09379
Substrate
ATP [CPD:C00002];
(R)-4-phosphopantoate [CPD:C18911];
beta-alanine [CPD:C00099]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
(R)-4'-phosphopantothenate [CPD:C03492]
Comment
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 [pantoate---beta-alanine ligase] and EC 2.7.1.33 [pantothenate kinase], respectively). In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine. The two archaeal enzymes that catalyse this conversion are EC 2.7.1.169, pantoate kinase, and this enzyme.
History
EC 6.3.2.36 created 2011
Pathway
ec00410  beta-Alanine metabolism
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
Orthology
K09722  4-phosphopantoate---beta-alanine ligase
Genes
SSMSpirs_1722
STASTHERM_c02160
STQSpith_0200
MJAMJ_0209
MFEMefer_0471
MVUMetvu_1598
MFSMFS40622_0017
MIFMetin_0068
MJHJH146_1594
MESGMLAUSG7_0446
MESAMLASG1_0062
MIGMetig_1648
MMPMMP1306
MMQMmarC5_0287
MMXMmarC6_1368
MMZMmarC7_0551
MMDGYY_07355
MMAKMMKA1_15290
MMAOMMOS7_14100
MMADMMJJ_15360
MAEMaeo_0765
MVNMevan_0616
MVOMvol_0285
MOKMetok_1341
METFCFE53_06465
MTHMTH_435
MMGMTBMA_c08300
MWOMWSIV6_0819
MTEEMTTB_07610
METCMTCT_0375
METEtca_00400
METZMETMT2_0556
METKFVF72_00240
MTHMFZP57_03920
METJFZP68_08965
MSTMsp_0560
METBAW729_04165
MRUmru_1225(panC)
MSIMsm_0140
MEBAbm4_0816(panC)
MMILsm9_0909(panC)
MEYETL18_05735
MOLYLM1_0788
MAROMarbSA_01960
METVK4897_01150
MELMetbo_1164
MEWMSWAN_1043
METHMBMB1_1178
MFCBRM9_1383
MFIDSM1535_2082
MCUBMCBB_1081
MSUBBK009_02390
METNBK008_10055
METTCIT01_00575
METOCIT02_02755
MEMEHYG87_01195
MFVMfer_0656
MKAMK0712
AFUAF_0927
AFGAFULGI_00010160
APOArcpr_0288
AVEArcve_1265
ASTAsulf_01592
FPLFerp_1528
GACGACE_1473
GAHGAH_01054
PFUPF1387
PFIPFC_06160
PHOPH1470(PH1470)
PABPAB1906
PYNPNA2_0056
PYAPYCH_03000
PYSPy04_1364
PYCTQ32_09580
TKOTK1686
TONTON_1374
TGATGAM_0403
TSITSIB_0551
TBATERMP_01371
THEGQS_08705
THATAM4_1085
THMCL1_1361
TLTOCC_04345
THSTES1_1388
TNUBD01_1978
TEUTEU_04510
TGYX802_05910
THVADU37_CDS05090
TCHCHITON_1690
TPEPA0127_06830
TGGA3K92_06990
TCEA3L02_04320
TBSA3L01_07585
THHCDI07_07995
TSLA3L11_00455
TTDA3L14_09940
TPRFA3L09_00310
TRLA3L10_06985
TPAFA3L08_00770
THYA3L12_02155
TICFH039_10515
TCQTIRI35C_1838
THEMFPV09_10625
THEIK1720_05885
PPACPAP_09620
MBAMbar_A3254
MBYMSBRM_1907
MBWMSBRW_1477
MBARMSBR2_0501
MBAKMSBR3_0048
MACMA_1278
MMAMM_2281
MMAZMmTuc01_2337
MMJMSMAS_2413
MMACMSMAC_2034
MVCMSVAZ_1598
MEKMSKOL_1527
MLSMSLAZ_0768
METMMSMTP_0821
MEFMSWH1_2239
MEQMSWHS_2834
MSJMSSAC_1058
MSZMSSIH_0918
MSWMSSIT_0951
MTHRMSTHT_0989
MTHEMSTHC_2318
MHORMSHOH_1049
MFZAOB57_011515
MBUMbur_1184
MMETMCMEM_1652
MELOJ7W08_07120
MMHMmah_0519
MHAZBHR79_00825
MEVMetev_0804
MZHMzhil_0498
MPYMpsy_1001
MZIHWN40_03485
MHZMetho_1912
MTPMthe_1434
MCJMCON_3477
MHIMhar_0610
MHUMhun_0832
MRTJKHC33_09455
MLAMlab_0920
MEMMemar_1234
MBGBN140_0997
MEMAMMAB1_1321
MCHKMchiMG62_14300
MSUMOH143_00395
MPIMpet_0987
MENDL6E24_12170
MBNMboo_1665
MFOMetfor_1343
MPLMpal_1882
MPDMCP_2267
MEZMtc_0974
RCIRCIX860
HALVNG_0250C
HSLOE_1394R
HDLHALDL1_05400
HHBHhub_1405
HAGSJT689_02420
HABOJRZ79_00925
HNOLT974_02050
HLULT972_11570
HANRLJ422_01135
HJEHacjB3_12990
HALHHTSR_1478
HHSRHSR6_1550(pps)
HSUHLASF_0579
HSFHLASA_0575
SALRFQU85_02425
HALREFA46_005870
HAADMW046_08640
HALXM0R89_10540
HAXZM0R88_10990
SALIL593_09565
SAIMK0C01_03150
HARAAArcS_1964
HMArrnAC1793
HHIHAH_2321
HHNHISP_11820
HABSG26_04150
HTABVU17_11300
HALJG9465_06960
HSINKDQ40_01820
NPHNP_0848A
NMONmlp_1060
NHOHWV23_11810
NSALHWV07_06170
HUTHuta_2721
HTIHTIA_2468
HALAHrd1104_02055
HMUHmuk_3221
HALZE5139_03325
HALLLC1Hm_2561(pps)
HAZPGBQ70_03325
HALIBV210_05575
HSNDV733_08795
HDSHSR122_0803
HRRHZS55_08705
HPELHZS54_09825
HLTI7X12_05295
HARCHARCEL1_09630
HDOMUK72_05225
SSAIN0B31_01220
HWAHQ_1272A
HWCHqrw_1301
HVOHVO_0674
HMEHFX_0637
HGIABY42_03210
HALEG3A49_03430
HLSKU306_07925
HBOHbor_25430
HAQDU484_06825
HAJDU500_07095
HAERDU502_04755
HRAEI982_08990
HLMDV707_12670
HALMFCF25_10420
HLAHlac_1180
HALBEKH57_06890
HEZZEO776_05560
HALQHrr1229_000080
HSSJ7656_11085
HSAIHPS36_01440
HAZZKI388_03020
SRUBC2R22_04065
HAEhalTADL_1090
HALGHUG10_14905
HALUHUG12_01305
HMPK6T50_11100
HREK6T36_10890
HRMK6T25_05165
HACBHbl1158_03265
HDFAArcSl_1448(pps)
HTUHtur_2675
HDABB347_08700
HSALJMJ58_15470
HLOJ0X27_05165
HAKZJ0X25_01575
NMGNmag_1075
HXAHalxa_2489
NATNJ7G_1983
NPENatpe_0953
NVRFEJ81_04915
NPLFGF80_05940
NAYHYG81_06020
HALYHYG82_09005
HJTDVR14_14065
NGENatgr_2091
HRUHalru_1152
NOUNatoc_2690
HLRHALLA_12895
HLCCHINAEXTREME09815
NAJB1756_12365
NAGAArcMg_0541
NANAArc1_0553
NBGDV706_10945
NASGCU68_01165
SAWLNGM29_17010
MELUMTLP_00480 MTLP_03120
MEAMMU439_00440
TARTALC_00077
MAXMMALV_00560
MERMMINT_02640
MEARMpt1_c11920
MEUZKRP56_00550
MARCAR505_1789
ABIAboo_1374
ACFAciM339_1188
APEAPE_1937.1
ACJACAM_1211
SMRSmar_1379
SHCShell_1069
IHOIgni_0452
IISEYM_02255
IPCIPA_00770
DKADKAM_0336
DFDDesfe_0418
DMUDesmu_0743
TAGTagg_0656
THGTCELL_1109
HBUHbut_0343
PFMPyrfu_1592
PDLPyrde_0351
STOSTK_05320
SOHD1869_02490
SSOSSO2399
SOLSsol_0205
SSOASULA_0197
SSOLSULB_0198
SSOFSULC_0197
SSHIJ5U23_01201
SCASSACC_18970
SAISaci_0949
SACNSacN8_04605
SACRSacRon12I_04595
SACSSUSAZ_04355
SISLS215_0221
SIAM1425_0190
SIMM1627_0190
SIDM164_0209
SIYYG5714_0194
SINYN1551_2796
SIILD85_0194
SIHSiH_0196
SIRSiRe_0190
SICSiL_0183
SULEGFS03_02500
SULOGFS33_08725
SULLEWF20_04015
MSEMsed_0614
MEMJMJ1HA_0723
MCNMcup_1489
MHKDFR87_02800
MPRUDFR88_03510
MTENGWK48_09310
MJNMjAS7_1376
AHOAhos_2193
AMANB6F84_03145
ABRIDFR85_00705
ASULDFR86_03145
AAMBD1866_05945
ACIHHS5_10040
SACDHS1genome_1438
SAZOD1868_07825
CSTYKN1_08460
STEPIC006_2575
PAIPAE3406
PISPisl_1361
PCLPcal_0384
PASPars_2001
PYRP186_1236
POGPogu_0121
TNETneu_0315
PYWPYWP30_00486
CMACmaq_1781
TTNTTX_1081
TUZTUZN_1336
VDIVdis_0593
VMOVMUT_1928
VSOVsou_19750
ASCASAC_0272
ACIASE86_01980
CLGCalag_0335
FFOFFONT_0842
NMRNmar_1719
NIRNSED_09155
NKRNKOR_09130
NIDNPIRD3C_0168
NINNADRNF5_0153
NIWNisw_05440
NCLC5F47_08835
NOXC5F49_08715
NUEC5F50_12210
NIPNsoK4_09795
NCTNMSP_1635
NICDSQ20_09755
CSYCENSYa_1501
NGANgar_c11050
NVNNVIE_011900
NEVNTE_02600
TAANMY3_01865
NFNNFRAN_2676
NCVNCAV_0022
NBVT478_1432
TAHSU86_005785
NIUDSQ19_00400
NDVNDEV_2028(pps)
BARBAOA66_0497
FLTSv326_0969
LOKILokiarch_34300
PSYTDSAG12_00599
AGWQT03_C0001G0028
 » show all
Reference
1  [PMID:19666462]
  Authors
Yokooji Y, Tomita H, Atomi H, Imanaka T
  Title
Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea.
  Journal
J Biol Chem 284:28137-45 (2009)
DOI:10.1074/jbc.M109.009696
  Sequence
[tko:TK1686]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.36
IUBMB Enzyme Nomenclature: 6.3.2.36
ExPASy - ENZYME nomenclature database: 6.3.2.36
BRENDA, the Enzyme Database: 6.3.2.36

DBGET integrated database retrieval system