Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy

(R)-4'-phosphopantothenate:L-cysteine ligase

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine [RN:R04231]

R04231
Reaction

CTP [CPD:C00063];
(R)-4'-phosphopantothenate [CPD:C03492];
L-cysteine [CPD:C00097]

A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC 6.3.2.51, which requires ATP. Cysteine can be replaced by some of its derivatives.

EC 6.3.2.5 created 1961, modified 2003, modified 2017