Entry
Name
phosphopantothenate---cysteine ligase (CTP);
phosphopantothenoylcysteine synthetase (ambiguous);
phosphopantothenate---cysteine ligase (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
(R)-4'-phosphopantothenate:L-cysteine ligase
Reaction(IUBMB)
CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine [RN:
R04231 ]
Reaction(KEGG)
Substrate
Product
CMP [CPD:
C00055 ];
diphosphate [CPD:
C00013 ];
N-[(R)-4'-phosphopantothenoyl]-L-cysteine [CPD:
C04352 ]
Comment
A key enzyme in the production of coenzyme A. The bacterial enzyme requires CTP, in contrast to the eukaryotic enzyme, EC
6.3.2.51 , which requires ATP. Cysteine can be replaced by some of its derivatives.
History
EC 6.3.2.5 created 1961, modified 2003, modified 2017
Pathway
ec00770 Pantothenate and CoA biosynthesis
Orthology
K13038 phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase
K21977 phosphopantothenate---cysteine ligase (CTP)
Genes
EHI : EHI_092330 EHI_164490(50.t00036)
EDI : EDI_280130 EDI_302820
ECF : ECH74115_5009(coaBC)
ECOO : ECRM13514_4628(dfp)
ECOH : ECRM13516_4427(dfp)
ECW : EcE24377A_4140(coaBC)
EDJ : ECDH1ME8569_3524(dfp)
ECOI : ECOPMV1_03973(coaBC)
EAL : EAKF1_ch2303c(coaBC)
SBC : SbBS512_E4064(coaBC)
EHU : D5067_0000610(coaBC)
RTG : NCTC13098_00126(coaBC_3)
REE : electrica_00109(coaBC)
BCHR : BCHRO640_659(coaBC)
CLAP : NCTC11466_04542(coaBC)
KIE : NCTC12125_03924(coaBC)
AHN : NCTC12129_04894(coaBC_1)
SGOE : A8O29_001065(coaBC)
PSHI : SAMEA2665130_2901(coaBC)
PSGC : G163CM_36950(coaBC)
YPG : YpAngola_A0054(coaBC)
YPI : YpsIP31758_0060(coaBC)
SERA : Ser39006_001770(coaBC)
SFJ : SAMEA4384070_4776(coaBC)
SOF : NCTC11214_01633(coaBC_1) NCTC11214_01634(coaBC_2)
PAQU : DMB82_0019665(coaBC)
DIC : Dpoa569_003775(coaBC)
PLF : PANA5342_0129(coaBC)
MINT : C7M51_03404(coaBC_2)
TPTY : NCTC11468_03737(coaBC)
PHEI : NCTC12003_03921(coaBC)
PRJ : NCTC6933_03942(coaBC)
LRI : NCTC12151_00136(coaBC)
HIW : NTHI477_00754(coaBC)
HIC : NTHIC486_00020(coaBC)
HIX : NTHI723_00659(coaBC)
HPIT : NCTC13334_00188(coaBC)
HHZ : NCTC10839_01861(coaBC)
HAEG : NCTC8502_00041(coaBC)
PDAG : 4362423_00009(coaBC)
PCAI : K7G93_000009(coaBC)
ADP : NCTC12871_00583(dfp)
ALIG : NCTC10568_02365(dfp)
ASEG : NCTC10977_00722(coaBC)
AVT : NCTC3438_00721(coaBC)
RPNE : NCTC8284_03415(coaBC)
PAET : NCTC13378_01654(coaBC)
XFU : XFF4834R_chr38020(dfp)
XPH : XppCFBP6546_14830(coaBC)
XHD : LMG31886_40500(coaBC)
LLZ : LYB30171_02476(coaBC_1)
VCE : Vch1786_I2498(coaBC)
VAU : VANGNB10_cI2549(coaBC)
VEU : IXK98_09240(coaBC) IXK98_16725
VPL : SA104470976_02529(coaBC)
PAEB : NCGM1900_6163(coaC)
PAMG : BKM19_002595(coaBC)
PVD : CFBP1590_0198(coaBC)
PPRC : PFLCHA0_c60110(coaBC)
PFW : PF1751_v1c53960(coaBC)
PPUU : PputUW4_05324(coaBC)
PSEC : CCOS191_5180(coaBC)
PMOE : HV782_000130(coaBC)
PTRT : HU722_0000110(coaBC)
PSAM : HU731_015205(coaBC)
PSHH : HU773_000110(coaBC)
PPRG : HU725_022290(coaBC)
PANH : HU763_024010(coaBC)
PTW : TUM18999_02040(coaC)
PTAE : NCTC10697_00094(coaBC)
ASJ : AsACE_CH02401(coaBC)
ACUM : C9E88_001510(coaBC)
MCAT : MC25239_01348(coaBC)
MCUN : NCTC10297_00986(coaBC)
SCAA : TUM17387_03340(dfp)
SEUR : FM038_001670(coaBC)
PSEN : PNC201_02005(coaBC)
APEL : CA267_009645(coaBC)
HMI : soil367_15885(coaBC)
CBS : COXBURSA331_A1061(coaBC)
ASIP : AQUSIP_01740(coaBC)
LLG : 44548918_00388(coaBC)
LJR : NCTC11533_00395(coaBC)
LCJ : NCTC11976_00160(dfp)
LWA : SAMEA4504053_0945(coaBC)
LSS : NCTC12082_02507(coaBC)
LADL : NCTC12735_00518(coaBC)
MOZ : MoryE10_01790(coaBC)
MISZ : MishRS11D_06940(coaBC)
THIO : AYJ59_02590 AYJ59_03560
MPIN : LGT42_014155(coaBC)
TIB : THMIRHAM_19700(coaBC)
TSE : THMIRHAS_22880(coaBC)
TZO : THMIRHAT_02850(coaBC)
TNI : TVNIR_0394(coaBC_[H])
GAI : IMCC3135_32935(coaBC)
THIC : TspCOW1_27620(coaBC)
HOL : HORIV_06800 HORIV_06810
HAXI : HAALTHF_01740n HAALTHF_01750n HAALTHF_01760n
AEL : NCTC12917_00075(coaBC)
CHJ : NCTC10426_01383(coaBC)
CDIZ : CEDIAZO_00358(coaBC)
NMH : NMBH4476_0564(coaBC)
NMD : NMBG2136_1534(coaBC)
NMM : NMBM01240149_0526(coaBC)
NMS : NMBM01240355_1584(coaBC)
NMQ : NMBM04240196_0573(coaBC)
NMZ : NMBNZ0533_1636(coaBC)
NMX : NMA510612_2158(coaBC)
NWE : SAMEA3174300_0647(coaBC)
NZO : SAMEA4504057_1666(coaBC)
NCI : NCTC10296_01147(coaBC)
NCZ : NCTC10294_01124(coaBC)
NANI : NCTC12227_01178(coaBC)
KOA : H3L93_05565(coaBC) H3L93_10345(coaBC)
ECOR : SAMEA4412678_0720(coaBC)
BMV : BMASAVP1_A2660(coaBC)
BML : BMA10229_A1035(coaBC)
BMN : BMA10247_2114(coaBC)
BPM : BURPS1710b_1120(coaBC)
BPL : BURPS1106A_0969(coaBC)
BPD : BURPS668_0965(coaBC)
PLG : NCTC10937_00183(coaBC)
LMIR : NCTC12852_02246(coaBC)
VTR : MYVALT_F_01130(coaBC)
BTRM : SAMEA390648702748(coaBC)
AXX : ERS451415_03882(coaBC)
LIM : L103DPR2_01423(coaBC)
LIH : L63ED372_01450(coaBC)
HYC : E5678_01620(coaBC) E5678_02635
CPRA : CPter91_1207(coaBC)
SUTT : SUTMEG_05720(coaBC)
NLC : EBAPG3_013670(coaBC)
URU : DSM104443_00842(coaBC)
UPL : DSM104440_00803(coaBC)
FPHO : SHINM1_002000(coaBC)
HPO : HMPREF4655_20755(coaBC)
HPX : HMPREF0462_0566(coaBC)
HCL : NCTC13205_00344(coaBC)
CJJ : CJJ81176_0839(coaBC)
CJD : JJD26997_1192(coaBC)
CCOC : CCON33237_1204(dfp)
CPIN : CPIN18020_1030(dfp)
CAMZ : CVIC12175_0914(dfp)
GBN : GEOBRER4_24860(coaBC)
GNT : KP003_00385 KP003_11345(coaBC)
PSEF : PSDVSF_22680(coaBC)
PPOR : JCM14722_18090(coaBC)
PAUU : E8A73_016070(coaBC)
HOH : Hoch_4196 Hoch_5016 Hoch_5536 Hoch_5537
RBS : RHODOSMS8_03239(coaBC)
SMEL : SM2011_c01161(coaBC)
SFD : USDA257_c62140(coaBC)
SAME : SAMCFNEI73_Ch0363(coaB)
ALF : CFBP5473_00375(coaBC)
REC : RHECIAT_CH0000379(dfp)
REL : REMIM1_CH00347(coaBC)
REP : IE4803_CH00371(coaBC)
REI : IE4771_CH00378(coaBC)
RTR : RTCIAT899_CH02100(coaBC)
RPUS : CFBP5875_14130(coaBC)
RGA : RGR602_CH00364(coaBC)
RHN : AMJ98_CH00355(coaBC)
RPHA : AMC79_CH00382(coaBC)
RHX : AMK02_CH00355(coaBC)
REZ : AMJ99_CH00355(coaBC)
RJG : CCGE525_02720(coaBC)
RHID : FFM81_019360(coaBC)
PDES : FE840_006255(coaBC)
BSI : BS1330_II1056(coaBC)
BSUI : BSSP1_II1019(coaBC)
BSUP : BSPT1_II1016(coaBC)
BSUV : BSPT2_II1018(coaBC)
BSUC : BSSP2_II1027(coaBC)
BSV : BSVBI22_B1055(coaBC)
BVL : BF3285c2_0615(coaBC)
BIO : BR141012304_20846(coaBC)
BSEP : HAP48_0016160(coaBC)
BQB : J4P68_0020005(coaBC)
BBAN : J4G43_000415(coaBC)
VGO : GJW-30_1_04294(coaBC)
BHS : BM1374165_00040(dfp)
BBK : BARBAKC583_1349(coaBC)
BTX : BM1374166_00035(dfp)
BEZ : NCTC12898_01655(coaBC)
MMES : MMSR116_21815(coaBC)
MTUN : MTUNDRAET4_2586(dfp)
MHEY : H2LOC_020530(coaBC)
BVY : NCTC9239_03140(coaBC)
TSV : DSM104635_03995(coaBC)
RLI : RLO149_c035800(coaBC)
PHP : PhaeoP97_02607(coaBC)
PPIC : PhaeoP14_02409(coaBC)
OAT : OAN307_c38920(coaBC)
SINL : DSM14862_02904(coaBC)
SPSE : SULPSESMR1_00061(coaBC)
RMM : ROSMUCSMR3_01239(coaBC)
AHT : ANTHELSMS3_01621(coaBC)
RCP : RCAP_rcc00456(coaBC)
LVS : LOKVESSMR4R_02755(coaBC)
SPAU : DRN02_018720(coaBC)
SFLA : SPHFLASMR4Y_02750(coaBC)
EBLA : JGUZn3_07660(coaBC_1) JGUZn3_17340(coaBC_2)
SMUC : JL100_029825(coaBC)
SROE : JL101_028615(coaBC)
THAC : CSC3H3_19815(coaBC)
BSH : BSU6051_15700(coaBC)
BAML : BAM5036_1489(coaBC)
BAZ : BAMTA208_09295(coaBC)
BCR : BCAH187_A3917(coaBC)
BCB : BCB4264_A3968(coaBC)
BCG : BCG9842_B1275(coaBC)
BMOB : MLA2C4_20220(coaBC)
BMET : BMMGA3_05860(coaBC)
BFD : NCTC4823_02532(coaBC)
BKW : BkAM31D_15035(coaBC)
ASED : IRT44_06670 IRT44_18005(coaBC)
LGY : T479_04760 T479_08670
LFU : HR49_15245 HR49_18800
LYS : LBYS11_04690(coaBC) LBYS11_07815
LYB : C3943_05790(coaBC) C3943_20265
LYZ : DCE79_04115(coaBC) DCE79_06490
LPAK : GDS87_05045(coaBC) GDS87_09010
LAGR : FJQ98_05810(coaBC) FJQ98_09540
LMAC : I6G82_10170 I6G82_13645(coaBC)
LYC : FH508_0005185(coaBC) FH508_0009280
LCAP : ICJ70_16415 ICJ70_19565(coaBC)
NTM : BTDUT50_07085(coaBC)
MLIT : KDJ21_021480(coaBC)
BLEN : NCTC4824_02716(coaBC)
BVQ : FHE72_09545(coaBC) FHE72_16930
BOU : I5818_16075(coaBC) I5818_18445
SAA : SAUSA300_1104(coaBC)
SUJ : SAA6159_01064(coaBC)
SUK : SAA6008_01166(coaBC)
SUQ : HMPREF0772_12021(coaBC)
SAUT : SAI1T1_2008610(coaBC)
SAUJ : SAI2T2_1008630(coaBC)
SAUK : SAI3T3_1008620(coaBC)
SAUQ : SAI4T8_1008610(coaBC)
SDP : NCTC12225_01825(coaBC)
SCAP : AYP1020_0518(coaBC)
SPIC : SAMEA4384060_1733(coaBC)
SSH : NCTC13712_01156(coaBC)
SSIM : SAMEA4384339_1098(coaBC)
SSTE : SAMEA4384403_1619(coaBC)
LMOC : LMOSLCC5850_1887(coaBC)
LMF : LMOf2365_1853(coaBC)
LMOL : LMOL312_1834(coaBC)
LMOZ : LM1816_11312(coaBC)
LMW : LMOSLCC2755_1886(coaBC)
LMX : LMOSLCC2372_1891(coaBC)
LMZ : LMOSLCC2482_1887(coaBC)
LMON : LMOSLCC2376_1786(coaBC)
LMOS : LMOSLCC7179_1798(coaBC)
LMOO : LMOSLCC2378_1848(coaBC)
LMOY : LMOSLCC2479_1889(coaBC)
LMOT : LMOSLCC2540_1907(coaBC)
LMOA : LMOATCC19117_1842(coaBC)
LGZ : NCTC10812_00999(coaBC)
LMAR : LAX80_008965(coaBC)
GMO : NCTC11323_00871(coaBC)
GHA : NCTC10459_00862(coaBC)
BAGR : BA6348_12445(coaBC)
PCHI : PC41400_22120(coaBC)
COHN : KCTCHS21_39300(dfp)
TUM : CBW65_01835 CBW65_16460
TAB : CIG75_04550 CIG75_12520(coaBC)
SIV : SSIL_2604 SSIL_3056(coaBC)
SOB : CSE16_04155(coaBC) CSE16_06490
KZO : NCTC404_00111(coaBC)
PLAY : DNR44_010320(coaBC)
SPYM : M1GAS476_0993(dpfB)
SPH : MGAS10270_Spy1049(dpfB)
SPI : MGAS10750_Spy1084(dpfB)
SPJ : MGAS2096_Spy0994(dpfB)
SPK : MGAS9429_Spy1038(dpfB)
STG : MGAS15252_0932(coaB)
STZ : SPYALAB49_000926(coaB)
SPR : spr1110(dfp_C-terminus)
SNV : SPNINV200_10050(dpfB)
SNC : HMPREF0837_11270(coaB)
SPNE : SPN034156_01880(dpfB)
SPNU : SPN034183_11000(dpfB)
SPNM : SPN994038_10890(dpfB)
SPNO : SPN994039_10900(dpfB)
SAGR : SAIL_11770 SAIL_11780
SDQ : SDSE167_1144 SDSE167_1145
SGG : SGGBAA2069_c11070(dpfB)
SCP : HMPREF0833_10460(coaB)
SVB : NCTC12167_00812(dfp2)
SMEN : SAMEA4412692_0691(ppcs)
SFER : NCTC12278_00951(coaB)
SCAI : NCTC12191_01701(dpfB)
SPSU : NCTC13786_00250(coaB)
SPOC : NCTC10925_00919(coaB)
SAUP : NCTC3168_01740(coaB)
SURN : NCTC13766_01210(coaB)
SVF : NCTC3166_01007(coaB)
LRU : HMPREF0538_20179(coaBC)
EFU : HMPREF0351_10694(coab)
AUR : HMPREF9243_1605(coaBC)
CPAE : CPAST_c21070(coaBC)
CACE : CACET_c20960(coaBC)
CCOH : SAMEA4530647_1030(coaBC)
CAUN : CLAUR_008040(coaBC)
HHW : NCTC503_01548(coaBC)
CLO : HMPREF0868_0650(coaBC)
RHER : EHE19_018870(coaBC)
SMAN : C12CBH8_07870(coaBC)
PFAA : MM59RIKEN_29680(coaBC)
CSCI : HDCHBGLK_02230(coaBC)
PDC : CDIF630_02840(coaBC)
CDL : CDR20291_2473(coaBC)
PDF : CD630DERM_25870(coaBC)
FAA : HMPREF0389_00063(coaBC)
PHX : KGNDJEFE_00865(coaBC)
AMIC : Ami3637_08545(coaBC)
ABUT : Ami103574_15465(coaBC)
ETM : CE91St48_13920(coaBC)
CDIA : CaldiYA01_14730(coaBC)
CNAG : OTJ99_001178(coaBC)
PHAR : NCTC13077_00759(coaBC)
PIV : NCTC13079_00766(coaBC)
VRM : 44547418_00858(coaBC)
VDN : NCTC11831_01103(coaBC)
DHO : Dia5BBH33_09220(coaBC)
MANA : MAMMFC1_03733(coaBC)
PFAC : PFJ30894_01584(coaBC)
AARG : Aargi30884_28940(coaBC)
ABSI : A9CBEGH2_01140(coaBC)
FIT : Fi14EGH31_14670(coaBC)
LCG : L3BBH23_21700(coaBC)
MCOU : NCTC10179_00565(coaBC)
MCIT : NCTC10181_00493(coaBC)
EFR : EFREU_v1c05820(coaB)
SSYR : SSYRP_v1c06190(dfp)
STAI : STAIW_v1c04910(dfp)
SAPI : SAPIS_v1c05510(dfp)
SSAB : SSABA_v1c05210(dfp)
SATR : SATRI_v1c08140(dfp)
SERI : SERIO_v1c07950(dfp)
SCOU : SCORR_v1c04000(dfp)
SPRN : S100390_v1c06550(dfp)
SPIT : STU14_v1c06550(dfp)
SMOO : SMONO_v1c03910(dfp)
SALX : SALLE_v1c05260(dfp)
SCHI : SCHIN_v1c06300(coaBC)
SPLT : SPLAT_v1c05220(dfp)
MBAI : MB901379_02032(coaBC)
MHEK : JMUB5695_02876(coaBC)
MPHL : MPHLCCUG_02934(coaBC)
MTHN : 4412656_02572(coaBC)
MAUU : NCTC10437_02510(coaBC)
MMUC : C1S78_013225(coaBC)
MFLV : NCTC10271_02897(coaBC)
MBRM : L2Z93_002192(coaBC)
MSAL : DSM43276_02518(coaBC)
MMIN : MMIN_00080 MMIN_00090 MMIN_39120(coaBC)
CDIP : ERS451417_01326(dfp)
CPP : CpP54B96_1142(coaBC)