KEGG   ENZYME: 6.3.2.60
Entry
EC 6.3.2.60                 Enzyme                                 

Name
glutamate---[amino group carrier protein] ligase;
argX (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
L-glutamate:an [amino-group carrier protein]-C-terminal-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + L-glutamate + an [amino-group carrier protein]-C-terminal-L-glutamate = ADP + phosphate + an [amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate [RN:R10929]
Reaction(KEGG)
R10929
Substrate
ATP [CPD:C00002];
L-glutamate [CPD:C00025];
[amino-group carrier protein]-C-terminal-L-glutamate
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
[amino-group carrier protein]-C-terminal-gamma-(L-glutamyl)-L-glutamate
Comment
The enzyme, originally characterized from the archaeon Sulfolobus acidocaldarius, is involved in L-arginine biosynthesis. The enzyme from the archaeon Thermococcus kodakarensis is bifunctional and also catalyses the activity of EC 6.3.2.43, [amino-group carrier protein]---L-2-aminoadipate ligase.
History
EC 6.3.2.60 created 2021
Pathway
ec00220  Arginine biosynthesis
ec01100  Metabolic pathways
Orthology
K19412  glutamate---[amino group carrier protein] ligase
K25032  alpha-aminoadipate-LysW ligase/glutamate-LysW ligase
Genes
MIG: Metig_0633
MVN: Mevan_0912
MOK: Metok_1139
METF: CFE53_00515
PFU: PF1682
PFI: PFC_10195
PHO: PH1721(PH1721)
PAB: PAB0290(rimK)
PYN: PNA2_0329 PNA2_0499
PYS: Py04_1636
TKO: TK0278
THS: TES1_0507
FAI: FAD_1383
IHO: Igni_1403
IIS: EYM_00645
STO: STK_15050(argE)
SOH: D1869_08455(lysX)
SSO: SSO0645(rimK-2)
SOL: Ssol_1704
SSOA: SULA_1732(lysX)
SSOL: SULB_1733(lysX)
SSOF: SULC_1731(lysX)
SCAS: SACC_03370
SAI: Saci_1621
SID: M164_1489
SII: LD85_1699
SIH: SiH_1458
SIR: SiRe_1368
SIC: SiL_1371
SULE: GFS03_08525(lysX)
SULO: GFS33_00300(lysX)
SULL: EWF20_09625(lysX)
MSE: Msed_1991
MCN: Mcup_0295
MHK: DFR87_08550(lysX)
MPRU: DFR88_08220(lysX)
MTEN: GWK48_03775(lysX)
AHO: Ahos_1105
ABRI: DFR85_09220(lysX)
ASUL: DFR86_08280(lysX)
AAMB: D1866_00395(lysX)
SAZO: D1868_05495(lysX)
CSTY: KN1_27050
STEP: IC006_1362
PYR: P186_2397
TNE: Tneu_0136
TUZ: TUZN_1890
VDI: Vdis_0196
VMO: VMUT_1535
NAA: Nps_00535
 » show all
Reference
1  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_1621]
Reference
2  [PMID:27566549]
  Authors
Yoshida A, Tomita T, Atomi H, Kuzuyama T, Nishiyama M
  Title
Lysine Biosynthesis of Thermococcus kodakarensis with the Capacity to Function as an Ornithine Biosynthetic System.
  Journal
J Biol Chem 291:21630-21643 (2016)
DOI:10.1074/jbc.M116.743021
  Sequence
[tko:TK0278]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.60
IUBMB Enzyme Nomenclature: 6.3.2.60
ExPASy - ENZYME nomenclature database: 6.3.2.60
BRENDA, the Enzyme Database: 6.3.2.60

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