KEGG   ENZYME: 6.3.2.7
Entry
EC 6.3.2.7                  Enzyme                                 
Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase;
MurE synthetase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase;
uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase;
UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase;
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate:L-lysine gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [RN:R02786]
Reaction(KEGG)
R02786
Substrate
ATP [CPD:C00002];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate [CPD:C00692];
L-lysine [CPD:C00047]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine [CPD:C05892]
Comment
Involved in the synthesis of a cell-wall peptide in bacteria. This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase) adds 2,6-diaminopimelate instead.
History
EC 6.3.2.7 created 1961, modified 2002
Pathway
ec00550  Peptidoglycan biosynthesis
ec01100  Metabolic pathways
Orthology
K05362  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase
Genes
SDOSD1155_07410
BACOOXB_1857
OIHOB1998
LSPBsph_1281
LFUHR49_19765
LYSLBYS11_03725
LYBC3943_04735
LYZDCE79_03385
LYGC1N55_05265
LPAKGDS87_04015
LAGRFJQ98_04825
LMACI6G82_14570
VIRX953_06650
BVQFHE72_08510
RMFD5E69_08915
SAUSA0876(murE)
SAVSAV1018(murE)
SAWSAHV_1012(murE)
SAHSaurJH1_1035
SAJSaurJH9_1016
SAMMW0899(murE)
SASSAS0887
SARSAR0988(murE)
SACSACOL1023(murE)
SAXUSA300HOU_0976(murE1)
SAASAUSA300_0919(murE)
SAOSAOUHSC_00954
SAENWMN_0888(murE)
SADSAAV_0980
SUUM013TW_0943
SUVSAVC_04255
SUESAOV_0963
SUJSAA6159_00874(murE)
SUKSAA6008_00973(murE)
SUCECTR2_873(murE)
SUTSAT0131_01053
SUQHMPREF0772_12216(murE)
SUZMS7_0974(murE)
SUDST398NM01_1014
SUXSAEMRSA15_08480(murE)
SUWSATW20_10150(murE)
SUGSAPIG1014
SUFSARLGA251_09330(murE)
SAUASAAG_02127
SAUERSAU_000903(murE)
SAUNSAKOR_00936
SAUSSA40_0888(murE)
SAUUSA957_0903(murE)
SAUGSA268_0905(murE)
SAUZSAZ172_0959(murE)
SAUTSAI1T1_2007200
SAUJSAI2T2_1007220
SAUKSAI3T3_1007210
SAUQSAI4T8_1007200
SAUVSAI7S6_1007210(murE)
SAUWSAI5S5_1007170(murE)
SAUXSAI6T6_1007180(murE)
SAUYSAI8T7_1007210(murE)
SAUFX998_1016
SABSAB0884(murE)
SUYSA2981_0972(murE)
SAUBC248_1042(murE)
SAUMBN843_9230
SAUCCA347_935(murE)
SAURSABB_00986(murE)
SAUIAZ30_04840
SAUDCH52_00795
SAMSNI36_04845
SUHSAMSHR1132_08650
SERSERP0607(murE)
SEPSE_0718
SEPPSEB_00697
SEPSDP17_2003(murE)
SHASH1941(murE)
SHHShL2_01803(murE)
SSPSSP1767
SCASCA_0621(murE)
SLGSLGD_01850
SLNSLUG_18440(murE)
SSDSPSINT_0714
SDTSPSE_1819(murE)
SDPNCTC12225_02039(murE)
SWAA284_08685
SPASSTP1_2087
SXYBE24_02440
SXLSXYLSMQ121_1766
SXOSXYL_01914(murE)
SHUSHYC_09250(murE-2)
SCAPAYP1020_0275(murE)
SSCHLH95_08705
SSCZRN70_09185
SAGQEP23_00740
SEQOSE1039_07730
SSIFAL483_06880
SCVA4G25_04830
SPETCEP67_11885
SLZB5P37_09085
SCOHBZ166_00755
SNLBJD96_09795
SKLC7J89_10925
SFQC7J90_06800
SHOMEGX58_01800(murE)
SMUSC7J88_10310
SCARDWB96_09560(murE)
SCHRDWB92_09015(murE)
SARLSAP2_18050(murE)
SPICSAMEA4384060_1942(murE)
SSHNCTC13712_00961(murE)
SSIMSAMEA4384339_0867(murE)
SDBCNQ82_04845(murE)
SLLOISP08_08885
SAULI6G39_08185
SSACI6I31_07320
SRAILN051_08190
SPSDJMB28_09590
SSCUCEP64_08610
SFFFOB90_10775
SSTESAMEA4384403_1838(murE)
MLENH3V22_13400
MVTI6J10_02135
MCLMCCL_0631(murE)
MCAKMCCS_08580(murE)
MACRBHM04_06280
MBOEHT586_04535
MARYLAU42_03710
MBRUMGG13_03915
SHVAAT16_03595
SBACBVH56_06325
JEAJEM45_04525
NAMPKPF49_02030
GOTAXE85_03625
GMONCTC11323_01073(murE)
GEQCG018_05765
GSAFOC50_07515
GHANCTC10459_00697(murE)
SIVSSIL_3199
SSILSOLI23_02570
SOBCSE16_03405
PLNPlano_2069
PKUAUO94_05340
PRTAUC31_16570
PLLI858_012485
PANABBH88_08720
PDGBCM40_04900
PHCBBI08_07600
PMARB0X71_12800
PPLABBI15_06065
PFAEAJGP001_12205
PLXCW734_12065
PMATBBI11_11520
PDECH1Q58_10780
JEOJMA_14530
KURASO14_2324(murE)
KZONCTC404_00255(murE)
SPSYAZE41_16520
SPORSporoP33_13420
SPOPSporoP37_13755
SURESporoP32a_14055
SPOSDV702_01735
SPAEE2C16_09495
SPOOJ3U78_06745
RSTATY39_01725
PAEKD3873_03840
PANCE2636_11030
PLAYDNR44_009310
VIJJNUCC6_18910
LLKLLKF_1979(murE)
LLTCVCAS_1739(murE)
LLSlilo_1789(murE)
LLDP620_10210
LLXNCDO2118_1912(murE)
LLJLG36_1762(murE)
LLCLACR_1987
LLRllh_3110
LLNLLNZ_10265(murE)
LLIuc509_1759(murE)
LLWkw2_1860(murE)
LGRLCGT_0383
LGVLCGL_0383
LPKLACPI_2096(murE)
LRNCMV25_06495
LACTD7I46_06865(murE)
LTIJW886_08480
LPAABHS01_09930
SPYSPy_0388(murE)
SPZM5005_Spy0325(murE)
SPYMM1GAS476_0392(murE)
SPYAA20_0373c(murE)
SPMspyM18_0440(murE)
SPGSpyM3_0284(murE)
SPSSPs1575
SPHMGAS10270_Spy0320(murE)
SPIMGAS10750_Spy0321(murE)
SPJMGAS2096_Spy0343(murE)
SPKMGAS9429_Spy0324(murE)
SPFSpyM51533(murE)
SPAM6_Spy0351
SPBM28_Spy0314(murE)
STGMGAS15252_0351(murE.1)
STXMGAS1882_0351(murE.1)
SOZSpy49_0319c(murE)
STZSPYALAB49_000354(murE)
SPYHL897_01765
SPNSP_1530(murE)
SPDSPD_1359(murE)
SPRspr1384(murE)
SPWSPCG_1517(murE)
SJJSPJ_1434
SNVSPNINV200_13670(murE)
SPXSPG_1456(murE)
SNTSPT_1468
SNDMYY_1460
SPNNT308_06950
SNESPN23F14930(murE)
SPVSPH_1643
SNCHMPREF0837_11764(murE)
SNMSP70585_1569
SPPSPP_1552
SNIINV104_13020(murE)
SPNGHMPREF1038_01514
SNBSP670_1613
SNPSPAP_1552
SNXSPNOXC13410(murE)
SNUSPNA45_00691(murE)
SPNESPN034156_04290(murE)
SPNUSPN034183_13400(murE)
SPNMSPN994038_13290(murE)
SPNOSPN994039_13300(murE)
SAGSAG1391(murE)
SANgbs1461
SAKSAK_1424(murE)
SGCA964_1305(murE)
SAGSSaSA20_1131(murE)
SAGLGBS222_1144(murE)
SAGMBSA_14720
SAGIMSA_15140
SAGRSAIL_14460
SAGPV193_06190
SAGCDN94_06190
SAGTGBSCOH1_1262
SAGEEN72_07725
SAGGEN73_06915
SAGNW903_1407(murE)
SMUSMU_1677(murE)
SMCSmuNN2025_0440(murE)
SMUTSMUGS5_07580
SMJSMULJ23_0456(murE)
SMUASMUFR_1459
STCstr0349(murE)
STLstu0349(murE)
STESTER_0387
STNSTND_0341
STUSTH8232_0447(mure)
STWY1U_C0334
STHET303_02880
STHSAVT04_03150
SSASSA_1739(murE)
SSBSSUBM407_1216(murE)
SSUSSU05_0651
SSVSSU98_0652
SSISSU0608(murE)
SSSSSUSC84_0581(murE)
SSFSSUA7_0606(murE)
SSWSSGZ1_0642
SUPYYK_02890
SSUSNJAUSS_0712
SSTSSUST3_0812(murE)
SSUYYB51_4025
SSKSSUD12_1217(murE)
SUISSUJS14_0741(murE)
SUOSSU12_0607(murE)
SRPSSUST1_1159(murE)
SSUTTL13_1126(murE)
SSUIT15_1332(murE)
SGOSGO_1638(murE)
SEZSez_1617(murE)
SEQSZO_03550
SEZOSeseC_02166(murE)
SEQUQ426_00770
SEUSEQ_1835
SUBSUB0425(murE)
SDSSDEG_0435(murE)
SDGSDE12394_02090
SDAGGS_0424(murE)
SDCSDSE_0454(murE)
SDQSDSE167_0474(murE)
SGAGALLO_1770(murE)
SGGSGGBAA2069_c17290(murE)
SGTSGGB_1757(murE)
SMBsmi_1512(murE)
SORSOR_0659(murE)
STKSTP_1332
STBSGPB_1578(murE.2)
SCPHMPREF0833_10974(murE)
SCFSpaf_1551(murE2)
SSRSALIVB_0346(murE)
STFSsal_01844(murE)
STJSALIVA_0324(murE)
STRSSSAL8618_01905
SSAHHSISS4_00276(murE)
STDSPPN_07500
SMNSMA_1676(murE)
SIFSinf_1499(murE)
SIESCIM_0429(murE)
SIBSIR_1231(murE)
SIUSII_1255(murE)
SANGSAIN_0463(murE)
SANCSANR_0481(murE)
SANSDK43_07865
SCGSCI_0511(murE)
SCONSCRE_0491(murE)
SCOSSCR2_0491(murE)
SOII872_05895
SIKK710_1552
SIQDQ08_07240
SIODW64_07225
SIZSI82_07345
SLUKE3_1632
SIGN596_04825
SIPN597_06680
STVV470_02995
SPATA0O21_01685
STRAATM98_04500
STRNSNAG_0628(murE)
SSOBDK181_08630(murE)
SRQSR187_6770
SEQIA6J79_04620(murE)
SKID7D50_05820(murE)
SPEIEHW89_02275(murE)
SRATFY406_06125
SGWD7D53_05730(murE)
SPLRC0J00_02250
STRGSRT_04560(murE)
SVBNCTC12167_00375(murE_1)
SMENSAMEA4412692_1073(murE)
SFERNCTC12278_01481(murE)
SCAINCTC12191_00119(murE)
SPSUNCTC13786_01732(murE)
SCHJDDV21_008855(murE)
SPOCNCTC10925_01423(murE)
SPABKQ224_10235
SLATJ4854_08020
SAUPNCTC3168_01256(murE)
SURNNCTC13766_01698(murE)
SACOSAME_00581(murE_1)
SVFNCTC3166_01492(murE)
SOSINT76_03075
FPENKIW23_09135
LMULBLM1_00055
LVALV515_09230(murE)
LPONLP475_08555(murE)
LGASLG045_09270(murE) LG045_09275(murE)
LNNF0161_11015(murE)
EFAEF0668(murE)
EFLEF62_1038(murE)
EFIOG1RF_10399(murE)
EFDEFD32_0482
EFSEFS1_0515(murE)
EFNDENG_00697(murE)
EFQDR75_2617(murE)
EFCEFAU004_02569
EFAUEFAU085_02652
EFUHMPREF0351_12511(murE2)
EFMM7W_2527
EFTM395_11930
EHREHR_05945
ECASECBG_02266
EMUEMQU_2676
EDULIU_02615
EGAAL523_03305
ESSATZ33_15015
ETHCK496_11385
EGVEGCR1_10725(murE)
EAVEH197_22045(murE)
ESGEsVE80_02820(murE2)
ELACI4Q40_11975
ECECNCTC12421_02150(murE)
ERAFJ9537_12845
EIEENLAB_14990(murE_2)
MPSMPTP_1715
MPXMPD5_0348
THLTEH_01090(murE)
TEYGLW17_06280(murE)
TOOC7K38_03850
TKRC7K43_09960
VTEBHY08_05245
VPIBW732_00325
VACE4Z98_04960(murE)
VAOFA707_05565(murE)
VAHG7081_05755
VCPH9L18_08285
VHYG7082_12370
VFVK5K99_09460
VLUM2919_01605(murE)
AUIAPT62_06795
ACGAWM71_05850
AVSAWM76_03400
AUHAWM75_06455
CMLBN424_209(murE)
CARNFPV25_04635(murE)
DPMFNV33_08880(murE)
FSAC5Q98_01550
COOCCU_09610
CCOMI6K69_13995
CEVLK421_04065 LK421_09800
QDOH9Q78_12455
WHJH9Q79_08600(murE)
IBUIB211_00151
LASAL9O85_14680(argB)
BDEBDP_1522(mur)
BDNBBDE_1446
BSUEBS3272_03770
OLOADJ70_02405
TIOINP52_09145
CGOCorgl_0162
 » show all
Reference
1
  Authors
Ito, E. and Strominger, J.L.
  Title
Enzymatic synthesis of the peptide in bacterial uridine nucleotides. I. Enzymatic addition of L-alanine, D-glutamic acid, and L-lysine.
  Journal
J Biol Chem 237:2689-2695 (1962)
Reference
2  [PMID:11699883]
  Authors
van Heijenoort J
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.7
IUBMB Enzyme Nomenclature: 6.3.2.7
ExPASy - ENZYME nomenclature database: 6.3.2.7
BRENDA, the Enzyme Database: 6.3.2.7
CAS: 9023-51-2

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