KEGG   ENZYME: 6.3.3.7
Entry
EC 6.3.3.7                  Enzyme                                 
Name
Ni-sirohydrochlorin a,c-diamide reductive cyclase;
cfbC (gene name);
cfbD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Cyclo-ligases
Sysname
Ni-sirohydrochlorin a,c-diamide reductive cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + Ni-sirohydrochlorin a,c-diamide + 3 reduced electron acceptor + H2O = ADP + phosphate + 15,173-seco-F430-173-acid + 3 electron acceptor [RN:R11628]
Reaction(KEGG)
R11628
Substrate
ATP [CPD:C00002];
Ni-sirohydrochlorin a,c-diamide [CPD:C21511];
reduced electron acceptor;
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512];
electron acceptor
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, participates in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.3.3.7 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21610  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbC
K21611  Ni-sirohydrochlorin a,c-diamide reductive cyclase subunit CfbD
Genes
MJAMJ_1423
MFEMefer_1398
MVUMetvu_0736
MFSMFS40622_0630
MIFMetin_0570
MJHJH146_0545
MESGMLAUSG7_0646(cfbD)
MESAMLASG1_0179(cfbD)
MIGMetig_1723
MMPMMP0428
MMQMmarC5_1209
MMXMmarC6_0483
MMZMmarC7_1425
MMDGYY_02215
MMAKMMKA1_04480
MMAOMMOS7_04440
MMADMMJJ_06040
MAEMaeo_1313
MVNMevan_1413
MVOMvol_1630
MOKMetok_0580
METFCFE53_05865
MTHMTH_1522 MTH_643
MMGMTBMA_c01050 MTBMA_c10230(nifH2)
METCMTCT_0570 MTCT_1386
MWOMWSIV6_0061 MWSIV6_1015(nifH2)
METEtca_00613(nifH1_1) tca_01470(nifD_1)
METZMETMT2_0422 METMT2_1600
METKFVF72_04015 FVF72_08355(cfbC)
MTHMFZP57_00245 FZP57_04835(cfbC)
METJFZP68_01455 FZP68_05275(cfbC)
MTEEMTTB_06850 MTTB_15090
MSTMsp_1120(nifH) Msp_1461
METBAW729_08130 AW729_10175
MRUmru_0181 mru_1466
MSIMsm_1160 Msm_1707
MEBAbm4_0121 Abm4_0733
MMILsm9_0152 sm9_1376
MEYETL18_04160 TL18_10060
MOLYLM1_0966 YLM1_1498
MAROMarbSA_02330 MarbSA_10930
MELMetbo_0037 Metbo_2093
MEWMSWAN_0064 MSWAN_0543
METHMBMB1_0045 MBMB1_0311(nifH2)
MFCBRM9_0099 BRM9_1962
MFIDSM1535_0151(nifH2-1) DSM1535_1422
MCUBMCBB_0063 MCBB_0533(nifH2)
MSUBBK009_10140 BK009_11725
METNBK008_05605 BK008_07360
METTCIT01_00825(nifH) CIT01_06000
METOCIT02_05310 CIT02_06840
MEMEHYG87_02415(cfbC) HYG87_06895(cfbD)
MFVMfer_0362 Mfer_0380
MKAMK1385(nifD)
MBAMbar_A0346 Mbar_A0347
MBYMSBRM_0572 MSBRM_0573
MBWMSBRW_0650 MSBRW_0651
MBARMSBR2_1806 MSBR2_1807
MBAKMSBR3_2861 MSBR3_2862
MACMA_3627(nifH) MA_3628
MMAMM_0514(nifH2) MM_0515
MMAZMmTuc01_0532 MmTuc01_0533
MMJMSMAS_0791 MSMAS_0792
MMACMSMAC_0770 MSMAC_0771
MVCMSVAZ_3046 MSVAZ_3047
MEKMSKOL_2991 MSKOL_2992
MLSMSLAZ_2304 MSLAZ_2305
METMMSMTP_0886 MSMTP_0887
MEFMSWH1_2457 MSWH1_2458
MEQMSWHS_2585 MSWHS_2586
MSJMSSAC_1227 MSSAC_1228
MSZMSSIH_2813 MSSIH_2814
MSWMSSIT_2847 MSSIT_2848
MTHRMSTHT_2450 MSTHT_2451
MTHEMSTHC_0831 MSTHC_0832
MHORMSHOH_0894 MSHOH_0895
MFZAOB57_003165(cfbC) AOB57_003170
MBUMbur_1037 Mbur_1038
MMETMCMEM_1519 MCMEM_1520
MELOJ7W08_06405(cfbD) J7W08_06410(cfbC)
MMHMmah_1412 Mmah_1413
MHAZBHR79_06610 BHR79_06615
MEVMetev_0555 Metev_0556
MZHMzhil_0468 Mzhil_0469
MPYMpsy_0958 Mpsy_0959
MZIHWN40_03735(cfbD) HWN40_03740(cfbC)
MHZMetho_0542 Metho_0543
MTPMthe_0106 Mthe_1178
MCJMCON_0503(nifH) MCON_1930
MHIMhar_0047 Mhar_2391
MHUMhun_0670
MRTJKHC33_10020(cfbD)
MLAMlab_0520
MEMMemar_1733
MBGBN140_0718
MCHKMchiMG62_19350
MPIMpet_1002
MBNMboo_1419
MFOMetfor_1748
MPLMpal_0679
MPDMCP_0363 MCP_0364(nifH-1)
MEZMtc_0063 Mtc_0064(nifH-1)
RCIRCIX2002(nifH-2) RCIX2003
MELUMTLP_03850
MEAMMU439_05075 MU439_05080(cfbD)
TARTALC_01251
MAXMMALV_13210
MERMMINT_17220 MMINT_17230
MEARMpt1_c08020(bchB2)
MARCAR505_0362
 » show all
Reference
1  [PMID:3691535]
  Authors
Pfaltz A, Kobelt A, Huster R, Thauer RK
  Title
Biosynthesis of coenzyme F430 in methanogenic bacteria. Identification of 15,17(3)-seco-F430-17(3)-acid as an intermediate.
  Journal
Eur J Biochem 170:459-67 (1987)
DOI:10.1111/j.1432-1033.1987.tb13722.x
Reference
2  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 6.3.3.7
IUBMB Enzyme Nomenclature: 6.3.3.7
ExPASy - ENZYME nomenclature database: 6.3.3.7
BRENDA, the Enzyme Database: 6.3.3.7

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