KEGG   ENZYME: 6.3.4.24
Entry
EC 6.3.4.24                 Enzyme                                 
Name
tyramine---L-glutamate ligase;
mfnD (gene name)
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
tyramine:L-glutamate gamma-ligase (ADP-forming)
Reaction(IUBMB)
ATP + tyramine + L-glutamate = ADP + phosphate + gamma-glutamyltyramine [RN:R10902]
Reaction(KEGG)
R10902
Substrate
ATP [CPD:C00002];
tyramine [CPD:C00483];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
gamma-glutamyltyramine [CPD:C20926]
Comment
The enzyme, which has been characterized from the archaea Methanocaldococcus fervens, participates in the biosynthesis of the cofactor methanofuran. Requires a divalent cation for activity, with Mn2+ giving the highest activity, followed by Mg2+, Co2+, Zn2+, and Fe2+.
History
EC 6.3.4.24 created 2014
Pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
Orthology
K06914  tyramine---L-glutamate ligase
Genes
EMODM558_09860
MCAMCA2868
METUGNH96_03505
MMTMetme_2270
MDNJT25_019360
MDHAYM39_08565
MKOMKLM6_1783
METLU737_14795
MPADKEF85_11450
MELLIVG45_03955
MAHMEALZ_2433
MBUREQU24_09090
MPSYCEK71_02030
MMAIsS8_3388
MMOBF6R98_18225
MEINmethR_P1410
MOZMoryE10_04100
MISZMishRS11D_40180
MESLKKZ03_09110
MEJQ7A_50
MECQ7C_1777
NOCNoc_0257
NHLNhal_3881
NWANwat_0355
NWRE3U44_04650
NTTTAO_1759
TSYTHSYN_31755
NTGNSCAC_0079
SEDSAAY24_01680
COXE0W60_31985
BUGBC1001_3969
BGFBC1003_5433
BYIBYI23_B014250
BUEBRPE67_BCDS01220
BUQAC233_22140
BPHBphy_5936 Bphy_6502
BGEBC1002_3202
BCAIK788_0001566 K788_0007399
PSPWBJG93_19500
PARABTO02_23540
PHSC2L64_21765
PTERC2L65_26230
PGPCUJ91_21390
PCJCUJ87_23530
BUOBRPE64_BCDS01340
VAPVapar_3069
VPDVAPA_1c31340
MPTMpe_A2621
METPC1M51_15035
RGERGE_40360
MFLAGO485_25020
MPLIE1742_23890
LCHLcho_3138
METRBSY238_3386
MFAMfla_1650
MMBMmol_1335
MEHM301_1544
MEIMsip34_1493
MEPMPQ_1556
MBACBN1209_0774
MEUACJ67_07435
MPAUZMTM_11920
SPLBSFPGR_25910
AZAAZKH_p0261
AZDCDA09_11455
DDZDSYM_25740
XAUXaut_1790
XDIEZH22_23940
SNOSnov_0746
STARG3545_09800
ANCGBB76_00730
APRAG3A50_16475
APOLK9D25_20210
CMETK6K41_25455
ALIAZOLI_p10884
ABSAZOBR_p270078
ABQABAZ39_25495
ABFAMK58_22305
ATIAL072_21135
AZTTSH58p_01230
AZMDM194_22135
AOZHUE56_08895
FWADCMF_03940
HASHalsa_0958
RBARB11969
PSLPsta_3591
RULUC8_21010
RMLFF011L_17930
MFFMFFC18_09560
ROLCA51_35250
AHELQ31a_40000
LCREPla8534_39490
AAGGETAA8_35450
BVOPan97_22160
RLCK227x_21260
LPAVPLANPX_2816
AMUCPan181_27090
PNDPla175_21270
AMOBHG15A2_27280
PLMPlim_0283
PEHSpb1_10390
PBSPlabr_4663
PLHVT85_05490
FMRFuma_03108
GMRGmarT_45480
GPNPan110_43600
MRIMal4_12180
SDYNMal52_29050
PLONPla110_07530
GESVT84_16265
GOGC1280_17355
GMSSOIL9_38910
TIMGMBLW1_22340
LRSPX52LOC_05125
FTJFTUN_7518
ULIETAA1_22520
TSPHKIH39_21365
SACISinac_1217
PBORBSF38_00158
AGVOJF2_59340
MOXDAMO_2657
MJAMJ_0815
MFEMefer_1180
MVUMetvu_0080
MFSMFS40622_1347
MIFMetin_1143
MJHJH146_1087
MESGMLAUSG7_1214(mfnD)
MESAMLASG1_0563(mfnD)
MIGMetig_1750
MMPMMP0564
MMQMmarC5_1043
MMXMmarC6_0329
MMZMmarC7_1583
MMDGYY_03655
MMAKMMKA1_06120
MMAOMMOS7_06070
MMADMMJJ_04200
MAEMaeo_0448
MVNMevan_1440
MVOMvol_0760
MOKMetok_1374
METFCFE53_01545
MTHMTH_835
MMGMTBMA_c12330
MWOMWSIV6_1212(mfnD)
MTEEMTTB_05400
METCMTCT_0749
METEtca_00802
METZMETMT2_0908
METKFVF72_07365
MTHMFZP57_05755
METJFZP68_00450
MSTMsp_0387
METBAW729_05135
MRUmru_1696
MSIMsm_0852
MEBAbm4_0504
MMILsm9_1779
MEYETL18_07950
MOLYLM1_1164
MAROMarbSA_18740
METVK4897_07220
MELMetbo_1949
MEWMSWAN_0670
METHMBMB1_0690
MFCBRM9_1505
MFIDSM1535_2199
MCUBMCBB_0701(mfnD)
MSUBBK009_01670
METNBK008_09255
METTCIT01_01990
METOCIT02_03320
MEMEHYG87_03505
MFVMfer_0210
MKAMK0114
AFUAF_1061
AFGAFULGI_00011600
AVEArcve_1368
ASTAsulf_01700
FPLFerp_2285
GACGACE_0439
GAHGAH_01280
MBAMbar_A3436
MBYMSBRM_1199
MBWMSBRW_1297
MBARMSBR2_1211
MBAKMSBR3_1316
MACMA_1475
MMAMM_2510
MMAZMmTuc01_2559
MMJMSMAS_2193
MMACMSMAC_2261
MVCMSVAZ_1446
MEKMSKOL_1391
MLSMSLAZ_0912
METMMSMTP_0947
MEFMSWH1_1890
MEQMSWHS_3183
MSJMSSAC_1475
MSZMSSIH_1484
MSWMSSIT_1540
MTHRMSTHT_0225
MTHEMSTHC_0507
MHORMSHOH_2802
MFZAOB57_001295
MBUMbur_1315
MMETMCMEM_1762
MELOJ7W08_07840
MMHMmah_1619
MHAZBHR79_05630
MEVMetev_0255
MZHMzhil_1619
MPYMpsy_2546
MZIHWN40_09635
MHZMetho_0940
MTPMthe_1641
MCJMCON_1686
MHIMhar_1058
MHUMhun_0571
MRTJKHC33_08690
MLAMlab_0268
MEMMemar_1384
MBGBN140_1324
MEMAMMAB1_1685
MCHKMchiMG62_15810
MPIMpet_1053
MBNMboo_0920
MFOMetfor_1879
MPLMpal_0581
MPDMCP_1324
MEZMtc_1029
RCIRCIX2220
MELUMTLP_02150
MEUZKRP56_00755
BARBAOA66_0934(mptN)
LOKILokiarch_26760(ddl)
 » show all
Reference
1  [PMID:25211225]
  Authors
Wang Y, Xu H, Harich KC, White RH
  Title
Identification and characterization of a tyramine-glutamate ligase (MfnD) involved in methanofuran biosynthesis.
  Journal
Biochemistry 53:6220-30 (2014)
DOI:10.1021/bi500879h
  Sequence
[mja:MJ_0815] [mfe:Mefer_1180]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.24
IUBMB Enzyme Nomenclature: 6.3.4.24
ExPASy - ENZYME nomenclature database: 6.3.4.24
BRENDA, the Enzyme Database: 6.3.4.24

DBGET integrated database retrieval system