KEGG   ENZYME: 6.4.1.6
Entry
EC 6.4.1.6                  Enzyme                                 
Name
acetone carboxylase
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
Sysname
acetone:carbon-dioxide ligase (AMP-forming)
Reaction(IUBMB)
acetone + hydrogen carbonate + 2 ATP + 3 H2O = acetoacetate + 2 AMP + 4 phosphate [RN:R05735]
Reaction(KEGG)
R05735
Substrate
acetone [CPD:C00207];
hydrogen carbonate [CPD:C00288];
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
acetoacetate [CPD:C00164];
AMP [CPD:C00020];
phosphate [CPD:C00009]
Comment
Requires Mg2+ and ATP. The reaction involves separate phosphorylation of hydrogencarbonate and acetone, forming carboxyphosphate and phosphoenolacetone, respectively, which are combined to form the final product. The enzyme from Xanthobacter sp. strain Py2 also carboxylates butan-2-one to 3-oxopentanoate.
History
EC 6.4.1.6 created 2001
Orthology
K10854  acetone carboxylase, alpha subunit
K10855  acetone carboxylase, beta subunit
K10856  acetone carboxylase, gamma subunit
Genes
GHOAL542_03630 AL542_03635 AL542_03640
AVNAvin_20910(acxA) Avin_20920(acxB) Avin_20930(acxC)
AVLAvCA_20910(acxA) AvCA_20920(acxB) AvCA_20930(acxC)
AVDAvCA6_20910(acxA) AvCA6_20920(acxB) AvCA6_20930(acxC)
ACXAchr_24430(acxC) Achr_24440(acxB) Achr_24450(acxA)
PARPsyc_1448 Psyc_1450(acxC)
PPISB1L02_05720 B1L02_05725 B1L02_05730
GAGGlaag_3576
KIMG3T16_12200
AEHMlg_1029 Mlg_1030 Mlg_1031
SDFACG33_03915 ACG33_03920 ACG33_03925
SOKD0B54_03980
SINIGT972_03325 GT972_09300
CHROCXB49_13600 CXB49_13605 CXB49_13610
AQSDKK66_16610 DKK66_16615 DKK66_16620
CNCCNE_2c13060(acxA) CNE_2c13070(acxB) CNE_2c13080(acxC) CNE_BB1p08470(acxC)
CUHBJN34_28755 BJN34_28760 BJN34_28765
REUReut_C6172 Reut_C6173 Reut_C6174
RMERmet_4105(acxA) Rmet_4106(acxB) Rmet_4107(acxC)
CBWRR42_s0950 RR42_s0952 RR42_s1691 RR42_s1692 RR42_s1693
CCUPBKK81_02135 BKK81_09935 BKK81_09940 BKK81_09945
CUPBKK80_01465 BKK80_10375 BKK80_10380 BKK80_10385
CUUBKK79_02725 BKK79_02730 BKK79_02735 BKK79_10740
COXE0W60_18765 E0W60_18770 E0W60_18775
BOKDM82_4513(acxC) DM82_4514(acxB) DM82_4515(acxA)
BOCBG90_6078 BG90_6079 BG90_6080(acxC)
BUUWS70_19475 WS70_19480 WS70_19485
BURBcep18194_B1205
BMKDM80_3943
BCTGEM_3539
BANNJFN94_28000 JFN94_28005 JFN94_28010
BURKDM992_21385 DM992_21390 DM992_21395
BPHBphy_6150 Bphy_6151 Bphy_6152
PUDG9Q38_03440
AKATKWG_04145 TKWG_04150
AMIMMIM_c06390(acxA) MIM_c06400(acxB) MIM_c06410(acxC)
PNAPnap_0941 Pnap_0942 Pnap_0943 Pnap_1164
VEIVeis_1832 Veis_1834
ADNAlide_1502 Alide_1503 Alide_1504
ADKAlide2_3422 Alide2_3423 Alide2_3424
HTNKI616_16680 KI616_16685 KI616_16690
IDCLRM40_07745 LRM40_07750 LRM40_07755
METRBSY238_3044 BSY238_3045 BSY238_3046
EBAebA4700(acxA) ebA4701(acxB) ebA4702(acxC)
ABREpbN1_07560(acxC) pbN1_07570(acxB) pbN1_07580(acxA)
APETToN1_19230(acxC) ToN1_19240(acxB) ToN1_19250(acxA)
DARDaro_1018 Daro_1019 Daro_1020
DEYHYN24_03010 HYN24_03020
DDENKI615_08160 KI615_08165 KI615_08170
AZAAZKH_0561(acxA) AZKH_0562(acxB) AZKH_0563(acxC) AZKH_3165(apc) AZKH_3167(apc)
AZIAzCIB_4004 AzCIB_4005 AzCIB_4006
ACOMCEW83_18660 CEW83_18665 CEW83_18670
AZDCDA09_19355 CDA09_19360 CDA09_19365
AZRCJ010_03035
TMZTmz1t_3469 Tmz1t_3470 Tmz1t_3471
THKCCZ27_01695 CCZ27_01700 CCZ27_01705 CCZ27_15950
AZQG3580_00140 G3580_00145 G3580_00150 G3580_01405 G3580_01415
HPYHP_0697
HEOC694_03590 C694_03595 C694_03600
HPJjhp_0631
HPAHPAG1_0682
HPSHPSH_03365 HPSH_03370
HHPHPSH112_03530 HPSH112_03535 HPSH112_03540
HHQHPSH169_03575 HPSH169_03580 HPSH169_03585
HHRHPSH417_03340 HPSH417_03345 HPSH417_03350
HPGHPG27_652 HPG27_653
HPPHPP12_0707 HPP12_0708
HPBHELPY_0673 HELPY_0674
HPLHPB8_896(hyuA3) HPB8_897(acxB) HPB8_898(acxC)
HPCHPPC_03295 HPPC_03300 HPPC_03305
HCAHPPC18_03375 HPPC18_03380 HPPC18_03385
HPMHPSJM_03525 HPSJM_03530 HPSJM_03535
HPEHPELS_03065 HPELS_03070 HPELS_03075
HPOHMPREF4655_20905 HMPREF4655_20906 HMPREF4655_20907
HPIhp908_0699 hp908_0700
HPQhp2017_0677 hp2017_06781
HPWhp2018_0678 hp2018_06791
HPUHPCU_03745 HPCU_03750 HPCU_03755
HEFHPF16_0707 HPF16_0708 HPF16_0709
HPFHPF30_0635 HPF30_0636 HPF30_0637
HEQHPF32_0627 HPF32_0628 HPF32_0629
HEXHPF57_0720 HPF57_0721 HPF57_0722
HPTHPSAT_03320 HPSAT_03325 HPSAT_03330
HPZHPKB_0650 HPKB_0651(hyuB) HPKB_0652
HPVHPV225_0703 HPV225_0704 HPV225_0705
HPXHMPREF0462_0758 HMPREF0462_0759 HMPREF0462_0760
HENHPSNT_03580 HPSNT_03585 HPSNT_03590
HPHHPLT_03470 HPLT_03475 HPLT_03480
HEGHPGAM_03565 HPGAM_03570 HPGAM_03575
HPNHPIN_03160 HPIN_03165 HPIN_03170
HEPHPPN120_03230 HPPN120_03235 HPPN120_03240
HEUHPPN135_03425 HPPN135_03430 HPPN135_03435
HESHPSA_03295 HPSA_03300 HPSA_03305
HPYSHPSA20_0727 HPSA20_0728 HPSA20_0729
HCNHPB14_03205 HPB14_03210 HPB14_03215
HPDKHP_0625 KHP_0626 KHP_0627(hyuA)
HEYMWE_0807 MWE_0808 MWE_0809
HERC695_03590 C695_03600 C695_03605
HEIC730_03595 C730_03605 C730_03610
HPYAHPAKL117_03290 HPAKL117_03295 HPAKL117_03300
HPYKHPAKL86_03670 HPAKL86_03675
HPYOHPOK113_0707 HPOK113_0708 HPOK113_0709
HPYLHPOK310_0685 HPOK310_0686 HPOK310_0687
HPYBHPOKI102_03545 HPOKI102_03550
HPYCHPOKI112_03555 HPOKI112_03560 HPOKI112_03565
HPYDHPOKI128_03310 HPOKI128_03315 HPOKI128_03320
HPYEHPOKI154_03540 HPOKI154_03545 HPOKI154_03550
HPYFHPOKI422_03545 HPOKI422_03550 HPOKI422_03555
HPYGHPOKI673_03515 HPOKI673_03520 HPOKI673_03525
HPYHHPOKI828_03535 HPOKI828_03540 HPOKI828_03545
HPYJHPOKI898_03550 HPOKI898_03555 HPOKI898_03560
HPYRK747_07580 K747_07585 K747_13225
HPYIK750_05755 K750_05760 K750_05765
HPYUK751_03890 K751_03895 K751_03900
HPYMK749_02195 K749_02200 K749_02205
HEMK748_00665 K748_00670 K748_00675
HEBU063_0999 U063_1000 U063_1001
HEZU064_1003 U064_1004 U064_1005
HACHac_0949 Hac_0950(hyuB)
HMSHMU05020 HMU05040
HFEHFELIS_05910 HFELIS_05930
HBIHBZC1_00460
HHMBN341_16750 BN341_16770
GURGura_4359 Gura_4361
MLOmlr5246 mlr5247
MLNA9174_01300 A9174_01305 A9174_01310
MCIMesci_0253 Mesci_0254 Mesci_0255
MOPMesop_2073 Mesop_2074 Mesop_2075
MAMOA6B35_06455 A6B35_06460 A6B35_06465
MESWA9K65_001265 A9K65_001270 A9K65_001275
MHUAMCHK_6295 MCHK_6296 MCHK_6297
MJREB229_01325 EB229_01330 EB229_01335
MERDEB233_01400 EB233_01405 EB233_01410
NIYFQ775_13445
PLAPlav_1150
KMNHW532_13065 HW532_13070 HW532_13075
SMESM_b20407(hyuB) SM_b20408
SMKSinme_3770 Sinme_3771 Sinme_3772
SMQSinmeB_4266 SinmeB_4267 SinmeB_4268
SMIBN406_06264 BN406_06265 BN406_06266(acxA)
SMELSM2011_b20406(hyuA) SM2011_b20407(hyuB) SM2011_b20408
SMERDU99_31260 DU99_31265 DU99_31270
SMDSmed_3715 Smed_3716 Smed_3717
RPCRPC_3603 RPC_3604 RPC_3605
XAUXaut_1339 Xaut_3509 Xaut_3510 Xaut_3511
XDIEZH22_17690 EZH22_17695 EZH22_17700
AZCAZC_2921 AZC_2922 AZC_2923
LNEFZC33_11855 FZC33_11860 FZC33_11865
APRAG3A50_11265
APOLK9D25_22125 K9D25_22130 K9D25_22135
MCHMchl_5521 Mchl_5522 Mchl_5523
HMCHYPMC_0473(acxC) HYPMC_0474(acxB) HYPMC_0475(acxA)
RVARvan_3476 Rvan_3477 Rvan_3478
NTDEGO55_12190
MMEDMame_04504(acxA) Mame_04505(acxB) Mame_04506(acxC)
CIDP73_2858 P73_2859 P73_2860
CEHCEW89_06010 CEW89_06020
CONTQ29_15905 TQ29_15910 TQ29_15915
CAZTLV780_20910 LV780_20915 LV780_20920
RCPRCAP_rcc01336(acxA) RCAP_rcc01337(acxB) RCAP_rcc01338(acxC)
PDEPden_4261 Pden_4262 Pden_4263
PYEA6J80_00050 A6J80_00055 A6J80_00060
PKDF8A10_17600 F8A10_17605 F8A10_17610
PPANESD82_13605 ESD82_13610 ESD82_13615
RSUNHU_02461 NHU_02462 NHU_02463
RHMB5V46_07325 B5V46_07330 B5V46_07335
RHCRGUI_4268 RGUI_4269 RGUI_4270
PALGHFP57_16440 HFP57_16450
SMICSmB9_09020
RAPRHOA_4205(acxA) RHOA_4206(acxB) RHOA_4207(acxC)
TMOTMO_1428 TMO_1429 TMO_1430(hyuA)
BMETBMMGA3_02520(acxA) BMMGA3_02525(acxB) BMMGA3_02530(acxC)
BFDNCTC4823_02247(acxC) NCTC4823_02248(acxB_4) NCTC4823_02249(acxA_4)
BACIB1NLA3E_12270 B1NLA3E_12275 B1NLA3E_12280
BAQUK6959_06485 K6959_06490 K6959_06495
GWCGWCH70_1201
GMCGY4MC1_2265 GY4MC1_2266 GY4MC1_2267 GY4MC1_2586 GY4MC1_2587 GY4MC1_2588
GTHGeoth_2352 Geoth_2353 Geoth_2354 Geoth_2606 Geoth_2607 Geoth_2608
PTLAOT13_09530 AOT13_09535 AOT13_09540 AOT13_11005 AOT13_11010 AOT13_11015
PTBDER53_10555 DER53_10560 DER53_10565
PARGPspKH34_25260 PspKH34_25270 PspKH34_25280
LAOAOX59_03500 AOX59_03505 AOX59_03510
APAKAP3564_08145 AP3564_08150 AP3564_08155
RUEDT065_12355 DT065_12360 DT065_12365
SCIAHUG15_09350 HUG15_09355 HUG15_09360
HYIK2M58_07205 K2M58_07210 K2M58_07215
PNPIJ22_15810 IJ22_15860
BTSBtus_1119 Btus_1121 Btus_1124 Btus_1125 Btus_1126 Btus_2467 Btus_2468 Btus_2469
KYRCVV65_05895 CVV65_05900 CVV65_05905 CVV65_10520 CVV65_10525 CVV65_10545 CVV65_10560 CVV65_10565 CVV65_10570 CVV65_12340 CVV65_12345 CVV65_12350 CVV65_16065
EFFskT53_16340 skT53_16350 skT53_16360
PABSJIR001_05790 JIR001_05800 JIR001_05810
DGIDesgi_3875
THEFE1B22_00250 E1B22_00255 E1B22_00260
MVAMvan_4899
MNED174_08810 D174_08820
MYNMyAD_08655 MyAD_08665
MHEVMHEL_59420 MHEL_59440
CFNCFAL_06320 CFAL_06325 CFAL_06330
CZOIAU67_07105
RAVAAT18_20235 AAT18_20245
RRZCS378_09680 CS378_09690
RHODAOT96_30890
SUBTKPL76_03470 KPL76_03480
ARUASPU41_08145 ASPU41_08155
ARTPE5206_01165 E5206_01175
XYLET495_04280
TEHGKE56_14085 GKE56_14095
BLINBLSMQ_3475 BLSMQ_3477
AEBC6I20_10900 C6I20_10910
SAIUJ4H86_13870 J4H86_13875
FRAFrancci3_2238 Francci3_2506
SVISvir_21470
AACDLWP59_05635
PDXPsed_5912
PAUTPdca_35830
PMADBAY61_27245
RXYRxyl_1849
RRSRoseRS_2091 RoseRS_2093
RCARcas_1776 Rcas_1778
NHOHWV23_00160 HWV23_00165 HWV23_00170
HDOMUK72_17495 MUK72_17500 MUK72_17505 MUK72_17520
HAKZJ0X25_19135
NBGDV706_18735 DV706_18740
NASGCU68_16825 GCU68_16850 GCU68_16855 GCU68_16860
SCASSACC_14250 SACC_14260
SULLEWF20_01245 EWF20_01250
 » show all
Reference
1  [PMID:9237998]
  Authors
Sluis MK, Ensign SA.
  Title
Purification and characterization of acetone carboxylase from Xanthobacter strain Py2.
  Journal
Proc Natl Acad Sci U S A 94:8456-61 (1997)
DOI:10.1073/pnas.94.16.8456
  Sequence
Reference
2  [PMID:22020645]
  Authors
Schuhle K, Heider J.
  Title
Acetone and butanone metabolism of the denitrifying bacterium "Aromatoleum aromaticum" demonstrates novel biochemical properties of an ATP-dependent aliphatic ketone carboxylase.
  Journal
J Bacteriol 194:131-41 (2012)
DOI:10.1128/JB.05895-11
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.6
IUBMB Enzyme Nomenclature: 6.4.1.6
ExPASy - ENZYME nomenclature database: 6.4.1.6
BRENDA, the Enzyme Database: 6.4.1.6
CAS: 189258-15-9

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