KEGG   ENZYME: 6.4.1.9
Entry
EC 6.4.1.9                  Enzyme                                 
Name
coenzyme F430 synthetase;
cfbE (gene name)
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
Sysname
15,173-seco-F430-173-acid cyclo-ligase (ADP-forming)
Reaction(IUBMB)
ATP + 15,173-seco-F430-173-acid = ADP + phosphate + coenzyme F430 [RN:R11629]
Reaction(KEGG)
R11629
Substrate
ATP [CPD:C00002];
15,17(3)-seco-F430-17(3)-acid [CPD:C21512]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
coenzyme F430 [CPD:C05777]
Comment
The enzyme, studied from the methanogenic archaeon Methanosarcina acetivorans, catalyses the last step in the biosynthesis of the nickel-containing tetrapyrrole cofactor coenzyme F430, which is required by EC 2.8.4.1, coenzyme-B sulfoethylthiotransferase.
History
EC 6.4.1.9 created 2017
Pathway
ec00860  Porphyrin metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K21612  coenzyme F430 synthetase
Genes
MJAMJ_0258
MFEMefer_0369
MVUMetvu_0835
MFSMFS40622_0485
MIFMetin_0369
MJHJH146_0166
MESGMLAUSG7_0002(cfbE)
MESAMLASG1_1035
MIGMetig_0368
MMPMMP0173
MMQMmarC5_1502
MMXMmarC6_0778
MMZMmarC7_1173
MMDGYY_00885
MMAKMMKA1_01780
MMAOMMOS7_02040
MMADMMJJ_09110
MAEMaeo_1414
MVNMevan_1177
MVOMvol_1454
MOKMetok_0796
METFCFE53_01605
MTHMTH_873
MMGMTBMA_c12680(murF)
METCMTCT_0791
MWOMWSIV6_1247
METEtca_00838(murF)
METZMETMT2_0941
METKFVF72_07190(cfbE)
MTHMFZP57_05930(cfbE)
METJFZP68_00275(cfbE)
MTEEMTTB_05080
MSTMsp_1331
METBAW729_08865
MRUmru_1745
MSIMsm_0880
MEBAbm4_0460
MMILsm9_1831
MEYETL18_08530
MOLYLM1_1199
MAROMarbSA_18380
MELMetbo_2343
MEWMSWAN_0316
METHMBMB1_0355
MFCBRM9_1909
MFIDSM1535_0095
MCUBMCBB_0331
MSUBBK009_11970
METNBK008_07610
METTCIT01_02205
METOCIT02_05050
MEMEHYG87_03660(cfbE)
MFVMfer_1205
MKAMK1590(murF)
MBAMbar_A0345
MBYMSBRM_0574
MBWMSBRW_0652
MBARMSBR2_1805
MBAKMSBR3_2860
MACMA_3630(murD)
MMAMM_0516
MMJMSMAS_0790
MMACMSMAC_0769
MVCMSVAZ_3048
MEKMSKOL_2990
MLSMSLAZ_2303
METMMSMTP_0888
MEFMSWH1_2456
MEQMSWHS_2587
MSJMSSAC_1226
MSZMSSIH_2812
MSWMSSIT_2846
MTHRMSTHT_2449
MTHEMSTHC_0833
MHORMSHOH_0893
MFZAOB57_003180(cfbE)
MBUMbur_1036
MMETMCMEM_1518
MELOJ7W08_06400(cfbE)
MMHMmah_1411
MHAZBHR79_06620
MEVMetev_0557
MZHMzhil_0470
MPYMpsy_0961
MZIHWN40_03730(cfbE)
MHZMetho_0544
MTPMthe_0105
MCJMCON_1929
MHIMhar_2390
MHUMhun_0669
MRTJKHC33_10025(cfbE)
MLAMlab_0519
MEMMemar_1732
MBGBN140_0719
MCHKMchiMG62_19340
MPIMpet_1001
MBNMboo_1418
MFOMetfor_1749
MPLMpal_0680
MPDMCP_0362
MEZMtc_0062(murD)
RCIRCIX2005(murD)
MELUMTLP_03860
MEAMMU439_05085
TARTALC_01252
MAXMMALV_13220
MERMMINT_17240
MEARMpt1_c08030
MARCAR505_0361
 » show all
Reference
1  [PMID:27846569]
  Authors
Zheng K, Ngo PD, Owens VL, Yang XP, Mansoorabadi SO
  Title
The biosynthetic pathway of coenzyme F430 in methanogenic and methanotrophic archaea.
  Journal
Science 354:339-342 (2016)
DOI:10.1126/science.aag2947
  Sequence
[mac:MA_3630]
Other DBs
ExplorEnz - The Enzyme Database: 6.4.1.9
IUBMB Enzyme Nomenclature: 6.4.1.9
ExPASy - ENZYME nomenclature database: 6.4.1.9
BRENDA, the Enzyme Database: 6.4.1.9

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