KEGG   ENZYME: 6.5.1.4
Entry
EC 6.5.1.4                  Enzyme                                 
Name
RNA 3'-terminal-phosphate cyclase (ATP);
rtcA (gene name);
RNA cyclase (ambiguous);
RNA-3'-phosphate cyclase (ambiguous)
Class
Ligases;
Forming phosphoric-ester bonds;
Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
Sysname
RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)
Reaction(IUBMB)
ATP + [RNA]-3'-(3'-phospho-ribonucleoside) = AMP + diphosphate + [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside (overall reaction) [RN:R04274];
(1a) ATP + [RNA 3'-phosphate cyclase]-L-histidine = [RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + diphosphate;
(1b) [RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine + [RNA]-3'-(3'-phospho-ribonucleoside) = [RNA 3'-phosphate cyclase]-L-histidine + [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine);
(1c) [RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine) = [RNA]-3'-(2',3'-cyclophospho)-ribonucleoside + AMP
Reaction(KEGG)
R04274
Substrate
ATP [CPD:C00002];
[RNA]-3'-(3'-phospho-ribonucleoside);
[RNA 3'-phosphate cyclase]-L-histidine;
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine;
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
[RNA]-3'-(2',3'-cyclophospho)-ribonucleoside;
[RNA 3'-phosphate cyclase]-Ntau-(5'-adenylyl)-L-histidine;
[RNA 3'-phosphate cyclase]-L-histidine;
[RNA]-3'-ribonucleoside-3'-(5'-diphosphoadenosine)
Comment
The enzyme converts the 3'-terminal phosphate of various RNA substrates into the 2',3'-cyclic phosphodiester in an ATP-dependent reaction. Catalysis occurs by a three-step mechanism, starting with the activation of the enzyme by ATP, forming a phosphoramide bond between adenylate and a histidine residue [5,6]. The adenylate group is then transferred to the 3'-phosphate terminus of the substrate, forming the capped structure [RNA]-3'-(5'-diphosphoadenosine). Finally, the enzyme catalyses an attack of the vicinal O-2' on the 3'-phosphorus, which results in formation of cyclic phosphate and release of the adenylate. The enzyme also has a polynucleotide 5' adenylylation activity [7]. cf. EC 6.5.1.5, RNA 3'-terminal-phosphate cyclase (GTP).
History
EC 6.5.1.4 created 1986, modified 1989, modified 2013, modified 2016
Orthology
K01974  RNA 3'-terminal phosphate cyclase (ATP)
Genes
HSA8634(RTCA)
PTR457057(RTCA)
PPS100974493(RTCA)
GGO101150498(RTCA)
PON100173273(RTCA)
NLE100582453(RTCA)
MCC711623(RTCA)
MCF101925644(RTCA)
CSAB103224372(RTCA)
CATY105590150(RTCA)
PANU101006912(RTCA)
TGE112607169(RTCA)
RRO104673253(RTCA)
RBB108524174(RTCA)
TFN117074661(RTCA)
PTEH111525755(RTCA)
CJC100414538(RTCA)
SBQ101046652(RTCA)
CSYR103267101(RTCA)
MMUR105862381(RTCA)
LCAT123635349(RTCA)
OGA100966097(RTCA)
MMU66368(Rtca)
MCAL110290815(Rtca)
MPAH110320070(Rtca)
RNO295395(Rtca)
MCOC116093682(Rtca)
MUN110551873(Rtca)
CGE100760159
MAUA101832469(Rtca)
PLEU114707416(Rtca)
MORG121452597(Rtca)
AAMP119801348(Rtca)
NGI103741869(Rtca)
HGL101722773(Rtca)
CPOC100731520(Rtca)
CCAN109674575 109688166(Rtca)
DORD105997123(Rtca)
DSP122110772(Rtca)
NCAR124982109
OCU100346550(RTCA)
OPI101534703(RTCA)
TUP102489783(RTCA)
CFA479928(RTCA)
VVP112918471(RTCA)
VLG121488224(RTCA)
AML100479171(RTCA)
UMR103669331(RTCA)
UAH113254351(RTCA)
UAR123795159(RTCA)
ELK111143351
LLV125097701
MPUF101685283(RTCA)
ORO101371582(RTCA)
EJU114208033(RTCA)
ZCA113910082(RTCA)
MLX118019085(RTCA)
FCA101088349(RTCA)
PYU121027559(RTCA)
PBG122480835(RTCA)
PTG102960304(RTCA)
PPAD109271923(RTCA)
AJU106976376(RTCA)
HHV120229464(RTCA)
BTA510469(RTCA)
BOM102270625(RTCA)
BIU109556017(RTCA)
BBUB102401043(RTCA)
CHX102176575(RTCA)
OAS101121230(RTCA)
ODA120856802(RTCA)
CCAD122436639(RTCA)
SSC100154102(RTCA)
CFR102517326(RTCA)
CBAI105065357(RTCA)
CDK105084962(RTCA)
VPC102536209(RTCA)
BACU103002876(RTCA)
LVE103087605(RTCA)
OOR101283702(RTCA)
DLE111180115(RTCA)
PCAD102990608(RTCA)
PSIU116739186(RTCA)
ECB100055854(RTCA)
EPZ103541778
EAI106837780(RTCA)
MYB102251068(RTCA)
MYD102754246(RTCA)
MMYO118673339(RTCA)
MLF102424051(RTCA)
MNA107530664(RTCA)
PKL118727487(RTCA)
HAI109374617(RTCA) 109392054
DRO112314037(RTCA)
SHON118990633(RTCA)
AJM119054985(RTCA)
PDIC114488979(RTCA)
PHAS123804438(RTCA)
MMF118637893(RTCA)
RFQ117015449(RTCA)
PALE102882496(RTCA)
PGIG120607936(RTCA)
PVP105297586(RTCA)
RAY107504377(RTCA)
MJV108386582(RTCA)
TOD119235864(RTCA)
SARA101544807(RTCA)
LAV100660191(RTCA)
TMU101344327
DNM101435839(RTCA)
MDO100032963(RTCA)
GAS123247089(RTCA)
SHR100914213(RTCA)
PCW110217484(RTCA)
OAA100081829(RTCA)
GGA424468(RTCA)
PCOC116243466(RTCA)
MGP100550040(RTCA)
CJO107317456(RTCA)
NMEL110402431(RTCA)
APLA101791727(RTCA)
ACYG106039451(RTCA)
AFUL116492091(RTCA)
TGU100226387(RTCA)
LSR110470298(RTCA)
SCAN103814863(RTCA)
PMOA120506562(RTCA)
OTC121344988(RTCA)
PRUF121361979(RTCA)
GFR102042466(RTCA)
FAB101820228(RTCA)
PHI102099079(RTCA)
PMAJ107208443(RTCA)
CCAE111932564(RTCA)
CCW104695573(RTCA)
ETL114061657(RTCA)
ZAB102068073(RTCA)
FPG101912157(RTCA)
FCH102055807(RTCA)
CLV102093114(RTCA)
EGZ104134031(RTCA)
NNI104015515(RTCA)
PLET104619943(RTCA)
ACUN113482870(RTCA)
TALA104362391(RTCA)
PADL103925177(RTCA)
ACHC115348833(RTCA)
AAM106499748(RTCA)
AROW112966838(RTCA)
NPD112946231(RTCA)
DNE112979814(RTCA)
ASN102374105(RTCA)
AMJ102560205(RTCA)
CPOO109307243(RTCA)
GGN109286883(RTCA)
PSS102463803(RTCA)
CMY102930355(RTCA)
CPIC101948413(RTCA)
TST117882146(RTCA)
CABI116839197(RTCA)
MRV120370276(RTCA)
ACS100558404(rtca)
PVT110076493(RTCA)
SUND121929995(RTCA)
PBI103056112(RTCA)
PMUR107302501(RTCA)
PGUT117677262(RTCA)
VKO123024607(RTCA)
PMUA114598706(RTCA)
ZVI118088734(RTCA)
GJA107112238(RTCA)
STOW125432856(RTCA)
XLA444463(rtca.L)
XTR100145308(rtca)
NPR108791465(RTCA)
RTEM120945624(RTCA)
BBUF120979408(RTCA)
BGAR122943951(RTCA)
DRE321129(rtca)
SRX107715104 107757457(rtca)
SANH107653637 107669846
SGH107588058(rtca) 107592745
CCAR109047785 109047789
CAUA113040125 113064896 113064901
PPRM120486502(rtca)
MAMB125251368(rtca)
IPU108271320(rtca)
PHYP113536427(rtca)
SMEO124391154(rtca)
TFD113650720(rtca)
AMEX103035915(rtca)
EEE113574516(rtca)
TRU101065174(rtca)
TNGGSTEN00008275G001
LCO104936351(rtca)
ELY117253589(rtca)
PLEP121938858
SLUC116059040(rtca)
ECRA117950778(rtca)
PFLV114552161(rtca)
GAT120823412(rtca)
PPUG119216180(rtca)
MSAM119888639 119888643
CUD121511908(rtca)
ALAT119028803(rtca)
MZE101479866(rtca)
ONL100691371(rtca)
OAU116320851(rtca)
OLA101167358(rtca)
OML112136670(rtca)
XMA102227450(rtca)
XCO114141449(rtca)
XHE116725143 116725161
PRET103463164(rtca)
PFOR103150012(rtca)
PLAI106954339(rtca)
PMEI106922594(rtca)
GAF122838563(rtca)
CVG107094685(rtca)
CTUL119784558(rtca)
GMU124873342(rtca)
NFU107395690(rtca)
KMR108248665(rtca)
ALIM106525060(rtca)
NWH119407612(rtca)
AOCE111581772(rtca)
CSEM103398583(rtca)
POV109647392(rtca)
SSEN122780739(rtca)
HHIP117759843(rtca)
HSP118121431(rtca)
LCF108874199(rtca)
SDU111236225(rtca)
SLAL111668193(rtca)
XGL120790410(rtca)
HCQ109506829(rtca)
BPEC110166726(rtca)
MALB109965312(rtca)
BSPL114853547(rtca)
SASA100195223(rtc1) 106573946(rtca)
OTW112250704 112252088(rtca)
OMY110489111 110524106
OGO123997468 123997803(rtca)
ONE115108144 115109102
SALP111952483(rtca) 111975701
SNH120053702(rtca) 120054663
ELS105011374(rtca)
SFM108919009(rtca)
PKI111844663(rtca)
AANG118224504(rtca)
LOC102699189(rtca)
PSPA121294137(rtca) 121326379
ARUT117402744 117416729
LCM102358154(RTCA)
CMK103184742(rtca)
RTP109930857(rtca)
BFO118431907
BBEL109483590
CIN100181920
SCLV120341941
SPU593585
APLC110982804
SKO100377576
DMEDmel_CG4061(Rtca)
DER6555614
DSE6616080
DSIDsimw501_GD16584(Dsim_GD16584)
DYADyak_GE16231
DSR110181757
DPODpse_GA17926
DPE6600771
DMN108159721
DWI6644753
DGR6566247
DMODmoj_GI21602
DAZ108618536
DNV108656427
DHE111594264
DVI6633720
CCAT101458641
BOD106626481
MDE101892049
SCAC106090906
LCQ111690630
LSQ119603100
HIS119647123
AGAAgaP_AGAP004820
ACOZ120950522
AARA120895324
ASTE118512304
AAG5572189
CQUCpipJ_CPIJ009234 CpipJ_CPIJ009235
CPII120430390 120430838
CNS116352406
BCOO119081693
AME552554
ACER108000496
ALAB122717662
BIM100748932
BBIF117211122
BVK117238505
BVAN117160310
BTER100650826
BPYO122577292
CCAL108629107 108629174
OBB114879248
MGEN117227591
NMEA116424540
SOC105201586
MPHA105833992
AEC105143842
ACEP105620060
PBAR105432150
VEM105567362
HST105181611
DQU106740825
CFO105249538
FEX115245558
LHU105678419
PGC109855912
OBO105275615
PCF106790949
PFUC122519942
VPS122630590
NVI103316568
CSOL105362567
TPRE106650325
MDL103578903
CGLO123261911
FAS105272312
DAM107040120
AGIF122858576
CCIN107270598
TCA659795
DPA109537005
SOY115881923 115890473
ATD109599006
CSET123308675
AGB108914108
LDC111503517
NVL108569189
APLN108742408
PPYR116158993
OTU111416749 111422967
BMOR101745321
BMAN114250415
MSEX115451801
DPLKGM_202883
BANY112047057
PMAC106715790
PPOT106102181
PXU106113971
PRAP110998822
ZCE119832704
HAW110381301
TNL113505419
SLIU111357843
OFU114359147
PXY105388601
API100162591
DNX107173446
RMD113554007
BTAB109038669
DCI103512250 103518901
NLU111046781 111061198
PHUPhum_PHUM120180
FOC113211794
TPAL117642184
ZNE110829068
CSEC111866155
FCD110846520
DPXDAPPUDRAFT_210359 DAPPUDRAFT_68089
DMK116925706
PVM113823441
PJA122246125
PCHN125036717
HAME121858799
PCLA123759340
PTRU123504756
HAZT108669352
EAF111700584
LSM121113637
PPOI119111170
DSV119433662
RSAN119404351
RMP119168707 119180591
VDE111244996
VJA111267212
DPTE113789061
DFR124490681
CSCU111626850
PTEP107447267
SDM118196740
TSPTsp_00325
HROHELRODRAFT_91513
LGILOTGIDRAFT_208285
PCAN112574440
BGT106068935
GAE121378795
HRF124111603
HRJ124266929
CRG105326684
MYI110441339
PMAX117325463
OBI106880391
OSN115222171 115229048
LAK106171736
SMMSmp_134370
SHXMS3_0013867
OVIT265_11864
EGLEGR_03339
NVE5507516 5512324
EPA110235180 110253271
ATEN116287938 116308232
ADF107335528
PDAM113665565 113674500
SPIS111336690 111337980
DGT114530258 114540705
XEN124435514 124439239
HMG100207388
AQU100640113
QSU111999052 112026884
SMOSELMODRAFT_3084 SELMODRAFT_3085
PPP112290400
VCNVOLCADRAFT_80268
MNGMNEG_0965
CSLCOCSUDRAFT_33699
CVRCHLNCDRAFT_136921
APROF751_5686
MISMICPUN_53854
MPPMICPUCDRAFT_10870
CCPCHC_T00001058001
NCRNCU00604
NTENEUTE1DRAFT126855(NEUTE1DRAFT_126855)
SMPSMAC_01292
PANPODANSg2307 PODANSg3933
TTTTHITE_2112839
MTMMYCTH_2089286
CTHRCTHT_0014820
TMNUCRPA7_8573
SSCKSPSK_09129
FGRFGSG_06400
FPUFPSE_12304
FVRFVEG_15864
FOXFOXG_08206
NHENECHADRAFT_32251
TRETRIREDRAFT_80056
TRRM419DRAFT_101244
MAJMAA_01038
CMTCCM_05232
PLJVFPFJ_06138
VALVDBG_01816
VDAVDAG_01736
CFJCFIO01_02891
CHIGCH63R_07152
ELAUCREL1_2021
PFYPFICI_02870
BFUBCIN_08g03450
MBEMBM_07563
PSCOLY89DRAFT_657242
GLZGLAREA_10725
ANIAN7762.2
AFMAFUA_5G07640
ACTACLA_010850
NFINFIA_079620
AORAO090701000669
AFVAFLA_005186
ACHEACHE_40700A
APUUAPUU_80105A
PCSPc22g15200
PDPPDIP_52790
TMFPMAA_037690
TRGTRUGW13939_08199
CIMCIMG_11683(CIMG06129)
CPWCPC735_026870
PBLPAAG_11957(PAAG_04932)
PBNPADG_11469(PADG_02670)
ABEARB_03978
TVETRV_01812
BGHBDBG_04082
PNOSNOG_02949
PTEPTT_10085
BZECOCCADRAFT_104153 COCCADRAFT_84269
BSCCOCSADRAFT_142934
BORCOCMIDRAFT_17
AALTCC77DRAFT_1043343
ZTRMYCGRDRAFT_69926
PFJMYCFIDRAFT_134777
FFUCLAFUR5_06398
BCOMBAUCODRAFT_26381
PPLPOSPLDRAFT_87886
TVSTRAVEDRAFT_57827
DSQDICSQDRAFT_103813
PCOPHACADRAFT_173930
SHSSTEHIDRAFT_64677
HIRHETIRDRAFT_379682
PSQPUNSTDRAFT_144227
LBCLACBIDRAFT_316113
MPRMPER_15856
MRRMoror_9466
MOREE1B28_002604
CCICC1G_05184
SCMSCHCODRAFT_14206
ABPAGABI1DRAFT34403(AGABI1DRAFT_34403)
ABVAGABI2DRAFT115327(AGABI2DRAFT_115327)
PCUBJR316_0003320
CPUTCONPUDRAFT_48025
SLASERLADRAFT_440921
SREPTSG_06025
DDIDDB_G0276159(rtc1)
DPPDICPUDRAFT_88174
DFADFA_09405(rtc1)
EHIEHI_177570(20.t00037)
EDIEDI_049950
EIVEIN_018530
ACANACA1_082140 ACA1_145190
TETTTHERM_00361720
PTMGSPATT00026180001 GSPATT00033056001
SMINv1.2.040713.t1(symbB.v1.2.040713.t1)
PTIPHATRDRAFT_42732
FCYFRACYDRAFT_139048
NGDNGA_2047300
PIFPITG_17155
SPARSPRG_15152
EHXEMIHUDRAFT_213004 EMIHUDRAFT_427089
GTTGUITHDRAFT_162235
NGRNAEGRDRAFT_63701
ECOb4475(rtcA)
ECJJW5688(rtcA)
ECDECDH10B_3594(rtcA)
EBWBWG_3113(rtcA)
ECOKECMDS42_2865(rtcA)
ECEZ4778
ECSECs_4263(rtcA)
ECFECH74115_4728(rtcA)
ETWECSP_4372(rtcA)
ELXCDCO157_4004
EOIECO111_4228(rtcA)
EOJECO26_4507(rtcA)
EOHECO103_4137(rtcA)
ECOOECRM13514_4369
ECOHECRM13516_4166
ESLO3K_01965
ESOO3O_23685
ESMO3M_02010
ECKEC55989_3827(rtcA)
ECGE2348C_3664(rtcA)
EOKG2583_4119(rtcA)
ELRECO55CA74_19665
ELHETEC_3669
ECWEcE24377A_3895(rtcA)
EUNUMNK88_4187(rtcA)
ECPECP_3505
ECVAPECO1_3047(rtcA)
ECOAAPECO78_20885
ECXEcHS_A3617(rtcA)
ECMEcSMS35_3700(rtcA)
ECYECSE_3686
ECRECIAI1_3563(rtcA)
ECQECED1_4080(rtcA)
EUMECUMN_3878(rtcA)
ECTECIAI39_3900(rtcA)
EOCCE10_3940(rtcA)
EBRECB_03271(rtcA)
EBLECD_03271(rtcA)
EBEB21_03223(rtcA)
EBDECBD_0322
ECIUTI89_C3920(rtcA)
EIHECOK1_3835(rtcA)
ECZECS88_3808(rtcA)
ECCc4197
ELOEC042_3680(rtcA)
ELNNRG857_16925
ECLEcolC_0294
EKOEKO11_0324
EKFKO11_05685(rtcA)
EABECABU_c38400(rtcA)
EDHEcDH1_0294
EDJECDH1ME8569_3298(rtcA)
ELUUM146_17155
ELWECW_m3677(rtcA)
ELLWFL_17965(rtcA)
ELCi14_3868
ELDi02_3868
ELPP12B_c3520(rtcA)
ELFLF82_2041(rtcA)
ECOLLY180_17535
ECOIECOPMV1_03726(rtcA)
EFEEFER_3388(rtcA)
EALEAKF1_ch2544(rtcA)
EMAC1192_14965
ESZFEM44_08050(rtcA)
STMSTM3518(rtcA)
SEOSTM14_4237(rtcA)
SEVSTMMW_35081
SEYSL1344_3485(rtcA)
SEMSTMDT12_C35730
SEJSTMUK_3504(rtcA)
SEBSTM474_3686(rtcA)
SEFUMN798_3821(rtcA)
SETUSTU288_17790
SETCCFSAN001921_22855
SENRSTMDT2_34051(rtcA)
SENDDT104_35021(rtcA)
SENICY43_18285
SEENSE451236_03315
SEISPC_3587(rtcA)
SECSCH_3449(rtcA)
SEHSeHA_C3826(rtcA)
SHBSU5_03993
SENHCFSAN002069_14585
SEEHSEEH1578_03670
SEASeAg_B3719(rtcA)
SENSQ786_17170
SEGSG3920(rtcA)
SELSPUL_4061(rtcA)
SEGASPUCDC_4047(rtcA)
SETSEN3344(rtcA)
SENAAU38_17060
SENOAU37_17250
SENVAU39_17255
SENQAU40_19225
SENLIY59_17685
SEECCFSAN002050_24545
SEEBSEEB0189_002280
SENEIA1_17060
SENCSEET0819_01180
SALZEOS98_01690
SFLSF3442(yhgJ)
SFXS4323(yhgJ)
SFVSFV_3427(yhgKJ)
SFESFxv_3758(rtcA)
SFNSFy_4897
SFSSFyv_4970
SFTNCTC1_03723(yhgKJ)
SSNSSON_3551(yhgKJ)
SBOSBO_3408(yhgKJ)
SBCSbBS512_E3800(rtcA)
SDYSDY_3655(yhgKJ)
SDZAsd1617_04832
SHQA0259_20855
KLWDA718_02160
LPVHYN51_02375
PFQQQ39_10275
PRAGEKN56_09160
XSASB85_18905
STEMCLM74_20730
SINCDAIF1_40820(rtcA)
LABLA76x_0970(rtcA)
LAQGLA29479_2185(rtcA)
LCPLC55x_4476(rtcA)
LGULG3211_4286(rtcA)
LEZGLE_4347(rtcA)
LEMLEN_0869
TCNH9L16_08510
DCSISN74_18370
LRZBJI69_07320
LPYFIV34_20805
XBAC7S18_02545
PAEPA4585(rtcA)
PAEVN297_4736(rtcA)
PAEIN296_4736(rtcA)
PAUPA14_60670(rtcA)
PAGPLES_49681(rtcA)
PAFPAM18_4678(rtcA)
PNCNCGM2_1009(rtcA)
PAEBNCGM1900_2425(rtcA)
PDKPADK2_24355
PSGG655_24160
PRPM062_24140
PAEPPA1S_24855
PAERPA1R_gp2490
PAEMU769_25115
PAELT223_25375
PAESSCV20265_5214
PAEUBN889_05096(rtcA)
PAEGAI22_09190
PAECM802_4734(rtcA)
PAEOM801_4601(rtcA)
PMYPmen_1191
PMUIG4G71_27910
PFVPsefu_3730
PFLPFL_2308(rtcA)
PPRCPFLCHA0_c23730(rtcA)
PPROPPC_2349(rtcA)
PFOPfl01_1948(rtcA)
PTVAA957_02885
PMEDE3Z27_11715
PLULFOB45_07525
PCHEY04_10645
PCZPCL1606_38450
PCPJM49_19260
PSESPSCI_2980(rtcA)
PSEMTO66_11510
PSOSPOS17_2295(rtcA)
PKRAYO71_13060
PYMAK972_2180
PKEDLD99_10595
POJPtoMrB4_10540(rtcA)
PGYAWU82_02775
PVKEPZ47_14660
PKHJLK41_06215
PATAJWU58_17175(rtcA)
PZEHU754_019260(rtcA)
PSEPC4K39_2211
PVWHU752_013195(rtcA)
PTRTHU722_0012005(rtcA)
PTZHU718_011250(rtcA)
PASGKSS96_12490(rtcA)
PALVKSS97_15005(rtcA)
PTWTUM18999_11480(rtcA)
PIEHU724_010875(rtcA)
PGFJ0G10_11775(rtcA)
PALIA3K91_1761
PSYGAK825_04310
PSYCDABAL43B_0970(rtcA)
PSYAAOT82_804
PSYPE5677_04590(rtcA)
ACBA1S_2273
ABADABD1_22710(rtcA)
ABABBJAB0715_02672
ABAZP795_5550
ABALABLAC_12270
ACALBUM88_13025
ASEII8T81_06190
ACDAOLE_05670
AJNBVL33_10695
ADVDJ533_09935
AWUBEN71_07505
AGUAS4_27040(rtcA)
ADSFPL17_04045
ABERBSR55_13430
ACHICDG60_11890
AGYLFPL18_17990
MBAHHYN46_15650
SALGBS332_02650
PPHEPP2015_3268
PRRAT705_20165
PLZS4054249_23355
TTUTERTU_2560(rtcA)
MICCAUP74_01505(rtcA)
ALGAQULUS_08860(rtcA)
MCAMCA1212
METUGNH96_11885(rtcA)
MMTMetme_3306
MELLIVG45_21625
MPSYCEK71_01295
MMAIsS8_0086 sS8_5241
MISZMishRS11D_26460(rtcA)
TIGTHII_2670
BLEPAL038_08170
NHLNhal_2148
NWRE3U44_14385
TGRTgr7_1692
TNITVNIR_1256(rtcA_[H])
TTITHITH_10625
TTCFOKN1_1411
HCHHCH_00166
HAHEENC22_00790
GSNYC6258_00471
OMEOLMES_3918
SVASVA_0225
IODEJO50_00660
RSORSc0226(rtcA)
RSCRCFBP_21261(rtcA)
RSLRPSI07_3184(rtcA)
RSNRSPO_c03174(rtcA)
RSMCMR15_30723(rtcA)
RSEF504_243
RSYRSUY_30520(rtcA)
RINACS15_0114(rtcA)
RPUCDC45_01170
CARIFNU76_11890
ACHRC2U31_17470
ADYHLG70_27340(rtcA)
PACRFXN63_03240
RSBRS694_03810
POLBpro_1474
PNAPnap_0499
AAAAcav_0017
ACKC380_03570
ACIOEAG14_18325
DACDaci_0680
DELDelCs14_5851
DTSBI380_21330
DHKBO996_03465
DLAI6G47_21265
VAPVapar_4419
VPEVarpa_5102
VPDVAPA_1c45910(rtcA)
VBOCKY39_27780
VAMC4F17_23585
CTESO987_17705
CSERCCO03_04765
CODOLAD35_05475(rtcA)
OTDJ1M35_20255(rtcA)
DIHG7047_23120
DAERH9K75_13995
DRGH9K76_20725
PBHAAW51_0250
JABVN23_12375
JAZYQ44_22290
JALBZG29_05875
JASFJQ89_21545
JLVG3257_28175
HHFE2K99_00115
CPRACPter91_0055(rtcA)
MNRACZ75_20550
MASSCR152_06130
MASZC9I28_05970
MASYDPH57_16050
MALIEYF70_30650 EYF70_30670
MUMFCL38_18730
MFLAGO485_14370
MPLIE1742_19910
MANCIV454_12275
RDPRD2015_47
MIUABE85_18845
RGUA4W93_00390 A4W93_04425
BBAYA4V04_11400
NIINit79A3_2699
NCOAAW31_00700
NMUNmul_A2158
APPCAP2UW1_1765
GEMGM21_1393
GEBGM18_2687
GURGura_1665
GEOGeob_0963(rtcA)
GBMGbem_2819(rtcA)
GBNGEOBRER4_14030
GERKP004_06590(rtcA)
GSUBKP001_08760(rtcA)
GNTKP003_06070(rtcA)
GPLM1B72_14285(rtcA)
PCAPcar_2495(rtcA-2) Pcar_2836(rtcA-1)
DVEDESUT3_38230
DMLDmul_26740(rtcA)
DLIdnl_43600(rtcA)
ADEAdeh_1676
ACPA2cp1_2269
AFWAnae109_2128
ANKAnaeK_2180
MXAMXAN_3809(rtcA) MXAN_4981(rtcA)
MSDMYSTI_04105 MYSTI_05472
MYMA176_001907 A176_003116
MFBMFUL124B02_22200 MFUL124B02_29845
CCXCOCOR_02474(rtcA) COCOR_04175(rtcA1)
MFULILAB_27240 LILAB_32830
MMASMYMAC_003753 MYMAC_004863
SURSTAUR_4359(rtcA) STAUR_5803
AGEAA314_03872 AA314_05638
AVMJQX13_33445(rtcA) JQX13_41970(rtcA)
MBDMEBOL_005826
CFUSCYFUS_004848 CYFUS_006796
SCLsce7157(rtcA)
SCUSCE1572_41685
CCROCMC5_038530
PAUUE8A73_014870(rtcA)
SAMYDB32_008700
LLUAKJ09_01228 AKJ09_09363
MRMA7982_13458
HOHHoch_0236
SATSYN_00093
DAODesac_1948
DTIDesti_4242
SFUSfum_2542
DBRDeba_1622
PCAYFRD00_10035
DHRLGS26_07030(rtcA)
MHEYH2LOC_000615
MTWCQW49_21260
HBCAEM38_01305
SMAGAN936_20215
SPHQBWQ93_08205
SSANNX02_17425
SPANAWL63_09075
SPLMBXU08_13610
SPHCCVN68_13280
SECHB18_13095
SRHIH9L12_00860
SPAPH3Z74_19655
SSUAFPZ54_12530
SSYSLG_10950(rtcA)
SYBTZ53_04220
SMICSmB9_19770(rtcA)
SPHSETR14_18915
ANHA6F65_00509(rtcA)
ERRDVR09_02390
ERFFIU90_13360(rtcA)
PNSA9D12_07465
AZLAZL_a09690
NAOY958_07850
KOZKFF44_13510(rtcA)
DAUDaud_1143
GLPGlo7428_4799
CYCPCC7424_1826
CYJCyan7822_1677
MICMic7113_2797
OACOscil6304_0477
CEPCri9333_0857
ANAalr1901
NPUNpun_F2920
NOPNos7524_0265
NONNOS3756_10000
NFLCOO91_03144
NSHGXM_06508
NEDHUN01_32740
AVAAva_3770
ANNEH233_23925
CSGCylst_2386
CALOCal7507_5223
FISFIS3754_47030
TOQHCG51_19485
NCNBZZ01_10125
PLPPle7327_1609
STANSTA3757_14780
ABATCFX1CAM_0151(rtcA)
PBFCFX0092_A2628(rtcA)
FGIOP10G_0921 OP10G_4089
LUOHHL09_04070
LAMBKBB96_16885(rtcA)
RBARB9359(rtcA)
PSLPsta_0359
PIRVN12_02935(rtcA)
MFFMFFC18_38320(rtcA)
ROLCA51_31450(rtcA)
AHELQ31a_10350(rtcA)
LCREPla8534_05020(rtcA)
AAGGETAA8_26480(rtcA)
LPAVPLANPX_3964
AMUCPan181_28090(rtcA)
PNDPla175_19090(rtcA)
AMOBHG15A2_25580(rtcA)
PLSVT03_20625(rtcA)
PLHVT85_00960(rtcA)
MRIMal4_32350(rtcA)
GESVT84_10820(rtcA)
GOGC1280_07770
GMSSOIL9_11790
TIMGMBLW1_19670
LRSPX52LOC_07423
FTJFTUN_6930
ULIETAA1_26580(rtcA)
IPAIsop_1407
SACISinac_0456
PBORBSF38_02936(rtcA)
AGVOJF2_06120(rtcA)
KSTKSMBR1_0702(rtcA)
BPITBPIT_31840
JETL3J17_14710(rtcA)
HBSIPV69_14855
UAMUABAM_04155
VBCC5Q97_19065
BHCJFL75_04885(rtcA)
ABAAcid345_1272
PFERIRI77_18520
ABACLuPra_00137(rtcA)
SCORJ3U87_14935(rtcA)
RMRRmar_0239
RMGRhom172_0222
AAEaq_642
TIDThein_0778
TOPTOPB45_0975
TCMHL41_04660
THETF1847_02620(rtcA)
CTHITHC_0499
TAVG4V39_10730
MOXDAMO_1516(rtcA)
MJAMJ_0025
MFEMefer_1247
MVUMetvu_0958
MFSMFS40622_0957
MIFMetin_0267
MJHJH146_1529
MESGMLAUSG7_1260(rtcA)
MESAMLASG1_0518(rtcA)
MIGMetig_0193
MMPMMP0648(rtcA)
MMQMmarC5_0956
MMXMmarC6_0241
MMZMmarC7_1672
MMDGYY_03220
MAEMaeo_1458
MVNMevan_1545
MOKMetok_1583
MTHMTH_1915
MMGMTBMA_c04860(rtcA)
MTEEMTTB_11440
METJFZP68_07140
AFUAF_1435
AFGAFULGI_00015490
APOArcpr_0479
AVEArcve_2109
ASTAsulf_00761
FPLFerp_1612
GACGACE_1722
GAHGAH_00913
MBAMbar_A0961
MBYMSBRM_0040
MBWMSBRW_0037
MBARMSBR2_0038
MBAKMSBR3_0020
MACMA_4637(rtcA)
MMAMM_1297
MMAZMmTuc01_1345
MMJMSMAS_0017
MMACMSMAC_0017
MVCMSVAZ_0054
MEKMSKOL_0050
MLSMSLAZ_0018
METMMSMTP_0019
MEFMSWH1_0020
MEQMSWHS_0020
MSJMSSAC_0026
MSZMSSIH_0024
MSWMSSIT_0024
MTHRMSTHT_1805
MTHEMSTHC_1481
MHORMSHOH_0019
MFZAOB57_008290
MBUMbur_1766
MMETMCMEM_0024
MELOJ7W08_10155
MMHMmah_1076
MEVMetev_0029
MZHMzhil_0025
MPYMpsy_1793(rtcA)
MHZMetho_2415
MTPMthe_0003
MCJMCON_3080(rtcA)
MHIMhar_1312
MEMMemar_0274
MBGBN140_0153
MEMAMMAB1_0198(rtcA)
MCHKMchiMG62_03950
MPLMpal_2696
MPDMCP_2445(rtcA)
MEZMtc_2211(rtcA)
RCIRCIX2147(rtcA)
HALVNG_0732G(tpc)
HSLOE_2081R(rtcA)
HDLHALDL1_08050
HHBHhub_1915(rtcA)
HAGSJT689_04300(rtcA)
HABOJRZ79_02800(rtcA)
HNOLT974_04490(rtcA)
HLULT972_08705(rtcA)
HANRLJ422_03025(rtcA)
HALHHTSR_1141(rtcA)
HHSRHSR6_1176(rtcA)
HSUHLASF_1187
HSFHLASA_1175
HALREFA46_007040
HARAAArcS_1063(rcl1)
HALXM0R89_18675(rtcA)
NPHNP_5244A(rtcA)
NSALHWV07_14265
HUTHuta_2572
HTIHTIA_2334
HALAHrd1104_01460
HALIBV210_08005
HSNDV733_10100
HDSHSR122_0046(rcl1)
HVOHVO_0427(rtcA)
HMEHFX_0393(tpc)
HGIABY42_01950
HALEG3A49_02215
HBOHbor_27680
HAQDU484_17900
HAJDU500_00940
HAERDU502_08245
HLMDV707_13945
SRUBC2R22_01905
HDFAArcSl_0229(rtcA)
HTUHtur_3216
HDABB347_10115
HSALJMJ58_12380(rtcA)
HLOJ0X27_13795(rtcA)
HAKZJ0X25_03250(rtcA)
NMGNmag_1291(rtcA)
HXAHalxa_2065
NATNJ7G_2216
NPENatpe_0711
NVRFEJ81_03760
NPLFGF80_07015
NAYHYG81_07235(rtcA)
HJTDVR14_12890
NGENatgr_2725
HRUHalru_0503
NOUNatoc_2180
SALIL593_01115
SAIMK0C01_03455(rtcA)
HLRHALLA_16605
HLCCHINAEXTREME07610
NAJB1756_11250
NAGAArcMg_2970
NANAArc1_0732
NBGDV706_09690
NASGCU68_02370
SAWLNGM29_06830(rtcA)
NACAQV86_01360
TARTALC_00249
MAXMMALV_02340
MERMMINT_16310
MEARMpt1_c11200(rtcA)
MEUZKRP56_01270(rtcA)
MARCAR505_1601
ABIAboo_0789
APEAPE_0511.1(rtcA)
ACJACAM_0395(rtcA)
SMRSmar_0935
SHCShell_1530
IHOIgni_0532
IISEYM_00695
DKADKAM_1285
DFDDesfe_1384
DMUDesmu_1271
TAGTagg_1255
IAGIgag_0037
THGTCELL_0219
HBUHbut_1561
PFMPyrfu_0207
PDLPyrde_0481
STOSTK_05700(rtcA)
SOHD1869_02710
SSOSSO2446(rtcA)
SOLSsol_0249
SSOASULA_0240
SSOLSULB_0241
SSOFSULC_0240
SSHIJ5U23_01232
SCASSACC_18510
SAISaci_0556(rtcA)
SACNSacN8_02715
SACRSacRon12I_02705
SACSSUSAZ_02510
SISLS215_0266
SIAM1425_0235
SIMM1627_0235
SIDM164_0253
SIYYG5714_0238
SINYN1551_2842
SIILD85_0240
SIHSiH_0241
SIRSiRe_0234
SICSiL_0227
SULABFU36_10900
SULEGFS03_02720
SULOGFS33_08505
SULLEWF20_04235
MSEMsed_0600
MCNMcup_1503
MHKDFR87_03795
MPRUDFR88_03590
MJNMjAS7_1360
MEMJMJ1HA_0708
AHOAhos_2235
AMANB6F84_02925
ABRIDFR85_00915
ASULDFR86_02925
AAMBD1866_06160
ACIHHS5_10470
SAZOD1868_08010
CSTYKN1_08070
STEPIC006_0179
PAIPAE3596
PISPisl_0753
PCLPcal_2009
PASPars_2210
PYRP186_0723
POGPogu_2656
TNETneu_0917
PYWPYWP30_01043
CMACmaq_0295
TTNTTX_1653(rcl1)
TUZTUZN_1858
VDIVdis_1705
VMOVMUT_2265
TPETpen_0217
THBN186_01935
TCBTCARB_1472
THFMA03_00435
ASCASAC_0823
ACIASE86_05675
FFOFFONT_0962
NMRNmar_1733
NIRNSED_09225
NKRNKOR_09210
NIDNPIRD3C_0183
NINNADRNF5_0138(rtcA)
NIWNisw_05365(rtcA)
NCLC5F47_08940(rtcA)
NOXC5F49_08785(rtcA)
NUEC5F50_12280(rtcA)
NIPNsoK4_09720(rtcA)
NICDSQ20_09825(rtcA)
CSYCENSYa_1552
NGANgar_c07570(rtcA)
NVNNVIE_013140(rtcA)
NEVNTE_02716
TAANMY3_00875(rtcA)
NCVNCAV_1762(rtcA)
CSUCSUB_C1504
TAHSU86_006075
NIUDSQ19_00100(rtcA)
NDVNDEV_2063(rtcA)
KCRKcr_1282
BARCAOA65_0386
LOKILokiarch_10150(rtcA)
PSYTDSAG12_00117
AGWQT03_C0001G1130
 » show all
Reference
1  [PMID:6828385]
  Authors
Filipowicz W, Konarska M, Gross HJ, Shatkin AJ.
  Title
RNA 3'-terminal phosphate cyclase activity and RNA ligation in HeLa cell extract.
  Journal
Nucleic Acids Res 11:1405-18 (1983)
DOI:10.1093/nar/11.5.1405
Reference
2  [PMID:2581947]
  Authors
Reinberg D, Arenas J, Hurwitz J.
  Title
The enzymatic conversion of 3'-phosphate terminated RNA chains to 2',3'-cyclic phosphate derivatives.
  Journal
J Biol Chem 260:6088-97 (1985)
Reference
3  [PMID:9184239]
  Authors
Genschik P, Billy E, Swianiewicz M, Filipowicz W
  Title
The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.
  Journal
EMBO J 16:2955-67 (1997)
DOI:10.1093/emboj/16.10.2955
Reference
4  [PMID:9738023]
  Authors
Genschik P, Drabikowski K, Filipowicz W
  Title
Characterization of the Escherichia coli RNA 3'-terminal phosphate cyclase and its sigma54-regulated operon.
  Journal
J Biol Chem 273:25516-26 (1998)
DOI:10.1074/jbc.273.39.25516
Reference
5  [PMID:10574971]
  Authors
Billy E, Hess D, Hofsteenge J, Filipowicz W
  Title
Characterization of the adenylation site in the RNA 3'-terminal phosphate cyclase from Escherichia coli.
  Journal
J Biol Chem 274:34955-60 (1999)
DOI:10.1074/jbc.274.49.34955
Reference
6  [PMID:19690099]
  Authors
Tanaka N, Shuman S
  Title
Structure-activity relationships in human RNA 3'-phosphate cyclase.
  Journal
RNA 15:1865-74 (2009)
DOI:10.1261/rna.1771509
Reference
7  [PMID:21098490]
  Authors
Chakravarty AK, Shuman S
  Title
RNA 3'-phosphate cyclase (RtcA) catalyzes ligase-like adenylylation of DNA and RNA 5'-monophosphate ends.
  Journal
J Biol Chem 286:4117-22 (2011)
DOI:10.1074/jbc.M110.196766
Reference
8  [PMID:23945037]
  Authors
Das U, Shuman S
  Title
2'-Phosphate cyclase activity of RtcA: a potential rationale for the operon organization of RtcA with an RNA repair ligase RtcB in Escherichia coli and other bacterial taxa.
  Journal
RNA 19:1355-62 (2013)
DOI:10.1261/rna.039917.113
Other DBs
ExplorEnz - The Enzyme Database: 6.5.1.4
IUBMB Enzyme Nomenclature: 6.5.1.4
ExPASy - ENZYME nomenclature database: 6.5.1.4
BRENDA, the Enzyme Database: 6.5.1.4
CAS: 85638-41-1

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