KEGG   ENZYME: 7.2.2.13
Entry
EC 7.2.2.13                 Enzyme                                 

Name
Na+/K+-exchanging ATPase;
(Na+ + K+)-activated ATPase;
Na,K-activated ATPase;
Na,K-pump;
Na+,K+-ATPase;
sodium/potassium-transporting ATPase;
Na+/K+-exchanging ATPase
Class
Translocases;
Catalysing the translocation of inorganic cations;
Linked to the hydrolysis of a nucleoside triphosphate
Sysname
ATP phosphohydrolase (P-type, Na+/K+-exchanging)
Reaction(IUBMB)
ATP + H2O + Na+[side 1] + K+[side 2] = ADP + phosphate + Na+[side 2] + K+[side 1]
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
Na+[side 1];
K+[side 2]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Na+[side 2];
K+[side 1]
Comment
A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This is a plasma membrane enzyme, ubiquitous in animal cells, that catalyses the efflux of three Na+ and influx of two K+ per ATP hydrolysed. It is involved in generating the plasma membrane electrical potential.
History
EC 7.2.2.13 created 1984 EC 3.6.1.37, transferred 2000 to EC 3.6.3.9, modified 2001, transferred 2018 to EC 7.2.2.13
Orthology
K01539  sodium/potassium-transporting ATPase subunit alpha
Genes
HSA: 476(ATP1A1) 477(ATP1A2) 478(ATP1A3) 480(ATP1A4)
PTR: 456068(ATP1A3) 457152(ATP1A1) 457432(ATP1A2) 458010(ATP1A4)
PPS: 100968564(ATP1A2) 100968910(ATP1A4) 100973141(ATP1A3) 100992562(ATP1A1)
GGO: 101132606(ATP1A2) 101133472(ATP1A4) 101136136(ATP1A3) 101154367(ATP1A1)
PON: 100172203(ATP1A2) 100174388(ATP1A1) 100440055(ATP1A3) 100451523(ATP1A4)
NLE: 100585801(ATP1A2) 100586342(ATP1A4) 100596870(ATP1A1) 100604238(ATP1A3)
MCC: 706513(ATP1A3) 710368(ATP1A1) 719623(ATP1A4) 720191(ATP1A2)
MCF: 102122869(ATP1A3) 102124503(ATP1A1) 102144576(ATP1A4) 102145563(ATP1A2)
CSAB: 103223730(ATP1A4) 103223733(ATP1A2) 103224143(ATP1A1) 103234751(ATP1A3)
CATY: 105589285(ATP1A2) 105589286(ATP1A4) 105596327(ATP1A1) 105598041(ATP1A3)
PANU: 101007483(ATP1A1) 101014462(ATP1A4) 101015462(ATP1A3) 103877144(ATP1A2)
RRO: 104658863(ATP1A3) 104660405(ATP1A4) 104660406(ATP1A2) 104665933(ATP1A1)
RBB: 108524039(ATP1A4) 108524041(ATP1A2) 108528132(ATP1A1)
TFN: 117074222(ATP1A4) 117074224(ATP1A2) 117075599(ATP1A3) 117075655(ATP1A1)
PTEH: 111530437(ATP1A3) 111543868(ATP1A2) 111543869 111549608(ATP1A1)
CJC: 100393318(ATP1A1) 100402438(ATP1A2) 100403160(ATP1A4) 100410682(ATP1A3)
SBQ: 101035314 101035941(ATP1A2) 101041249(ATP1A1) 101044048(ATP1A3)
MMUR: 105862683(ATP1A4) 105862687 105867991(ATP1A3) 105869763(ATP1A1)
MMU: 11928(Atp1a1) 232975(Atp1a3) 27222(Atp1a4) 98660(Atp1a2)
MCAL: 110290752(Atp1a1) 110291780(Atp1a4) 110296540 110297290(Atp1a3)
MPAH: 110319913(Atp1a1) 110321177(Atp1a4) 110322617 110337068(Atp1a3)
RNO: 24211(Atp1a1) 24212(Atp1a2) 24213(Atp1a3) 29132(Atp1a4)
MCOC: 116093511(Atp1a1) 116101831(Atp1a3) 116103673(Atp1a4) 116103692
CGE: 100758209(Atp1a3) 100763191(Atp1a4) 100763478(Atp1a2) 100771378(Atp1a1)
PLEU: 114685348(Atp1a3) 114690690(Atp1a2) 114690694 114698572(Atp1a1)
NGI: 103734951(Atp1a1) 103740231(Atp1a2) 103740266(Atp1a4) 103744609(Atp1a3)
HGL: 101697634(Atp1a1) 101721060(Atp1a4) 101721146(Atp1a3) 101721770(Atp1a2)
CPOC: 100192382(Atp1a1) 100712985(Atp1a3) 100729524(Atp1a2) 100729796
CCAN: 109681948 109688512(Atp1a3) 109690073(Atp1a4) 109690076
OCU: 100008756(ATP1A2) 100302415(ATP1A1) 100349382(ATP1A3) 100358269(ATP1A4)
OPI: 101525499(ATP1A1) 101527265(ATP1A3) 101529459(ATP1A2) 101529874
TUP: 102475448(ATP1A3) 102483255(ATP1A2) 102483994(ATP1A1)
CFA: 403992(ATP1A1) 488636(ATP1A4) 612463(ATP1A3)
VVP: 112910077 112910081 112916773(ATP1A1) 112931443(ATP1A3)
VLG: 121471339(ATP1A2) 121471981 121485787(ATP1A3) 121490989(ATP1A1)
AML: 100477585(ATP1A3) 100477989(ATP1A1) 100480641 100480890(ATP1A4)
UMR: 103669413(ATP1A1) 103672049(ATP1A4) 103672113(ATP1A2) 103680185(ATP1A3)
UAH: 113243247(ATP1A3) 113244381(ATP1A1) 113246653(ATP1A4) 113246737
ORO: 101366083(ATP1A1) 101376936(ATP1A3) 101379349(ATP1A2) 101379646(ATP1A4)
MPUF: 101677161(ATP1A3) 101678357(ATP1A2) 101678857(ATP1A4) 101689482(ATP1A1)
EJU: 114197049(ATP1A3) 114199132(ATP1A2) 114199201 114208034(ATP1A1)
MLX: 117997950(ATP1A3) 118000481(ATP1A1) 118013976(ATP1A2) 118013977
FCA: 101083636(ATP1A3) 101083695(ATP1A1) 101096375(ATP1A4) 101096785
PBG: 122476358(ATP1A4) 122476359 122480994(ATP1A1) 122493969(ATP1A3)
PTG: 102954810 102955336(ATP1A3) 102955398 102971148(ATP1A1)
PPAD: 109257219 109257221(ATP1A2) 109257944(ATP1A3) 109272127(ATP1A1)
AJU: 106969643(ATP1A1) 106978517(ATP1A4) 106985576 106987698(ATP1A3)
HHV: 120238762(ATP1A1) 120241370(ATP1A4) 120241371(ATP1A2) 120243678(ATP1A3)
BTA: 282144(ATP1A1) 282598(ATP1A3) 515161(ATP1A2) 537960(ATP1A4)
BOM: 102270922(ATP1A3) 102271837(ATP1A2) 102272122(ATP1A4) 102287260(ATP1A1)
BIU: 109555876(ATP1A1) 109571737(ATP1A3) 109578704(ATP1A4) 109578722
BBUB: 102396896(ATP1A3) 102404308(ATP1A1) 102405290 102405960(ATP1A4)
CHX: 102179588(ATP1A3) 102183561(ATP1A1) 102186069(ATP1A4) 102186539(ATP1A2)
OAS: 101103751(ATP1A3) 101118148(ATP1A2) 101118398 443381(ATP1A1)
ODA: 120855582(ATP1A2) 120855583(ATP1A4) 120856023(ATP1A1) 120872368(ATP1A3)
CCAD: 122420162(ATP1A3) 122430948(ATP1A4) 122430955 122435720(ATP1A1)
SSC: 100157711 100329126(ATP1A3) 396828(ATP1A2) 397481(ATP1A1)
CFR: 102509736(ATP1A1) 102516053(ATP1A2) 102516646(ATP1A4) 102517975(ATP1A3)
CBAI: 105062463(ATP1A3) 105069515 105069516 105079466(ATP1A1)
CDK: 105089616(ATP1A1) 105090227(ATP1A3) 105100141(ATP1A2) 116147050(ATP1A4)
BACU: 102998568(ATP1A1) 103005321(ATP1A4) 103005600(ATP1A2) 103011003(ATP1A3)
LVE: 103068908(ATP1A3) 103074614(ATP1A4) 103074894(ATP1A2) 103085693(ATP1A1)
OOR: 101279507(ATP1A1) 101280223(ATP1A3) 101288540(ATP1A4) 101288792(ATP1A2)
DLE: 111166986 111166987 111179983(ATP1A1) 111180802(ATP1A3)
PCAD: 102981487 102982135 102983659(ATP1A1) 102985775(ATP1A3)
PSIU: 116738896(ATP1A1) 116742064(ATP1A2) 116744406(ATP1A3) 116755861
ECB: 100034139(ATP1A1) 100058251(ATP1A2) 100058301(ATP1A4) 100069796(ATP1A3)
EPZ: 103543741 103547749(ATP1A1) 103551135(ATP1A4) 103551139(ATP1A2)
EAI: 106835689(ATP1A1) 106835754(ATP1A4) 106835755 106847933(ATP1A3)
MYB: 102242637(ATP1A3) 102243691(ATP1A1) 102243972(ATP1A4) 102244267(ATP1A2)
MYD: 102757270(ATP1A2) 102757556(ATP1A4) 102762810(ATP1A3) 102770472(ATP1A1)
MMYO: 118673132(ATP1A2) 118673235 118673770(ATP1A1) 118674644(ATP1A3)
MLF: 102417711 102420715(ATP1A3) 102429118(ATP1A2) 102432129(ATP1A1) 102441641
MNA: 107534181(ATP1A3) 107538456 107545330(ATP1A1)
PKL: 118702301(ATP1A3) 118721573(ATP1A2) 118721574 118727140(ATP1A1)
HAI: 109374464(ATP1A3) 109386501(ATP1A2) 109392813(ATP1A1)
DRO: 112313776(ATP1A1) 112315807 112317734(ATP1A2) 112320186(ATP1A3)
SHON: 118982030(ATP1A1) 118996417 118996431 119000480(ATP1A3)
AJM: 119041702(ATP1A1) 119048466 119048473(ATP1A4) 119060145(ATP1A3)
PDIC: 114489216(ATP1A1) 114511606(ATP1A3) 114511824(ATP1A2) 114511839
MMF: 118636912 118637061(ATP1A2) 118637940(ATP1A1) 118638724(ATP1A3)
RFQ: 117014324(ATP1A1) 117014362 117035060(ATP1A3)
PALE: 102884868(ATP1A4) 102885125 102888359(ATP1A1) 102893697(ATP1A3)
PGIG: 120584288(ATP1A4) 120584290 120585084(ATP1A1) 120592362(ATP1A3)
RAY: 107499819(ATP1A1) 107502600(ATP1A3) 107507949(ATP1A2) 107507966(ATP1A4)
MJV: 108390973(ATP1A1) 108393642(ATP1A3) 108402828 108402834
TOD: 119237084(ATP1A1) 119241403 119241404 119249373(ATP1A3)
LAV: 100661428(ATP1A1) 100667801 100668326(ATP1A3) 100674070(ATP1A2)
MDO: 100029754(ATP1A4) 100029759(ATP1A2)
GAS: 123240805(ATP1A3) 123244129(ATP1A1) 123246045 123247014
SHR: 100914130(ATP1A2) 100918637 100922123(ATP1A3) 100928210(ATP1A1)
PCW: 110203112(ATP1A2) 110203115 110219354(ATP1A1) 110220180(ATP1A3)
OAA: 100083795 100088125(ATP1A3) 100088592(ATP1A1) 103166927
GGA: 396530(ATP1A1)
PCOC: 116238833 116242449(ATP1A1)
MGP: 100303690(ATP1A1) 104915899
NMEL: 110399227(ATP1A1)
APLA: 101801864(ATP1A1)
ACYG: 106029333 106037472(ATP1A1)
TGU: 100190719(ATP1A1) 105760330
SCAN: 103827109(ATP1A1)
PMOA: 120504822 120506317(ATP1A1)
OTC: 121339036 121339371(ATP1A1)
PRUF: 121351728(ATP1A1) 121359325
GFR: 102036467(ATP1A1)
FAB: 101813002(ATP1A1) 101813385
PHI: 102104980 102106372(ATP1A1) 102107817(ATP1A2)
PMAJ: 107207264(ATP1A1)
CCAE: 111938980(ATP1A1)
CCW: 104687046(ATP1A1)
ETL: 114055106(ATP1A1)
FPG: 101914787(ATP1A1) 101915017(ATP1A2)
FCH: 102050259(ATP1A1) 102059303(ATP1A2)
CLV: 102092496(ATP1A1) 102093141
EGZ: 104126505(ATP1A1)
NNI: 104008633(ATP1A1) 104012600(ATP1A2)
ACUN: 113485715
PADL: 103921389(ATP1A1)
AAM: 106490649(ATP1A1) 106500059(ATP1A2)
NPD: 112955223 112956869(ATP1A1)
DNE: 112989406(ATP1A1) 112997239
AMJ: 102567591(ATP1A1) 102575084(ATP1A2) 106737151
CPOO: 109314483(ATP1A3) 109319226(ATP1A1)
GGN: 109304290(ATP1A1)
CMY: 102936217(ATP1A1) 102938341
CPIC: 101931556(ATP1A3) 101933418(ATP1A1) 101950302
TST: 117869615 117886721(ATP1A1)
MRV: 120390167 120390183(ATP1A3) 120400237(ATP1A1)
SUND: 121915398(ATP1A3) 121915467 121916840 121921395(ATP1A1)
PMUR: 107289344(ATP1A1) 107298220 107299011(ATP1A3)
PGUT: 117657954 117661891(ATP1A1) 117670090 117677582(ATP1A3)
VKO: 123019603 123023542 123025794(ATP1A3) 123034800(ATP1A1)
PMUA: 114585062 114586449 114587332(ATP1A1) 114603364(ATP1A3)
ZVI: 118075785 118086200(ATP1A3) 118097087 118097547(ATP1A1)
XLA: 108697760 108699431(atp1a2.L) 380132(atp1a3.L) 398583(atp1a1.S) 398752(atp1a2.S) 399285(atp1a1.L)
XTR: 100125050(atp1a2) 100145440(atp1a3) 395044(atp1a1)
DRE: 245703(atp1a1a.5) 64609(atp1a2a) 64610(atp1a3a) 64611(atp1a3b) 64612(atp1a1a.1) 64613(atp1a1a.2) 64614(atp1a1a.3) 64615(atp1a1a.4) 64616(atp1a1b)
ELY: 117250162 117250223 117263377(atp1a3a) 117265974(atp1a3b) 117271639(atp1a2a)
PLEP: 121945226(atp1a3b) 121951800(atp1a2a) 121957722(atp1a3a) 121962711 121962712
SLUC: 116040546(atp1a2a) 116044414 116044417 116047081(atp1a3a) 116049754(atp1a3b)
MSAM: 119897389(atp1a3b) 119901745(atp1a2a) 119904401 119904410 119907432(atp1a3a)
CUD: 121506161 121506174 121513482(atp1a3b) 121519836(atp1a2a) 121523345(atp1a3a)
OML: 112143633(atp1a3b) 112151412(atp1a2a) 112156656 112156657 112161935(atp1a3a)
GAF: 122827365 122827368 122831080(atp1a3b) 122841814(atp1a2a) 122843578(atp1a3a)
CTUL: 119779563(atp1a2a) 119780786 119780787 119783037(atp1a3b) 119795003(atp1a3a)
KMR: 108232880(atp1a2a) 108235385(atp1a3b) 108242195 108242200 108242662(atp1a3a)
SSEN: 122758131(atp1a1a.1) 122758605(atp1a1a.4) 122769140(atp1a2a) 122775031(atp1a3b) 122786298(atp1a3a)
HHIP: 117770917(atp1a3a) 117776767(atp1a3b) 117777835 117777837 117777887(atp1a2a)
XGL: 120784055(atp1a3b) 120786164(atp1a3a) 120798093 120798101 120798710(atp1a2a)
LCM: 102352604(ATP1A2) 102353554(ATP1A1) 102356851(ATP1A3)
BFO: 118424338
BBEL: 109484030
SCLV: 120326521
APLC: 110976714
SKO: 100370816(ATP1A1)
DME: Dmel_CG45062(CG45062) Dmel_CG45760 Dmel_CG5670(Atpalpha)
DSI: Dsimw501_GD19388(Dsim_GD19388) Dsimw501_GD19691(Dsim_GD19691) Dsimw501_GD29095(Dsim_GD29095)
DAN: 6500777
DVI: 6632311
CCAT: 101448826
BOD: 106616042
MDE: 101893028
SCAC: 106093479
LCQ: 111678276
ACOZ: 120950886
AARA: 120897925
AAG: 5575790
CPII: 120429815
NMEA: 116423924
NVI: 100116320
CLEC: 106667156
HHAL: 106678115
ZNE: 110827645
CSEC: 111866732
PJA: 122242743
HAME: 121869643
HAZT: 108679958
DSV: 119455962
RSAN: 119394018
RMP: 119172146
CEL: CELE_B0365.3(eat-6) CELE_C01G12.8(catp-4) CELE_C02E7.1(catp-2) CELE_Y105E8A.12(catp-1)
CBR: CBG_01656 CBG_08751(Cbr-catp-1) CBG_09434(Cbr-eat-6)
BMY: BM_BM10442(Bma-catp-4) BM_BM1779(Bma-eat-6) BM_BM8870(Bma-catp-1)
GAE: 121386257
CRG: 105338008
MYI: 110459295
PMAX: 117341055
OBI: 106880261
OSN: 115211699
EGL: EGR_08003
ADF: 107343492
DGT: 114524594
AQU: 100634317
QSU: 111989924
PIC: PICST_60178(PMR2)
CAL: CAALFM_CR01630CA(CaO19.2552) CAALFM_CR01640CA(CaO19.2553)
SLB: AWJ20_4150(PMR1)
MBE: MBM_04409
ANI: AN8941.2
ANG: ANI_1_1014084(An09g00930) ANI_1_352124(An14g02290)
PTE: PTT_00480
TASA: A1Q1_02917
SMIN: v1.2.028598.t1(symbB.v1.2.028598.t1)
METL: U737_16210
MMAI: sS8_5209
TCX: Tcr_1065
HMAR: HVMH_1068
CYQ: Q91_1618
TAU: Tola_1844
PSE: NH8B_2287
SLT: Slit_1198
GCA: Galf_2615
SLAC: SKTS_18720
ABRE: pbN1_39610
APET: ToN1_09380
DAR: Daro_1851
AZA: AZKH_2708
SULR: B649_05270
GUR: Gura_3300
GEO: Geob_1849
PCA: Pcar_2279
PPD: Ppro_1564
SAT: SYN_02485
MGRY: MSR1_15930
MAGX: XM1_2567
MAGN: WV31_04655
LBF: LBF_2665
ABAC: LuPra_03991(yloB_2)
NDE: NIDE3786
CTHI: THC_0765
MOX: DAMO_0992
MBAR: MSBR2_3266
MBAK: MSBR3_3261
MAC: MA_4378
MMA: MM_1069
MMAC: MSMAC_0238
METM: MSMTP_0268
MHOR: MSHOH_0294
MBU: Mbur_0431
MPY: Mpsy_0778
 » show all
Reference
1  [PMID:13412736]
  Authors
SKOU JC.
  Title
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
  Journal
Biochim Biophys Acta 23:394-401 (1957)
DOI:10.1016/0006-3002(57)90343-8
Reference
2  [PMID:14284759]
  Authors
POST RL, SEN AK, ROSENTHAL AS.
  Title
A PHOSPHORYLATED INTERMEDIATE IN ADENOSINE TRIPHOSPHATE-DEPENDENT SODIUM AND POTASSIUM TRANSPORT ACROSS KIDNEY MEMBRANES.
  Journal
J Biol Chem 240:1437-45 (1965)
Reference
3  [PMID:2166689]
  Authors
Skou JC.
  Title
The fourth Datta lecture. The energy coupled exchange of Na+ for K+ across the cell membrane. The Na+, K(+)-pump.
  Journal
FEBS Lett 268:314-24 (1990)
DOI:10.1016/0014-5793(90)81278-V
Reference
4  [PMID:26205423]
  Authors
Castillo JP, Rui H, Basilio D, Das A, Roux B, Latorre R, Bezanilla F, Holmgren M
  Title
Mechanism of potassium ion uptake by the Na(+)/K(+)-ATPase.
  Journal
Nat Commun 6:7622 (2015)
DOI:10.1038/ncomms8622
Other DBs
ExplorEnz - The Enzyme Database: 7.2.2.13
IUBMB Enzyme Nomenclature: 7.2.2.13
ExPASy - ENZYME nomenclature database: 7.2.2.13
BRENDA, the Enzyme Database: 7.2.2.13

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