KEGG   COMPOUND: C00410
Entry
C00410                      Compound                               

Name
Progesterone;
4-Pregnene-3,20-dione
Formula
C21H30O2
Exact mass
314.2246
Mol weight
314.4617
Structure
Remark
Same as: D00066
Reaction
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04114  Oocyte meiosis
map04913  Ovarian steroidogenesis
map04914  Progesterone-mediated oocyte maturation
map04917  Prolactin signaling pathway
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
map05224  Breast cancer
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Module
M00107  Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Enzyme
1.1.1.145       1.1.1.149       1.3.1.3         1.3.1.22        
1.3.99.6        1.14.13.54      1.14.14.16      1.14.14.19      
1.14.15.4       1.14.15.8       1.14.99.4       1.14.99.14      
5.3.3.1
Brite
Compounds with biological roles [BR:br08001]
 Steroids
  21-Carbon atoms
   Pregnane derivatives
    C00410  Progesterone
 Hormones and transmitters
  Steroid hormones
   Progestagens
    C00410  Progesterone
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA04 Progesterone
      D00066  Progesterone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Progesterone
    D00066  Progesterone (JP18/USP/INN)
 Infertility Agents
  Progesterone
   D00066  Progesterone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2477  Progesterones
     D00066  Progesterone (JP18/USP/INN)
Animal drugs in Japan [BR:br08331]
 94  Agents for breeding
  941  Hormone preparations (except posterior-pituitary hormone and preparations)
   9415  Luteinizing hormone and preparations
    C00410  Progesterone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00066  Progesterone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00066  Progesterone
  D00066  Progesterone injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00066
Other DBs
CAS: 57-83-0
PubChem: 3700
ChEBI: 17026
ChEMBL: CHEMBL103
LIPIDMAPS: LMST02030159
KNApSAcK: C00034649
PDB-CCD: STR[PDBj]
3DMET: B01238
NIKKAJI: J2.329I
KCF data

ATOM        23
            1   C1y C    23.0350  -18.9936
            2   C1y C    24.2088  -19.6769
            3   C1z C    21.8554  -19.6827
            4   C1x C    23.0233  -17.6271
            5   C1y C    25.4002  -18.9819
            6   C1x C    24.1913  -21.0784
            7   C2y C    21.8554  -21.0375
            8   C1x C    20.6873  -19.0112
            9   C1a C    21.8437  -18.2754
            10  C1x C    24.2030  -16.9322
            11  C1z C    25.4060  -17.6097
            12  C1x C    27.7653  -18.9936
            13  C1x C    23.0409  -21.7092
            14  C2x C    20.6873  -21.7150
            15  C1x C    19.5194  -19.6827
            16  C1y C    26.5974  -16.9263
            17  C1a C    25.3943  -16.2081
            18  C1x C    27.7712  -17.6213
            19  C5x C    19.5194  -21.0375
            20  C5a C    26.6032  -15.5948
            21  O5x O    18.3690  -21.6975
            22  C1a C    25.3885  -14.8823
            23  O5a O    27.8121  -14.8882
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1
            18   14  19 1
            19   16  20 1 #Up
            20   19  21 2
            21   20  22 1
            22   20  23 2
            23    7  13 1
            24   10  11 1
            25   15  19 1
            26   16  18 1

» Japanese version

KEGG   COMPOUND: C08150
Entry
C08150                      Compound                               

Name
Medroxyprogesterone acetate;
6-alpha-Methyl-17-alpha-acetoxyprogesterone;
6-alpha-Methyl-17-alpha-hydroxyprogesterone acetate
Formula
C24H34O4
Exact mass
386.2457
Mol weight
386.5244
Structure
Remark
Same as: D00951
Pathway
map05207  Chemical carcinogenesis - receptor activation
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC06 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA02 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AB Progestogens
     L02AB02 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Contraceptives
  Contraceptives, Other
   Medroxyprogesterone
    D00951  Medroxyprogesterone acetate (JP18/USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Medroxyprogesterone
    D00951  Medroxyprogesterone acetate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2478  Synthetic progestins
     D00951  Medroxyprogesterone acetate (JP18/USP)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00951  Medroxyprogesterone acetate
Other DBs
CAS: 71-58-9
PubChem: 10350
ChEBI: 6716
ChEMBL: CHEMBL287148 CHEMBL305242 CHEMBL717
NIKKAJI: J5.247G
KCF data

ATOM        28
            1   C1z C    28.1133  -17.0474
            2   C1z C    26.9252  -17.7172
            3   C1x C    29.2900  -17.7348
            4   O7a O    29.2900  -16.3485
            5   C5a C    28.1718  -15.6728
            6   C1y C    26.9192  -19.0861
            7   C1x C    25.7544  -17.0299
            8   C1a C    26.9078  -16.3485
            9   C1x C    29.2843  -19.0978
            10  C7a C    30.4782  -17.0299
            11  C1a C    26.9019  -14.9796
            12  O5a O    29.3543  -14.9738
            13  C1y C    25.7311  -19.7675
            14  C1x C    24.5603  -17.6998
            15  C1a C    31.6606  -16.3426
            16  O6a O    30.4724  -18.4045
            17  C1y C    24.5487  -19.0685
            18  C1x C    25.7311  -21.1364
            19  C1z C    23.3603  -19.7559
            20  C1y C    24.5370  -21.8238
            21  C2y C    23.3546  -21.1248
            22  C1x C    22.1781  -19.0628
            23  C1a C    23.3488  -18.3812
            24  C1a C    24.5253  -23.1868
            25  C2x C    22.1781  -21.8178
            26  C1x C    20.9840  -19.7559
            27  C5x C    20.9840  -21.1248
            28  O5x O    19.7957  -21.8062
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 2
            12    6  13 1
            13    7  14 1
            14   10  15 1
            15   10  16 2
            16   13  17 1
            17   13  18 1
            18   17  19 1
            19   18  20 1
            20   19  21 1
            21   19  22 1
            22   19  23 1 #Up
            23   20  24 1 #Down
            24   21  25 2
            25   22  26 1
            26   25  27 1
            27   27  28 2
            28    6   9 1
            29   14  17 1
            30   20  21 1
            31   26  27 1

» Japanese version

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