KEGG   DRUG: Zalcitabine
Entry
D00412                      Drug                                   
Name
Zalcitabine (JAN/USP/INN);
Hivid (TN)
  Abbr
ddC
Formula
C9H13N3O3
Exact mass
211.0957
Mol weight
211.2178
Structure
Simcomp
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG01440  Arabinofuranosyl type antiviral
 DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Transporter substrate
 DG02859  SLC22A6 substrate
Remark
Same as: C07207
ATC code: J05AF03
Efficacy
Antiviral, Reverse transcriptase inhibitor
Target
HIV-1 reverse transcriptase [KO:K24802]
Metabolism
Transporter: SLC22A6 [HSA:9356]
Interaction
Structure map
map07044  Antiviral agents
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF03 Zalcitabine
      D00412  Zalcitabine (JAN/USP/INN)
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   D00412  Zalcitabine
  DG01440  Arabinofuranosyl type antiviral
   D00412  Zalcitabine
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    D00412  Zalcitabine
 Transporter substrate
  DG02859  SLC22A6 substrate
   D00412  Zalcitabine
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D00412  Zalcitabine (JAN/USP/INN)
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D00412  Zalcitabine (JAN/USP/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00412
Other DBs
CAS: 7481-89-2
PubChem: 7847478
ChEBI: 10101
LigandBox: D00412
NIKKAJI: J277.119E
KCF data

ATOM        15
            1   C1x C    18.1827  -18.2480
            2   C1y C    18.5900  -16.9111
            3   O2x O    17.4593  -16.0809
            4   C1y C    16.3457  -16.9339
            5   C1x C    16.7800  -18.2622
            6   N4y N    19.7751  -16.1976
            7   C8y C    20.9746  -16.8869
            8   N5x N    22.2298  -16.1727
            9   C8y C    22.2156  -14.7700
            10  C8x C    21.0162  -14.0808
            11  C8x C    19.7609  -14.7950
            12  O5x O    20.9888  -18.2895
            13  N1a N    23.4007  -14.0565
            14  C1b C    15.1463  -16.2446
            15  O1a O    13.9611  -16.9581
BOND        16
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     2   6 1 #Up
            7     6   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12    6  11 1
            13    7  12 2
            14    9  13 1
            15    4  14 1 #Up
            16   14  15 1

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