KEGG   DRUG: Zonisamide
Entry
D00538                      Drug                                   
Name
Zonisamide (JP18/USP/INN);
Excegran (TN)
Product
  Generic
Formula
C8H8N2O3S
Exact mass
212.0256
Mol weight
212.2257
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
 DG01967  Antiparkinson agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C07504
Therapeutic category: 1139 1169
ATC code: N03AX15
Product: D00538<JP/US>
Efficacy
Anticonvulsant, Antiepileptic, Antiparkinsonian
Comment
Benzisoxazole derivative
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07033  Anticonvulsants
map07057  Antiparkinsonian agents
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX15 Zonisamide
      D00538  Zonisamide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Zonisamide
    D00538  Zonisamide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00538  Zonisamide (JP18/USP/INN)
   116  Antiparkinsonian agents
    1169  Others
     D00538  Zonisamide (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    D00538  Zonisamide
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D00538  Zonisamide
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D00538  Zonisamide
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   D00538  Zonisamide
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN2A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN3A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN4A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN5A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN8A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN9A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN10A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
    SCN11A
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
   Calcium channels
    CACNA1-T
     D00538  Zonisamide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00538  Zonisamide
  D00538  Zonisamide tablets
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D00538
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00538
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00538
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00538
Other DBs
CAS: 68291-97-4
PubChem: 7847604
ChEBI: 10127
PDB-CCD: ZON[PDBj]
LigandBox: D00538
NIKKAJI: J20.559A
KCF data

ATOM        14
            1   C8y C    23.2246  -18.0420
            2   C8y C    24.5519  -17.6112
            3   C8y C    23.2246  -19.4447
            4   C8x C    22.0139  -17.3435
            5   N5x N    25.3783  -18.7462
            6   O2x O    24.5576  -19.8813
            7   C8x C    22.0139  -20.1433
            8   C8x C    20.7973  -18.0420
            9   C8x C    20.7973  -19.4447
            10  C1b C    24.5519  -16.2112
            11  S4a S    25.7651  -15.5107
            12  O3c O    26.9775  -14.8107
            13  N1a N    25.0763  -14.3183
            14  O3c O    26.4767  -16.7426
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     5   6 1
            10    8   9 1
            11    2  10 1
            12   10  11 1
            13   11  12 2
            14   11  13 1
            15   11  14 2

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