KEGG   DRUG: Benztropine mesylate
Entry
D00778                      Drug                                   

Name
Benztropine mesylate (USP);
Benztropine mesilate (JAN);
Cogentin (TN)
Product
  Generic
BENZTROPINE MESYLATE (Cipla USA), BENZTROPINE (Contract Pharmacy Services-PA), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (A-S Medication Solutions), BENZTROPINE MESYLATE (Akorn), BENZTROPINE MESYLATE (American Health Packaging), BENZTROPINE MESYLATE (Aphena Pharma Solutions - Tennessee), BENZTROPINE MESYLATE (Aphena Pharma Solutions - Tennnessee), BENZTROPINE MESYLATE (Bayshore Pharmaceuticals LLC (NJ)), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Bryant Ranch Prepack), BENZTROPINE MESYLATE (Cardinal Health), BENZTROPINE MESYLATE (Chartwell RX), BENZTROPINE MESYLATE (Clinical Solutions Wholesale), BENZTROPINE MESYLATE (DIRECT RX), BENZTROPINE MESYLATE (Fresenius Kabi USA), BENZTROPINE MESYLATE (Hikma Pharmaceuticals USA), BENZTROPINE MESYLATE (Leading Pharma), BENZTROPINE MESYLATE (Major Pharmaceuticals), BENZTROPINE MESYLATE (NCS HealthCare of KY), BENZTROPINE MESYLATE (Navinta LLC), BENZTROPINE MESYLATE (Par Pharmaceutical), BENZTROPINE MESYLATE (Proficient Rx LP), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (REMEDYREPACK), BENZTROPINE MESYLATE (Upsher-Smith Laboratories), BENZTROPINE MESYLATE (West-Ward Pharmaceuticals Corp), BENZTROPINE MESYLATE (Wintac Limited), BENZTROPINE MESYLATE (Zydus Pharmaceuticals USA)
Formula
C21H25NO. CH4SO3
Exact mass
403.1817
Mol weight
403.535
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
ATC code: N04AC01
Chemical structure group: DG00859
Product (DG00859): D00778<US>
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
  Disease
Parkinsonism [DS:H01600]
Comment
Tropane derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Structure map
map07057  Antiparkinsonian agents
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AC Ethers of tropine or tropine derivatives
     N04AC01 Benzatropine
      D00778  Benztropine mesylate (USP) <US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Anticholinergics
   Benztropine
    D00778  Benztropine mesylate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D00778  Benztropine mesylate (USP) <US>
Other DBs
CAS: 132-17-2
PubChem: 7847843
ChEBI: 3049
DrugBank: DB00245
LigandBox: D00778
NIKKAJI: J237.902C
KCF data

ATOM        28
            1   S4a S    33.2140  -18.8297
            2   C1a C    31.8828  -18.8243
            3   O1d O    34.5508  -18.8297
            4   O1d O    33.2084  -17.4986
            5   O1d O    33.2084  -20.1610
            6   C1x C    20.7530  -17.8020
            7   C1x C    21.0706  -16.6678
            8   C1y C    21.8872  -17.5298
            9   C1y C    22.2047  -16.3956
            10  N1y N    20.9799  -15.1254
            11  C1x C    23.7018  -17.5298
            12  C1x C    23.4296  -16.3956
            13  C1y C    24.6999  -18.0742
            14  O2a O    25.7433  -18.9362
            15  C1a C    20.2548  -13.9791
            16  C1c C    27.1433  -18.9362
            17  C8y C    27.8622  -20.1811
            18  C8y C    27.8331  -17.7424
            19  C8x C    29.2596  -17.7435
            20  C8x C    29.9605  -16.5316
            21  C8x C    29.2614  -15.3186
            22  C8x C    27.8349  -15.3175
            23  C8x C    27.1340  -16.5294
            24  C8x C    27.1708  -21.3786
            25  C8x C    27.8707  -22.5911
            26  C8x C    29.2707  -22.5912
            27  C8x C    29.9621  -21.3937
            28  C8x C    29.2622  -20.1812
BOND        30
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     1   5 2
            5     6   7 1
            6     6   8 1
            7     7   9 1
            8     8  10 1
            9     8  11 1
            10    9  12 1
            11   11  13 1
            12   13  14 1 #Down
            13    9  10 1
            14   12  13 1
            15   10  15 1
            16   14  16 1
            17   16  17 1
            18   16  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   21  22 1
            23   22  23 2
            24   18  23 1
            25   17  24 2
            26   24  25 1
            27   25  26 2
            28   26  27 1
            29   27  28 2
            30   17  28 1

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