KEGG   DRUG: Ceftizoxime sodium
Entry
D00923                      Drug                                   
Name
Ceftizoxime sodium (JP18/USP);
Cefizox (TN);
Epocelin (TN)
Formula
C13H12N5O5S2. Na
Exact mass
405.0178
Mol weight
405.3846
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01776  Third-generation cephalosporin
 DG01804  Oxyimino beta-lactam
Transporter substrate
 DG02860  SLC22A8 substrate
Remark
Same as: C08118
Therapeutic category: 6132
ATC code: J01DD07
Chemical structure group: DG00576
Product (DG00576): D00923<JP>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Metabolism
Transporter: SLC22A8 [HSA:9376]
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
map07013  Cephalosporins - oral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DD Third-generation cephalosporins
     J01DD07 Ceftizoxime
      D00923  Ceftizoxime sodium (JP18/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D00923  Ceftizoxime sodium (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00576  Ceftizoxime
      D00923  Ceftizoxime sodium
  DG01776  Third-generation cephalosporin
   DG00576  Ceftizoxime
    D00923  Ceftizoxime sodium
  DG01804  Oxyimino beta-lactam
   DG00576  Ceftizoxime
    D00923  Ceftizoxime sodium
 Transporter substrate
  DG02860  SLC22A8 substrate
   D00923  Ceftizoxime sodium
Drug classes [BR:br08332]
 Antibacterial
  DG01488  Cephem
   D00923  Ceftizoxime sodium
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    D00923  Ceftizoxime sodium (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00923  Ceftizoxime sodium
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00923
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00576  Ceftizoxime
  DG01776  Third-generation cephalosporin
   DG00576  Ceftizoxime
  DG01804  Oxyimino beta-lactam
   DG00576  Ceftizoxime
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Third-generation cephalosporin
    DG00576  Ceftizoxime
Other DBs
CAS: 68401-82-1
PubChem: 7847986
ChEBI: 3512
LigandBox: D00923
NIKKAJI: J18.749F
KCF data

ATOM        26
            1   C1y C    27.6266  -18.8498
            2   N1y N    27.6266  -20.2389
            3   C2y C    28.8298  -20.9335
            4   C2x C    30.0328  -20.2389
            5   C1x C    30.0328  -18.8498
            6   S2x S    28.8298  -18.1552
            7   C1y C    26.2373  -18.8498
            8   C5x C    26.2373  -20.2389
            9   N1b N    25.0345  -18.1552
            10  C5a C    23.8313  -18.8498
            11  O5a O    23.8313  -20.2389
            12  O5x O    25.0345  -20.9335
            13  C2c C    22.6281  -18.1552
            14  C8y C    21.4059  -18.8613
            15  C8x C    20.2754  -18.0309
            16  S2x S    19.1316  -18.8479
            17  C8y C    19.5551  -20.2580
            18  N5x N    20.9606  -20.2695
            19  N2b N    22.6280  -16.7447
            20  C6a C    28.8298  -22.3394
            21  O6a O    30.0435  -23.0401 #-
            22  O6a O    27.6177  -23.0393
            23  N1a N    18.7515  -21.3864
            24  O2a O    23.8330  -16.0487
            25  C1a C    23.8333  -14.6304
            26  Z   Na   31.5041  -22.9885 #+
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 1
            19   17  18 2
            20   14  18 1
            21   13  19 2
            22    3  20 1
            23   20  21 1
            24   20  22 2
            25   17  23 1
            26   19  24 1
            27   24  25 1

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