| Entry |
|
|---|
| Name |
Tacrine hydrochloride (USP);
Cognex (TN) |
|---|
| Formula |
C13H14N2. HCl
|
|---|
| Exact mass |
234.0924
|
|---|
| Mol weight |
234.7246
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01968 Antidementia agent
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
|
|---|
| Remark |
|
|---|
| Efficacy |
Dementia therapeutic agent, Acetylcholinesterase inhibitor |
|---|
| Comment |
Acridine derivative
Cognition adjuvant, Dementia symptoms treatment adjunct
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07056 | Agents for Alzheimer-type dementia |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06D ANTI-DEMENTIA DRUGS
N06DA Anticholinesterases
N06DA01 Tacrine
D02068 Tacrine hydrochloride (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00982 Tacrine
D02068 Tacrine hydrochloride
DG01968 Antidementia agent
DG00982 Tacrine
D02068 Tacrine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00982 Tacrine
D02068 Tacrine hydrochloride
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D02068 Tacrine hydrochloride (USP)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02068
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00982 Tacrine
DG01968 Antidementia agent
DG00982 Tacrine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00982 Tacrine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 16
1 C8y C 30.8048 -18.5255
2 C8y C 30.8048 -17.1322
3 N5x N 32.0124 -19.2221
4 C8x C 29.5974 -19.2221
5 C8y C 32.0124 -16.4356
6 C8x C 29.5974 -16.4356
7 C8y C 33.2199 -18.5255
8 C8x C 28.3897 -18.5255
9 C8y C 33.2199 -17.1322
10 N1a N 32.0124 -15.0887
11 C8x C 28.3897 -17.1322
12 C1x C 34.4275 -19.2221
13 C1x C 34.4275 -16.3892
14 C1x C 35.6814 -18.5255
15 C1x C 35.6816 -17.0858
16 X Cl 38.3993 -17.5338
BOND 17
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 5 9 2
9 5 10 1
10 6 11 2
11 7 12 1
12 9 13 1
13 12 14 1
14 13 15 1
15 7 9 1
16 8 11 1
17 14 15 1
|
|---|
