KEGG   DRUG: Chloramphenicol sodium succinate
Entry
D02185                      Drug                                   

Name
Chloramphenicol sodium succinate (JP18/USP);
Chloromycetin succinate (TN)
Product
  Generic
Formula
C15H15Cl2N2O8. Na
Exact mass
444.0103
Mol weight
445.184
Structure
Simcomp
Class
Antibacterial
 DG01576  Amphenicol type antibacterial
Remark
Same as: C13962
Therapeutic category: 6151
ATC code: D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08
Chemical structure group: DG00399
Product (DG00399): D00104<JP> D02185<JP/US>
Efficacy
Antibacterial, Antirickettsial, Protein biosynthesis inhibitor
  Disease
Typhoid [DS:H00111]
Cystic fibrosis [DS:H00218]
Comment
Amphenicol derivative
Active form of prodrug: Chloramphenicol [DR:D00104]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Antibacterials, Other
   Chloramphenicol
    D02185  Chloramphenicol sodium succinate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   615  Acting mainly on gram-positive bacteria, gram-negative bacteria, rickettsia and chlamydia
    6151  Chloramphenicols
     D02185  Chloramphenicol sodium succinate (JP18/USP)
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Amphenicol
    D02185  Chloramphenicol sodium succinate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02185  Chloramphenicol sodium succinate
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Amphenicol
    DG00399  Chloramphenicol
Prodrugs [br08324.html]
 DG00399
Other DBs
CAS: 982-57-0
PubChem: 7849245
ChEBI: 3606
ChEMBL: CHEMBL1200729
DrugBank: DB00446
LigandBox: D02185
NIKKAJI: J74.861G
KCF data

ATOM        28
            1   C8y C    21.3161  -15.5137
            2   C1c C    21.3153  -16.9056
            3   C8x C    20.1197  -14.7987
            4   C8x C    22.5374  -14.8000
            5   C1c C    22.5186  -17.6023
            6   O1a O    20.1125  -17.5884
            7   C8x C    20.1205  -13.3951
            8   C8x C    22.5380  -13.3964
            9   N1b N    23.7158  -16.9128
            10  C8y C    21.3175  -12.7058
            11  C5a C    24.9188  -17.6095
            12  N2b N    21.3185  -11.3139 #+
            13  C1c C    26.1289  -16.9199
            14  O5a O    24.9182  -19.0013
            15  O3a O    20.1220  -10.6173
            16  O3a O    22.5166  -10.6070 #-
            17  X   Cl   27.3249  -17.6166
            18  X   Cl   26.0890  -15.5280
            19  C1b C    22.5172  -19.0063
            20  O7a O    21.3020  -19.7065
            21  C7a C    21.3006  -21.1401
            22  O6a O    20.0910  -21.8371
            23  C1b C    22.5548  -21.8661
            24  C1b C    23.7829  -21.1588
            25  C6a C    24.9813  -21.8524
            26  O6a O    26.1975  -21.1519 #-
            27  O6a O    24.9798  -23.2741
            28  Z   Na   27.7330  -21.4961 #+
BOND        27
            1     5   9 1
            2     7  10 2
            3     9  11 1
            4    10  12 1
            5    11  13 1
            6    11  14 2
            7    12  15 2
            8    12  16 1
            9    13  17 1
            10   13  18 1
            11    8  10 1
            12    1   2 1
            13    1   3 2
            14    1   4 1
            15    2   5 1
            16    2   6 1 #Down
            17    3   7 1
            18    4   8 2
            19    5  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 2
            23   21  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 2

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