KEGG   DRUG: Mazaticol hydrochloride hydrate
Entry
D03264                      Drug                                   
Name
Mazaticol hydrochloride hydrate (JAN);
Mazaticol hydrochloride;
Pentona (TN)
Formula
C21H27NO3S2. HCl. H2O
Exact mass
459.1305
Mol weight
460.0502
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
Therapeutic category: 1169
ATC code: N04AA10
Chemical structure group: DG00857
Product (DG00857): D03264<JP>
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
Target
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA10 Mazaticol
      D03264  Mazaticol hydrochloride hydrate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D03264  Mazaticol hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
     D03264  Mazaticol hydrochloride hydrate
  DG01967  Antiparkinson agent
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
     D03264  Mazaticol hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D03264  Mazaticol hydrochloride hydrate (JAN) <JP>
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
  DG01967  Antiparkinson agent
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
Other DBs
PubChem: 17397417
LigandBox: D03264
KCF data

ATOM        29
            1   C1y C    32.4800  -20.0200
            2   N1y N    31.9200  -17.2200
            3   C1z C    33.3900  -20.6500
            4   C1x C    31.2200  -20.0200
            5   C1y C    31.9200  -18.6900
            6   C1x C    34.5100  -18.6900
            7   C1y C    30.3100  -20.5800
            8   C1x C    33.1800  -19.3900
            9   C1x C    30.6600  -19.3900
            10  O7a O    29.1900  -19.9500
            11  C7a C    28.0700  -20.5800
            12  O6a O    28.0700  -21.8400
            13  C1a C    32.6900  -21.9100
            14  C1a C    34.6500  -21.3500
            15  C1d C    26.9500  -19.9500
            16  C8y C    26.9500  -18.6200
            17  C8y C    25.8300  -20.5800
            18  O1a O    25.8300  -19.1100
            19  C8x C    28.0000  -17.9200
            20  C8x C    27.5800  -16.6600
            21  C8x C    26.3200  -16.6600
            22  S2x S    25.9000  -17.8500
            23  S2x S    24.6400  -20.0200
            24  C8x C    23.7300  -21.0000
            25  C8x C    24.4300  -22.1200
            26  C8x C    25.6900  -21.8400
            27  C1a C    31.9200  -15.7500
            28  X   Cl   38.8500  -18.7600
            29  O0  O    43.3300  -18.7600
BOND        30
            1     3  13 1
            2     3  14 1
            3     1   2 1
            4    11  15 1
            5     1   3 1
            6    15  16 1
            7     1   4 1
            8    15  17 1
            9     2   5 1
            10   15  18 1
            11    3   6 1
            12    4   7 1
            13    5   8 1
            14    5   9 1
            15   16  19 2
            16   19  20 1
            17   20  21 2
            18   21  22 1
            19   22  16 1
            20    7  10 1
            21   10  11 1
            22   11  12 2
            23    6   8 1
            24   17  23 1
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  17 2
            29    7   9 1
            30    2  27 1

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
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   PubChem (1)   
Gene (10)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (5)   
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KEGG   DRUG: Mazaticol
Entry
D08157                      Drug                                   
Name
Mazaticol (INN)
Formula
C21H27NO3S2
Exact mass
405.1432
Mol weight
405.574
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
ATC code: N04AA10
Chemical structure group: DG00857
Product (DG00857): D03264<JP>
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
Target
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA10 Mazaticol
      D08157  Mazaticol (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
     D08157  Mazaticol
  DG01967  Antiparkinson agent
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
     D08157  Mazaticol
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D08157  Mazaticol (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
  DG01967  Antiparkinson agent
   DG01745  Anticholinergic antiparkinson agent
    DG00857  Mazaticol
Other DBs
CAS: 42024-98-6
PubChem: 96024847
LigandBox: D08157
NIKKAJI: J343.943G
KCF data

ATOM        27
            1   C1y C    27.4400  -19.0400
            2   N1y N    26.8800  -16.2400
            3   C1z C    28.3500  -19.6700
            4   C1x C    26.1800  -19.0400
            5   C1y C    26.8800  -17.7100
            6   C1x C    29.4700  -17.7100
            7   C1y C    25.2700  -19.6000
            8   C1x C    28.1400  -18.4100
            9   C1x C    25.6200  -18.4100
            10  O7a O    24.1500  -18.9700
            11  C7a C    23.0300  -19.6000
            12  O6a O    23.0300  -20.8600
            13  C1a C    27.6500  -20.9300
            14  C1a C    29.6100  -20.3700
            15  C1d C    21.9100  -18.9700
            16  C8y C    21.9100  -17.6400
            17  C8y C    20.7900  -19.6000
            18  O1a O    20.7900  -18.1300
            19  C8x C    22.9600  -16.9400
            20  C8x C    22.5400  -15.6800
            21  C8x C    21.2800  -15.6800
            22  S2x S    20.8600  -16.8700
            23  S2x S    19.6000  -19.0400
            24  C8x C    18.6900  -20.0200
            25  C8x C    19.3900  -21.1400
            26  C8x C    20.6500  -20.8600
            27  C1a C    26.8800  -14.7700
BOND        30
            1     3  13 1
            2     3  14 1
            3     1   2 1
            4    11  15 1
            5     1   3 1
            6    15  16 1
            7     1   4 1
            8    15  17 1
            9     2   5 1
            10   15  18 1
            11    3   6 1
            12    4   7 1
            13    5   8 1
            14    5   9 1
            15   16  19 2
            16   19  20 1
            17   20  21 2
            18   21  22 1
            19   22  16 1
            20    7  10 1
            21   10  11 1
            22   11  12 2
            23    6   8 1
            24   17  23 1
            25   23  24 1
            26   24  25 2
            27   25  26 1
            28   26  17 2
            29    7   9 1
            30    2  27 1

» Japanese version   » Back

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   NIKKAJI (1)   
Gene (10)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (5)   
All databases (18)   

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