KEGG   DRUG: Rivastigmine
Entry
D03822                      Drug                                   
Name
Rivastigmine (JAN/USP/INN);
Exelon (TN);
Prometax (TN)
Product
EXELON (Novartis Pharmaceuticals Corporation)
  Generic
RIVASTIGMINE TRANSDERMAL SYSTEM (Adhexpharma), RIVASTIGMINE (Amneal Pharmaceuticals LLC), RIVASTIGMINE TRANSDERMAL SYSTEM (Breckenridge Pharmaceutical), RIVASTIGMINE TRANSDERMAL SYSTEM (Bryant Ranch Prepack), RIVASTIGMINE TRANSDERMAL SYSTEM (Bryant Ranch Prepack), RIVASTIGMINE TRANSDERMAL SYSTEM (Bryant Ranch Prepack), RIVASTIGMINE TRANSDERMAL SYSTEM (Bryant Ranch Prepack), RIVASTIGMINE TRANSDERMAL SYSTEM (Bryant Ranch Prepack), RIVASTIGMINE (Cadila Healthcare Limited), RIVASTIGMINE (Mylan Pharmaceuticals), RIVASTIGMINE (Northstar Rx LLC.), RIVASTIGMINE (Sandoz), RIVASTIGMINE (Zydus Pharmaceuticals (USA)), RIVASTIGMINE TRANSDERMAL SYSTEM (Alvogen)
Formula
C14H22N2O2
Exact mass
250.1681
Mol weight
250.3367
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
  DG01594  Butyrylcholinesterase inhibitor
 DG01968  Antidementia agent
Remark
Same as: C11766
Therapeutic category: 1190
ATC code: N06DA03
Chemical structure group: DG00984
Product (DG00984): D03822<JP/US> D02558<US>
Efficacy
Dementia therapeutic agent, Acetylcholinesterase inhibitor
  Disease
Alzheimer's disease [DS:H00056]
Comment
Physostigmine derivative
Target
ACHE [HSA:43] [KO:K01049]
BCHE [HSA:590] [KO:K01050]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA03 Rivastigmine
      D03822  Rivastigmine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Rivastigmine
    D03822  Rivastigmine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D03822  Rivastigmine (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00984  Rivastigmine
     D03822  Rivastigmine
   DG01594  Butyrylcholinesterase inhibitor
    DG00984  Rivastigmine
     D03822  Rivastigmine
  DG01968  Antidementia agent
   DG00984  Rivastigmine
    D03822  Rivastigmine
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D03822  Rivastigmine (JAN/USP/INN) <JP/US>
    BCHE
     D03822  Rivastigmine (JAN/USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03822
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03822
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00984  Rivastigmine
   DG01594  Butyrylcholinesterase inhibitor
    DG00984  Rivastigmine
  DG01968  Antidementia agent
   DG00984  Rivastigmine
Other DBs
CAS: 123441-03-2
PubChem: 17397908
ChEBI: 8874
LigandBox: D03822
NIKKAJI: J982.502I
KCF data

ATOM        18
            1   C8y C    33.4600  -18.9700
            2   C8x C    34.6500  -18.2700
            3   C8x C    33.4600  -20.3700
            4   O7a O    32.2000  -18.2700
            5   C8y C    35.8400  -18.9700
            6   C8x C    34.6500  -21.0700
            7   C7a C    31.0100  -18.9700
            8   C8x C    35.8400  -20.3700
            9   N1c N    29.8200  -18.2700
            10  O6a O    31.0100  -20.3700
            11  C1a C    28.5600  -18.9700
            12  C1c C    37.1000  -18.2700
            13  N1c N    38.2900  -18.9700
            14  C1a C    37.1000  -16.8700
            15  C1a C    38.2900  -20.3700
            16  C1a C    39.4800  -18.2700
            17  C1b C    29.8200  -16.8700
            18  C1a C    31.0800  -16.1700
BOND        18
            1     5   8 2
            2     7   9 1
            3     7  10 2
            4     9  11 1
            5     6   8 1
            6     5  12 1
            7     1   2 2
            8    12  13 1
            9     1   3 1
            10   12  14 1 #Down
            11    1   4 1
            12   13  15 1
            13    2   5 1
            14   13  16 1
            15    3   6 2
            16    9  17 1
            17    4   7 1
            18   17  18 1

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KEGG   DRUG: Rivastigmine tartrate
Entry
D02558                      Drug                                   
Name
Rivastigmine tartrate;
Rivastigmine hydrogen tartrate;
Exelon (TN);
Nimvastid (TN)
Product
  Generic
RIVASTIGMINE TARTRATE (Alembic Pharmaceuticals Limited), RIVASTIGMINE TARTRATE (American Health Packaging), RIVASTIGMINE TARTRATE (Aurobindo Pharma Limited), RIVASTIGMINE TARTRATE (Breckenridge Pharmaceutical), RIVASTIGMINE TARTRATE (Cadila Pharmaceuticals Limited), RIVASTIGMINE TARTRATE (Dr. Reddy's Laboratories Limited), RIVASTIGMINE TARTRATE (Macleods Pharmaceuticals Limited), RIVASTIGMINE TARTRATE (Major Pharmaceuticals), RIVASTIGMINE TARTRATE (Major Pharmaceuticals), RIVASTIGMINE TARTRATE (Modavar Pharmaceuticals LLC), RIVASTIGMINE TARTRATE (Nivagen Pharmaceuticals), RIVASTIGMINE TARTRATE (REMEDYREPACK), RIVASTIGMINE TARTRATE (Sun Pharmaceutical Industries)
Formula
C14H22N2O2. C4H6O6
Exact mass
400.1846
Mol weight
400.4235
Structure
Class
Neuropsychiatric agent
 DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
  DG01594  Butyrylcholinesterase inhibitor
 DG01968  Antidementia agent
Remark
ATC code: N06DA03
Chemical structure group: DG00984
Product (DG00984): D03822<JP/US> D02558<US>
Efficacy
Dementia therapeutic agent, Acetylcholinesterase inhibitor
  Disease
Alzheimer's disease [DS:H00056]
Comment
Physostigmine derivative
Treatment of Alzheimer's disease
Target
ACHE [HSA:43] [KO:K01049]
BCHE [HSA:590] [KO:K01050]
  Pathway
hsa00564  Glycerophospholipid metabolism
hsa04725  Cholinergic synapse
Interaction
Structure map
map07056  Agents for Alzheimer-type dementia
map07220  Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DA Anticholinesterases
     N06DA03 Rivastigmine
      D02558  Rivastigmine tartrate <US>
USP drug classification [BR:br08302]
 Antidementia Agents
  Cholinesterase Inhibitors
   Rivastigmine
    D02558  Rivastigmine tartrate
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00984  Rivastigmine
     D02558  Rivastigmine tartrate
   DG01594  Butyrylcholinesterase inhibitor
    DG00984  Rivastigmine
     D02558  Rivastigmine tartrate
  DG01968  Antidementia agent
   DG00984  Rivastigmine
    D02558  Rivastigmine tartrate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D02558  Rivastigmine tartrate <US>
    BCHE
     D02558  Rivastigmine tartrate <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02558
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02558
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02558
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00984  Rivastigmine
   DG01594  Butyrylcholinesterase inhibitor
    DG00984  Rivastigmine
  DG01968  Antidementia agent
   DG00984  Rivastigmine
Other DBs
CAS: 129101-54-8
PubChem: 17396729
ChEBI: 64358
LigandBox: D02558
NIKKAJI: J391.508E
KCF data

ATOM        28
            1   C8y C    26.6428  -17.5078
            2   C8x C    27.8616  -16.8021
            3   C8x C    26.6486  -18.9132
            4   O7a O    25.4297  -16.8080
            5   C8y C    29.0745  -17.5078
            6   C8x C    27.8616  -19.6129
            7   C7a C    24.2168  -17.5135
            8   C8x C    29.0745  -18.9074
            9   N1c N    22.9980  -16.8137
            10  O6a O    24.2168  -18.9191
            11  C1a C    21.7908  -17.5195
            12  C1c C    30.2840  -16.8122
            13  N1c N    31.4912  -17.5118
            14  C1a C    30.2864  -15.4169
            15  C1a C    31.4888  -18.9071
            16  C1a C    32.7005  -16.8163
            17  C1b C    23.0621  -15.4005
            18  C1a C    24.2797  -14.7690
            19  O6a O    36.3299  -17.4300
            20  C6a C    37.5423  -16.7300
            21  C1c C    38.7548  -17.4300
            22  C1c C    39.9672  -16.7300
            23  C6a C    41.1795  -17.4300
            24  O6a O    42.3920  -16.7300
            25  O6a O    37.5423  -15.3301
            26  O6a O    41.1795  -18.8299
            27  O1a O    38.7799  -18.8300
            28  O1a O    39.9699  -15.3299
BOND        27
            1     5   8 2
            2     7   9 1
            3     7  10 2
            4     9  11 1
            5     6   8 1
            6     5  12 1
            7     1   2 2
            8    12  13 1
            9     1   3 1
            10   12  14 1 #Down
            11    1   4 1
            12   13  15 1
            13    2   5 1
            14   13  16 1
            15    3   6 2
            16    4   7 1
            17    9  17 1
            18   17  18 1
            19   19  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   23  24 1
            24   20  25 2
            25   23  26 2
            26   21  27 1 #Up
            27   22  28 1 #Up

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Pathway (2)   
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Disease (1)   
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Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
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Gene (4)   
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