KEGG   DRUG: Latanoprost and timolol maleate
Entry
D07505            Mixture   Drug                                   

Name
Latanoprost and timolol maleate;
Xalacom (TN)
Component
Latanoprost [DR:D00356], Timolol maleate [DR:D00603]
Remark
Therapeutic category: 1319
ATC code: S01ED51
Product: D07505<JP>
Efficacy
Antiglaucoma
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D07505  Latanoprost and timolol maleate <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D07505  Latanoprost and timolol maleate
Other DBs
PubChem: 124490298

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KEGG   DRUG: Dorzolamide hydrochloride and timolol maleate
Entry
D08493            Mixture   Drug                                   

Name
Dorzolamide hydrochloride and timolol maleate (JP18);
Cosopt (TN)
Product
  Generic
DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (A-S Medication Solutions), DORZOLAMIDE HCL AND TIMOLOL MALEATE (Akorn), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Bausch & Lomb Incorporated), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Golden State Medical Supply), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Hi-Tech Pharmacal), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE OPHTHALMIC SOLUTION (Micro Labs Limited), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Sandoz), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (Somerset Therapeutics), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE OPHTHALMIC SOLUTION (Alembic Pharmaceuticals), DORZOLAMIDE AND TIMOLOL (Leading Pharma), DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE PRESERVATIVE FREE (Aurobindo Pharma Limited), DORZOLAMIDE HYDROCHLORIDE-TIMOLOL MALEATE (Lannett Company)
Component
Dorzolamide hydrochloride [DR:D00653], Timolol maleate [DR:D00603]
Remark
Therapeutic category: 1319
ATC code: S01ED51
Product: D08493<JP/US>
Efficacy
Antiglaucoma
  Disease
Open-angle glaucoma [DS:H00612]
Comment
carbonic anhydrase inhibitor / beta-blocker combination
Dorzolamide is primarily metabolized by CYP2C9, CYP2C19 and CYP3A4.
Timolol is primarily metabolized by CYP2D6.
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D08493  Dorzolamide hydrochloride and timolol maleate (JP18) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Combinations
   Dorzolamide Hydrochloride/ Timolol Maleate
    D08493  Dorzolamide hydrochloride and timolol maleate (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D08493  Dorzolamide hydrochloride and timolol maleate (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D08493  Dorzolamide hydrochloride and timolol maleate ophthalmic solution
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08493
Other DBs
PubChem: 124490301

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KEGG   DRUG: Travoprost and timolol maleate
Entry
D09815            Mixture   Drug                                   

Name
Travoprost and timolol maleate;
Duotrav (TN)
Component
Travoprost [DR:D01964], Timolol maleate [DR:D00603]
Remark
Therapeutic category: 1319
ATC code: S01ED51
Product: D09815<JP>
Efficacy
Antiglaucoma
Comment
Prostaglandin F2alpha derivative / beta-blocker combination
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D09815  Travoprost and timolol maleate <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D09815  Travoprost and timolol maleate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09815
Other DBs
PubChem: 124490555

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KEGG   DRUG: Brimonidine tartrate and timolol maleate
Entry
D10298            Mixture   Drug                                   

Name
Brimonidine tartrate and timolol maleate;
Combigan (TN);
Aibeta (TN)
Product
Component
Brimonidine tartrate [DR:D02076], Timolol maleate [DR:D00603]
Remark
Therapeutic category: 1319
ATC code: S01ED51
Product: D10298<JP/US>
Efficacy
Antiglaucoma
  Disease
Glaucoma [DS:H00612]
Comment
Treatment of glaucoma, ocular hypertension
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D10298  Brimonidine tartrate and timolol maleate <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Combinations
   Brimonidine Tartrate/ Timolol Maleate
    D10298  Brimonidine tartrate and timolol maleate
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D10298  Brimonidine tartrate and timolol maleate
Other DBs
PubChem: 163312329

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