KEGG   DRUG: Chloramphenicol succinate
Entry
D07675                      Drug                                   

Name
Chloramphenicol succinate;
Chloramphenicol ICN (TN)
Formula
C15H16Cl2N2O8
Exact mass
422.0284
Mol weight
423.2021
Structure
Simcomp
Class
Antibacterial
 DG01576  Amphenicol type antibacterial
Remark
Same as: C11727
ATC code: D06AX02 D10AF03 G01AA05 J01BA01 S01AA01 S02AA01 S03AA08
Chemical structure group: DG00399
Product (DG00399): D00104<JP> D02185<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Comment
Amphenicol derivative
Active form of prodrug: Chloramphenicol [DR:D00104]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX02 Chloramphenicol
      D07675  Chloramphenicol succinate
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF03 Chloramphenicol
      D07675  Chloramphenicol succinate
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA05 Chloramphenicol
      D07675  Chloramphenicol succinate
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01B AMPHENICOLS
    J01BA Amphenicols
     J01BA01 Chloramphenicol
      D07675  Chloramphenicol succinate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA01 Chloramphenicol
      D07675  Chloramphenicol succinate
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA01 Chloramphenicol
      D07675  Chloramphenicol succinate
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA08 Chloramphenicol
      D07675  Chloramphenicol succinate
Drug groups [BR:br08330]
 Antibacterial
  DG01576  Amphenicol type antibacterial
   DG00399  Chloramphenicol
    D07675  Chloramphenicol succinate
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Amphenicol
    D07675  Chloramphenicol succinate
Prodrugs [br08324.html]
 D07675
Drug groups [BR:br08330]
 Antibacterial
  DG01576  Amphenicol type antibacterial
   DG00399  Chloramphenicol
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Amphenicol
    DG00399  Chloramphenicol
Prodrugs [br08324.html]
 DG00399
Other DBs
CAS: 3544-94-3
PubChem: 51091977
ChEBI: 3606
ChEMBL: CHEMBL1201281 CHEMBL1358255
PDB-CCD: CL8[PDBj]
LigandBox: D07675
NIKKAJI: J186.557I
KCF data

ATOM        27
            1   C8y C    21.4900  -15.5400
            2   C1c C    21.4900  -16.9400
            3   C8x C    20.3000  -14.7700
            4   C8x C    22.7500  -14.7700
            5   C1c C    22.7500  -17.5700
            6   O1a O    20.3000  -17.5700
            7   C8x C    20.3000  -13.3700
            8   C8x C    22.7500  -13.3700
            9   N1b N    23.9400  -16.9400
            10  C8y C    21.4900  -12.7400
            11  C5a C    25.1300  -17.6400
            12  N2b N    21.4900  -11.3400 #+
            13  C1c C    26.3200  -16.9400
            14  O5a O    25.1300  -18.9700
            15  O3a O    20.3000  -10.6400
            16  O3a O    22.6800  -10.6400 #-
            17  X   Cl   27.5100  -17.6400
            18  X   Cl   26.3200  -15.5400
            19  C1b C    22.7500  -19.0400
            20  O7a O    21.4900  -19.7400
            21  C7a C    21.4900  -21.1400
            22  O6a O    20.3000  -21.8400
            23  C1b C    22.7500  -21.8400
            24  C1b C    24.0100  -21.1400
            25  C6a C    25.2000  -21.8400
            26  O6a O    26.3900  -21.1400
            27  O6a O    25.2000  -23.3100
BOND        27
            1     5   9 1
            2     7  10 2
            3     9  11 1
            4    10  12 1
            5    11  13 1
            6    11  14 2
            7    12  15 2
            8    12  16 1
            9    13  17 1
            10   13  18 1
            11    8  10 1
            12    1   2 1
            13    1   3 2
            14    1   4 1
            15    2   5 1
            16    2   6 1 #Down
            17    3   7 1
            18    4   8 2
            19    5  19 1
            20   19  20 1
            21   20  21 1
            22   21  22 2
            23   21  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   25  27 2

» Japanese version   » Back

DBGET integrated database retrieval system