KEGG   DRUG: Fenfluramine
Entry
D07945                      Drug                                   
Name
Fenfluramine (INN);
Ponderax (TN)
Product
Formula
C12H16F3N
Exact mass
231.1235
Mol weight
231.2574
Structure
Simcomp
Class
Gastrointestinal agent
 DG01705  Anoretic
  DG01704  Phenethylamine anorexic
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02919  CYP2B6 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
Same as: C06996
ATC code: A08AA02 N03AX26
Chemical structure group: DG00103
Product (DG00103): D07945<US>
Efficacy
Appetite suppressant
Target
SLC6A4 (HTT) [HSA:6532] [KO:K05037]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]; CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA02 Fenfluramine
      D07945  Fenfluramine (INN) <US>
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX26 Fenfluramine
      D07945  Fenfluramine (INN) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Fenfluramine
    D07945  Fenfluramine (INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00103  Fenfluramine
     D07945  Fenfluramine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00103  Fenfluramine
    D07945  Fenfluramine
  DG02919  CYP2B6 substrate
   DG00103  Fenfluramine
    D07945  Fenfluramine
  DG01642  CYP2C9 substrate
   DG00103  Fenfluramine
    D07945  Fenfluramine
  DG01639  CYP2C19 substrate
   DG00103  Fenfluramine
    D07945  Fenfluramine
  DG01644  CYP2D6 substrate
   DG00103  Fenfluramine
    D07945  Fenfluramine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00103  Fenfluramine
     D07945  Fenfluramine
  DG02925  CYP3A5 substrate
   DG00103  Fenfluramine
    D07945  Fenfluramine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    HTR2
     D07945  Fenfluramine (INN) <US>
 Transporters
  Solute carrier family
   SLC6
    SLC6A4 (HTT)
     D07945  Fenfluramine (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07945
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00103  Fenfluramine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00103  Fenfluramine
  DG02919  CYP2B6 substrate
   DG00103  Fenfluramine
  DG01642  CYP2C9 substrate
   DG00103  Fenfluramine
  DG01639  CYP2C19 substrate
   DG00103  Fenfluramine
  DG01644  CYP2D6 substrate
   DG00103  Fenfluramine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00103  Fenfluramine
  DG02925  CYP3A5 substrate
   DG00103  Fenfluramine
Other DBs
CAS: 458-24-2
PubChem: 96024640
ChEBI: 5000
LigandBox: D07945
NIKKAJI: J5.760F
KCF data

ATOM        16
            1   C8y C    18.1300  -16.0300
            2   C8x C    16.8700  -15.3300
            3   C8x C    18.1300  -17.4300
            4   C1b C    19.3200  -15.3300
            5   C8y C    15.6100  -16.0300
            6   C8x C    16.8700  -18.1300
            7   C1c C    20.5800  -16.0300
            8   C8x C    15.6100  -17.4300
            9   C1d C    14.4200  -15.3300
            10  N1b N    21.7700  -15.3300
            11  C1a C    20.5800  -17.4300
            12  X   F    13.0900  -14.5600
            13  X   F    13.7900  -16.3800
            14  X   F    15.1900  -14.2100
            15  C1b C    23.0300  -16.0300
            16  C1a C    24.2200  -15.3300
BOND        16
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    7  11 1
            11    9  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1
            15   15  16 1
            16    6   8 1

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