KEGG   DRUG: Ezogabine
Entry
D09569                      Drug                                   

Name
Ezogabine (USAN);
Retigabine (INN);
Potiga (TN)
Formula
C16H18FN3O2
Exact mass
303.1383
Mol weight
303.3314
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02037  GABA mimetic antiepileptic
Transporter inhibitor
 DG01622  ABCB1 inhibitor
 DG02866  SLC22A8 inhibitor
Remark
Same as: C13826
ATC code: N03AX21
Efficacy
Antiepileptic
Comment
Adjunctive therapy for partial onset seizures
Target
  Pathway
hsa04725  Cholinergic synapse
Interaction
Transporter inhibition: SLC22A8 [HSA:9376], ABCB1 [HSA:5243]
Structure map
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX21 Retigabine
      D09569  Ezogabine (USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02037  GABA mimetic antiepileptic
    D09569  Ezogabine
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   D09569  Ezogabine
  DG02866  SLC22A8 inhibitor
   D09569  Ezogabine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNQ
     D09569  Ezogabine (USAN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09569
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09569
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09569
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D09569
Other DBs
CAS: 150812-12-7
PubChem: 124490309
ChEBI: 68584
ChEMBL: CHEMBL41355
PDB-CCD: FBX[PDBj]
LigandBox: D09569
KCF data

ATOM        22
            1   C8x C    17.0100  -26.2500
            2   C8y C    17.0100  -27.6500
            3   C8x C    18.2700  -28.3500
            4   C8x C    19.4600  -27.6500
            5   C8y C    19.4600  -26.2500
            6   C8x C    18.2700  -25.5500
            7   C1b C    20.6500  -25.5500
            8   N1b N    21.9100  -26.2500
            9   C8y C    23.1000  -25.5500
            10  C8x C    24.2900  -26.2500
            11  C8y C    25.5500  -25.5500
            12  C8y C    25.5500  -24.1500
            13  C8x C    24.2900  -23.4500
            14  C8x C    23.1000  -24.1500
            15  N1b N    26.7400  -23.4500
            16  C7a C    27.9300  -24.1500
            17  O7a O    29.1900  -23.4500
            18  C1b C    30.3800  -24.1500
            19  C1a C    31.5700  -23.4500
            20  O6a O    27.9300  -25.5500
            21  N1a N    26.7400  -26.2500
            22  X   F    15.8200  -28.3500
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   16  20 2
            22   11  21 1
            23    2  22 1

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