KEGG   DRUG: Solanezumab
Entry
D10058                      Drug                                   
Name
Solanezumab (USAN/INN);
Solanezumab (genetical recombination) (JAN)
Formula
C6396H9922N1712O1996S42
Exact mass
143993.5792
Mol weight
144082.2207
Sequence
(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAASGFTFS RYSMSWVRQA PGKGLELVAQ INSVGNSTYY
PDTVKGRFTI SRDNAKNTLY LQMNSLRAED TAVYYCASGD YWGQGTLVTV SSASTKGPSV
FPLAPSSKST SGGTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ SSGLYSLSSV
VTVPSSSLGT QTYICNVNHK PSNTKVDKKV EPKSCDKTHT CPPCPAPELL GGPSVFLFPP
KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV
LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL
TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC
SVMHEALHNH YTQKSLSLSP G
(Light chain)
DVVMTQSPLS LPVTLGQPAS ISCRSSQSLI YSDGNAYLHW FLQKPGQSPR LLIYKVSNRF
SGVPDRFSGS GSGTDFTLKI SRVEAEDVGV YYCSQSTHVP WTFGQGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H96, H139-H195, H215-L219, H221-H'221, H224-H'224, H256-H316, H362-H420, H'22-H'96, H'139-H'195, H'215-L'219, H'256-H'316, H'362-H'420, L23-L93, L139-L199, L'23-L'93, L'139-L'199)
  Type
Peptide
Class
Neuropsychiatric agent
 DG01968  Antidementia agent
Efficacy
Dementia therapeutic agent
Comment
Monoclonal antibody
Alzheimer's disease
Target
Amyloid beta [CPD:C16514 C16515]
Structure map
map07056  Agents for Alzheimer-type dementia
Brite
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01968  Antidementia agent
   D10058  Solanezumab
Other DBs
CAS: 955085-14-0
PubChem: 135626778

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