KEGG   DRUG: Bebtelovimab
Entry
D12174                      Drug                                   
Name
Bebtelovimab (USAN);
Bebtelovimab (TN)
Product
  Other
Formula
C6386H9950N1684O2009S42
Exact mass
143717.6461
Mol weight
143806.1406
Sequence
(Heavy chain)
QITLKESGPT LVKPTQTLTL TCTFSGFSLS ISGVGVGWLR QPPGKALEWL ALIYWDDDKR
YSPSLKSRLT ISKDTSKNQV VLKMTNIDPV DTATYYCAHH SISTIFDHWG QGTLVTVSSA
STKGPSVFPL APSSKSTSGG TAALGCLVKD YFPEPVTVSW NSGALTSGVH TFPAVLQSSG
LYSLSSVVTV PSSSLGTQTY ICNVNHKPSN TKVDKRVEPK SCDKTHTCPP CPAPELLGGP
SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS
TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM
TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ
QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
(Light chain)
QSALTQPASV SGSPGQSITI SCTATSSDVG DYNYVSWYQQ HPGKAPKLMI FEVSDRPSGI
SNRFSGSKSG NTASLTISGL QAEDEADYYC SSYTTSSAVF GGGTKLTVLG QPKAAPSVTL
FPPSSEELQA NKATLVCLIS DFYPGAVTVA WKADSSPVKA GVETTTPSKQ SNNKYAASSY
LSLTPEQWKS HRSYSCQVTH EGSTVEKTVA PTECS
(Disulfide bridge: H22-H97, H146-H202, H222-L214, H228-H'228, H231-H'231, H263-H323, H369-H427, H'22-H'97, H'146-H'202, H'222-L'214, H'263-H'323, H'369-H'427, L22-L90, L137-L196, L'22-L'90, L'137-L'196)
  Type
Peptide
Class
Antiviral
 DG03174  Anti-SARS-CoV-2 agent
Remark
Product: D12174<US>
Efficacy
Antiviral
  Disease
Coronavirus disease 2019 [DS:H02398]
Comment
Monoclonal antibody
Treatment of SARS-CoV-2 infection
Target
SARS-CoV-2 spike glycoprotein [KO:K24152]
  Pathway
ko03230  Viral genome structure
ko05171  Coronavirus disease - COVID-19
Brite
Drug groups [BR:br08330]
 Antiviral
  DG03174  Anti-SARS-CoV-2 agent
   D12174  Bebtelovimab
Drug classes [BR:br08332]
 Antiviral
  DG03174  Anti-SARS-CoV-2 agent
   D12174  Bebtelovimab
Antimicrobials [BR:br08307]
 Antivirals
  Entry, fusion or uncoating inhibitor
   Coronavirus spike protein
    D12174  Bebtelovimab (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12174
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12174
Other DBs
CAS: 2578319-11-4

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