KEGG   DRUG: Nirmatrelvir and ritonavir
Entry
D12269            Mixture   Drug                                   
Name
Nirmatrelvir and ritonavir;
Paxlovid (TN)
Product
  Other
Component
Nirmatrelvir [DR:D12244], Ritonavir [DR:D00427]
Class
Antiviral
 DG03174  Anti-SARS-CoV-2 agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Remark
Therapeutic category: 6250
Product: D12269<JP/US>
Efficacy
Antiviral
  Disease
Coronavirus disease 2019 [DS:H02398]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551]
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D12269  Nirmatrelvir and ritonavir
Drug groups [BR:br08330]
 Antiviral
  DG03174  Anti-SARS-CoV-2 agent
   D12269  Nirmatrelvir and ritonavir
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D12269  Nirmatrelvir and ritonavir
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   D12269  Nirmatrelvir and ritonavir
Drug classes [BR:br08332]
 Antiviral
  DG03174  Anti-SARS-CoV-2 agent
   D12269  Nirmatrelvir and ritonavir
Antimicrobials [BR:br08307]
 Antivirals
  Polyprotein cleavage inhibitor
   SARS-CoV 3C protease inhibitor
    D12269  Nirmatrelvir and ritonavir <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D12269
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D12269
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D12269
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D12269
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D12269
Other DBs
ChEBI: 192712

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