KEGG   DRUG: Crexavibart
Entry
D12322                      Drug                                   
Name
Crexavibart (USAN)
Formula
C6490H9992N1728O2064S42
Exact mass
146503.8304
Mol weight
146593.8487
Sequence
(Heavy chain)
EVQLVESGGG LIQPGGSLRL SCAASGFTVS NNYMSWVRQA PGKGLEWVSV IYSGGSTYYA
DSVKGRFTIS RDKSKNTLYL QMNSLRAEDT AVYYCAREGE VEGYNDFWSG YSRDRYYFDY
WGQGTLVTVS SASTKGPSVF PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG
VHTFPAVLQS SGLYSLSSVV TVPSSSLGTQ TYICNVNHKP SNTKVDKRVE PKSCDKTHTC
PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN
AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP
QVYTLPPSRE EMTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL
YSKLTVDKSR WQQGNVFSCS VLHEALHSHY TQKSLSLSPG
(Light chain)
QSALTQPASV SGSPGQSITI SCTGTSSDVG GYNYVSWYQQ HPGKAPKLMI YDVSNRPSGV
SNRFSGSKSG NTASLTISGL QAEDEADYYC SSYTSSSTRV FGTGTKVTVL GQPKAAPSVT
LFPPSSEELQ ANKATLVCLI SDFYPGAVTV WKADSSPVK AGVETTTPSK QSNNKYAASS
YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS
(Disulfide bridge: H22-H95, H158-H214, H234-L215, H240-H'240, H243-H'243, H275-H335, H381-H439, H'22-H'95, H'158-H'214, H'234-L'215, H'275-H'335, H'381-H'439, L22-L90, L138-L197, L'22-L'90, L'138-L'197)
  Type
Peptide
Class
Antiviral
 DG03174  Anti-SARS-CoV-2 agent
Efficacy
Antiviral
Comment
Monoclonal antibody
Treatment of SARS-CoV-2 infection
Target
SARS-CoV-2 spike glycoprotein [KO:K24152]
  Pathway
ko03230  Viral genome structure
ko05171  Coronavirus disease - COVID-19
Brite
Drug groups [BR:br08330]
 Antiviral
  DG03174  Anti-SARS-CoV-2 agent
   D12322  Crexavibart
Antimicrobials [BR:br08307]
 Antivirals
  Entry, fusion or uncoating inhibitor
   Coronavirus spike protein
    D12322  Crexavibart (USAN)
Other DBs
CAS: 2599039-61-7

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