Entry
Name
ADP-D-ribose pyrophosphorylase;
NUDIX5;
NUDT5 (gene name);
diphosphate---ADP-D-ribose adenylyltransferase;
diphosphate adenylyltransferase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
ATP:D-ribose 5-phosphate adenylyltransferase
Reaction(IUBMB)
ATP + D-ribose 5-phosphate = diphosphate + ADP-D-ribose [RN:
R11553 ]
Reaction(KEGG)
Substrate
Product
Comment
The human enzyme produces ATP in nuclei in situations of high energy demand, such as chromatin remodeling. The reaction is dependent on the presence of diphosphate. In its absence the enzyme catalyses the reaction of EC
3.6.1.13 , ADP-ribose diphosphatase. cf. EC
2.7.7.35 , ADP ribose phosphorylase.
History
EC 2.7.7.96 created 2016
Orthology
K13987 ADP-ribose diphosphatase / 8-oxo-dGDP phosphatase / ADP-D-ribose pyrophosphorylase
Genes
PON : 100172071(NUDT5) 129059921
PPYG : 129006410(NUDT5) 134739718
ANAN : 105710906(NUDT5) 105713501
UMR : 103673192 103676270(NUDT5)
UAH : 113241068(NUDT5) 113242298
UAR : 123789983(NUDT5) 123800652
BMUS : 118891284(NUDT5) 118899461
MMF : 118615257(NUDT5) 118632073
PPAM : 129079686 129086846(NUDT5)
RFQ : 117012780 117019138(NUDT5)
PBRV : 138175839(NUDT5) 138175990
XLA : 108713048(nudt5.S) 432263(nudt5.L)
SANH : 107656337 107658859
SGH : 107580386 107584018(nudt5)
CCAR : 109054944 109066493(nudt5)
SASA : 100196024(nudt5) 106609278(NUDT5)
STRU : 115180241 115198845
OTW : 112215017 112216934(nudt5)
OKE : 118366282 118392403(nudt5)
OCLA : 139378632 139392597
SALP : 111949778 111951434
SFON : 129838360 129865201
CCLU : 121543580 121559076
ARUT : 117415728 117419430
LVG : 121411927 121412156 121412157
SDM : 118202731(LOC118202731)
CANU : 128161679 128161685
MAEA : 128217507 128226666
ACAN : ACA1_131000 ACA1_177470
» show all
Taxonomy
Reference
Authors
Wright RH, Lioutas A, Le Dily F, Soronellas D, Pohl A, Bonet J, Nacht AS, Samino S, Font-Mateu J, Vicent GP, Wierer M, Trabado MA, Schelhorn C, Carolis C, Macias MJ, Yanes O, Oliva B, Beato M
Title
ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.96
ExPASy - ENZYME nomenclature database: 2.7.7.96